The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury
Open accessAbstract
Acute brain lesions induce profound alterations of the peripheral immune response comprising the opposing phenomena of early immune activation and subsequent immunosuppression. The mechanisms underlying this brain-immune signaling are largely unknown. We used animal models for experimental brain ischemia as a paradigm of acute brain lesions and additionally investigated a large cohort of stroke patients. We investigated the inflammatory potency of HMGB1 and its signaling pathways by immunological in vivo and in vitro techniques. Features of the complex behavioral sickness behavior syndrome were characterized by homecage behavior analysis. HMGB1 downstream signaling, particularly with RAGE, was studied in various transgenic animal models and by pharmacological blockade. Our results indicate that HMGB1 was released from the ischemic brain in the hyperacute phase of stroke in mice and patients. Cytokines secreted in the periphery in response to brain injury induced sickness behavior, which could be abrogated by inhibition of the HMGB1-RAGE pathway or direct cytokine neutralization. Subsequently, HMGB1-release induced bone marrow egress and splenic proliferation of bone marrow-derived suppressor cells, inhibiting the adaptive immune responses in vivo and vitro. Furthermore, HMGB1-RAGE signaling resulted in functional exhaustion of mature monocytes and lymphopenia, the hallmarks of immune suppression after extensive ischemia. This study introduces the HMGB1-RAGE-mediated pathway as a key mechanism explaining the complex postischemic brain-immune interactions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This concept originally references peripheral immune processes, such as sterile injury, but similar processes have been observed in the CNS, including ischemia (Liesz et al, 2015), and recently, psychological stress.”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Liesz et al, 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Antoine, D. J., Jenkins, R. E., Dear, J. W., Williams, D. P., McGill, M. R., Sharpe, M. R., Craig, D. G. N., Simpson, K. J., Jaeschke, H., & Park, B. K. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.019 · Cited by 307
RetractedFrom inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000412 · Cited by 7,300
Myeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753
Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research
Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.72351 · Cited by 6,277
Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,263
Bederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681
The immunology of stroke: from mechanisms to translation
Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490
Self-citationTargeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358
Research works printed but not linked: 1
- 10.1177/09680519050110050901 · DOI
Cited by
Sorted by citations
Items 101–200 of 332
Amiri, S., Yousefi‐Ahmadipour, A., Hosseini, M., Haj‐Mirzaian, A., Momeny, M., Hosseini-Chegeni, H., Mokhtari, T., Kharrazi, S., Hassanzadeh, G., Amini, S. M., et al. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.03.006 · Cited by 50
Microglia Polarization: A Novel Target of Exosome for Stroke Treatment
Wan, T., Huang, Y., Gao, X., Wu, W., & Guo, W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.842320 · Cited by 50
Song, Q., Pan, R., Jin, Y., Wang, Y., Cheng, Y., Liu, J., Wu, B., & Liu, M. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04355-z · Cited by 50
Roles of HMGB1 in regulating myeloid-derived suppressor cells in the tumor microenvironment
Jin, S., Yang, Z., Hao, X., Tang, W., Ma, W., & Zong, H. (2020) · Biomarker Research · doi:10.1186/s40364-020-00201-8 · Cited by 50
Molecular insights into the therapeutic promise of targeting HMGB1 in depression
Rana, T., Behl, T., Mehta, V., Uddin, M. S., & BUNGAU, S. G. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00163-6 · Cited by 49
Zhang, Y., Miao, L., Peng, Q., Fan, X., Song, W., Yang, B., Zhang, P., Liu, G., & Liu, J. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154373 · Cited by 49
Dong, Y., Guo, R., Ji, J., Cao, L., Zhang, L., Chen, Z., Huang, J., Wu, J., Lu, J. L., & Sun, X. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13596 · Cited by 47
Vieyra-Garcia, P. A., & Wolf, P. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00232 · Cited by 47
Henry, N., Frank, J. A., McLouth, C. J., Trout, A. L., Morris, A. J., Chen, J., Stowe, A. M., Fraser, J. F., & Pennypacker, K. R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.797302 · Cited by 49
Neurogenic cardiac outcome in patients after acute ischemic stroke: The brain and heart connection
Min, J., Young, G., Umar, A., Kampfschulte, A., Ahrar, A., Miller, M., Khan, N. I., Wees, N., Chalfoun, N. T., & Khan, M. (2022) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2022.106859 · Cited by 47
Wang, Y., Chen, Y., Meng, L., Wu, B.-F., OuYang, L., Peng, R., Hou, D., Liu, S., Lu, S.-F., Jing, X., et al. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114324 · Cited by 46
The Roles of High Mobility Group Box 1 in Cerebral Ischemic Injury
Gou, X., Ying, J., Yue, Y., Qiu, X., Hu, P., Qu, Y., Li, J., & Mu, D. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.600280 · Cited by 46
The immunopathology of B lymphocytes during stroke-induced injury and repair
Malone, M. K., Ujas, T. A., Britsch, D. R. S., Cotter, K. M., Poinsatte, K., & Stowe, A. M. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00971-3 · Cited by 45
Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice
Bellut, M., Bieber, M., Kraft, P., Weber, A. N. R., Stoll, G., & Schuhmann, M. K. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02674-w · Cited by 48
Zhang, M., Guo, B., Zhang, X., Han, D., Lv, L., Yan, X., Su, C., Chai, D., Zhao, N., Yan, X., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03492-6 · Cited by 46
Gelderblom, M., Sobey, C. G., Kleinschnitz, C., & Magnus, T. U. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.07.004 · Cited by 44
The role of circulating cell-free DNA as an inflammatory mediator after stroke
Roth, S., Wernsdorf, S. R., & Liesz, A. (2023) · Seminars in Immunopathology · doi:10.1007/s00281-023-00993-5 · Cited by 44
Self-citationA comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
Owjfard, M., Rahimian, Z., Karimi, F., Borhani‐Haghighi, A., & Mallahzadeh, A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34121 · Cited by 44
Cross, K., Vetter, S. W., Alam, Y., Hasan, M. Z., Nath, A. D., & Leclerc, E. (2024) · Biomolecules · doi:10.3390/biom14121550 · Cited by 45
Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke
Jickling, G. C., Ander, B. P., Shroff, N., Orantia, M., Stamova, B. S., Dykstra-Aiello, C., Hull, H., Zhan, X., Liu, D., & Sharp, F. R. (2016) · Neurology · doi:10.1212/wnl.0000000000003354 · Cited by 43
Kowalska, K., Klimiec, E., Węglarczyk, K., Pera, J., Słowik, A., Siedlar, M., & Dziedzic, T. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1156-y · Cited by 42
Giede-Jeppe, A., Bobinger, T., Gerner, S. T., Madžar, D., Sembill, J. A., Lücking, H., Kloska, S. P., Keil, T., Kuramatsu, J. B., & Huttner, H. B. (2016) · Stroke · doi:10.1161/strokeaha.116.013003 · Cited by 42
Hazeldine, J., Lord, J. M., & Hampson, P. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.10.003 · Cited by 41
Giede-Jeppe, A., Madžar, D., Sembill, J. A., Sprügel, M. I., Atay, S., Hoelter, P., Lücking, H., Huttner, H. B., & Bobinger, T. (2019) · Neurocritical Care · doi:10.1007/s12028-019-00859-5 · Cited by 41
Gill, D., Sivakumaran, P., Aravind, A., Tank, A., Dosh, R., & Veltkamp, R. C. (2017) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2017.08.023 · Cited by 40
Self-citationComplex interplay of multiple biological systems that contribute to post-stroke infections
Shim, R., & Wong, C. H. Y. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.03.019 · Cited by 40
Myeloid-derived suppressor cells in non-neoplastic inflamed organs
Sendo, S., Saegusa, J., & Morinobu, A. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0076-7 · Cited by 40
Ferroptosis—A Novel Mechanism With Multifaceted Actions on Stroke
Fang, X., Ding, S.-Y., Du, X., Wang, J.-H., & Li, X. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.881809 · Cited by 42
Metabolism and inflammation: implications for traumatic brain injury therapeutics
Killen, M. J., Giorgi-Coll, S., Helmy, A. E., Hutchinson, P. J., & Carpenter, K. L. H. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1582332 · Cited by 39
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke
Zhang, Y., Li, F., Chen, C., Li, Y., Xie, W., Huang, D., Zhai, X., Yu, W., Wan, J., & Li, P. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211067133 · Cited by 39
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2844-6 · Cited by 39
Sharma, V. K., Tan, B. Y., & Paliwal, P. R. (2019) · Annals of Indian Academy of Neurology · doi:10.4103/aian.aian_483_19 · Cited by 38
Inhibiting HMGB1 Reduces Cerebral Ischemia Reperfusion Injury in Diabetic Mice
Wang, C., Jiang, J., Zhang, X., Song, L., Sun, K., & Xu, R. (2016) · Inflammation · doi:10.1007/s10753-016-0418-z · Cited by 37
Le, K., Mo, S., Lu, X., Abdoulaye, I. A., Yu, D., & Guo, Y. (2018) · Neurological Research · doi:10.1080/01616412.2018.1497254 · Cited by 37
Li, M., Chen, S., Shi, X., Lyu, C., Zhang, Y., Tan, M., Wang, C., Zang, N., Liu, X., Hu, Y., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1267-5 · Cited by 39
Mai, N., Miller‐Rhodes, K., Knowlden, S. A., & Halterman, M. W. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19835552 · Cited by 40
Zhang, Y., Jia, P., Wang, K., Zhang, Y., Lv, Y., Fan, P., Yang, L., Zhang, S., Wang, T., Zhao, J., et al. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.02.002 · Cited by 37
Yang, S., Li, X., Yan, J., Jiang, F., Fan, X., Jin, J., Zhang, W., Zhong, D., & Li, G. (2024) · Scientific Reports · doi:10.1038/s41598-024-64981-x · Cited by 36
Chen, J., Huang, Q.-Y., Zhao, Y., Chen, W., Lin, S., & Shi, Q.-Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.785717 · Cited by 36
HMGB1, angel or devil, in ischemic stroke
Gao, B., Wang, S., Li, J., Han, N., Ge, H., Zhang, G., & Chang, M. (2023) · Brain and Behavior · doi:10.1002/brb3.2987 · Cited by 32
Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways
Guan, Z., Hellman, J., & Schumacher, M. A. (2016) · F1000Research · doi:10.12688/f1000research.8710.1 · Cited by 36
Qin, J., Zhu, L., Gong, G., Li, H., Chen, L., Song, B., Liu, X., Shi, C., Yang, J., Yang, T., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211833 · Cited by 35
Newly Detected Atrial Fibrillation after Acute Stroke: A Narrative Review of Causes and Implications
Wang, Y., Qian, Y., Smerin, D., Zhang, S., Zhao, Q., & Xiong, X. (2019) · Cardiology · doi:10.1159/000502971 · Cited by 34
Danger-associated molecular patterns are locally released during occlusion in hyper-acute stroke
Schuhmann, M. K., Kollikowski, A. M., März, A. G., Bieber, M., Pham, M., & Stoll, G. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100270 · Cited by 35
Current Approaches and Future Perspectives for Nanobodies in Stroke Diagnostic and Therapy
Jank, L., Pinto-Espinoza, C., Duan, Y., Koch‐Nolte, F., Magnus, T., & Rissiek, B. (2019) · Antibodies · doi:10.3390/antib8010005 · Cited by 35
Chen, Y., Luan, P., Liu, J., Wei, Y., Wang, C., Wu, R. X., Wu, Z., & Jing, M. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01680-w · Cited by 34
Chen, J., Jin, J., Li, K., Shi, L., Wen, X., & Fang, F. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.868323 · Cited by 33
Horner, E. C., Lord, J. M., & Hazeldine, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1239683 · Cited by 33
The immunology of stroke and dementia
Iadecola, C., & Anrather, J. (2025) · Immunity · doi:10.1016/j.immuni.2024.12.008 · Cited by 37
Bone Fracture Enhances Trauma Brain Injury
Yang, L., Guo, Y., Wen, D., Yang, L., Chen, Y., Zhang, G., & Fan, Z. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12393 · Cited by 31
Farris, B. Y., Monaghan, K. L., Zheng, W., Amend, C. D., Hu, H., Ammer, A. G., Coad, J. E., Ren, X. S., & Wan, E. C. K. (2019) · Immunity Inflammation and Disease · doi:10.1002/iid3.277 · Cited by 30
Understanding the Role of Innate Immunity in the Response to Intracortical Microelectrodes
Hermann, J. K., & Capadona, J. R. (2018) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.2018027166 · Cited by 31
IRAK-M Deficiency Exacerbates Ischemic Neurovascular Injuries in Experimental Stroke Mice
Lyu, C., Zhang, Y., Gu, M., Huang, Y., Liu, G., Wang, C., Li, M., Chen, S., Pan, S., & Gu, Y. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00504 · Cited by 28
Lee, J. D., Liu, N., Levin, S. C., Ottosson, L., Andersson, U., Harris, H. E., & Woodruff, T. M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1435-2 · Cited by 28
Hao, T., Du, X., Shen, Y., Zhang, Y., & Liang, F. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118099 · Cited by 28
Attenuation of postoperative adhesions using a modeled manual therapy
Bove, G. M., Chapelle, S. L., Hanlon, K. E., Diamond, M. P., & Mokler, D. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178407 · Cited by 28
Frequencies of circulating B- and T-lymphocytes as indicators for stroke outcomes
Wang, Y., Liu, J., Wang, X., Liu, Z., Li, F., Chen, F., Geng, X., Ji, Z., Du, H., & Hu, X. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s148073 · Cited by 28
Higher risk of herpes zoster in stroke patients
Tung, Y. C., Tu, H., Wu, M., Kuo, K., Su, Y., Lu, Y., Lin, C., & Wu, C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228409 · Cited by 26
Letko-Khait, N., Ho, E., & Shoichet, M. S. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202010674 · Cited by 27
Astrocyte and Oligodendrocyte Responses From the Subventricular Zone After Injury
David‐Bercholz, J., Kuo, C. T., & Deneen, B. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.797553 · Cited by 26
Sung, P., Chen, K., Lin, H.-S., Chu, C., Chiang, J. Y., & Yip, H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020190 · Cited by 26
Neumann, S., Boothman-Burrell, L., Gowing, E. K., Jacobsen, T. A., Ahring, P. K., Young, S. L., Sandager‐Nielsen, K., & Clarkson, A. N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01133 · Cited by 27
Liu, Y., Li, S., Wang, R., Pu, H., Zhao, Y., Ye, Q., & Shi, Y. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105257 · Cited by 26
Bromelain supplementation and inflammatory markers: A systematic review of clinical trials
Pereira, I. C., Vieira, E. E. S., Torres, L. R. D. O., da Silva, F. C. C., Sousa, J. M. D. C. E., & Torres‐Leal, F. L. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.02.028 · Cited by 28
Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations
Poblete, R. A., Yaceczko, S. D., Aliakbar, R., Saini, P., Hazany, S., Breit, H., Louie, S. G., Lyden, P. D., & Partikian, A. (2023) · Biomedicines · doi:10.3390/biomedicines11092551 · Cited by 31
Lee, S., Hwang, H., Yamal, J., Goodman, J. C., Aisiku, I. P., Gopinath, S. P., & Robertson, C. S. (2019) · Journal of neurosurgery · doi:10.3171/2018.8.jns18676 · Cited by 26
Zarriello, S., Neal, E. G., Kaneko, Y., & Borlongan, C. V. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040537 · Cited by 26
Dong, X., Dong, J., & Zhang, J. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01165-6 · Cited by 24
Cannabidiol reduces lung injury induced by hypoxic–ischemic brain damage in newborn piglets
Arruza, L., Pazos, M. R., Mohammed, N., Escribano, N., Lafuente, H., Santos, M., Alvarez, F. J., Hind, W. H., & Martínez-Orgado, J. A. (2017) · Pediatric Research · doi:10.1038/pr.2017.104 · Cited by 25
Old Dog New Tricks; Revisiting How Stroke Modulates the Systemic Immune Landscape
Krishnan, S., & Lawrence, C. B. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00718 · Cited by 24
Poh, L., Rajeev, V., Selvaraji, S., Lai, M. K. P., Chen, C., Arumugam, T. V., & Fann, D. Y. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105109 · Cited by 24
Zhang, C., Liu, C., Li, F., Zheng, M.-T., Liu, Y., Li, L., Yang, H., Zhang, S., Wang, C., Rong, H., et al. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00566-8 · Cited by 23
Self-citationThe age-dependent immune response to ischemic stroke
Tuohy, M. C., Hillman, E. M. C., Marshall, R. S., & Agalliu, D. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102670 · Cited by 23
The Aggregate Index of Systemic Inflammation as a Predictor of Mortality in Stroke Patients
Göçmen, A., & Demir, T. G. (2024) · Cureus · doi:10.7759/cureus.64007 · Cited by 22
Roth, S., Yang, J., Cramer, J. V., Malik, R., & Liesz, A. (2020) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2020.11.016 · Cited by 23
Self-citationChen, J., Chang, Y., Zhu, J., Peng, Y., Li, Z., Zhang, K., Zhang, Y., Lin, C., Lin, Z., Pan, S., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02571-2 · Cited by 22
HMGB1 in depression: An overview of microglial HMBG1 in the pathogenesis of depression
Huang, X., Wang, B., Yang, J., Lian, Y., Yu, H.-Z., & Wang, Y. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100641 · Cited by 23
Acquired Immunoglobulin G deficiency in stroke patients and experimental brain ischemia
Liesz, A., Roth, S., Zorn, M., Sun, L., Hofmann, K., & Veltkamp, R. C. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.021 · Cited by 22
Self-citationIntestinal Barrier Dysfunction Participates in the Pathophysiology of Ischemic Stroke
Wei, M., Huang, Q., Liu, Z., Luo, Y., & Xia, J. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210322115808 · Cited by 19
Ji, Y., Xu, X., Wu, K., Sun, Y., Wang, H., Guo, Y., Yang, K., Xu, J., Yang, Q., Huang, X., et al. (2022) · Clinical Interventions in Aging · doi:10.2147/cia.s365553 · Cited by 21
Perspective Review of Myeloid Immune Cell Responses and Poststroke Immunosuppression
Xie, W., Simats, A., Guo, Y., Huang, T., Sun, X., Chen, W., Lin, Y., Wang, X., Lai, Z., Yu, W., et al. (2023) · Stroke · doi:10.1161/strokeaha.122.042075 · Cited by 21
Self-citationPost‐stroke immunosuppression: Exploring potential implications beyond infections
Brea, D. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16174 · Cited by 20
Changes in Regulatory T-Cell Levels in Acute Cerebral Ischemia
Pang, X., & Qian, W. (2017) · Journal of Neurological Surgery Part A Central European Neurosurgery · doi:10.1055/s-0037-1599055 · Cited by 20
Derk, J., Bermudez‐Hernandez, K., Rodriguez, M., He, M., Koh, H., Abedini, A., Li, H., Fenyö, D., & Schmidt, A. M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180088 · Cited by 21
Strategies for PET imaging of the receptor for advanced glycation endproducts (RAGE)
Drake, L. R., Brooks, A. F., Stauff, J., Sherman, P. S., Arteaga, J., Koeppe, R. A., Reed, A. D., Montavon, T. J., Skaddan, M. B., & Scott, P. J. H. (2020) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2020.07.009 · Cited by 18
Borlongan, M. C., Kingsbury, C., Salazar, F. E., Toledo, A. R. L., Monroy, G. R., Sadanandan, N., Cozene, B., Gonzales‐Portillo, B., Saft, M., Wang, Z.-J., et al. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-021-08656-0 · Cited by 20
Barnett‐Vanes, A., Sharrock, A. E., Eftaxiopoulou, T., Arora, H., Macdonald, W., Bull, A. M. J., & Rankin, S. M. (2016) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000001116 · Cited by 19
Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders
Liu, Y., Lin, W. C., Bai, Z., Ge, Y., Xiao, Y., Zhu, F., Zhang, J., Wang, B., Li, Q., Gao, L., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.09.018 · Cited by 20
Liu, J., Luo, Q., Ke, J., Zhang, D., Xu, Y., Liao, W., Chen, X., & Zhang, X. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/5157417 · Cited by 18
Protein biomarkers of epileptogenicity after traumatic brain injury
Agoston, D., & Kamnaksh, A. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.07.017 · Cited by 15
Abikenari, M. A., Ha, J. H., Liu, J., Ren, A. L., Cho, K. B., Lim, J., Kim, L. H., Medikonda, R. T., Choi, J. H., & Lim, M. K. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1668480 · Cited by 18
Stroke research at the crossroads – where are we heading?
Roth, S., & Liesz, A. (2016) · Swiss Medical Weekly · doi:10.4414/smw.2016.14329 · Cited by 17
Self-citationUdovičić, I., Stanojević, I., Djordjevic, D., Zeba, S., Rondović, G., Abazovic, T., Lazic, S., Vojvodić, D., To, K., Abazović, D., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245815 · Cited by 19
Stoll, G., Schuhmann, M. K., Nieswandt, B., Kollikowski, A. M., & Pham, M. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221105764 · Cited by 17
Updates of the role of B-cells in ischemic stroke
Wu, S., Tabassum, S., Payne, C. T., Hu, H., Gusdon, A. M., Choi, H. A., & Ren, X. S. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1340756 · Cited by 20
Nguyen, V., Crewther, S. G., Howells, D. W., Wijeratne, T., Ma, H., Hankey, G. J., Davis, S. M., Donnan, G. A., & Carey, L. M. (2020) · Neurorehabilitation and neural repair · doi:10.1177/1545968320948607 · Cited by 17
Sun, B., Zhang, J., Li, Z., Wang, J., Zhao, C., & Xu, X. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf043 · Cited by 18
Stroke Promotes Systemic Endothelial Inflammation and Atherosclerosis
Rust, R., Hofer, A., & Schwab, M. E. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.008 · Cited by 16
McCulloch, L. J., Allan, S. M., Emsley, H. C. A., Smith, C. J., & McColl, B. W. (2019) · F1000Research · doi:10.12688/f1000research.19308.2 · Cited by 17
Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)
Kauppinen, A., Kaarniranta, K., & Salminen, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00384 · Cited by 15
Metadata
- Authors
- Liesz, A., Dalpke, A., Mracsko, E., Roth, S., Zhou, W., Yang, H., Na, S.-Y., Akhisaroglu, M., Fleming, T., Eigenbrod, T., Nawroth, P. P., Tracey, K. J., & Veltkamp, R.
- Affiliations
- Heidelberg University (DE)
- LMU Klinikum (DE)
- Feinstein Institute for Medical Research (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2015-01-14
- Volume
- 35
- Issue
- 2
- Pages
- 583-598
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4293412
- OpenAlex
- W2128591402
- Cited by
- 334
- References
- 56
- Citations by year
- 2026: 25 · 2025: 23 · 2024: 24 · 2023: 26 · 2022: 39 · 2021: 31 · 2020: 31 · 2019: 33 · 2018: 32 · 2017: 16 · 2016: 33 · 2015: 21
- FWCI
- 27.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Deutsche Forschungsgemeinschaft (SFB1118)
- Medical Research Council (MR/L006758/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- HMGB1, RAGE, ischemic stroke, brain injury, sickness behavior, immunosuppression, suppressor cells, lymphopenia, cytokines
- MeSH terms
- Receptor for Advanced Glycation End Products, Adult, Aged, Aged, 80 and over, Animals, Bone Marrow, Female, Humans, Male, Mice, Inbred C57BL, Middle Aged, Receptors, Immunologic, Spleen, T-Lymphocytes, Signal Transduction, Case-Control Studies, Cytokines, Protein Isoforms, Infarction, Middle Cerebral Artery, Stroke, HMGB1 Protein, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review