The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Complementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems
Open accessAbstract
To sense myriad environmental odors, animals have evolved multiple, large families of divergent olfactory receptors. How and why distinct receptor repertoires and their associated circuits are functionally and anatomically integrated is essentially unknown. We have addressed these questions through comprehensive comparative analysis of the Drosophila olfactory subsystems that express the ionotropic receptors (IRs) and odorant receptors (ORs). We identify ligands for most IR neuron classes, revealing their specificity for select amines and acids, which complements the broader tuning of ORs for esters and alcohols. IR and OR sensory neurons exhibit glomerular convergence in segregated, although interconnected, zones of the primary olfactory center, but these circuits are extensively interdigitated in higher brain regions. Consistently, behavioral responses to odors arise from an interplay between IR- and OR-dependent pathways. We integrate knowledge on the different phylogenetic and developmental properties of these receptors and circuits to propose models for the functional contributions and evolution of these distinct olfactory subsystems.
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Yu, J. Y., Kanai, M. I., Demir, E., Jefferis, G. S. X. E., & Dickson, B. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.08.025 · Cited by 349
Self-citationSexual Dimorphism in the Fly Brain
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Liu, C., Pitts, R. J., Bohbot, J. D., Jones, P. L., Wang, G., & Zwiebel, L. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000467 · Cited by 154
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Metadata
- Authors
- Silbering, A. F., Rytz, R., Grosjean, Y., Abuin, L., Ramdya, P., Jefferis, G. S. X. E., & Benton, R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-09-21
- Volume
- 31
- Issue
- 38
- Pages
- 13357-13375
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1979639373
- Cited by
- 499
- References
- 5
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Silbering, A. F., Rytz, R., Grosjean, Y., Abuin, L., Ramdya, P., Jefferis, G. S. X. E., & Benton, R. (2011). Complementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2360-11.2011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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