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Functional Magnetic Resonance Imaging Shows Oxytocin Activates Brain Regions Associated with Mother–Pup Bonding during Suckling
Open accessAbstract
Oxytocin is released in the maternal brain during breastfeeding and may help strengthen the mother–infant relationship. Here, we used functional magnetic resonance imaging to determine whether oxytocin modulates brain activity in postpartum day 4–8 dams receiving suckling stimulation. During imaging sessions, dams were exposed to pup suckling before and after administration of an oxytocin receptor antagonist. Another group of dams received oxytocin alone. Changes in brain activation in response to suckling closely matched that elicited by oxytocin administration. The overlapping brain areas included the olfactory system, nucleus accumbens, insular cortex, prefrontal cortex, ventral tegmental area, cortical amygdala, and several cortical and hypothalamic nuclei. Blockade of oxytocin receptors largely attenuated activation in these regions. The data suggest that oxytocin may strengthen mother–infant bond formation partly by acting through brain areas involved in regulating olfactory discrimination, emotions, and reward.
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“The neuropeptide oxytocin can selectively gate cortical responses to infant stimuli to subsequently enable maternal care”
From Neuromodulation of maternal circuits by oxytocin (2019) · cites this paper as Febo et al., 2005
In the citing paper
“Brain imaging in rats when pup-suckling shows activations in the paraventricular nucleus of hypothalamus, olfactory tubercle, anterior olfactory nucleus, piriform cortex, amygdala, medial preoptic area, ventral tegmentum area, insular cortex and prefrontal cortex (27).”
From Neuroendocrinology of Parental Response to Baby‐Cry (2011) · cites this paper as [27]
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Metadata
- Authors
- Febo, M., Numan, M., & Ferris, C. F.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Boston College (US)
- Corresponding author
- Febo, Marcelo
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-12-14
- Volume
- 25
- Issue
- 50
- Pages
- 11637-11644
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6726012
- OpenAlex
- W2168959320
- Cited by
- 197
- References
- 51
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 3 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 12 · 2014: 21 · 2013: 10 · 2012: 14
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Science Foundation (0312380)
- National Institute on Drug Abuse (R01 DA13517, R01DA013517)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, suckling, mother-infant relationship, oxytocin receptor antagonist, olfactory system, nucleus accumbens, insula, prefrontal cortex, ventral tegmental area, cortical amygdala, hypothalamus, odor discrimination, reward, maternal behavior
- MeSH terms
- Animals, Animals, Suckling, Brain Mapping, Emotions, Female, Magnetic Resonance Imaging, Maternal Behavior, Object Attachment, Oxytocin, Reward, Rats, Sprague-Dawley, Receptors, Oxytocin, Rats
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