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Distinct Regions of Prefrontal Cortex Mediate Resistance and Vulnerability to Depression
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The neuroanatomical correlates of depression remain unclear. Functional imaging data have associated depression with abnormal patterns of activity in prefrontal cortex (PFC), including the ventromedial (vmPFC) and dorsolateral (dlPFC) sectors. If vmPFC and dlPFC are critical neural substrates for the pathogenesis of depression, then damage to either area should affect the expression of depressive symptoms. Using patients with brain lesions we show that, relative to nonfrontal lesions, bilateral vmPFC lesions are associated with markedly low levels of depression, whereas bilateral dorsal PFC lesions (involving dorsomedial and dorsolateral areas in both hemispheres) are associated with substantially higher levels of depression. These findings demonstrate that vmPFC and dorsal PFC are critically and causally involved in depression, although with very different roles: vmPFC damage confers resistance to depression, whereas dorsal PFC damage confers vulnerability.
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“damage to VMPFC is associated with low levels of depression, and damage to DLPFC is associated with high levels of depression 206.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [206]
In the citing paper
“damage to VMPFC is associated with low levels of depression, and damage to DLPFC is associated with high levels of depression 206.”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [206]
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“By virtue of its well-established capacity for regulating mood, attention, memory, and action34, 54-56”
From Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety (2014) · cites this paper as [56]
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319
Beck, A. T., Steer, R. A., & Brown, G. (2011) · PsycTESTS Dataset · doi:10.1037/t00742-000 · Cited by 7,535
Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications
Clark, L. A., & Watson, D. (1991) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.100.3.316 · Cited by 4,601
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199403000-00005 · Cited by 3,431 · cited 1×
“The CT image of each brain was spatially normalized to a CT template brain image in MNI space (Collins et al., 1994).”
MethodRethinking feelings: an fMRI study of the cognitive regulation of emotion
Ochsner, K. N., Bunge, S. A., Gross, J. J., & Gabrieli, J. D. E. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760807212 · Cited by 2,520
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214
Ochsner, K. N., Ray, R. D., Cooper, J. C., Robertson, E. R., Chopra, S., Gabrieli, J. D. E., & Gross, J. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.030 · Cited by 2,113
Research works printed but not linked: 2
- Damasio H Damasio AR (1989) Lesion analysis in neurospychology (Oxford UP, New York).
- First MB Spitzer RL Gibbon M Williams JBW (2002) Structured clinical interview for DSM-IV-TR axis I disorders, research version (Biometrics Research, New York State Psychiatric Institute, (SCID-I/P) New York) patient edition.
Cited by
Sorted by citations
Fox, M. D., Buckner, R. L., White, M. P., Greicius, M. D., & Pascual-Leone, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.028 · Cited by 1,270
Hiser, J., & Koenigs, M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.030 · Cited by 972
Self-citationKoenigs, M., & Grafman, J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.004 · Cited by 956
Self-citationEmotion and the prefrontal cortex: an integrative review
Dixon, M. L., Thiruchselvam, R., Todd, R., & Christoff, K. (2017) · Psychological Bulletin · doi:10.1037/bul0000096 · Cited by 745
Targeted electrode-based modulation of neural circuits for depression.
Mayberg, H. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38454 · Cited by 542
Neural correlates of rumination in depression
Cooney, R. E., Joormann, J., Eugène, F., Dennis, E. L., & Gotlib, I. H. (2010) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.10.4.470 · Cited by 493
Ventromedial Prefrontal Cortex Is Critical for the Regulation of Amygdala Activity in Humans
Motzkin, J. C., Philippi, C. L., Wolf, R. C., Baskaya, M. K., & Koenigs, M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.014 · Cited by 454
Self-citationExploring the convergence of posttraumatic stress disorder and mild traumatic brain injury
Stein, M. B., & McAllister, T. W. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08101604 · Cited by 391
Okon-Singer, H., Hendler, T., Pessoa, L., & Shackman, A. J. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00058 · Cited by 371
Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders
Myers-Schulz, B., & Koenigs, M. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.88 · Cited by 333
Self-citationDownar, J. H., Geraci, J., Salomons, T. V., Dunlop, K., Wheeler, S. M., McAndrews, M. P., Bakker, N., Blumberger, D. M., Daskalakis, Z. J., Kennedy, S. H., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.026 · Cited by 362
Fettes, P., Schulze, L., & Downar, J. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00025 · Cited by 299
Yan, Z., & Rein, B. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01092-3 · Cited by 300
“While both DLPFC and VMPFC are involved in MDD, they play different roles: damage to VMPFC is associated with low levels of depression, and damage to DLPFC is associated with high levels of depression [206].”
BackgroundAcute and sustained effects of cognitive emotion regulation in major depression
Erk, S., Mikschl, A., Stier, S., Ciaramidaro, A., Gapp, V., Weber, B., & Walter, H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1856-10.2010 · Cited by 313
Posttraumatic stress disorder: the role of medial prefrontal cortex and amygdala.
Koenigs, M., & Grafman, J. (2009) · The Neuroscientist · doi:10.1177/1073858409333072 · Cited by 368
Self-citationFTD and ALS: A Tale of Two Diseases
Ferrari, R., Kapogiannis, D., Huey, E. D., & Momeni, P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795563700 · Cited by 285
Self-citationNew targets for rTMS in depression: A review of convergent evidence
Downar, J., & Daskalakis, Z. J. (2013) · Brain Stimulation · doi:10.1016/j.brs.2012.08.006 · Cited by 257
A Human Depression Circuit Derived From Focal Brain Lesions
Padmanabhan, J. L., Cooke, D. L., Joutsa, J., Siddiqi, S., Ferguson, M., Darby, R. R., Soussand, L., Horn, A., Kim, N. Y., Voss, J. L., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.023 · Cited by 251
Self-citationMitchell, D. G. V. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.030 · Cited by 234
Yoshimura, S., Okamoto, Y., Onoda, K., Matsunaga, M., Ueda, K., Suzuki, S.-I., & ShigetoYamawaki (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.06.017 · Cited by 206
Impact of early adversity on glucocorticoid regulation and later mental disorders
Strüber, N., Strüber, D., & Roth, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.015 · Cited by 173
Tata, D. A., & Anderson, B. J. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.09.008 · Cited by 173
“Like the hippocampus, the frontal lobe dysfunction has been implicated in depression [29-31] and the frontal lobe, like the hippocampus undergoes structural modification in response to glucocorticoids and stress [32-35].”
BackgroundEconomic decision-making in psychopathy: A comparison with ventromedial prefrontal lesion patients
Koenigs, M. R., Kruepke, M., & Newman, J. P. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.04.012 · Cited by 184
Self-citationMcCormick, C., Ciaramelli, E., Luca, F. D., & Maguire, E. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.066 · Cited by 174
Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety
Birn, R. M., Shackman, A. J., Oler, J. A., Williams, L. E., McFarlin, D. R., Rogers, G. M., Shelton, S. E., Alexander, A. L., Pine, D. S., Slattery, M. J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.46 · Cited by 159
The future is here: A review of foresight systems in anxiety and depression
Miloyan, B., Pachana, N. A., & Suddendorf, T. (2014) · Cognition and Emotion · doi:10.1080/02699931.2013.863179 · Cited by 160
The Neurobiological Role of the Dorsolateral Prefrontal Cortex in Recovery From Trauma
Lyoo, I. K., Kim, J. E., Yoon, S. J., Hwang, J., Bae, S., & Kim, D. J. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.70 · Cited by 160
Fotopoulou, A., Pernigo, S., Maeda, R., Rudd, A., & Kopelman, M. (2010) · Brain : a journal of neurology · doi:10.1093/brain/awq233 · Cited by 126
Human lesion studies of ventromedial prefrontal cortex
Schneider, B., & Koenigs, M. R. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.09.035 · Cited by 162
Self-citationThe role of prefrontal cortex in psychopathy
Koenigs, M. R. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0036 · Cited by 160
Self-citation“Studying Injured Minds” – The Vietnam Head Injury Study and 40 Years of Brain Injury Research
Raymont, V., Salazar, A. Μ., Krüeger, F., & Grafman, J. H. (2011) · Frontiers in Neurology · doi:10.3389/fneur.2011.00015 · Cited by 157
Self-citationVoineskos, D., Blumberger, D. M., Zomorrodi, R., Rogasch, N. C., Farzan, F., Foussias, G., Rajji, T. K., & Daskalakis, Z. J. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.032 · Cited by 141
McLaughlin, R. J., Hill, M. N., & Gorzalka, B. B. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.006 · Cited by 142
Depression Following Traumatic Brain Injury: Epidemiology, Risk Factors and Management
Rapoport, M. J. (2012) · CNS Drugs · doi:10.2165/11599560-000000000-00000 · Cited by 125
Deletion of Glutamate Delta-1 Receptor in Mouse Leads to Aberrant Emotional and Social Behaviors
Yadav, R., Gupta, S. C., Hillman, B. G., Bhatt, J. M., Stairs, D. J., & Dravid, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032969 · Cited by 129
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Wang, M., Perova, Z., Arenkiel, B. R., & Li, B. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5294-13.2014 · Cited by 116
Edwards, S., Baynes, B. B., Carmichael, C. Y., Zamora-Martinez, E. R., Barrus, M. M., Koob, G. F., & Gilpin, N. W. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.70 · Cited by 120
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Self-citationDamage to the left ventromedial prefrontal cortex impacts affective theory of mind
Leopold, A., Krüeger, F., Monte, O. D., Pardini, M., Pulaski, S. J., Solomon, J. M., & Grafman, J. H. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr071 · Cited by 117
Self-citationGreening, S. G., Osuch, E. A., Williamson, P. C., & Mitchell, D. G. V. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst027 · Cited by 99
Clinical Considerations for the Diagnosis of Major Depression After Moderate to Severe TBI
Seel, R. T., Macciocchi, S. N., & Kreutzer, J. S. (2010) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e3181ce3966 · Cited by 104
Philippi, C. L., Motzkin, J. C., Pujara, M. S., & Koenigs, M. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.10.005 · Cited by 93
Self-citationQi, X., Kamphuis, W., Wang, S., Wang, Q., Lucassen, P. J., Zhou, J., & Swaab, D. F. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.09.014 · Cited by 100
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Manoochehri, M., & Huey, E. D. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0302-7 · Cited by 101
Self-citationTrapp, N. T., Purgianto, A., Taylor, J. J., Singh, M. K., Oberman, L. M., Mickey, B. J., Youssef, N. A., Solzbacher, D., Zebley, B., Cabrera, L. Y., et al. (2025) · Clinical Neurophysiology · doi:10.1016/j.clinph.2024.12.015 · Cited by 89
The neuropsychology of self-reflection in psychiatric illness
Philippi, C. L., & Koenigs, M. R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.03.004 · Cited by 100
Self-citationPrefrontal cortical regulation of REM sleep
Hong, J., Lozano, D. E., Beier, K. T., Chung, S., & Weber, F. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01398-1 · Cited by 83
Zhou, F., Geng, Y., Xin, F., Li, J., Feng, P., Liu, C., Zhao, W., Feng, T., Guastella, A. J., Ebstein, R. P., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.007 · Cited by 70
Yang, X., Peng, Z., Ma, X., Meng, Y., Li, M., Zhang, J., Song, X., Liu, Y., Fan, H., Zhao, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02828-4 · Cited by 72
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Falquez, R., Couto, B., Ibáñez, A. M., Freitag, M. T., Berger, M. C., Arens, E. A., Lang, S., & Barnow, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00165 · Cited by 76
Classifying Major Depressive Disorder Using fNIRS During Motor Rehabilitation
Zhu, Y., Jayagopal, J. K., Mehta, R. K., Erraguntla, M., Nuamah, J. K., McDonald, A. D., Taylor, H. B., & Chang, S. (2020) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2020.2972270 · Cited by 72
Noda, Y., Zomorrodi, R., Vila‐Rodriguez, F., Downar, J. H., Farzan, F., Cash, R. F. H., Rajji, T. K., Daskalakis, Z. J., & Blumberger, D. M. (2018) · Depression and Anxiety · doi:10.1002/da.22738 · Cited by 69
Downar, J., Sankar, A., Giacobbe, P., Woodside, B., & Colton, P. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00030 · Cited by 74
Chung, J. K., Initiative, A. D. N., Plitman, E., Nakajima, S., Chow, T. W., Chakravarty, M. M., Caravaggio, F., Gerretsen, P., Brown, E. E., Iwata, Y., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142931 · Cited by 70
The predator odor avoidance model of post-traumatic stress disorder in rats
Albrechet‐Souza, L., & Gilpin, N. W. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000460 · Cited by 69
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Manohar, S. G., & Husain, M. (2016) · Cortex · doi:10.1016/j.cortex.2016.01.005 · Cited by 62
Horato, N., Quagliato, L. A., & Nardi, A. E. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01927-9 · Cited by 62
Zhu, W., Wang, S., Liu, M.-M., Shi, H., Zhang, R., Liu, J., Ding, Z., & Lü, L. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120228 · Cited by 64
Large-scale lesion symptom mapping of depression identifies brain regions for risk and resilience
Trapp, N. T., Bruss, J., Manzel, K. W., Grafman, J. H., Tranel, D., & Boes, A. D. (2022) · Brain · doi:10.1093/brain/awac361 · Cited by 66
Self-citationScopinho, A. A., Scopinho, M., Lisboa, S. F. D. S., Corrêa, F. M. D. A., Guimarães, F. S., & Joca, S. R. L. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.06.018 · Cited by 62
Grajny, K., Pyata, H., Katherine, S., Lacey, E. H., Xing, S., Brophy, C. M., & Turkeltaub, P. E. (2016) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.16010004 · Cited by 58
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Wang, J., Tambini, A., & Lapate, R. C. (2022) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2022.09.005 · Cited by 60
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Feinstein, J. S. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.12.007 · Cited by 56
Management of frontotemporal dementia in mental health and multidisciplinary settings
Wylie, M. A., Shnall, A., Onyike, C. U., & Huey, E. D. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.776949 · Cited by 58
Self-citationVentromedial prefrontal cortex modulates fatigue after penetrating traumatic brain injury
Pardini, M., Krüeger, F., Raymont, V., & Grafman, J. H. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d25b6b · Cited by 57
Self-citationImpaired social decision making in patients with major depressive disorder
Wang, Y., Zhou, Y., Li, S., Wang, P., Wu, G.-W., & Liu, Z.-N. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-18 · Cited by 53
Mechanisms of Reward Circuit Dysfunction in Psychiatric Illness
Pujara, M. S., & Koenigs, M. R. (2013) · The Neuroscientist · doi:10.1177/1073858413499407 · Cited by 51
Self-citationMotzkin, J. C., Philippi, C. L., Oler, J. A., Kalin, N. H., Başkaya, M. K., & Koenigs, M. R. (2014) · Cortex · doi:10.1016/j.cortex.2014.11.013 · Cited by 50
Self-citationPrecise Modulation Strategies for Transcranial Magnetic Stimulation: Advances and Future Directions
Zhong, G., Yang, Z., & Jiang, T. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00781-x · Cited by 52
Scult, M. A., Knodt, A. R., Swartz, J. R., Brigidi, B. D., & Hariri, A. R. (2016) · Clinical Psychological Science · doi:10.1177/2167702616654688 · Cited by 49
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Baeken, C., Wu, G., & van Heeringen, K. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0377-x · Cited by 46
Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy
Butler, T., Blackmon, K., McDonald, C. R., Carlson, C., Barr, W., Devinsky, O., Kuzniecky, R., DuBois, J. M., French, J. A., Halgren, E., et al. (2011) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2011.10.001 · Cited by 45
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Lyoo, I. K., Yoon, S. J., Jacobson, A. M., Hwang, J., Musen, G., Kim, J. E., Simonson, D. C., Bae, S., Bolo, N. R., Kim, D. J., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.543 · Cited by 43
Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder
Zhong, J., Li, S., Zeng, W., Li, X., Gu, C., Liu, J., & Luo, X. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0345-4 · Cited by 46
Neural correlates of social exchanges during the Prisoner’s Dilemma game in depression
Gradin, V. B., Pérez, A., Macfarlane, J. A., Cavin, I., Waiter, G., Tone, E. B., Dritschel, B., Maiche, A., & Steele, J. D. (2016) · Psychological Medicine · doi:10.1017/s0033291715002834 · Cited by 41
Unschuld, P. G., Joel, S. E., Pekar, J. J., Reading, S. A. J., Oishi, K., McEntee, J., Shanahan, M. R., Bakker, A., Margolis, R. L., Bassett, S. S., et al. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.01.002 · Cited by 44
Schulze, L., Wheeler, S. M., McAndrews, M. P., Solomon, C. J., Giacobbe, P., & Downar, J. H. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.04.004 · Cited by 46
Ploski, J. E., & Vaidya, V. A. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.009 · Cited by 46
Reward responsiveness and fatigue in multiple sclerosis
Pardini, M., Capello, E., Krüeger, F., Mancardi, G., & Uccelli, A. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458512451509 · Cited by 42
Song, Z., Zhang, M., & Huang, P. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.81 · Cited by 41
Naghibi, S., Joneydi, M. S., Barzegari, A., Davoodabadi, A., Ebrahimi, A., Eghdami, E., Fahimpour, N., Ghorbani, M., Mohammadikia, E., Rostami, M., et al. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113595 · Cited by 40
Steffens, D. C., Wang, L., Manning, K. J., & Pearlson, G. D. (2017) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.03.017 · Cited by 40
Genetic Polymorphisms Influence Recovery from Traumatic Brain Injury
Weaver, S. M., Chau, A., Tremont, J. N. P., & Grafman, J. H. (2012) · The Neuroscientist · doi:10.1177/1073858411435706 · Cited by 40
Self-citationLeWinn, K. Z., Strigo, I. A., Connolly, C. G., Ho, T. C., Tymofiyeva, O., Sacchet, M. D., Weng, H. Y., Blom, E. H., Simmons, A. N., & Yang, T. T. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.020 · Cited by 38
Biological substrates of addiction
Joffe, M. E., Grueter, C. A., & Grueter, B. A. (2014) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1273 · Cited by 42
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Metadata
- Authors
- Koenigs, M., Huey, E. D., Calamia, M., Raymont, V., Tranel, D., & Grafman, J.
- Affiliations
- University of Wisconsin–Madison (US)
- National Institutes of Health (US)
- University of Iowa (US)
- Henry M. Jackson Foundation (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-11-19
- Volume
- 28
- Issue
- 47
- Pages
- 12341-12348
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2644261
- OpenAlex
- W2128478192
- Cited by
- 243
- References
- 58
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 13 · 2023: 11 · 2022: 15 · 2021: 11 · 2020: 17 · 2019: 16 · 2018: 6 · 2017: 19 · 2016: 13 · 2015: 13 · 2014: 18 · 2013: 18 · 2012: 17
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Civil War Book Review (submittedVersion)
- Funders
- National Institutes of Health (Z99 NS999999)
- National Institute on Drug Abuse (R01DA022549)
- National Institute of Neurological Disorders and Stroke (P01 NS19632, P01NS019632, NS-19632, Z01NS002792)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- depression, prefrontal cortex, ventromedial prefrontal cortex, dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, brain lesions, lesion studies, depression vulnerability
- MeSH terms
- Adult, Brain Injuries, Brain Mapping, Cognition Disorders, Depression, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Movement Disorders, Severity of Illness Index, Tomography, X-Ray Computed, Veterans, Prefrontal Cortex
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