Cited by 158Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyPregnancy-related medical research

Oxytocin and the maternal brain

LENG, G, MEDDLE, S, DOUGLAS, A·2008·Current Opinion in Pharmacology

Abstract

Oxytocin released within the brain from both magnocellular and parvocellular systems of the hypothalamus has diverse effects on behavior. When oxytocin is released within the brain, its effects are to diminish fearfulness; this not only encourages social investigation of newcomers, but also may enhance a tendency to express aggression toward an intruder. Oxytocin supports social recognition, redirects behavior away from feeding directed behavior toward sexual behavior, and facilitates the formation of social bonds. This system, which depends not only upon release of oxytocin but also on oxytocin receptor distribution within the brain, becomes particularly important at parturition, when a bond is first formed between mother and offspring.

Integrity signals

Registry

Crossref · 10.1016/j.coph.2008.07.001

Cites

33 of 33 references verified0 citation errors · 0 not checkable

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  • Oxytocin is also released somatodendritically to act within the SON and PVN to facilitate synchronous firing and pulsatile release during parturition and nursing.

    “Oxytocin is also released somatodendritically to act within the SON and PVN to facilitate synchronous firing and pulsatile release during parturition and nursing”

    From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Leng et al. 2008

  • OT regulates bonding as well as selective aggression in pair-bonded prairie voles and lactating rats.

    “OT regulates bonding as well as selective aggression in pair-bonded prairie voles (Young et al., 2008) and in lactating rats (Leng et al., 2008).”
  • In humans, OT plays key roles in social bonding in general, as well as specific aspects of maternal brain function, including vaginal delivery, breastfeeding, and parental sensitivity.

    “In humans, OT plays key roles in social bonding in general (29), as well as specific aspects of maternal brain function (30), including: (i) vaginal delivery (31); (ii) breastfeeding (32); and (iii) parental sensitivity (33–36).”

    From Neuroendocrinology of Parental Response to Baby‐Cry (2011) · cites this paper as [30]

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Authors
LENG, G., MEDDLE, S., & DOUGLAS, A.
Affiliations
University of Edinburgh (GB)
Corresponding author
LENG, G
Venue
Current Opinion in Pharmacology
Publisher
Elsevier BV
Published
2008-12
Volume
8
Issue
6
Pages
731-734
ISSN
1471-4892 (ISSN-L)
OpenAlex
W2023582385
Cited by
158
References
33
Citations by year
2026: 4 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 11 · 2018: 5 · 2017: 14 · 2016: 6 · 2015: 10 · 2014: 10 · 2013: 12 · 2012: 11
FWCI
17.33
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Biotechnology and Biological Sciences Research Council (BB/C516428/1)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
Keywords
oxytocin, maternal brain, hypothalamus, magnocellular neurons, parvocellular neurons, fearlessness, social investigation, aggression, social recognition, sexual behavior, feeding behavior, social bonding, childbirth
MeSH terms
Animals, Female, Humans, Hypothalamus, Maternal Behavior, Oxytocin, Social Behavior, Receptors, Oxytocin

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