Oxytocin and the maternal brain
Abstract
Oxytocin released within the brain from both magnocellular and parvocellular systems of the hypothalamus has diverse effects on behavior. When oxytocin is released within the brain, its effects are to diminish fearfulness; this not only encourages social investigation of newcomers, but also may enhance a tendency to express aggression toward an intruder. Oxytocin supports social recognition, redirects behavior away from feeding directed behavior toward sexual behavior, and facilitates the formation of social bonds. This system, which depends not only upon release of oxytocin but also on oxytocin receptor distribution within the brain, becomes particularly important at parturition, when a bond is first formed between mother and offspring.
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Oxytocin is also released somatodendritically to act within the SON and PVN to facilitate synchronous firing and pulsatile release during parturition and nursing.
“Oxytocin is also released somatodendritically to act within the SON and PVN to facilitate synchronous firing and pulsatile release during parturition and nursing”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Leng et al. 2008
OT regulates bonding as well as selective aggression in pair-bonded prairie voles and lactating rats.
“OT regulates bonding as well as selective aggression in pair-bonded prairie voles (Young et al., 2008) and in lactating rats (Leng et al., 2008).”
From The effect of oxytocin on cooperation in a prisoner's dilemma depends on the social context and a person's social value orientation (2014) · cites this paper as Leng et al., 2008
In humans, OT plays key roles in social bonding in general, as well as specific aspects of maternal brain function, including vaginal delivery, breastfeeding, and parental sensitivity.
“In humans, OT plays key roles in social bonding in general (29), as well as specific aspects of maternal brain function (30), including: (i) vaginal delivery (31); (ii) breastfeeding (32); and (iii) parental sensitivity (33–36).”
From Neuroendocrinology of Parental Response to Baby‐Cry (2011) · cites this paper as [30]
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Self-citation
- Authors
- LENG, G., MEDDLE, S., & DOUGLAS, A.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- LENG, G
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 8
- Issue
- 6
- Pages
- 731-734
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2023582385
- Semantic Scholar
- a7282630bee6e1ae2886900593a62e4871edb5ee
- Cited by
- 158
- References
- 33
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 11 · 2018: 5 · 2017: 14 · 2016: 6 · 2015: 10 · 2014: 10 · 2013: 12 · 2012: 11
- FWCI
- 17.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/C516428/1)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Keywords
- oxytocin, maternal brain, hypothalamus, magnocellular neurons, parvocellular neurons, fearlessness, social investigation, aggression, social recognition, sexual behavior, feeding behavior, social bonding, childbirth
- MeSH terms
- Animals, Female, Humans, Hypothalamus, Maternal Behavior, Oxytocin, Social Behavior, Receptors, Oxytocin
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