The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex
Open accessAbstract
Despite their abundance, still little is known about the rather frequent, constantly proliferating progenitors spread throughout the adult mouse brain parenchyma. The majority of these progenitors express the basic-helix-loop-helix transcription factor Olig2, and their number further increases after injury. Here, we examine the progeny of this progenitor population by genetic fate mapping using tamoxifen-inducible Cre-recombination in the Olig2 locus to turn on permanent reporter gene expression in the adult brain. Consistent with Olig2 expression in proliferating NG2(+) progenitors, most reporter(+) cells seen shortly after initiating recombination at adult stages incorporated BrdU and contained the proteoglycan NG2 in both the gray (GM) and the white matter (WM) of the cerebral cortex. However, at longer time points after induction, we observed profound differences in the identity of reporter(+) cells in the WM and GM. Whereas most of the Olig2(+) progenitors had generated mature, myelinating oligodendrocytes in the WM, hardly any reporter(+) cells showing mature oligodendrocyte characteristics were detectable even up to 6 months after recombination in the GM. In the GM, most reporter(+) cells remained NG2(+), even after injury, but stopped proliferating rather soon after recombination. Thus, our results demonstrate the continuous generation of mature, myelinating oligodendrocytes in the WM, whereas cells in the GM generated mostly postmitotic NG2(+) glia.
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“Oligodendrocyte precursors (OPs) continue to proliferate and generate myelinating oligodendrocytes (OLs) well into adulthood.”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Dimou et al., 2008
Experimental — accuracy not yet measuredIn the citing paper
“The dataset-specific component of factor 28 showed that subject MD5828 had high expression of immediate early genes within polydendrocytes (Figure 4D), consistent with an acute injury (Dimou et al., 2008).”
From Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity (2019) · cites this paper as Dimou et al., 2008
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Citations
Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237
White matter in learning, cognition, and psychiatric disorders
Fields, R. D. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.04.001 · Cited by 1,337
Origin of oligodendrocytes in the subventricular zone of the adult brain
Menn, B., Garcia-Verdugo, J. M., Yaschine, C., Gonzalez-Perez, O., Rowitch, D., & Alvarez-Buylla, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1299-06.2006 · Cited by 972
NG2 cells generate both oligodendrocytes and gray matter astrocytes
Zhu, X., Bergles, D. E., & Nishiyama, A. (2007) · Development · doi:10.1242/dev.004895 · Cited by 699
The oligodendrocyte precursor cell in health and disease
Levine, J. M., Reynolds, R., & Fawcett, J. W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01691-x · Cited by 673
Widespread recombinase expression using FLPeR (Flipper) mice
Farley, F. W., Soriano, P. M., Steffen, L. S., & Dymecki, S. M. (2000) · genesis · doi:10.1002/1526-968x(200011/12)28:3/4 · Cited by 602
Endogenous progenitors remyelinate demyelinated axons in the adult CNS
Gensert, J. M., & Goldman, J. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80359-1 · Cited by 544
Dynamic Contribution of Nestin-Expressing Stem Cells to Adult Neurogenesis
Lagace, D. C., Whitman, M. C., Noonan, M. A., Ables, J. L., DeCarolis, N. A., Arguello, A. A., Donovan, M. H., Fischer, S. J., Farnbauch, L. A., Beech, R. D., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3812-07.2007 · Cited by 502
Takebayashi, H., Nabeshima, Y., Yoshida, S., Chisaka, O., Ikenaka, K., & Nabeshima, Y. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00926-0 · Cited by 500
Shen, S., Sandoval, J., Swiss, V. A., Li, J., Dupree, J. L., Franklin, R. J. M., & Casaccia‐Bonnefil, P. (2008) · Nature Neuroscience · doi:10.1038/nn.2172 · Cited by 499
Cited by
Sorted by citations
Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity
Welch, J. D., Kozareva, V., Ferreira, A., Vanderburg, C., Martin, C., & Macosko, E. Z. (2019) · Cell · doi:10.1016/j.cell.2019.05.006 · Cited by 1,193
Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 919
“However, OPs continue to divide and generate new-myelinating OLs well into adulthood (Dimou et al., 2008; Rivers et al., 2008; Psachoulia et al., 2009; Kang et al., 2010; Zhu et al., 2011; reviewed by Richardson et al., 2011).”
BackgroundPolydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
Nishiyama, A., Komitova, M., Suzuki, R., & Zhu, X. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2495 · Cited by 865
Hughes, E. G., Kang, S. H., Fukaya, M., & Bergles, D. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3390 · Cited by 808
Kang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 815
Metadata
- Authors
- Dimou, L., Simon, C., Kirchhoff, F., Takebayashi, H., & Götz, M.
- Affiliations
- Physiologisches Institut (DE)
- Helmholtz Munich (DE)
- Max Planck Society (DE)
- National Institute for Physiological Sciences (JP)
- Center for Integrated Protein Science Munich (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-10-08
- Volume
- 28
- Issue
- 41
- Pages
- 10434-10442
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6671038
- OpenAlex
- W2095490681
- Cited by
- 551
- References
- 51
- Citations by year
- 2026: 19 · 2025: 19 · 2024: 22 · 2023: 30 · 2022: 26 · 2021: 38 · 2020: 45 · 2019: 35 · 2018: 32 · 2017: 35 · 2016: 33 · 2015: 40 · 2014: 42 · 2013: 36 · 2012: 23
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Site cant be reached (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- Olig2, cerebral cortex, gray matter, white matter, NG2 glia, oligodendrocyte differentiation, myelination, fate mapping, Cre recombination, BrdU labeling, brain injury, progenitor cell proliferation
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Chondroitin Sulfate Proteoglycan 4, Animals, Antigens, Cell Differentiation, Cerebral Cortex, Mice, Inbred C57BL, Mitosis, Myelin Sheath, Nerve Tissue Proteins, Neuroglia, Oligodendroglia, Periaqueductal Gray, Proteoglycans, Stem Cells, Tamoxifen, Wounds, Stab, Gene Expression, Genes, Reporter, Integrases, Animals, Genetically Modified, Cell Proliferation, Mice, Basic Helix-Loop-Helix Proteins
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