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Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation
Open accessAbstract
Demyelination in the adult CNS can be followed by extensive repair. However, in multiple sclerosis, the differentiation of oligodendrocyte lineage cells present in demyelinated lesions is often inhibited by unknown factors. In this study, we test whether myelin debris, a feature of demyelinated lesions and an in vitro inhibitor of oligodendrocyte precursor differentiation, affects remyelination efficiency. Focal demyelinating lesions were created in the adult rat brainstem, and the naturally generated myelin debris was augmented by the addition of purified myelin. After quantification of myelin basic protein mRNA expression from lesion material obtained by laser capture microdissection and supported by histological data, we found a significant impairment of remyelination, attributable to an arrest of the differentiation and not the recruitment of oligodendrocyte precursor cells. These data identify myelin as an inhibitor of remyelination as well as its well documented inhibition of axon regeneration.
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“they also exhibit regenerative properties through the phagocytosis of myelin debris3, 4 and secretion of growth/neurotrophic factors5.”
From M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination (2013) · cites this paper as [3]
In the citing paper
“Efficient myelin debris removal and clearance by phagocytic cells are critical to eliminate inhibitory signals interfering with OPC activation, recruitment to the site of demyelination and/or differentiation into myelinating mature OLs [14, 26, 27].”
From TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis (2020) · cites this paper as [26]
In the citing paper
“One critical role for microglia during demyelination is the clearance of myelin debris, which acts as an inhibitor of remyelination [192–194].”
From Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination (2022) · cites this paper as [194]
In the citing paper
“Long-term demyelination occurs post-SCI, with lipid-containing myelin debris being absorbed and processed by inflammatory cells, including microglia—a process crucial for paving the way for regenerative reactions and inflammation resolution [9–11].”
From miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1 (2024) · cites this paper as [9]
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Cites
MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION1
Norton, W. T., & Poduslo, S. E. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb07519.x · Cited by 1,413
Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis
Chang, A., Tourtellotte, W. W., Rudick, R., & Trapp, B. D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010994 · Cited by 991
Caroni, P., & Schwab, M. E. (1988) · Neuron · doi:10.1016/0896-6273(88)90212-7 · Cited by 886
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
Filbin, M. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1195 · Cited by 873
Why does remyelination fail in multiple sclerosis?
Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 862
Self-citationLINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
Mi, S., Lee, X., Shao, Z., Thill, G., Ji, B., Relton, J. K., Levesque, M., Allaire, N., Perrin, S., Sands, B., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1188 · Cited by 827
p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
Wang, K., Kim, J. A., Sivasankaran, R., Segal, R. A., & He, Z. (2002) · Nature · doi:10.1038/nature01176 · Cited by 824
Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord
Horner, P. J., Power, A. E., Kempermann, G., Kuhn, H. G., Palmer, T. D., Winkler, J., Thal, L. J., & Gage, F. H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02218.2000 · Cited by 777
NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions
Chang, A., Nishiyama, A., Peterson, J. W., Prineas, J. W., & Trapp, B. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06404.2000 · Cited by 711
LINGO-1 negatively regulates myelination by oligodendrocytes
Mi, S., Miller, R. H., Lee, X., Scott, M. L., Shulag-Morskaya, S., Shao, Z., Chang, J., Thill, G., Levesque, M., Zhang, M., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1460 · Cited by 628
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Items 201–300 of 774
Ulrich, R., Seeliger, F., Kreutzer, M., Germann, P., & Baumgärtner, W. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.00956.x · Cited by 68
Pul, R., Moharregh-Khiabani, D., Škuljec, J., Skripuletz, T., Garde, N., Voß, E. V., & Stangel, M. (2010) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-010-9248-1 · Cited by 67
Ghasemlou, N., Jeong, S. Y., Lacroix, S., & David, S. (2006) · Glia · doi:10.1002/glia.20449 · Cited by 68
Central nervous system diseases related to pathological microglial phagocytosis
Wang, K., Li, J., Zhang, Y., Huang, Y., Chen, D., Shi, Z., Smith, A. D., Li, W., & Gao, Y. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13619 · Cited by 68
Self-citationFor Better or for Worse: A Look Into Neutrophils in Traumatic Spinal Cord Injury
Zivkovic, S., Ayazi, M., Hammel, G., & Ren, Y. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.648076 · Cited by 72
Brendecke, S. M., & Prinz, M. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0520-6 · Cited by 68
Regenerative Capacity of Macrophages for Remyelination
Rawji, K. S., Mishra, M. K., & Yong, V. W. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00047 · Cited by 70
Kataria, H., Alizadeh, A., Shahriary, G. M., Rizi, S. S., Henrie, R., Santhosh, K. T., Thliveris, J. A., & Karimi‐Abdolrezaee, S. (2017) · Glia · doi:10.1002/glia.23264 · Cited by 72
Chapman, T. W., Olveda, G. E., Bame, X., Pereira, E., & Hill, R. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01271-1 · Cited by 66
Remyelination — An effective means of neuroprotection
Bruce, C. C., Zhao, C., & Franklin, R. J. M. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.06.004 · Cited by 65
Self-citationMyelin regeneration in demyelinating disorders: new developments in biology and clinical pathology
Zawadzka, M., & Franklin, R. J. M. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32813aee7f · Cited by 65
Self-citationInhibition of oligodendrocyte precursor cell differentiation by myelin-associated proteins
Syed, Y. A., Baer, A. S., Lübec, G., Hoeger, H., Widhalm, G., & Kotter, M. (2008) · Neurosurgical FOCUS · doi:10.3171/foc/2008/24/3-4/e4 · Cited by 70
Self-citationA mouse model for testing remyelinating therapies
Bai, C. B., Sun, H. S., Roholt, A., Benson, E. K., Edberg, D. D., Medicetty, S., Dutta, R., Kidd, G. J., Macklin, W. B., & Trapp, B. D. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.06.033 · Cited by 68
Galloway, D. A., Blandford, S. N., Berry, T., Williams, J. B., Stefanelli, M., Ploughman, M., & Moore, C. S. (2019) · Glia · doi:10.1002/glia.23576 · Cited by 64
Yi, W., Schlüter, D., & Wang, X. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.029 · Cited by 67
Remyelination Therapy for Multiple Sclerosis
Keough, M. B., & Yong, V. W. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0152-7 · Cited by 64
Pifarré, P., Gutièrrez‐Mecinas, M., Prado, J., Usero, L., Roura‐Mir, C., Giralt, M., Hidalgo, J., & Garcı́a, A. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.10.021 · Cited by 62
CNS Remyelination and the Innate Immune System
McMurran, C. E., Jones, C. A., Fitzgerald, D. C., & Franklin, R. J. M. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00038 · Cited by 64
Self-citationBrennan, F. H., & Popovich, P. G. (2018) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000550 · Cited by 63
Zhang, Y., Bi, X., Adebiyi, O., Wang, J., Mooshekhian, A., Cohen, J., Wei, Z., Wang, F., & Li, X. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00332 · Cited by 62
MLean, N. A., & Verge, V. M. K. (2016) · Glia · doi:10.1002/glia.23021 · Cited by 62
Janjusevic, M., Gagno, G., Fluca, A. L., Padoan, L., Beltrami, A. P., Sinagra, G., Moretti, R., & Aleksova, A. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120193 · Cited by 63
Effect of glial cells on remyelination after spinal cord injury
Liu, B., Wang, Y.-Y., Wang, H., Liu, X.-K., Li, R., Zhang, P., Chu, Z., Wang, C., Liu, H.-R., Qi, J., et al. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.217354 · Cited by 63
Ferrer, I. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.07.004 · Cited by 65
Myelin repair: the role of stem and precursor cells in multiple sclerosis
Chandran, S., Hunt, D. P. J., Joannides, A. J., Zhao, C., Compston, A., & Franklin, R. J. M. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.2019 · Cited by 68
Self-citationVitamin D increases remyelination by promoting oligodendrocyte lineage differentiation
Gómez‐Pinedo, U., Cuevas, J. A., Benito‐Martín, M. S., Moreno‐Jiménez, L., Esteban-García, N., Torre‐Fuentes, L., Matías‐Guiu, J. A., Pytel, V., Montero, P., & Matías‐Guiu, J. (2019) · Brain and Behavior · doi:10.1002/brb3.1498 · Cited by 64
Boggs, J., Gao, W., & Hirahara, Y. (2008) · Biochimica et Biophysica Acta · doi:10.1016/j.bbagen.2007.10.015 · Cited by 70
D’Souza, C. A., & Moscarello, M. A. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9116-9 · Cited by 61
Hendriks, J. J. A., Slaets, H., Carmans, S., de Vries, H. E., Dijkstra, C. D., Stinissen, P., & Hellings, N. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.07.015 · Cited by 60
The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice
Siegert, E., Paul, F., Rothe, M., & Weylandt, K. H. (2017) · BMC Neuroscience · doi:10.1186/s12868-016-0312-5 · Cited by 60
Hypoxic-Ischaemic Encephalopathy and the Blood-Brain Barrier in Neonates
Lee, W. L. A., Michael-Titus, A. T., & Shah, D. K. (2017) · Developmental Neuroscience · doi:10.1159/000467392 · Cited by 59
Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation
Bogie, J. F. J., Stinissen, P., Hellings, N., & Hendriks, J. J. A. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-85 · Cited by 62
Rabchevsky, A. G., Sullivan, P. G., & Scheff, S. W. (2007) · Glia · doi:10.1002/glia.20508 · Cited by 59
Petković, F., Campbell, I. L., Gonzalez, B., & Castellano, B. (2016) · Glia · doi:10.1002/glia.23043 · Cited by 59
Syed, Y. A., Baer, A., Hofer, M. P., González, G. A., Rundle, J., Myrta, S., Huang, J. K., Zhao, C., Rossner, M. J., Trotter, M. W. B., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201303123 · Cited by 58
Self-citationSikkema, A. H., Stoffels, J. M. J., Wang, P., Basedow, F. J., Bulsink, R., Bajramovic, J. J., & Baron, W. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1238-x · Cited by 60
TAM receptors in phagocytosis: Beyond the mere internalization of particles
Burstyn‐Cohen, T., & Fresia, R. (2023) · Immunological Reviews · doi:10.1111/imr.13267 · Cited by 61
P2Y6 Receptor-Mediated Microglial Phagocytosis in Radiation-Induced Brain Injury
Xu, Y., Hu, W., Liu, Y., Xu, P., Li, Z., Wu, R., Shi, X., & Tang, Y. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9282-3 · Cited by 61
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Kondo, Y., Adams, J. M., Vanier, M. T., & Duncan, I. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6344-10.2011 · Cited by 58
Carbajal, K. S., Miranda, J. L., Tsukamoto, M. R., & Lane, T. E. (2011) · Glia · doi:10.1002/glia.21225 · Cited by 60
Shibahara, T., Ago, T., Tachibana, M., Nakamura, K., Yamanaka, K., Kuroda, J., Wakisaka, Y., & Kitazono, T. (2020) · Stroke · doi:10.1161/strokeaha.120.029827 · Cited by 61
Biancotti, J. C., Kumar, S., & de Vellis, J. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9792-8 · Cited by 69
Tiwari, V., Prajapati, B., Asare, Y., Damkou, A., Ji, H., Liu, L., Naser, N., Gouna, G., Leszczyńska, K. B., Mieczkowski, J., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.07.001 · Cited by 58
TREM2 ‐dependent microglial function is essential for remyelination and subsequent neuroprotection
Wang, Y., Kyauk, R. V., Shen, Y. A., Xie, L., Reichelt, M., Lin, H., Jiang, Z., Ngu, H., Shen, K., Greene, J. J., et al. (2023) · Glia · doi:10.1002/glia.24335 · Cited by 54
Inhibition of astroglial NF-kappaB enhances oligodendrogenesis following spinal cord injury
Bracchi-Ricard, V. C., Lambertsen, K. L., Ricard, J., Nathanson, L., Karmally, S., Johnstone, J. T., Ellman, D. G., Frydel, B. R., McTigue, D. M., & Bethea, J. R. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-92 · Cited by 56
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Huang, J. K., Fancy, S. P. J., Zhao, C., Rowitch, D. H., ffrench‐Constant, C., & Franklin, R. J. M. (2011) · Neurotherapeutics · doi:10.1007/s13311-011-0065-x · Cited by 57
Self-citationLaflamme, N., Cisbani, G., Préfontaine, P., Srour, Y., Bernier, J., St-Pierre, M.-K., Tremblay, M.-È., & Rivest, S. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00178 · Cited by 55
Baror, R., Neumann, B., Segel, M., Chalut, K. J., Fancy, S. P. J., Schafer, D. P., & Franklin, R. J. M. (2019) · Glia · doi:10.1002/glia.23612 · Cited by 54
Self-citationSharma, N., Upadhayay, S., Shandilya, A., Sahu, R., Singh, A., Rajkhowa, B., & Mehan, S. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100051 · Cited by 54
Stem cells for brain repair in neonatal hypoxia–ischemia
Chicha, L., Smith, T. N., & Guzman, R. G. (2013) · Child s Nervous System · doi:10.1007/s00381-013-2304-4 · Cited by 53
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Rist, J. M., & Franklin, R. J. M. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.04.027 · Cited by 55
Self-citationMelchor, G. S., Khan, T., Reger, J., & Huang, J. K. (2019) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00068 · Cited by 55
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Rajendran, R., Böttiger, G., Stadelmann, C., Karnati, S., & Berghoff, M. (2021) · Cells · doi:10.3390/cells10040884 · Cited by 56
Batterman, K. V., Cabrera, P. E., Moore, T. L., & Rosene, D. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.607691 · Cited by 53
Hammel, G., Zivkovic, S., Ayazi, M., & Ren, Y. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104591 · Cited by 55
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Broux, B., Gowing, E., & Prat, A. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0516-2 · Cited by 53
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van Wijngaarden, P., & Franklin, R. J. M. (2013) · Development · doi:10.1242/dev.092262 · Cited by 53
Self-citationActomyosin contractility controls cell surface area of oligodendrocytes
Kippert, A., Fitzner, D., Helenius, J. H., & Simons, M. (2009) · BMC Cell Biology · doi:10.1186/1471-2121-10-71 · Cited by 56
Oligodendrocyte differentiation and implantation: new insights for remyelinating cell therapy
Sher, F., Balasubramaniyan, V., Boddeke, E., & Copray, S. C. V. M. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32830f1e50 · Cited by 51
Boomkamp, S. D., Riehle, M. O., Wood, J. M., Olson, M. F., & Barnett, S. C. (2011) · Glia · doi:10.1002/glia.22278 · Cited by 50
Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination
Syed, Y. A., Zhao, C., Mahad, D., Möbius, W., Altmann, F., Foss, F., Sentürk, A., Acker-Palmer, A., Lubec, G., Lilley, K., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1521-1 · Cited by 50
Self-citationDrug discovery for remyelination and treatment of MS
Marshall-Phelps, K. L., Early, J. J., & Lyons, D. A. (2017) · Glia · doi:10.1002/glia.23166 · Cited by 54
千田, 裕., Kokubo, Y., Sato, S., Kuge, A., Takemura, S., Kondo, R., & Kayama, T. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.026 · Cited by 49
Škuljec, J., Gudi, V., Ulrich, R., Frichert, K., Yildiz, Ö., Pul, R., Voss, E. V., Wissel, K., Baumgärtner, W., & Stangel, M. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182294fad · Cited by 49
Zimmermann, J., Emrich, M., Krauthausen, M., Saxe, S., Nitsch, L., Heneka, M. T., Campbell, I. L., & Müller, M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0368-3 · Cited by 52
Bogie, J. F. J., Mailleux, J., Wouters, E., Jorissen, W., Grajchen, E., Vanmol, J., Wouters, K., Hellings, N., van Horssen, J., Vanmierlo, T., et al. (2017) · Scientific Reports · doi:10.1038/srep44794 · Cited by 48
Hadas, S., Spira, M., Hanisch, U., Reichert, F., & Rotshenker, S. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-166 · Cited by 49
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Pul, R., Morbiducci, F., Škuljec, J., Skripuletz, T., Singh, V., Diederichs, U., Garde, N., Voß, E. V., Trebst, C., & Stangel, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051867 · Cited by 47
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Reichert, F., & Rotshenker, S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00090 · Cited by 47
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Zhao, C., Fancy, S. P. J., ffrench-Constant, C., & Franklin, R. J. M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.04.007 · Cited by 47
Self-citationPurinergic receptors in multiple sclerosis pathogenesis
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Wellman, S. M., Guzman, K., Stieger, K. C., Brink, L. E., Sridhar, S., Dubaniewicz, M. T., Li, L., Cambi, F., & Kozai, T. D. Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119842 · Cited by 44
Scalabrino, G. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00989-x · Cited by 49
Tiane, A., Schepers, M., Riemens, R. J. M., Rombaut, B., Vandormael, P., Somers, V. A., Prickaerts, J., Hellings, N., van den Hove, D., & Vanmierlo, T. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03927-2 · Cited by 46
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Aparicio, E., Mathieu, P., Luppi, M. P., Gubiani, M. F. A., & Adamo, A. M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12440 · Cited by 47
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Duncan, G. J., Ingram, S. D., Emberley, K., Hill, J. Q., Cordano, C., Abdelhak, A., McCane, M., Jenks, J. E., Jabassini, N., Ananth, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53429-5 · Cited by 46
Zhu, K., Sun, J., Zheng, K., Zou, Z., Wu, G.-C., & Wang, J. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00613 · Cited by 46
Karttunen, M. J., Czopka, T., Goedhart, M., Early, J. J., & Lyons, D. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178058 · Cited by 44
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Smith, N. M., Giacci, M. K., Gough, A., Bailey, C. S. L., McGonigle, T. A., Black, A. M. B., Clarke, T. O., Bartlett, C. A., Iyer, K. S., Dunlop, S. A., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1227-0 · Cited by 45
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Zhang, N., Liu, C., Zhang, R., Jin, L., Yin, X., Zheng, X., Siebert, H., Li, Y., Wang, Z., Loers, G., et al. (2020) · Food & Function · doi:10.1039/c9fo02944c · Cited by 47
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Metadata
- Authors
- Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M.
- Affiliations
- University of Cambridge (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-01-04
- Volume
- 26
- Issue
- 1
- Pages
- 328-332
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6674302
- OpenAlex
- W2094044389
- Cited by
- 768
- References
- 30
- Citations by year
- 2026: 24 · 2025: 39 · 2024: 63 · 2023: 56 · 2022: 48 · 2021: 56 · 2020: 46 · 2019: 58 · 2018: 34 · 2017: 41 · 2016: 39 · 2015: 40 · 2014: 34 · 2013: 43 · 2012: 25
- FWCI
- 15.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Raymond and Beverly Sackler Foundation
- Multiple Sclerosis Society
- Austrian Science Fund
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- remyelination, myelin debris, oligodendrocyte precursor cells, oligodendrocyte differentiation, demyelination, multiple sclerosis, myelin basic protein, demyelinating lesions, axon regeneration, central nervous system repair
- MeSH terms
- Animals, Cell Differentiation, Central Nervous System, Female, Growth Inhibitors, Myelin Sheath, Nerve Fibers, Myelinated, Neural Inhibition, Oligodendroglia, Stem Cells, Rats, Sprague-Dawley, Rats
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