DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000412 · Cited by 7,300

Myeloid-derived-suppressor cells as regulators of the immune system

Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753

Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research

Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.72351 · Cited by 6,277

Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,263

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

Bederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681

The immunology of stroke: from mechanisms to translation

Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358

Risk factors and outcomes of lower respiratory tract infections after traumatic brain injury: a retrospective observational study

Cáceres, E. L., Olivella-Gómez, J., Yanez, M., Garcés, A. E. V., Estupiñan, L., Boada, N., Martín‐Loeches, I., & Reyes, L. F. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1077371 · Cited by 14

Liver Metabolism in Ischemic Stroke

Inderhees, J., & Schwaninger, M. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2023.12.013 · Cited by 14

Inhibition of Cerebral High-Mobility Group Box 1 Protein Attenuates Multiple Organ Damage and Improves T Cell-Mediated Immunity in Septic Rats

Ren, C., Li, X., Wu, Y., Dong, N., Tong, Y., & Yao, Y.-M. (2019) · Mediators of Inflammation · doi:10.1155/2019/6197084 · Cited by 14

Stroke-induced hexokinase 2 in circulating monocytes exacerbates vascular inflammation and atheroprogression

Sun, Y., Zhang, L., Cao, Y. Q., Li, X., Liu, F., Cheng, X., Du, J., Ran, H., Wang, Z., Li, Y., et al. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.02.021 · Cited by 13

Neuroprotection of Transcranial Cortical and Peripheral Somatosensory Electrical Stimulation by Modulating a Common Neuronal Death Pathway in Mice with Ischemic Stroke

Lee, H., Lee, J., Jung, D., Oh, H., Shin, H.-K., & Choi, B.-T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147546 · Cited by 13

Rat models of postintracerebral hemorrhage pneumonia induced by nasal inoculation with Klebsiella pneumoniae or intratracheal inoculation with LPS

Wang, R., Gan, C., Mao, R., Chen, Y., Yan, R., Li, G., Xiong, T., & Guo, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1477902 · Cited by 13

Autophagic regulation of neuroinflammation in ischemic stroke

Zheng, Y., Zhou, Z., Han, F., & Chen, Z. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105114 · Cited by 13

Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes

Locker, K. C. S., Kachapati, K., Wu, Y., Bednar, K. J., Adams, D., Patel, C., Tsukamoto, H., Heuer, L. S., Aronow, B. J., Herr, A. B., et al. (2022) · Diabetes · doi:10.2337/db21-0426 · Cited by 13

Reduced release of TNFα and IP-10 after ex vivo blood stimulation with endotoxin is associated with poor outcome after stroke

Klimiec, E., Kowalska, K., Pasińska, P., Pera, J., Słowik, A., & Dziedzic, T. (2017) · Cytokine · doi:10.1016/j.cyto.2017.12.015 · Cited by 13

C‐Reactive Protein Levels and Clinical Prognosis in LAA‐Type Stroke Patients: A Prospective Cohort Study

Zeng, Q., Zeng, Y., SLEVIN, M. A., Guo, B., Shen, Z., Deng, B., & Zhang, W. (2021) · BioMed Research International · doi:10.1155/2021/6671043 · Cited by 14

Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammationPreprint

Kolabas, Z. I., Kuemmerle, L. B., Perneczky, R., Förstera, B., Büttner, M., Çalışkan, Ö. Ş., Ali, M., Rong, Z., Mai, H., Hummel, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.24.473988 · Cited by 15

Identification of circulating immune landscape in ischemic stroke based on bioinformatics methods

Li, D., Li, L., Quan, F., Wang, T., Xu, S., Li, S., Tian, K., Feng, M., He, N., Tian, L., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.921582 · Cited by 12

Inflammatory biomarkers may be associated with poor outcomes after mechanical thrombectomy

Wang, H., Tian, X., Liao, Z., Yue, X., Sun, L., Li, X., Zou, M., & Ding, J. (2024) · Thrombosis Journal · doi:10.1186/s12959-024-00630-7 · Cited by 12

Roles of HMGB1 on life-threatening traumatic brain injury and sequential peripheral organ damage

Kawai, C., Miyao, M., Kotani, H., Minami, H., Abiru, H., Tamaki, K., & Nishitani, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-72318-x · Cited by 13

Immunity in Stroke: The Next Frontier

Li, T., & Liesz, A. (2022) · Thrombosis and Haemostasis · doi:10.1055/s-0042-1748890 · Cited by 12

Orally Administered Brain Protein Combined With Probiotics Increases Treg Differentiation to Reduce Secondary Inflammatory Damage Following Craniocerebral Trauma

Cui, Y., Xu, L., Wang, F., Wang, Z., Tong, X., & Yan, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.928343 · Cited by 12

CRS induces depression-like behavior after MCAO in rats possibly by activating p38 MAPK

Zhi, L., Zhang, F., Liu, H., Jiang, X., Zhang, Y., Yang, Q., Zhang, X., Liu, M., Zhang, Z., & Song, J. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114104 · Cited by 12

Different measures of HMGB1 location in cancer immunology

Gorgulho, C. M., Murthy, P., Liotta, L. A., Espina, V. A., & Lotze, M. T. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.10.011 · Cited by 12

Comparative transcriptomic analysis of rat versus mouse cerebral cortex after traumatic brain injury

Liu, B.-Y., Yang, M.-S., Xu, X.-J., Zhang, B., & Niu, F. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.301028 · Cited by 13

Cardiovascular disease and depression: a bidirectional relationship and its clinical implications

Wu, J., Tian, Z., Qi, Z., Liu, X., & Yu, P. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1675680 · Cited by 14

Anti-HMGB1 auto-Abs influence fatigue in patients with Crohn’s disease

Kvivik, I., Grimstad, T. B., Jonsson, G., Kvaløy, J. T., & Omdal, R. (2021) · Innate Immunity · doi:10.1177/17534259211014252 · Cited by 11

Janus Faced HMGB1 and Post-Aneurysmal Subarachnoid Hemorrhage (aSAH) Inflammation

Chaudhry, S. R., Shafique, S., Sajjad, S., Hänggi, D., & Muhammad, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911216 · Cited by 11

Low Lymphocyte-to-Monocyte Ratio as a Possible Predictor of an Unfavourable Clinical Outcome in Patients with Acute Ischemic Stroke after Mechanical Thrombectomy

Pinčáková, K., Krastev, G., Haring, J., Mako, M., Mikulášková, V., & Bošák, V. (2022) · Stroke Research and Treatment · doi:10.1155/2022/9243080 · Cited by 11

Stroke-Induced Modulation of Myeloid-Derived Suppressor Cells (MDSCs) and IL-10-Producing Regulatory Monocytes

Achmus, L., Ruhnau, J., Grothe, S., von Sarnowski, B., Bröker, B. M., Dressel, A., Schulze, J., & Vogelgesang, A. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.577971 · Cited by 11

Systemic Inflammatory Response Syndrome and Outcomes in Ischemic Patients Treated with Endovascular Treatment

Xu, X., Yuan, L., Wang, W., Xu, J., Yang, Q., Zhu, Y., Xu, Y., Yang, K., Ge, L., Huang, X., et al. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s281865 · Cited by 11

Under-recognized post-stroke acute kidney injury: risk factors and relevance for stroke outcome of a frequent comorbidity

Grosjean, F., Tonani, M., Maccarrone, R., Cerra, C., Spaltini, F., Silvestri, A. D., Falaschi, F., Migliazza, S., Tinelli, C., Rampino, T., et al. (2019) · International Urology and Nephrology · doi:10.1007/s11255-019-02203-4 · Cited by 11

Sepsis compromises post-ischemic stroke neurological recovery and is associated with sex differences

Joaquim, L. D. S., Steiner, B., Farias, B., Machado, R. S., Danielski, L. G., Mathias, K., Stork, S. D. S., Lanzzarin, E., Júnior, L. R. D. N., Bonfante, S., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122721 · Cited by 10

How Critical Illness Affects the Brain…and Vice Versa

Bleck, T. P. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000002944 · Cited by 10

Measuring of Advanced Glycation End Products in Acute Stroke Care: Skin Autofluorescence as a Predictor of Ischemic Stroke Outcome in Patients with Diabetes Mellitus

Filipov, A., Fuchshuber, H., Kraus, J., Ebert, A., Sandikci, V., & Alonso, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11061625 · Cited by 9

Stroke Exacerbates Cancer Progression by Upregulating LCN2 in PMN-MDSC

Huang, T., Li, Y., Zhou, Y., Lu, B., Zhang, Y., Tang, D., Gan, Y., He, Z., Chen, Z., Yu, W., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00299 · Cited by 9

Immune Alterations Following Neurological Disorders: A Comparison of Stroke and Seizures

Ruhnau, J., Tennigkeit, J., Ceesay, S., Koppe, C., Muszelewski, M., Grothe, S., Flöel, A., Süße, M., Dressel, A., von Podewils, F., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00425 · Cited by 9

Increased MYD88 blood transcript in a mouse model of Alzheimer’s disease

Cucoș, C. A., Dobre, M., Dragnea, E. M., Manda, G., & Milanesi, E. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00699-8 · Cited by 9

A Mouse Model of Post-Stroke Pneumonia Induced by Intra-Tracheal Inoculation with Streptococcus pneumoniae

Mracsko, E. Z., Stegemann‐Koniszewski, S., Na, S., Dalpke, A. H., Bruder, D., Lasitschka, F., & Veltkamp, R. C. (2017) · Cerebrovascular Diseases · doi:10.1159/000452136 · Cited by 9

Obesity, bone marrow adiposity, and leukemia: Time to act

Kumar, V., & Stewart, J. H. (2023) · Obesity Reviews · doi:10.1111/obr.13674 · Cited by 8

Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study

Uhle, F., Lichtenstern, C., Brenner, T., Fleming, T. H., Koch, C., Hecker, A., Heiß, C., Nawroth, P. P., Hofer, S., Weigand, M. A., et al. (2015) · Mediators of Inflammation · doi:10.1155/2015/691491 · Cited by 8

The trend of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in spontaneous intracerebral hemorrhage and the predictive value of short-term postoperative prognosis in patients

Zhang, J., Liu, C., Hu, Y., Yang, A., Zhang, Y., & Hong, Y. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1189898 · Cited by 8

Elevated plasma levels of galectin-3 binding protein are associated with post-stroke delirium – A pilot study

Klimiec, E., Pasińska, P., Kowalska, K., Klimkowicz‐Mrowiec, A., Pera, J., Słowik, A., & Dziedzic, T. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577579 · Cited by 8

The Burden of Diabetes and the Chance of a Previous Stroke: Thrombolysis for Recurrent Stroke in Diabetics

Filipov, A., Ebert, A., Neumaier‐Probst, E., & Alonso, A. (2018) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2017.12.027 · Cited by 7

Extracellular matrix remodelling in neurological diseases

Kwok, J. C. F., & Dityatev, A. E. (2026) · Nature Reviews Neurology · doi:10.1038/s41582-026-01209-8 · Cited by 9

IL-33 in Ischemic Stroke: Brain vs. Periphery

Mathias, K., Machado, R. S., Tiscoski, A. D. B., dos Santos, D., Lippert, F. W., Costa, M. A., Gonçalves, C. L., Generoso, J. S., Prophiro, J. S., Giustina, A. D., et al. (2024) · Inflammation · doi:10.1007/s10753-024-02148-6 · Cited by 6

Physiology of cellular demise: Apoptosis, necrosis, and autophagy

Kaur, D., & Deshmukh, R. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815762-6.00002-0 · Cited by 10

Impact of systemic inflammatory response syndrome on acute ischemic stroke patients treated with mechanical thrombectomy

Jafari, M., Katlowitz, K. A., DeLaGarza, C., Sellers, A., Moore, S., Hall, H., Desai, A., Singh, V., & Damani, R. H. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.119988 · Cited by 6

Disulfidptosis and its Role in Peripheral Blood Immune Cells after a Stroke: A New Frontier in Stroke Pathogenesis

Liu, S.-P., Liu, C., Xu, B., Zhou, H., & Zhao, H. (2023) · Current Neurovascular Research · doi:10.2174/0115672026286243240105115419 · Cited by 6

Clinical Improvement Following Stroke Promptly Reverses Post-stroke Cellular Immune Alterations

Vogelgesang, A., Witt, C., Heuer, C., Schulze, J., Gellrich, J., von Sarnowski, B., Langner, S., Dressel, A., & Ruhnau, J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00414 · Cited by 6

Polymer‐Formulated Nerve Growth Factor Shows Effective Therapeutic Efficacy for Cerebral Microinfarcts

Yan, L., Xu, K., Liu, C., Feng, Y., Guo, J., Hou, L., Feng, Y., Yang, M., Gong, Q., Qin, D., et al. (2024) · Advanced Materials · doi:10.1002/adma.202412843 · Cited by 5

Lipid metabolism, microglia, and stroke

Chen, L., Zhang, M., Wei, W., Li, Q., Wang, L., Zhao, M., He, L., Xu, H., Yang, P., & Zhang, P. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01523 · Cited by 7

Traumatic Brain Injury in the Long-COVID Era

Agoston, D. V. (2024) · Neurotrauma Reports · doi:10.1089/neur.2023.0067 · Cited by 5

Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?

Tekin, S., Avcı, E., Nar, R., Değirmenci, E., Demir, S., & Şenol, H. (2020) · Journal of Basic and Clinical Health Sciences · doi:10.30621/jbachs.2020.837 · Cited by 5

Inflammatory Mechanisms in Ischemic Cerebrovascular Disease

Nagai, M., & Granger, D. N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811709-5.00021-1 · Cited by 5

Stroke induces early recurrent vascular events by inflammasome-dependent atherosclerotic plaque rupturePreprint

Cao, J., Roth, S., Zhang, S., Kopczak, A., Georgakis, M. K., Li, X., Dutsch, A., Liman, T., Endres, M., Brough, D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.01.526550 · Cited by 5

Systemic immune-inflammation index associated with functional outcomes after endovascular thrombectomy in anterior circulation acute ischemic stroke

Han, L., Miao, T., Zheng, L.-Y., Hu, X., & Zhong, J.-W. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1663299 · Cited by 5

Association of IL-6 rs1800795, but not TNF-α rs1800629, and IL-1β rs16944 polymorphisms’ genotypes with recovery of ischemic stroke patients following thrombolysis

Pjević, M. D., Vojvodic, L., Grk, M., Todorović, J., Maksimović, N., Rasic, M., Perović, D., Damnjanović, T., Trickovic, J., Kačar, K., et al. (2023) · Neurological Research · doi:10.1080/01616412.2023.2258042 · Cited by 4

Research progress on immune-related therapeutic targets of brain injury caused by cerebral ischemia

He, Y., Jin, W., Wan, H., Zhang, L., & Yu, L. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156651 · Cited by 4

Role of astrocytes connexins - pannexins in acute brain injury

Tichauer, J. E., & Rovegno, M. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00523 · Cited by 5

Developing High-Fidelity In Vitro Models of Traumatic Brain Injury to Test Therapeutic Biomaterials

Adams, C. F., Kabiri, B., Basit, R. H., Wiseman, J. P., & Chari, D. M. (2024) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-031-49744-5_10 · Cited by 4

Transcriptome Analysis of the Striatum of Electroacupuncture-treated Naïve and Ischemic Stroke Mice

Lee, H. J., Shin, H. K., Kim, J.-H., & Choi, B. T. (2024) · Journal of pharmacopuncture · doi:10.3831/kpi.2024.27.2.162 · Cited by 3

Serum HMGB1 as a diagnostic biomarker and mediator of childhood trauma in adolescent depression

Xiang, J., Qin, Y., Jiang, R., Wang, X., Zhou, Y., Liu, J. J., & Kuang, L. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1584320 · Cited by 3

Myeloid-derived suppressor cells in metabolic and cardiovascular disorders

Yan, J., Guo, S., He, J., Huang, H. H., & Xu, Y. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.02.001 · Cited by 2

The long-term risk of atrial fibrillation after ischemic stroke: A propensity score matching analysis

Kang, J., Yoo, J. E., Ko, T. Y., Kim, Y., Kim, B., Chang, W. H., Park, Y., Han, K., & Shin, D. W. (2025) · International Journal of Stroke · doi:10.1177/17474930251348120 · Cited by 2

A customized affordable multiplexed immunofluorescence method visualizes early changes in the mouse brain microenvironment upon laser cytoreduction

Anandhan, S. S., Spence, J., Begum, F., Kaur, N., Henderson, D., Hombach‐Klonisch, S., & Klonisch, T. C. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1553058 · Cited by 2

The role of HMGB1 in central nervous system (CNS) diseases: mechanisms and therapeutic perspectives

Du, O., Wu, Y.-J., Li, M.-Y., & Du, J.-R. (2025) · Cytokine · doi:10.1016/j.cyto.2025.157099 · Cited by 4

Early HMGB1 Inhibition Reduces Hippocampal Injury During Adolescence in a Young Mouse Model of Radiation-Induced Brain Injury

Sun, Y., Shi, M., Ma, L., Xie, H., Hei, M., & Zuo, W. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01683-0 · Cited by 2

Relationship between relevant inflammatory markers and short-term functional outcomes of acute ischemic stroke treated with mechanical thrombectomy: a retrospective cohort study

Liu, J., Wen, J., Peng, S., Ren, H., Liu, Y., Zhou, C., Hu, X., & Li, Q. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1712415 · Cited by 2

Taking a Glimpse Into the Brain’s Immune System: Imaging and Blood-Based Biomarkers of the Poststroke Immune Response

Bosshart, S. L., Fernández-Vega, A., Kaufmann, J. E., Stebner, A., Tiedt, S., Montaner, J., Ospel, J. M., & Große, G. M. (2026) · Stroke · doi:10.1161/strokeaha.125.051472 · Cited by 2

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

An, P., An, Y., Chen, M., Wu, L., & Wang, R. (2026) · MedComm · doi:10.1002/mco2.70822 · Cited by 4

Divergent humoral responses to 23-valent pneumococcal polysaccharide vaccine in critically-ill burn and neurosurgical patients

Mueller, S. W., Baumgartner, L. J., MacLaren, R., Neumann, R. T., Wiktor, A. J., Kiser, T. H., Lindberg, G., Cava, L. F., Fish, D. N., & Janoff, E. N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197037 · Cited by 2

Angiotensin II-Mediated Increases in Damage-Associated Molecular Patterns During Acute Mental Stress

Stewart, D., Dong, Y., Zhu, H., & Harshfield, G. A. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000371 · Cited by 2

B-Cells in Stroke and Preconditioning-Induced Protection Against Stroke

Selvaraj, U. M., Poinsatte, K., & Stowe, A. M. (2016) · Springer series in translational stroke research · doi:10.1007/978-3-319-32337-4_12 · Cited by 2

Skin Autofluorescence is an Independent Predictor of Post Stroke Infection in Diabetes

Filipov, A., Fuchshuber, H., Kraus, J., Ebert, A., Sandikci, V., & Alonso, A. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2021.105949 · Cited by 2

Leukocyte neutrophil ratio (NLR) as biomarker for neuroinflammation in patients with intracerebral haemorrhage and traumatic brain injury

Ghosh, A., Pal, R., Mishra, R., Cincu, R., Moscote‐Salazar, L. R., & Agrawal, A. (2021) · Romanian Journal of Neurology · doi:10.37897/rjn.2021.3.5 · Cited by 2

Inflammation and Immune Response

García‐Bonilla, L., Iadecola, C., & Anrather, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-69424-7.00010-7 · Cited by 2

Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defencePreprint

McCulloch, L. J., Allan, S. M., Smith, C. J., & McColl, B. W. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/587881 · Cited by 2

Formation of Cellular Responses in the Adaptive Immune Response of 40–60-Year-Old Women Living in Northern Russia

Kabbani, M. S., Евгеньевна, Ф. О., Shashkova, E. Y., Men’shikova, M. V., & Shchegoleva, L. S. (2020) · Journal of Medical and Biological Research · doi:10.37482/2687-1491-z027 · Cited by 1

The Endocannabinoid System as a Target for Ischemic Stroke Therapy

Stork, S. D. S., Mathias, K., dos Santos, D., Lippert, F. W., Machado, R. S., Maragno, V. D. A., Joaquim, L. D. S., Stork, S. S., de Bitencourt, R. M., Bobinski, F., et al. (2025) · Cannabis and Cannabinoid Research · doi:10.1089/can.2024.0017 · Cited by 1

On the Pathophysiology of Stroke‐Associated Pneumonia: A Brief Review

Zhong, A. (2025) · Neurology and Clinical Neuroscience · doi:10.1111/ncn3.70030 · Cited by 1

Molecular Crosstalk in Traumatic Brain Injury

Godoy, D. A., Quintana‐Díaz, M., & Rovegno, M. (2025) · Springer eBooks · doi:10.1007/978-3-032-01024-7_7 · Cited by 1

Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke

Chen, W., Wang, X., Huang, T., Li, Y., Chen, C., Zhang, Y., Xie, W., Tang, D., Fan, Q., Pang, R., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20242025 · Cited by 1

Emerging nanomaterials for cfDNA clearance: A new frontier in inflammatory disease therapy

Wang, S., Wang, Y., Li, Y., Zhang, S., & Chen, Q. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124204 · Cited by 3

Pharmacological intervention of the HMGB1-pCTS-L axis to ameliorate inflammatory diseases

Chen, W., Li, J., Qiang, X., Li, L., Zhu, S., Deng, M., & Wang, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1843251 · Cited by 1

Natural killer T cells in intracerebral hemorrhage: phase-dependent immune responses and therapeutic implications

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Wang, J., Zhang, J., Ye, Y., Gao, Y., Li, Y., Zhu, H., Feng, S., Cheng, Z., Zeng, Z., Xiong, X., et al. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116962 · Cited by 1

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Land, W. G. (2020) · Springer eBooks · doi:10.1007/978-3-030-53868-2_9 · Cited by 1

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Xu, X., Yuan, L., Wang, W., Xu, J., Yang, Q., Zhu, Y., Xu, Y., Yang, K., Ge, L., Huang, X., et al. (2020) · doi:10.21203/rs.3.rs-29589/v1 · Cited by 1

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Su, A. (2016)

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Qiu, J., Nishimura, M., Wang, Y., Sims, J. R., Qiu, S., Savitz, S. I., Salomone, S., & Moskowitz, M. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600582 · Cited by 412

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