The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation
Open accessAbstract
Demyelination in the adult CNS can be followed by extensive repair. However, in multiple sclerosis, the differentiation of oligodendrocyte lineage cells present in demyelinated lesions is often inhibited by unknown factors. In this study, we test whether myelin debris, a feature of demyelinated lesions and an in vitro inhibitor of oligodendrocyte precursor differentiation, affects remyelination efficiency. Focal demyelinating lesions were created in the adult rat brainstem, and the naturally generated myelin debris was augmented by the addition of purified myelin. After quantification of myelin basic protein mRNA expression from lesion material obtained by laser capture microdissection and supported by histological data, we found a significant impairment of remyelination, attributable to an arrest of the differentiation and not the recruitment of oligodendrocyte precursor cells. These data identify myelin as an inhibitor of remyelination as well as its well documented inhibition of axon regeneration.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“they also exhibit regenerative properties through the phagocytosis of myelin debris3, 4 and secretion of growth/neurotrophic factors5.”
From M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination (2013) · cites this paper as [3]
In the citing paper
“Efficient myelin debris removal and clearance by phagocytic cells are critical to eliminate inhibitory signals interfering with OPC activation, recruitment to the site of demyelination and/or differentiation into myelinating mature OLs [14, 26, 27].”
From TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis (2020) · cites this paper as [26]
In the citing paper
“One critical role for microglia during demyelination is the clearance of myelin debris, which acts as an inhibitor of remyelination [192–194].”
From Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination (2022) · cites this paper as [194]
In the citing paper
“Long-term demyelination occurs post-SCI, with lipid-containing myelin debris being absorbed and processed by inflammatory cells, including microglia—a process crucial for paving the way for regenerative reactions and inflammation resolution [9–11].”
From miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1 (2024) · cites this paper as [9]
Citations
Cites
MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION1
Norton, W. T., & Poduslo, S. E. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb07519.x · Cited by 1,413
Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis
Chang, A., Tourtellotte, W. W., Rudick, R., & Trapp, B. D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010994 · Cited by 991
Caroni, P., & Schwab, M. E. (1988) · Neuron · doi:10.1016/0896-6273(88)90212-7 · Cited by 886
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
Filbin, M. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1195 · Cited by 873
Why does remyelination fail in multiple sclerosis?
Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 862
Self-citationLINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
Mi, S., Lee, X., Shao, Z., Thill, G., Ji, B., Relton, J. K., Levesque, M., Allaire, N., Perrin, S., Sands, B., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1188 · Cited by 827
p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
Wang, K., Kim, J. A., Sivasankaran, R., Segal, R. A., & He, Z. (2002) · Nature · doi:10.1038/nature01176 · Cited by 824
Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord
Horner, P. J., Power, A. E., Kempermann, G., Kuhn, H. G., Palmer, T. D., Winkler, J., Thal, L. J., & Gage, F. H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02218.2000 · Cited by 777
NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions
Chang, A., Nishiyama, A., Peterson, J. W., Prineas, J. W., & Trapp, B. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06404.2000 · Cited by 711
LINGO-1 negatively regulates myelination by oligodendrocytes
Mi, S., Miller, R. H., Lee, X., Scott, M. L., Shulag-Morskaya, S., Shao, Z., Chang, J., Thill, G., Levesque, M., Zhang, M., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1460 · Cited by 628
Cited by
Sorted by citations
Ahuja, C. S., Wilson, J. R., Nori, S., Kotter, M. R. N., Druschel, C., Curt, A., & Fehlings, M. G. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.18 · Cited by 2,441
Self-citationM2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,777
Self-citationRemyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Self-citationDebris clearance by microglia: an essential link between degeneration and regeneration
Neumann, H., Kotter, M. R., & Franklin, R. J. M. (2008) · Brain · doi:10.1093/brain/awn109 · Cited by 1,111
Self-citationMyelination of the Nervous System: Mechanisms and Functions
Nave, K.-A., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 983
Metadata
- Authors
- Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M.
- Affiliations
- University of Cambridge (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-01-04
- Volume
- 26
- Issue
- 1
- Pages
- 328-332
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6674302
- OpenAlex
- W2094044389
- Cited by
- 768
- References
- 30
- Citations by year
- 2026: 24 · 2025: 39 · 2024: 63 · 2023: 56 · 2022: 48 · 2021: 56 · 2020: 46 · 2019: 58 · 2018: 34 · 2017: 41 · 2016: 39 · 2015: 40 · 2014: 34 · 2013: 43 · 2012: 25
- FWCI
- 15.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Raymond and Beverly Sackler Foundation
- Multiple Sclerosis Society
- Austrian Science Fund
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- remyelination, myelin debris, oligodendrocyte precursor cells, oligodendrocyte differentiation, demyelination, multiple sclerosis, myelin basic protein, demyelinating lesions, axon regeneration, central nervous system repair
- MeSH terms
- Animals, Cell Differentiation, Central Nervous System, Female, Growth Inhibitors, Myelin Sheath, Nerve Fibers, Myelinated, Neural Inhibition, Oligodendroglia, Stem Cells, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
