Sex differences in microglia activity within the periaqueductal gray of the rat: A potential mechanism driving the dimorphic effects of morphine

CDC Guideline for Prescribing Opioids for Chronic Pain—United States, 2016

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Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α

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A Gender Gap in Autoimmunity: Task Force on Gender, Multiple Sclerosis and Autoimmunity

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The effects of hormones on sex differences in infection: from genes to behavior

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The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS

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Evidence that opioids may have toll-like receptor 4 and MD-2 effects

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Sex differences in pain and analgesia: the role of gonadal hormones

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Microglia Are Essential to Masculinization of Brain and Behavior

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Morphine activates neuroinflammation in a manner parallel to endotoxin

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Sex Differences in the Prevalence, Symptoms, and Associated Features of Migraine, Probable Migraine and Other Severe H eadache: Results of the A merican Migraine Prevalence and Prevention ( AMPP ) Study

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Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

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Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat

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The involvement of glial cells in the development of morphine tolerance

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Assessing Activation States in Microglia

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Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation

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Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward

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Glia: novel counter-regulators of opioid analgesia

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Sex Differences in Opioid Analgesia: “From Mouse to Man”

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Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia

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Opioid activation of Toll-Like receptor 4 contributes to drug reinforcement

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Opioid Guidelines in the Management of Chronic Non-Cancer Pain

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Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat

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Sex, glia, and development: Interactions in health and disease

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The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh‐TNF‐α, IL‐1β and IFN‐γ

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Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide

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Steroid Hormone Regulation of Cytokine Secretion by Proteolipid Protein-Specific CD4+ T Cell Clones Isolated from Multiple Sclerosis Patients and Normal Control Subjects

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Differential effects of stress on microglial cell activation in male and female medial prefrontal cortex

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Lipopolysaccharide-induced microglial activation in culture: temporal profiles of morphological change and release of cytokines and nitric oxide

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Peripheral lipopolysaccharide stimulation induces interleukin-1β messenger RNA in rat brain microglial cells

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Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats

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Fever induction pathways: evidence from responses to systemic or local cytokine formation

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Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway

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Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia

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Sex Differences in μ-Opioid Receptor Expression in the Rat Midbrain Periaqueductal Gray Are Essential for Eliciting Sex Differences in Morphine Analgesia

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Blockade of Toll-Like Receptor 4 Attenuates Morphine Tolerance and Facilitates the Pain Relieving Properties of Morphine

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Sex- and stress-steroids interactions and the immune system: evidence for a neuroendocrine-immunological sexual dimorphism

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17-β-Estradiol and progesterone modulate an intrinsic opioid analgesic system

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Gangliosides Trigger Inflammatory Responses via TLR4 in Brain Glia

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Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling

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Rapid upregulation of μ opioid receptor mrna in dorsal root ganglia in response to peripheral inflammation depends on neuronal conduction

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Intranasal Immune Challenge Induces Sex-Dependent Depressive-Like Behavior and Cytokine Expression in the Brain

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Sex differences in the anatomical and functional organization of the periaqueductal gray‐rostral ventromedial medullary pathway in the rat: A potential circuit mediating the sexually dimorphic actions of morphine

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Acute Neuroinflammation Impairs Context Discrimination Memory and Disrupts Pattern Separation Processes in Hippocampus

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Interleukin-1, interleukin-6, and tumor necrosis factor α are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone

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Nociceptive Sensitivity and Opioid Antinociception and Antihyperalgesia in Freund’s Adjuvant-Induced Arthritic Male and Female Rats

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Persistent pain model reveals sex difference in morphine potency

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Kinetics of systemic and intrahypothalamic IL-6 and tumor necrosis factor during endotoxin fever in guinea pigs

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Expression of N‐methyl D ‐aspartate receptor subunits in amoeboid microglia mediates production of nitric oxide via NF‐κB signaling pathway and oligodendrocyte cell death in hypoxic postnatal rats

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Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide

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PAG mu opioid receptor activation underlies sex differences in morphine antinociception

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Morphine preferentially activates the periaqueductal gray–rostral ventromedial medullary pathway in the male rat: A potential mechanism for sex differences in antinociception

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Mu opioid receptor activation modulates Toll like receptor 4 in murine macrophages

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Sex differences in astrocyte and microglia responses immediately following middle cerebral artery occlusion in adult mice

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Sex differences in morphine-induced analgesia of visceral pain are supraspinally and peripherally mediated

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Morphine Antinociceptive Potency on Chemical, Mechanical, and Thermal Nociceptive Tests in the Rat

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Persistent Peripheral Inflammation Attenuates Morphine-Induced Periaqueductal Gray Glial Cell Activation and Analgesic Tolerance in the Male Rat

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Sexually dimorphic activation of the periaqueductal gray–rostral ventromedial medullary circuit during the development of tolerance to morphine in the rat

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Dose‐ and time‐dependent estradiol modulation of morphine antinociception in adult female rats

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Inhibition of morphine analgesia by LPS: role of opioid and NMDA receptors and spinal glia

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