Neurofunctional maps of the ‘maternal brain’ and the effects of oxytocin: a multimodal voxel-based meta-analysis
Abstract
Several studies have tried to understand the possible neurobiological basis of mothering. The putative involvement of oxytocin, in this regard, has been deeply investigated. Performing a voxel-based meta-analysis, we aimed at testing the hypothesis of overlapping brain activation in functional magnetic resonance imaging (fMRI) studies investigating the mother-infant interaction and the oxytocin modulation of emotional stimuli in humans. We performed two systematic literature searches: fMRI studies investigating the neurofunctional correlates of the 'maternal brain' by employing mother-infant paradigms; and fMRI studies employing oxytocin during emotional tasks. A unimodal voxel-based meta-analysis was performed on each database, whereas a multimodal voxel-based meta-analytical tool was adopted to assess the hypothesis that the neurofunctional effects of oxytocin are detected in brain areas implicated in the 'maternal brain.' We found greater activation in the bilateral insula extending to the inferior frontal gyrus, basal ganglia and thalamus during mother-infant interaction and greater left insular activation associated with oxytocin administration versus placebo. Left insula extending to basal ganglia and frontotemporal gyri as well as bilateral thalamus and amygdala showed consistent activation across the two paradigms. Right insula also showed activation across the two paradigms, and dorsomedial frontal cortex activation in mothers but deactivation with oxytocin. Significant activation in areas involved in empathy, emotion regulation, motivation, social cognition and theory of mind emerged from our multimodal meta-analysis, supporting the need for further studies directly investigating the neurobiology of oxytocin in the mother-infant relationship.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
During pregnancy dramatic structural and functional changes occur in the oxytocin system of the mother's brain.
“During pregnancy dramatic structural and functional changes occur in the OT system of the mother's brain (Hillerer et al., 2014;Rocchetti et al., 2014).”
From Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis (2016) · cites this paper as Rocchetti et al., 2014
Cites
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648 · see citing works
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426 · see citing works
The feeling of what happens: body and emotion in the making of consciousness
(2000) · Choice Reviews Online · doi:10.5860/choice.37-6553 · Cited by 5,998 · see citing works
The distributed human neural system for face perception
Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01482-0 · Cited by 4,891 · see citing works
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502 · see citing works
The Feeling of What Happens: Body and Emotion in the Making of Consciousness
Panksepp, J., & Modell, A. H. (2000) · Neuropsychoanalysis · doi:10.1080/15294145.2000.10773287 · Cited by 3,421 · see citing works
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
The nature of the child’s tie to his mother 1
Bowlby, J. (2018) · Routledge eBooks · doi:10.4324/9780429475931-15 · Cited by 2,372 · see citing works
A unifying view of the basis of social cognition
GALLESE, V, KEYSERS, C., & RIZZOLATTI, G. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.002 · Cited by 2,236 · see citing works
Dissociable Roles of Ventral and Dorsal Striatum in Instrumental Conditioning
O'Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., & Dolan, R. J. (2004) · Science · doi:10.1126/science.1094285 · Cited by 2,088 · see citing works
Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas
Carr, L., Iacoboni, M., Dubeau, M.-C., Mazziotta, J. C., & Lenzi, G. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0935845100 · Cited by 1,978 · see citing works
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Attachment and development: A prospective, longitudinal study from birth to adulthood
Sroufe, L. A. (2005) · Attachment & Human Development · doi:10.1080/14616730500365928 · Cited by 1,685 · see citing works
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,448 · cited 1× · see citing works
“3 Talairach Bartels et al.(57) 2004 20 mothers 34 Healthy Infant pictures SPM99 Talairach Musser et al.”
BackgroundThe mirror neuron system and the consequences of its dysfunction
Iacoboni, M., & Dapretto, M. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2024 · Cited by 1,401 · see citing works
The Enigmatic temporal pole: a review of findings on social and emotional processing
Olson, I. R., Plotzker, A., & Ezzyat, Y. (2007) · Brain · doi:10.1093/brain/awm052 · Cited by 1,370 · see citing works
Fusar‐Poli, P., Placentino, A., Carletti, F., Landi, P., Allen, P., Surguladze, S., Benedetti, F., Abbamonte, M., Gasparotti, R., Barale, F., et al. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0953 · Cited by 1,292 · see citing works
Self-citationA common role of insula in feelings, empathy and uncertainty
Singer, T., Critchley, H. D., & Preuschoff, K. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.05.001 · Cited by 1,270 · see citing works
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258 · see citing works
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173 · see citing works
Psychiatric Disorders in Pregnant and Postpartum Women in the United States
Vesga-López, O., Blanco, C., Keyes, K., Olfson, M., Grant, B. F., & Hasin, D. S. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.7.805 · Cited by 1,065 · see citing works
The triune brain in evolution: Role in paleocerebral functions
Legg, C. R. (1990) · Biological Psychology · doi:10.1016/0301-0511(90)90083-9 · Cited by 981 · see citing works
(1990) · Medical Entomology and Zoology · Cited by 919 · see citing works
Is there a core neural network in empathy? an fMRI based quantitative meta-analysis
Fan, Y., Duncan, N. W., de Greck, M., & Northoff, G. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.009 · Cited by 902 · cited 1× · see citing works
“A recent meta-analysis, in fact, included this region in an empathy network, including insular, cingular and supplementary motor cortices.(78) Another frontal region, Brodmann area 6, according to our multimodal analysis, showed an overlapping modulation by oxytocin and mother–infant stimuli.”
BackgroundVoxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder
Radua, J., & Mataix-Cols, D. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.055046 · Cited by 863 · see citing works
Self-citationOxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856 · see citing works
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804 · see citing works
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · see citing works
Adult attachment predicts maternal brain and oxytocin response to infant cues.
Strathearn, L., Fonagy, P., Amico, J., & Montague, P. R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.103 · Cited by 773 · see citing works
Oxytocin and social affiliation in humans
Feldman, R. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.008 · Cited by 767 · see citing works
Radua, J., Mataix-Cols, D., Phillips, M. L., El-Hage, W., Kronhaus, D. M., Cardoner, N., & Surguladze, S. (2012) · European Psychiatry · doi:10.1016/j.eurpsy.2011.04.001 · Cited by 765 · see citing works
Hart, H., Radua, J., Nakao, T., Mataix-Cols, D., & Rubia, K. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.277 · Cited by 764 · see citing works
Nakao, T., Radua, J., Rubia, K., & Mataix-Cols, D. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020281 · Cited by 588 · see citing works
Self-citationLiu, Y., & Wang, Z. X. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00555-4 · Cited by 580 · cited 1× · see citing works
“This interaction has been investigated in the ventral striatum of prairie voles, where it seems to be crucial for pair bond formation.(131) A dopaminergic receptor remodeling in this area has further been linked with pair bond maintenance, based on aversive behavior towards unfamiliar individuals.”
BackgroundTost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer–Lindenberg, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003296107 · Cited by 564 · see citing works
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521 · see citing works
Uddin, L. Q., Supekar, K. S., Ryali, S., & Menon, V. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4465-11.2011 · Cited by 520 · see citing works
Swain, J. E., Lorberbaum, J. P., Kose, S., & Strathearn, L. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01731.x · Cited by 499 · see citing works
Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Gamer, M., Zurowski, B., & Büchel, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000985107 · Cited by 487 · see citing works
Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2008) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsn004 · Cited by 474 · see citing works
Aragona, B. J., Liu, Y., Yu, Y. J., Curtis, J. T., Detwiler, J. M., Insel, T. R., & Wang, Z. (2006) · Nature Neuroscience · doi:10.1038/nn1613 · Cited by 473 · cited 1× · see citing works
“A dopaminergic receptor remodeling in this area has further been linked with pair bond maintenance, based on aversive behavior towards unfamiliar individuals.(132) The regulation of attachment reward (in particular parental attachment) over novelty has also been explored in humans.”
BackgroundAnterior insula integrates information about salience into perceptual decisions about pain
Wiech, K., Lin, C.-S., Brodersen, K. H., Bingel, U., Ploner, M., & Tracey, I. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2087-10.2010 · Cited by 470 · see citing works
What’s in a smile? Maternal brain responses to infant facial cues
Strathearn, L., Li, J., Fonagy, P., & Montague, P. R. (2008) · Pediatrics · doi:10.1542/peds.2007-1566 · Cited by 460 · see citing works
Kim, P., Leckman, J. F., Mayes, L. C., Feldman, R., Wang, X., & Swain, J. E. (2010) · Behavioral Neuroscience · doi:10.1037/a0020884 · Cited by 440 · see citing works
Bora, E., Fornito, A., Raduà, J., Walterfang, M., Seal, M. L., Wood, S. J., Yücel, M., Velakoulis, D., & Pantelis, C. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2010.12.020 · Cited by 425 · see citing works
Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4572-07.2008 · Cited by 424 · see citing works
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423 · see citing works
Radua, J., van den Heuvel, O. A., Surguladze, S., & Mataix-Cols, D. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.70 · Cited by 400 · see citing works
Atzil, S., Hendler, T., & Feldman, R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.172 · Cited by 399 · see citing works
Palmiter, R. D. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.003 · Cited by 375 · see citing works
Orbitofrontal cortex tracks positive mood in mothers viewing pictures of their newborn infants
Nitschke, J. B., Nelson, E. E., Rusch, B. D., Fox, A. S., Oakes, T. R., & Davidson, R. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.10.005 · Cited by 371 · see citing works
Mirroring others' emotions relates to empathy and interpersonal competence in children
Pfeifer, J. H., Iacoboni, M., Mazziotta, J. C., & Dapretto, M. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.032 · Cited by 368 · see citing works
Riem, M. M. E., Bakermans-Kranenburg, M. J., Pieper, S., Tops, M., Boksem, M. A. S., Vermeiren, R. R. J. M., van IJzendoorn, M. H., & Rombouts, S. A. R. B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.006 · Cited by 366 · see citing works
Motivational systems and the neural circuitry of maternal behavior in the rat
Numan, M. (2007) · Developmental Psychobiology · doi:10.1002/dev.20198 · Cited by 358 · see citing works
Neural mechanisms of social risk for psychiatric disorders
Meyer‐Lindenberg, A., & Tost, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3083 · Cited by 342 · see citing works
A Defect in Nurturing in Mice Lacking the Immediate Early Gene fosB
Brown, J. R., Ye, H., Bronson, R. T., Dikkes, P., & Greenberg, M. E. (1996) · Cell · doi:10.1016/s0092-8674(00)80101-4 · Cited by 339 · see citing works
The Functional Neuroanatomy of Maternal Love: Mother’s Response to Infant’s Attachment Behaviors
Noriuchi, M., Kikuchi, Y., & Senoo, A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.018 · Cited by 334 · see citing works
Raduà, J., Borgwardt, S., Crescini, A., Mataix‐Cols, D., Meyer‐Lindenberg, A., McGuire, P. K., & Fusar‐Poli, P. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.012 · Cited by 333 · see citing works
Self-citationGetting a grip on other minds: Mirror neurons, intention understanding, and cognitive empathy
Kaplan, J. T., & Iacoboni, M. (2006) · Social Neuroscience · doi:10.1080/17470910600985605 · Cited by 333 · see citing works
Psychophysiology of neural, cognitive and affective integration: fMRI and autonomic indicants
Critchley, H. D. (2009) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2009.01.012 · Cited by 323 · see citing works
Oxytocin improves specific recognition of positive facial expressions
Marsh, A. A., Yu, H. H., Pine, D. S., & Blair, R. J. R. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1780-4 · Cited by 321 · see citing works
Rubia, K., Alegria, A. A., Cubillo, A. I., Smith, A. B., Brammer, M. J., & Radua, J. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.016 · Cited by 315 · see citing works
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Thompson, R., Ditzen, B., Patel, R., & Pagnoni, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.013 · Cited by 303 · see citing works
van Leengoed, E., Kerker, E., & Swanson, H. H. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.1120275 · Cited by 300 · see citing works
The role of oxytocin in parturition
BLANKS, A. (2003) · BJOG: An International Journal of Obstetrics and Gynaecology · doi:10.1016/s1470-0328(03)00024-7 · Cited by 296 · see citing works
Neuroanatomical Maps of Psychosis Onset: Voxel-wise Meta-Analysis of Antipsychotic-Naive VBM Studies
Fusar‐Poli, P., Raduà, J., McGuire, P. K., & Borgwardt, S. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr134 · Cited by 291 · see citing works
Self-citationOxytocin-Motivated Ally Selection is Moderated by Fetal Testosterone Exposure and Empathic Concern
Kret, M. E., & Dreu, C. K. W. D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00001 · Cited by 288 · see citing works
Immunohistochemical localization of oxytocin receptors in human brain
Boccia, M. L., Petrusz, P., Suzuki, K., Marson, L., & Pedersen, C. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.048 · Cited by 276 · see citing works
The animal and human neuroendocrinology of social cognition, motivation and behavior
McCall, C., & Singer, T. (2012) · Nature Neuroscience · doi:10.1038/nn.3084 · Cited by 273 · see citing works
Maternal neglect: oxytocin, dopamine and the neurobiology of attachment
Strathearn, L. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02228.x · Cited by 268 · see citing works
Meta-analysis of fMRI studies of timing in attention-deficit hyperactivity disorder (ADHD)
Hart, H., Radua, J., Mataix-Cols, D., & Rubia, K. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.08.003 · Cited by 258 · see citing works
Self-citationSinger, T., Snozzi, R., Bird, G., Petrovic, P., Silani, G., Heinrichs, M., & Dolan, R. J. (2008) · Emotion · doi:10.1037/a0014195 · Cited by 248 · see citing works
Nortje, G., Stein, D. J., Raduà, J., Mataix‐Cols, D., & Horn, N. R. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.05.034 · Cited by 247 · see citing works
Meta-analytic methods for neuroimaging data explained
Radua, J., & Mataix-Cols, D. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-6 · Cited by 246 · see citing works
Self-citationNeural correlates of recollection and familiarity: A review of neuroimaging and patient data
Skinner, E. I., & Fernandes, M. A. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.03.007 · Cited by 243 · see citing works
Oxytocin facilitates protective responses to aversive social stimuli in males
Striepens, N., Scheele, D., Kendrick, K. M., Becker, B., Schäfer, L., Schwalba, K., Reul, J., Maier, W., & Hurlemann, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208852109 · Cited by 242 · see citing works
The human parental brain: In vivo neuroimaging
Swain, J. E. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.10.017 · Cited by 234 · see citing works
Di Simplicio, M., Massey-Chase, R., Cowen, P., & Harmer, C. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108095705 · Cited by 229 · see citing works
Atzil, S., Hendler, T., Zagoory-Sharon, O., Winetraub, Y., & Feldman, R. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.06.008 · Cited by 225 · see citing works
Lischke, A., Berger, C., Prehn, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.015 · Cited by 221 · see citing works
Slade, A., Sadler, L. S., Dios-Kenn, C. D., Webb, D., Currier-Ezepchick, J., & Mayes, L. C. (2005) · The Psychoanalytic Study of the Child · doi:10.1080/00797308.2005.11800747 · Cited by 207 · see citing works
White Matter Development in Adolescence: Diffusion Tensor Imaging and Meta-Analytic Results
Peters, B. D., Szeszko, P. R., Raduà, J., Ikuta, T., Gruner, P., DeRosse, P., Zhang, J., Giorgio, A., Qiu, D., Tapert, S. F., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs054 · Cited by 203 · see citing works
Estrogen receptor α is essential for induction of oxytocin receptor by estrogen
Young, L. J., Wang, Z., Donaldson, R., & Rissman, E. F. (1998) · Neuroreport · doi:10.1097/00001756-199803300-00031 · Cited by 198 · see citing works
Oxytocin increases amygdala reactivity to threatening scenes in females
Lischke, A., Gamer, M., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.011 · Cited by 194 · see citing works
The hormonal control of ejaculation
Corona, G., Jannini, E. A., Vignozzi, L., Rastrelli, G., & Maggi, M. (2012) · Nature Reviews Urology · doi:10.1038/nrurol.2012.147 · Cited by 187 · see citing works
Meta-analysis of Gray Matter Abnormalities in Autism Spectrum Disorder
Via, E., Raduà, J., Cardoner, N., Happe, F. G. E., & Mataix‐Cols, D. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.27 · Cited by 184 · see citing works
Radua, J., Via, E., Catani, M., & Mataix-Cols, D. (2011) · Psychological Medicine · doi:10.1017/s0033291710002187 · Cited by 183 · see citing works
Self-citationDepressed mothers’ infants are less responsive to faces and voices
Field, T., Diego, M., & Hernandez-Reif, M. (2009) · Infant Behavior and Development · doi:10.1016/j.infbeh.2009.03.005 · Cited by 180 · see citing works
Oxytocin increases recognition of masked emotional faces
Schulze, L., Lischke, A., Greif, J., Herpertz, S. C., Heinrichs, M., & Domes, G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.011 · Cited by 180 · see citing works
The neural correlates of maternal sensitivity: an fMRI study
Musser, E. D., Kaiser-Laurent, H., & Ablow, J. C. (2012) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2012.04.003 · Cited by 177 · see citing works
Predictors of Maternal Sensitivity to Infant Distress
Leerkes, E. M. (2010) · Parenting · doi:10.1080/15295190903290840 · Cited by 177 · see citing works
Barrett, J., Wonch, K. E., Gonzalez, A., Ali, N., Steiner, M., Hall, G. B., & Fleming, A. S. (2012) · Social Neuroscience · doi:10.1080/17470919.2011.609907 · Cited by 177 · see citing works
Lenzi, D., Trentini, C., Pantano, P., Macaluso, E., Iacoboni, M., Lenzi, G. L., & Ammaniti, M. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn153 · Cited by 174 · see citing works
Sex differences in vasopressin and oxytocin innervation of the brain
DEVRIES, G. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00402-0 · Cited by 169 · see citing works
Human striatal activation reflects degree of stimulus saliency
Zink, C. F., Pagnoni, G., Chappelow, J., Martin-Skurski, M. E., & Berns, G. S. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.006 · Cited by 169 · see citing works
The neural basis of maternal responsiveness to infants: an fMRI study
Ranote, S., Elliott, R., Abel, K. M., Mitchell, R., Deakin, J. F. W., & Appleby, L. (2004) · NeuroReport · doi:10.1097/01.wnr.0000137078.64128.6a · Cited by 167 · see citing works
Association between the oxytocin receptor gene and amygdalar volume in healthy adults
Inoue, H., Yamasue, H., Tochigi, M., Abe, O., Liu, X., Kawamura, Y., Takei, K., Suga, M., Yamada, H., Rogers, M. A., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.019 · Cited by 164 · see citing works
Oxytocin receptor density is associated with male mating tactics and social monogamy
Ophir, A. G., Gessel, A., Zheng, D.-J., & Phelps, S. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.007 · Cited by 161 · see citing works
Effects of Postnatal Depression on Mother–Infant Interactions and Child Development
Murray, L., Halligan, S. L., & Cooper, P. (2010) · Wiley eBooks · doi:10.1002/9781444327588.ch8 · Cited by 156 · see citing works
Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis.
Palaniyappan, L., Balain, V., Radua, J., & Liddle, P. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.01.038 · Cited by 156 · see citing works
Self-citationLikowski, K. U., Mühlberger, A., Gerdes, A. B. M., Wieser, M. J., Pauli, P., & Weyers, P. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00214 · Cited by 152 · see citing works
Deep and Superficial Amygdala Nuclei Projections RevealedIn Vivoby Probabilistic Tractography
Bach, D. R., Behrens, T. E. J., Garrido, L., Weiskopf, N., & Dolan, R. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2744-10.2011 · Cited by 151 · see citing works
Maternal neural responses to infant cries and faces: relationships with substance use
Landi, N., Montoya, J., Kober, H., Rutherford, H. J. V., Mencl, W. E., Worhunsky, P. D., Potenza, M. N., & Mayes, L. C. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00032 · Cited by 146 · see citing works
Mattie Tops, A., Koole, S. L., IJzerman, H., & Buisman‐Pijlman, F. T. A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.07.015 · Cited by 146 · see citing works
Intranasal oxytocin modulates EEG mu/alpha and beta rhythms during perception of biological motion
Perry, A., Bentin, S., Shalev, I., Israel, S., Uzefovsky, F., Bar-On, D., & Ebstein, R. P. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.04.011 · Cited by 143 · see citing works
Labuschagne, I., Phan, K. L., WOOD, A. G., Angstadt, M., Chua, P. M.-L., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001489 · Cited by 139 · see citing works
Oxytocin Modulates Neural Reactivity to Children's Faces as a Function of Social Salience
Wittfoth-Schardt, D., Gründing, J., Wittfoth, M., Lanfermann, H., Heinrichs, M., Domes, G., Buchheim, A., Gündel, H., & Waller, C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.47 · Cited by 139 · see citing works
Boccia, M. L., Goursaud, A.-P. S., Bachevalier, J., Anderson, K. D., & Pedersen, C. A. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.05.009 · Cited by 136 · see citing works
Species-specific response to human infant faces in the premotor cortex
Caria, A., de Falco, S., Venuti, P., Lee, S., Esposito, G., Rigo, P., Birbaumer, N., & Bornstein, M. H. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.068 · Cited by 135 · see citing works
Kuroda, K. O., Tachikawa, K., Yoshida, S., Tsuneoka, Y., & Numan, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.02.008 · Cited by 134 · see citing works
Keyser‐Marcus, L., Stafisso-Sandoz, G., Gerecke, K. M., Jasnow, A. M., Nightingale, L., Lambert, K. G., Gatewood, J. D., & Kinsley, C. H. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00554-8 · Cited by 115 · see citing works
Lansley, J., Mataix‐Cols, D., Grau, M., Raduà, J., & Sastre‐Garriga, J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.006 · Cited by 114 · see citing works
Meta-analysis of functional network alterations in Alzheimer's disease: Toward a network biomarker
Jacobs, H. I. L., Raduà, J., Lückmann, H. C., & Sack, A. T. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.009 · Cited by 114 · see citing works
Do mirror neuron areas mediate mu rhythm suppression during imitation and action observation?
Braadbaart, L., Williams, J. H. G., & Waiter, G. D. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.05.019 · Cited by 109 · see citing works
Cooper, D., Barker, V., Raduà, J., Fusar‐Poli, P., & Lawrie, S. M. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.07.008 · Cited by 103 · see citing works
Self-citationThe role of oxytocin in mating and pregnancy
Borrow, A. P., & Cameron, N. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.001 · Cited by 101 · see citing works
Champagne, F. A., Curley, J. P., Swaney, W. T., Hasen, N. S., & Keverne, E. B. (2009) · Behavioral Neuroscience · doi:10.1037/a0015060 · Cited by 100 · see citing works
Akaishi, T., & Sakuma, Y. (1985) · Brain Research · doi:10.1016/0006-8993(85)90481-0 · Cited by 99 · see citing works
Бычков, Э. Р., Ahmed, M. R., & Gurevich, E. V. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000118 · Cited by 99 · see citing works
Nievar, M. A., & Becker, B. J. (2007) · Social Development · doi:10.1111/j.1467-9507.2007.00417.x · Cited by 91 · see citing works
Radua, J., Romeo, M., Mataix-Cols, D., & Fusar-Poli, P. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320030017 · Cited by 91 · see citing works
Self-citationPincus, D. (2010) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2010.00134 · Cited by 91 · see citing works
A Neural Signature of Affiliative Emotion in the Human Septohypothalamic Area
Moll, J., Bado, P., de Oliveira‐Souza, R., Bramati, I. E., Lima, D. O., Paiva, F. F., Sato, J. R., Tovar-Moll, F. F., & Zahn, R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6508-11.2012 · Cited by 87 · see citing works
Bodden, M., Kübler, D., Knake, S., Menzler, K., Heverhagen, J. T., Sommer, J. B., Kalbe, E., Krach, S., & Dodel, R. C. (2013) · Advances in Cognitive Psychology · doi:10.5709/acp-0129-6 · Cited by 86 · see citing works
Prehn, K., Kazzer, P., Lischke, A., Heinrichs, M., Herpertz, S. C., & Domes, G. (2013) · Psychophysiology · doi:10.1111/psyp.12042 · Cited by 81 · see citing works
Regulatory brain development: Balancing emotion and cognition
Perlman, S. B., & Pelphrey, K. A. (2010) · Social Neuroscience · doi:10.1080/17470911003683219 · Cited by 80 · see citing works
Bick, J. R., Dozier, M., Bernard, K., Grasso, D. J., & Simons, R. F. (2012) · Child Development · doi:10.1111/cdev.12008 · Cited by 76 · see citing works
Bodden, M., Kübler, D., Knake, S., et al. (2013) · PubMed · doi:10.17169/refubium-31155 · Cited by 75 · see citing works
Kinsley, C. H., & Amory, E. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02194.x · Cited by 69 · see citing works
Neurobiology of human affiliative behaviour: implications for psychiatric disorders
Bora, E., Yücel, M., & Allen, N. B. (2009) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328329e970 · Cited by 68 · see citing works
Neural mechanisms underlying the milk ejection burst and reflex
Hatton, G. I., & WANG, Y. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00414-7 · Cited by 61 · see citing works
Doi, H., & Shinohara, K. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.02.013 · Cited by 49 · see citing works
Zheng, D., Larsson, B., Phelps, S. M., & Ophir, A. G. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.024 · Cited by 48 · see citing works
Puglisi‐Allegra, S., & Ventura, R. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0076 · Cited by 45 · see citing works
Neural correlate of autistic-like traits and a common allele in the oxytocin receptor gene
Saito, Y., Suga, M., Tochigi, M., Abe, O., Yahata, N., Kawakubo, Y., Liu, X., Kawamura, Y., Sasaki, T., Kasai, K., et al. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst136 · Cited by 34 · see citing works
Affect-specific activation of shared networks for perception and execution of facial expressions
Kircher, T. T. J., Pohl, A., Krach, S., Thimm, M., Schulte‐Rüther, M., Anders, S., & Mathiak, K. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss008 · Cited by 34 · see citing works
Velden, F. S. T., Baas, M., Shalvi, S., Kret, M. E., & Dreu, C. K. W. D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.09.013 · Cited by 26 · see citing works
Hirosawa, T., Kikuchi, M., Higashida, H., Okumura, E., Ueno, S., Shitamichi, K., Yoshimura, Y., Munesue, T., Tsubokawa, T., Haruta, Y., et al. (2012) · Scientific Reports · doi:10.1038/srep00384 · Cited by 25 · see citing works
Rao, P. D. P., & Kanwal, J. S. (2004) · Brain Behavior and Evolution · doi:10.1159/000076241 · Cited by 21 · see citing works
Turner, J. M., Wittkowski, A., & Hare, D. J. (2008) · British Journal of Psychology · doi:10.1348/000712608x289971 · Cited by 21 · see citing works
Selection of Prime Actor in Humans during Bimanual Object Manipulation
Theorin, A., & Johansson, R. S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1624-10.2010 · Cited by 14 · see citing works
Dynamic sensory–motor oscillation and cerebral development
Sasso, G. (2009) · Cognitive Processing · doi:10.1007/s10339-009-0346-z · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Paloyelis, Y., Doyle, O. M., Zelaya, F. O., Maltezos, S., Williams, S. C., Fotopoulou, A., & Howard, M. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.005 · Cited by 187 · see citing works
Rutigliano, G., Rocchetti, M., Paloyelis, Y., Gilleen, J., Sardella, A., Cappucciati, M., Palombini, E., Dell’Osso, L., Caverzasi, E., Politi, P., et al. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.04.117 · Cited by 149 · see citing works
“During pregnancy dramatic structural and functional changes occur in the OT system of the mother's brain (Hillerer et al., 2014; Rocchetti et al., 2014).”
Self-citationGrace, S. A., Rossell, S. L., Heinrichs, M., Kordsachia, C., & Labuschagne, I. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.031 · Cited by 120 · see citing works
Human Maternal Brain Plasticity: Adaptation to Parenting
Kim, P. (2016) · New Directions for Child and Adolescent Development · doi:10.1002/cad.20168 · Cited by 102 · see citing works
Wang, D., Yan, X., Li, M., & Ma, Y. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx085 · Cited by 86 · see citing works
Less can be more: Fine tuning the maternal brain
Pawluski, J. L., Hoekzema, E., Leuner, B., & Lonstein, J. S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.045 · Cited by 91 · see citing works
- Authors
- Rocchetti, M., Radua, J., Paloyelis, Y., Xenaki, L., Frascarelli, M., Caverzasi, E., Politi, P., & Fusar‐Poli, P.
- Affiliations
- King's College London (GB)
- Department of Psychosis Studies Institute of Psychiatry King's College London London UK
- Department of Brain and Behavioral Sciences University of Pavia Pavia Italy
- University of Pavia (IT)
- Corresponding author
- Rocchetti, Matteo
- ORCID
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2014-06-09
- Volume
- 68
- Issue
- 10
- Pages
- 733-751
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W1536234704
- Cited by
- 83
- References
- 142
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 22 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 2 · 2014: 1
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Economic and Social Research Council (ES/K009400/1)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- maternal brain, oxytocin, mother-infant interaction, insula, thalamus, amygdala, basal ganglia, dorsomedial prefrontal cortex, emotion regulation, empathy, social cognition, theory of mind, placebo comparison
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Humans, Maternal Behavior, Mother-Child Relations, Oxytocin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
