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Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation
Open accessAbstract
Demyelination in the adult CNS can be followed by extensive repair. However, in multiple sclerosis, the differentiation of oligodendrocyte lineage cells present in demyelinated lesions is often inhibited by unknown factors. In this study, we test whether myelin debris, a feature of demyelinated lesions and an in vitro inhibitor of oligodendrocyte precursor differentiation, affects remyelination efficiency. Focal demyelinating lesions were created in the adult rat brainstem, and the naturally generated myelin debris was augmented by the addition of purified myelin. After quantification of myelin basic protein mRNA expression from lesion material obtained by laser capture microdissection and supported by histological data, we found a significant impairment of remyelination, attributable to an arrest of the differentiation and not the recruitment of oligodendrocyte precursor cells. These data identify myelin as an inhibitor of remyelination as well as its well documented inhibition of axon regeneration.
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In the citing paper
“they also exhibit regenerative properties through the phagocytosis of myelin debris3, 4 and secretion of growth/neurotrophic factors5.”
From M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination (2013) · cites this paper as [3]
In the citing paper
“Efficient myelin debris removal and clearance by phagocytic cells are critical to eliminate inhibitory signals interfering with OPC activation, recruitment to the site of demyelination and/or differentiation into myelinating mature OLs [14, 26, 27].”
From TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis (2020) · cites this paper as [26]
In the citing paper
“One critical role for microglia during demyelination is the clearance of myelin debris, which acts as an inhibitor of remyelination [192–194].”
From Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination (2022) · cites this paper as [194]
In the citing paper
“Long-term demyelination occurs post-SCI, with lipid-containing myelin debris being absorbed and processed by inflammatory cells, including microglia—a process crucial for paving the way for regenerative reactions and inflammation resolution [9–11].”
From miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1 (2024) · cites this paper as [9]
Citations
Cites
MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION1
Norton, W. T., & Poduslo, S. E. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb07519.x · Cited by 1,413
Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis
Chang, A., Tourtellotte, W. W., Rudick, R., & Trapp, B. D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010994 · Cited by 991
Caroni, P., & Schwab, M. E. (1988) · Neuron · doi:10.1016/0896-6273(88)90212-7 · Cited by 886
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
Filbin, M. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1195 · Cited by 873
Why does remyelination fail in multiple sclerosis?
Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 862
Self-citationLINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
Mi, S., Lee, X., Shao, Z., Thill, G., Ji, B., Relton, J. K., Levesque, M., Allaire, N., Perrin, S., Sands, B., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1188 · Cited by 827
p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
Wang, K., Kim, J. A., Sivasankaran, R., Segal, R. A., & He, Z. (2002) · Nature · doi:10.1038/nature01176 · Cited by 824
Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord
Horner, P. J., Power, A. E., Kempermann, G., Kuhn, H. G., Palmer, T. D., Winkler, J., Thal, L. J., & Gage, F. H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02218.2000 · Cited by 777
NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions
Chang, A., Nishiyama, A., Peterson, J. W., Prineas, J. W., & Trapp, B. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06404.2000 · Cited by 711
LINGO-1 negatively regulates myelination by oligodendrocytes
Mi, S., Miller, R. H., Lee, X., Scott, M. L., Shulag-Morskaya, S., Shao, Z., Chang, J., Thill, G., Levesque, M., Zhang, M., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1460 · Cited by 628
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Items 501–600 of 774
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Ding, Y., Hu, L., Wang, X., Sun, Q., Hu, T., Liu, J., Shen, D., Zhang, Y., Chen, W., Wei, C., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105914 · Cited by 13
Ganz, T., Zveik, O., Fainstein, N., Lachish, M., Rechtman, A., Sofer, L., Brill, L., Ben‐Hur, T., & Vaknin‐Dembinsky, A. (2023) · Glia · doi:10.1002/glia.24453 · Cited by 13
Anastasiadou, S., Liebenehm, S., Sinske, D., zu Reckendorf, C. M., Moepps, B., Nordheim, A., & Knöll, B. (2015) · Glia · doi:10.1002/glia.22794 · Cited by 13
Führmann, T., Gerardo‐Nava, J., & Brook, G. A. (2010) · Springer eBooks · doi:10.1007/978-3-642-02824-3_12 · Cited by 14
Liver X receptors: A therapeutic target in demyelinating disorders
Richartz, J., Yam, S. C., Zhan, N., Schepers, M., Tiane, A., Mulder, M. T., Wens, I., & Vanmierlo, T. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107861 · Cited by 12
Murray, C. J., Vecchiarelli, H. A., & Tremblay, M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1119552 · Cited by 12
Lotun, A., Li, D., Xu, H., Su, Q., Tuncer, S., Sanmiguel, J. C., Mooney, M., Baer, C. E., Ulbrich, R., Eyles, S. J., et al. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102460 · Cited by 12
Cui, F., Deng, S., Fu, Y. Y., Xu, T., Bao, S., Wang, S., Lin, Y., Wang, X., Zhao, F., Zhang, T., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115126 · Cited by 12
Self-citationAxonal activity-dependent myelination in development: Insights for myelin repair
Mitew, S., Xing, Y. L., & Merson, T. D. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.03.002 · Cited by 12
Cuprizone markedly decreases kynurenic acid levels in the rodent brain tissue and plasma
Polyák, H., Cseh, E. K., Bohár, Z., Rajda, C., Zádori, D., Klivènyi, P., Toldi, J., & Vécsei, L. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06124 · Cited by 14
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous SystemPreprint
Kornberg, M. D., & Calabresi, P. A. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041374 · Cited by 17
He, N., Mao, X., Ding, Y.-M., Zuo, T., Chen, Y., & Wang, L. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.367836 · Cited by 11
Kaplanis, S. I., Kaffe, D., Ktena, N., Lygeraki, A., Kolliniati, O., Savvaki, M., & Karagogeos, D. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1201317 · Cited by 13
Withana, M., & Castorina, A. (2023) · Cells · doi:10.3390/cells12222633 · Cited by 12
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Hammond, B. P., Panda, S. P., Kaushik, D. K., & Plemel, J. R. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_25 · Cited by 11
Perdaens, O., & Pesch, V. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312637 · Cited by 12
Modulation of OPC Mitochondrial Function by Inhibiting USP30 Promotes Their Differentiation
Soung, A., Kyauk, R. V., Pandey, S., Shen, Y. A., Reichelt, M., Lin, H., Jiang, Z., Kirshnamoorthy, P., Foreman, O., Lauffer, B. E. L., et al. (2024) · Glia · doi:10.1002/glia.24648 · Cited by 11
Fereidan‐Esfahani, M., Yue, W., Wilbanks, B. A., Johnson, A. J., Warrington, A. E., Howe, C. L., Rodriguez, M., & Maher, L. J. (2020) · Pharmaceuticals · doi:10.3390/ph13110403 · Cited by 11
Cooper, J. J. M., Polanco, J. J., Saraswat, D., Peirick, J. J., Seidl, A., Li, Y., Ma, D., & Sim, F. J. (2022) · Glia · doi:10.1002/glia.24324 · Cited by 9
Sidik, H., & Talbot, W. S. (2015) · Development · doi:10.1242/dev.128215 · Cited by 11
Clinical implications of myelin regeneration in the central nervous system
McMurran, C. E., Kodali, S., Young, A. M. H., & Franklin, R. J. M. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1421458 · Cited by 11
Self-citationWang, F., Ma, X.-R., Wu, Y., Xu, Y.-C., Gu, H., Wang, D.-X., Dong, Z.-J., Li, H., Wang, L., & Zhao, J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.768059 · Cited by 11
Levy, Y. A., Mausner-Fainberg, K., Amidror, T., Regev, K., Auriel, E., & Karni, A. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.01.012 · Cited by 11
Stem Cell Therapy in Wound Healing and Tissue Regeneration
Meiliana, A., Dewi, N. M., & Wijaya, A. (2016) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v8i2.191 · Cited by 9
Stem Cell Biology in Health and Disease
Dittmar, T., & Zänker, K. S. (2009) · Springer eBooks · doi:10.1007/978-90-481-3040-5 · Cited by 11
Rashidbenam, Z., Öztürk, E., Pagnin, M., Theotokis, P., Grigoriadis, N., & Petratos, S. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1197492 · Cited by 12
John, R. K., Vogel, S. P., Zia, S., Lee, K. V., Nguyen, A. T., Espin, A. T., Fenrich, K. K., Ng, C., Schmidt, E. K. A., Vavrek, R., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03379-6 · Cited by 10
A Single‐Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging
Jiang, Q., Cui, L., Nie, X., Cai, H., Zhang, W., Lu, X., Guo, Y., Hotaling, J. M., Cairns, B. R., Wang, X., et al. (2025) · Aging Cell · doi:10.1111/acel.70032 · Cited by 10
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Cantuti‐Castelvetri, L., Gökçe, Ö., & Simons, M. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101630 · Cited by 10
Effects of non-modifiable risk factors of Alzheimer’s disease on intracortical myelin content
Fernandez-Alvarez, M., Atienza, M., & Cantero, J. L. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01152-y · Cited by 11
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Thompson, C. H., Evans, B. M., Zhao, D. X., & Purcell, E. K. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.04.028 · Cited by 10
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Ellen, O., Ye, S., Nheu, D., Dass, M., Pagnin, M., Öztürk, E., Theotokis, P., Grigoriadis, N., & Petratos, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311112 · Cited by 11
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Funaki, M., Nio‐Kobayashi, J., Suzuki, R., & Bandô, Y. (2024) · Cells · doi:10.3390/cells13070612 · Cited by 11
Scalabrino, G. (2022) · Biomedicines · doi:10.3390/biomedicines10040815 · Cited by 10
Madalena, K. M., Brennan, F. H., & Popovich, P. G. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114114 · Cited by 10
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Beiter, R. M., Ennerfelt, H. E., Rivet-Noor, C. R., Merchak, A. R., Bai, R., Johanson, D. M., Slogar, E. R., Sol‐Church, K., Phillips, J. L., Bathe, T., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.06.981373 · Cited by 11
Gupta, S. J., Churchward, M. A., Todd, K. G., & Winship, I. R. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1549433 · Cited by 10
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Zawadzka, M., Yeghiazaryan, M., Niedziółka, S. M., Miazga, K., Kwaśniewska, A., Bekisz, M., & Sławińska, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010495 · Cited by 9
Cholesterol metabolism: Towards a therapeutic approach for multiple sclerosis
Gao, Y., & Li, X. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105501 · Cited by 9
Chen, T., Lo, Y., Li, S., Lin, Y.-C., Chang, C.-W., Liang, Y., Laiman, V., Hsiao, T.-C., Chuang, H., & Chen, Y. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115373 · Cited by 10
Chen, K., Padilla, C. G., Kiselyov, K. I., & Kozai, T. D. Y. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122316 · Cited by 9
Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination
Philp, A. R., Reyes, C. R., Mansilla, J. B., Sharma, A., Zhao, C., Valenzuela‐Krugmann, C., Rawji, K. S., Martinez, G. A. G., Dimas, P., Hinrichsen, B., et al. (2023) · eLife · doi:10.7554/elife.91757 · Cited by 11
Self-citationMartinović, K., Bauer, J., Kunze, M., Berger, J., & Forss‐Petter, S. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01595-w · Cited by 10
Remyelination of the Central Nervous System
Bruce, C. C., Franklin, R. J. M., & Relvas, J. B. (2007) · Springer eBooks · doi:10.1007/978-0-387-70830-0_19 · Cited by 9
Self-citationA review focuses on a neglected and controversial component of SCI: myelin debris
Zhou, Y., Xu, T., Zhou, Y., Han, W., Wu, Z., Yang, C., & Chen, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1436031 · Cited by 9
Age-impaired remyelination is associated with dysregulated microglial transitions
Zia, S., Traetta, M. E., Baaklini, C. S., Hammond, B. P., John, R. K., Souter, K. M., Meijns, N., Afun, L. K. A., Panda, S. P., Ibáñez, F. G., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64906-w · Cited by 10
Ban, Y., Dong, W., Zhang, L., Zhou, T. G., Altiti, A. S., Ali, K., Mootoo, D. R., Blaho, V. A., Hla, T., Ren, Y., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00404 · Cited by 9
(2022) · Methods in Cell Biology · doi:10.1016/bs.mcb.2021.12.011 · Cited by 8
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López-Muguruza, E., Peiró-Moreno, C., Ruiz, A., & Matute, C. (2025) · Advances in neurobiology · doi:10.1007/978-3-031-87919-7_12 · Cited by 9
Promoting return of function in multiple sclerosis: An integrated approach
Gacias, M., & Casaccia, P. (2013) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2013.04.002 · Cited by 9
Golan, M., Krivitsky, A., Mausner-Fainberg, K., Benhamou, M., Vigiser, I., Regev, K., Kolb, H., & Karni, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042182 · Cited by 9
Levy, Y. A., Mausner-Fainberg, K., Vaknin‐Dembinsky, A., Amidror, T., Regev, K., & Karni, A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.12.010 · Cited by 8
Wang, Q., Gao, R., Wang, M., Chen, Q., Xiao, M., Li, Z., Wang, L., & Chen, C. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134439 · Cited by 8
Ghosh, S., Bhatti, G. K., Sharma, P. K., Kandimalla, R. J. L., Mastana, S. S., & Bhatti, J. S. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01434-5 · Cited by 7
Mi, X.-J., Li, J., Feng, Z., Liu, Y., Zhang, C., Shao, Y., Wang, T., Yang, Z., Lv, H., & Liu, J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108312 · Cited by 7
Syage, A. R., Pachow, C., Murray, K. M., Henningfield, C. M., Fernandez, K., Du, A. X., Cheng, Y., Olivarria, G. M., Kawauchi, S., MacGregor, G. R., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03153-0 · Cited by 7
DeVries, S. A., Dimovasili, C., Medalla, M., Moore, T. L., & Rosene, D. L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1426975 · Cited by 7
Xu, C., Wang, Y., & Liao, M. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0932-0 · Cited by 7
Javor, J., Bucová, M., Ďurmanová, V., Radošinská, D., Párnická, Z., Čierný, D., Kurča, E., Čopíková‐Cudráková, D., Gmitterová, K., & Shawkatová, I. (2022) · Life · doi:10.3390/life12071094 · Cited by 7
Fuchs, L., Mausner-Fainberg, K., Luban, A., Asseyer, S., Golan, M., Benhamou, M., Volovitz, I., Regev, K., Vigiser, I., Piura, Y. D., et al. (2022) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2022.577936 · Cited by 7
Mausner-Fainberg, K., Benhamou, M., Golan, M., Kimelman, N. B., Danon, U., Marom, E., & Karni, A. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01068-9 · Cited by 7
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Franklin, R. J. M., Zhao, C., Lubetzki, C., & ffrench‐Constant, C. (2012) · Springer eBooks · doi:10.1007/978-1-4614-2218-1_4 · Cited by 7
Self-citationNew developments in the treatment of optic neuritis
Jenkins, T. M. (2010) · Eye and Brain · doi:10.2147/eb.s8386 · Cited by 7
Barnes-Vélez, J. A., Zhang, X., Peña Señeriz, Y. L., Scott, K. A., Guan, Y., & Hu, J. (2026) · Journal of Clinical Investigation · doi:10.1172/jci179985 · Cited by 6
“Myelin debris can impede remyelination by preventing maturation of newly formed oligodendrocytes (47, 48).”
Gao, Z., Guo, M., Chen, K., Jiang, M., Zhang, L., Mannelli, L. D. C., & Zhang, C. (2025) · Medicine Bulletin · doi:10.1002/mdb2.70007 · Cited by 6
Liu, Y., Yao, F., Li, Z., Jiang, Y. P., Li, J., Yu, S., Hu, X., Ouyang, F., Zheng, M., Li, C., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03445-z · Cited by 6
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Patani, R., & Chandran, S. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131114470 · Cited by 6
The development of myelin repair agents for treatment of multiple sclerosis
Murphy, R., Murphy, K. J., & Pickering, M. (2013) · Bioengineered · doi:10.4161/bioe.22835 · Cited by 6
Posporis, C., Beltrán, E., Dunning, M., Espadas, I., Gillespie, S., Barry, A. T., & Wessmann, A. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00415 · Cited by 8
Evaluation of Myelin Phagocytosis by Microglia/Macrophages in Nervous Tissue Using Flow Cytometry
Gómez‐López, A. R., Manich, G., Recasens, M., Almolda, B., González, B., & Castellano, B. (2021) · Current Protocols · doi:10.1002/cpz1.73 · Cited by 6
Tuladhar, A., Mitrousis, N., Führmann, T., & Shoichet, M. S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410396-2.00030-x · Cited by 8
Revitalizing Remyelination—the Answer Is Circulating
Redmond, S., & Chan, J. R. (2012) · Science · doi:10.1126/science.1221689 · Cited by 6
Oliveira, M. S., Reiche, L., Daniele, E., Kortebi, I., Faiz, M., & Küry, P. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.380879 · Cited by 6
Romero‐Ramírez, L., García‐Rama, C., & Mey, J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03963-6 · Cited by 5
Feng, Y., Ma, X., Zong, X., Jordan, J. D., Wu, C. Y., Tešić, V., Lee, R. H., & Zhang, Q. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117916 · Cited by 5
Dicer deficiency affects microglial function during demyelination and impairs remyelination
Tripathi, A. K., Kumar, N., Perles, A., Courtney, H., Jones, C. E., Sapra, A., Plemel, J. R., & Dutta, R. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106879 · Cited by 6
Zhao, C., Liu, Y., Que, H., Yang, S., Liu, Z. Q., Weng, X., Hui, H., & Liu, S. J. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9983-x · Cited by 5
Self-citationMellough, C., Cho, S., Wood, A., & Przyborski, S. A. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.01.015 · Cited by 5
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Xu, W., Xin, C., Lin, Q., Ding, F. H., Gong, W., Zhou, Y., Yu, J. M., Cui, P., & Hu, S. (2014) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2014.04.004 · Cited by 5
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Telegin, G. B., Чернов, А. С., Коновалов, Н. А., Belogurov, A. A., Балмасова, И. П., & Gabibov, A. (2020) · Acta Naturae · doi:10.32607/actanaturae.11096 · Cited by 5
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Rice, C. M., & Scolding, N. J. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0455-x · Cited by 5
Rinaldi, M., Thomas, L., & Pasquini, L. A. (2016) · Oncotarget · doi:10.18632/oncotarget.13455 · Cited by 5
Kasheke, G. D. S., Hendy, B. A. M., Dorighello, G. G., Uccelli, N. A., Gothié, J. M., Novorolsky, R. J., Oulton, M. J., Asainayagam, J., Makarov, A. I., Fraser, K., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01904-x · Cited by 4
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Popa, E., Cheval, H., & Zujovic, V. (2025) · Cells · doi:10.3390/cells14141054 · Cited by 5
Sun, Q.-Q., Bao, M., Gao, R., Wang, S.-K., Zhang, Y., Wang, L.-B., Zhang, Y., & Li, X. (2026) · Clinical Science · doi:10.1042/cs20258150 · Cited by 4
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Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases
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Could the inhibitor of DNA binding 2 and 4 play a role in white matter injury?
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Oligodendrocyte: Structure, Function and Pathology
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Immunosuppression in Multiple Sclerosis and Other Neurologic Disorders
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Identification of the Lipid Antigens Recognized by rHIgM22, a Remyelination-Promoting Antibody
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Metadata
- Authors
- Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M.
- Affiliations
- University of Cambridge (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-01-04
- Volume
- 26
- Issue
- 1
- Pages
- 328-332
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6674302
- OpenAlex
- W2094044389
- Cited by
- 768
- References
- 30
- Citations by year
- 2026: 24 · 2025: 39 · 2024: 63 · 2023: 56 · 2022: 48 · 2021: 56 · 2020: 46 · 2019: 58 · 2018: 34 · 2017: 41 · 2016: 39 · 2015: 40 · 2014: 34 · 2013: 43 · 2012: 25
- FWCI
- 15.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Raymond and Beverly Sackler Foundation
- Multiple Sclerosis Society
- Austrian Science Fund
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- remyelination, myelin debris, oligodendrocyte precursor cells, oligodendrocyte differentiation, demyelination, multiple sclerosis, myelin basic protein, demyelinating lesions, axon regeneration, central nervous system repair
- MeSH terms
- Animals, Cell Differentiation, Central Nervous System, Female, Growth Inhibitors, Myelin Sheath, Nerve Fibers, Myelinated, Neural Inhibition, Oligodendroglia, Stem Cells, Rats, Sprague-Dawley, Rats
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