The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome
Open accessAbstract
Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X mental retardation protein), a repressor of mRNA translation. According to the metabotropic glutamate receptor (mGluR) theory of FXS, excessive protein synthesis downstream of mGluR5 activation causes the synaptic pathophysiology that underlies multiple aspects of FXS. Here, we use an in vitro assay of protein synthesis in the hippocampus of male Fmr1 knock-out (KO) mice to explore the molecular mechanisms involved in this core biochemical phenotype under conditions where aberrant synaptic physiology has been observed. We find that elevated basal protein synthesis in Fmr1 KO mice is selectively reduced to wild-type levels by acute inhibition of mGluR5 or ERK1/2, but not by inhibition of mTOR (mammalian target of rapamycin). The mGluR5-ERK1/2 pathway is not constitutively overactive in the Fmr1 KO, however, suggesting that mRNA translation is hypersensitive to basal ERK1/2 activation in the absence of FMRP. We find that hypersensitivity to ERK1/2 pathway activation also contributes to audiogenic seizure susceptibility in the Fmr1 KO. These results suggest that the ERK1/2 pathway, and other neurotransmitter systems that stimulate protein synthesis via ERK1/2, represent additional therapeutic targets for FXS.
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“have demonstrated that dampening mGluR5 signalling rescues protein synthesis and many of the classic outcome measures (TABLE 1) used in the mouse and fly models30–35.”
From Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome (2018) · cites this paper as [33]
Experimental — accuracy not yet measuredIn the citing paper
“These findings are the basis of human clinical trials that aim to test the efficacy of mGluR5 antagonists for the treating Fragile X syndrome23,56–58.”
From Activity-dependent neuronal signalling and autism spectrum disorder (2013) · cites this paper as [57]
In the citing paper
“These findings of deficient mGluR–LTD in mice with deletions in Tsc1 or Tsc2 are in contrast with Fmr1 knockout mice, which have increased mGluR–LTD and excessive protein synthesis57.”
From Activity-dependent neuronal signalling and autism spectrum disorder (2013) · cites this paper as [57]
In the citing paper
“We found a small but significant increase in protein synthesis of both FMRP targets in the absence of functional FMRP, similar to results reported for Camk2a by Bear and colleagues in slice cultures (Osterweil et al., 2010), with no significant change in either overall protein synthesis or in the synthesis of the non-target PABP (Figure 6G and Figure S6).”
From FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism (2011) · cites this paper as Osterweil et al., 2010
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Cites
Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81780-8 · Cited by 2,551
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
Gingras, A., Raught, B., & Sonenberg, N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.913 · Cited by 2,103
The mGluR theory of fragile X mental retardation
Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580
Self-citationHara, K., Yonezawa, K., Weng, Q.-P., Kozlowski, M. T., BELHAM, C. M., & Avruch, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14484 · Cited by 1,370
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349
Self-citationBrown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00568-2 · Cited by 1,109
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015
Self-citationCorrection of Fragile X Syndrome in Mice
Dölen, G., Osterweil, E., Rao, B. S. S., Smith, G. B., Auerbach, B. D., Chattarji, S., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.12.001 · Cited by 979
Self-citationThe MEK/ERK cascade: From signaling specificity to diverse functions
Shaul, Y. D., & Seger, R. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.10.005 · Cited by 969
Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
Ehninger, D., Han, S., Shilyansky, C., Zhou, Y., Li, W., Kwiatkowski, D. J., Ramesh, V., & Silva, A. J. (2008) · Nature Medicine · doi:10.1038/nm1788 · Cited by 882
Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory
Kelleher, R. J., Govindarajan, A., Jung, H.-Y., Kang, H., & Tonegawa, S. (2004) · Cell · doi:10.1016/s0092-8674(04)00115-1 · Cited by 845
FMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding
Ashley, C. T., Wilkinson, K. D., Reines, D., & Warren, S. T. (1993) · Science · doi:10.1126/science.7692601 · Cited by 752
Zalfa, F., Giorgi, M., Primerano, B., Moro, A., Di Penta, A., Reis, S., Oostra, B., & Bagni, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00079-5 · Cited by 676
Weiler, I. J., Irwin, S. A., Klintsova, A. Y., Spencer, C. M., Brazelton, A. D., Miyashiro, K., Comery, T. A., Patel, B., Eberwine, J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5395 · Cited by 644 · cited 2×
“Group 1 (Gp1) metabotropic glutamate receptors (mGluR1 and mGluR5) stimulate mRNA translation at synapses (Weiler and Greenough, 1993; Weiler et al., 1997) and many lasting physiological consequences of Gp1 mGluR activation require rapid synaptic protein synthesis (Merlin et al.”
Evidence that fragile X mental retardation protein is a negative regulator of translation
Laggerbauer, B. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.4.329 · Cited by 571
Dysregulation of mTOR signaling in fragile X syndrome
Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3696-09.2010 · Cited by 557
Hou, L., & Klann, E. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0995-04.2004 · Cited by 527
Richter, J. D. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.04.004 · Cited by 526
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
Yan, Q. J., Rammal, M., Tranfaglia, M., & Bauchwitz, R. P. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.06.004 · Cited by 521
Signalling to translation: How signal transduction pathways control the protein synthetic machinery
Proud, C. G. (2007) · Biochemical Journal · doi:10.1042/bj20070024 · Cited by 520
Park, S., Park, J. M., Kim, S., Kim, J.-A., Shepherd, J. D., Smith-Hicks, C. L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A. G., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.023 · Cited by 516
Meikle, L. M., Pollizzi, K. N., Egnor, A., Kramvis, I., Lane, H. A., Şahin, M., & Kwiatkowski, D. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0955-08.2008 · Cited by 509
Chao, M. V. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251106 · Cited by 478
Hou, L., Antion, M. D., Hu, D., Spencer, C. M., Paylor, R., & Klann, E. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.005 · Cited by 469
Nerve growth factor mediates signal transduction through trk homodimer receptors
Jing, S., Tapley, P. M., & Barbacid, M. (1992) · Neuron · doi:10.1016/0896-6273(92)90066-m · Cited by 463
The fragile X mental retardation protein inhibits translation via interacting with mRNA
Li, Z. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.11.2276 · Cited by 448
Muddashetty, R. S., Kelić, S., Gross, C., Xu, M., & Bassell, G. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0937-07.2007 · Cited by 421
Schratt, G. M., Nigh, E. A., Chen, W., Hu, L. S., & Greenberg, M. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1739-04.2004 · Cited by 403
Huber, K. M., Roder, J., & Bear, M. F. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.321 · Cited by 390
Self-citationMazrouï, R. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.24.3007 · Cited by 369
Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice
de Vrij, F. M. S., Levenga, J., van der Linde, H. C., Koekkoek, S. K., De Zeeuw, C. I., Nelson, D. L., Oostra, B. A., & Willemsen, R. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.04.002 · Cited by 313
Nosyreva, E. D., & Huber, K. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01316.2005 · Cited by 301
Todd, P. K., Mack, K. J., & Malter, J. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336265100 · Cited by 280
Slices Have More Synapses than Perfusion-Fixed Hippocampus from both Young and Mature Rats
Kirov, S. A., Sorra, K. E., & Harris, K. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-02876.1999 · Cited by 279
Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome
Dölen, G., & Bear, M. F. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.150722 · Cited by 278
Self-citationEpilepsy in fragile X syndrome
Berry‐Kravis, E. (2002) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2002.tb00277.x · Cited by 271
Qin, M., Kang, J., Burlin, T. V., Jiang, C., & Smith, C. B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0093-05.2005 · Cited by 263
Metabotropic glutamate receptors trigger postsynaptic protein synthesis.
Weiler, I., & Greenough, W. (1993) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.90.15.7168 · Cited by 260
Gallagher, S. M., Daly, C. A., Bear, M. F., & Huber, K. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5407-03.2004 · Cited by 254
Self-citationMao, L., Yang, L., Tang, Q., Samdani, S., Zhang, G., & Wang, J. Q. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4360-04.2005 · Cited by 250
Nakamoto, M., Nalavadi, V., Epstein, M. P., Narayanan, U., Bassell, G. J., & Warren, S. T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707484104 · Cited by 245
Banko, J. L., Hou, L., Poulin, F., Sonenberg, N., & Klann, E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5196-05.2006 · Cited by 245
Brain-Derived Neurotrophic Factor Rescues Synaptic Plasticity in a Mouse Model of Fragile X Syndrome
Lauterborn, J. C., Rex, C. S., Kramár, E. A., Chen, L. Y., Pandyarajan, V., LYNCH, G. S., & Gall, C. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2624-07.2007 · Cited by 244
Ronesi, J. A., & Huber, K. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5019-07.2008 · Cited by 244
Tsc2-Rheb signaling regulates EphA-mediated axon guidance
Nie, D. A., Nardo, A. D., Han, J. M., Baharanyi, H., Kramvis, I., Huynh, T., Dabora, S. L., Codeluppi, S., Pandolfi, P. P., Pasquale, E. B., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2477 · Cited by 243
Raymond, C. R., Thompson, V. L., Tate, W. P., & Abraham, W. C. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-03-00969.2000 · Cited by 240
A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis
Osterweil, E. K., Wells, D. G., & Mooseker, M. S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200410091 · Cited by 236
Self-citationTrkA cross-linking mimics neuronal responses to nerve growth factor.
Clary, D. O., Weskamp, G., Austin, L. R., & Reichardt, L. F. (1994) · Molecular Biology of the Cell · doi:10.1091/mbc.5.5.549 · Cited by 221
Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory
Bolduc, F. V., Bell, K., Cox, H., Broadie, K. S., & Tully, T. (2008) · Nature Neuroscience · doi:10.1038/nn.2175 · Cited by 211
Weiler, I. J., Spangler, C. C., Klintsova, A. Y., Grossman, A. W., Kim, S. H., Bertaina-Anglade, V., Khaliq, H., de Vries, F. E., Lambers, F. A. E., Hatia, F., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407533101 · Cited by 210
Wang, X., Beugnet, A., Murakami, M., Yamanaka, S., & Proud, C. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2558-2572.2005 · Cited by 207
The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity
Avruch, J., BELHAM, C. M., Weng, Q. P., Hara, K., & Yonezawa, K. (2001) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-56688-2_5 · Cited by 181
Shin, C. Y., Kundel, M., & Wells, D. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2457-04.2004 · Cited by 151
Aschrafi, A., Cunningham, B. A., Edelman, G. M., & Vanderklish, P. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409803102 · Cited by 148
Activation of the extracellular signal‐regulated kinase 2 by metabotropic glutamate receptors
Ferraguti, F., Baldani‐Guerra, B., Corsi, M., Nakanishi, S., & Corti, C. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00626.x · Cited by 144
Identification of sites for exponential translation in living dendrites
Job, C., & Eberwine, J. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.231485698 · Cited by 135
Tucker, B., Richards, R. I., & Lardelli, M. T. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl422 · Cited by 133
Ferrari, F., Mercaldo, V., Piccoli, G., Sala, C., Cannata, S. M., Achsel, T., & Bagni, C. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.11.015 · Cited by 125
Adwanikar, H., Karim, F., & Gereau, R. W. (2004) · Pain · doi:10.1016/j.pain.2004.06.009 · Cited by 124
BC1 Regulation of Metabotropic Glutamate Receptor-Mediated Neuronal Excitability
Zhong, J. W., Chuang, S.-C., Bianchi, R., Zhao, W., Lee, H., Fenton, A. A., Wong, R. K. S., & Tiedge, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3893-08.2009 · Cited by 120
Antion, M., Hou, L., Wong, H., Hoeffer, C. A., & Klann, E. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00201-08 · Cited by 113
Chen, W. S., & Bear, M. F. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.003 · Cited by 108
Self-citationProtein synthesis-dependent long-term functional plasticity: methods and techniques
Sajikumar, S., Navakkode, S., & Frey, J. U. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.009 · Cited by 103
Requirement of Protein Synthesis for Group I mGluR-Mediated Induction of Epileptiform Discharges
Merlin, L. R., Bergold, P. J., & Wong, R. K. S. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.2.989 · Cited by 99
Kanhema, T., Dagestad, G., Panja, D., Tiron, A., Messaoudi, E., Håvik, B., Ying, S., Nairn, A. C., Sonenberg, N., & Bramham, C. R. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04158.x · Cited by 98
Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome
Kim, S. H., Markham, J. A., Weiler, I. J., & Greenough, W. T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800257105 · Cited by 97
Metabolic Stability of Hippocampal Slice Preparations During Prolonged Incubation
Whittingham, T. S., Lust, W. D., Christakis, D., & Passonneau, J. V. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb12788.x · Cited by 82
Karachot, L., Shirai, Y., Vigot, R., Yamamori, T., & Ito, M. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.280 · Cited by 75
Auerbach, B. D., & Bear, M. F. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00449.2010 · Cited by 71
Self-citationKang, H., Jia, L. Z., Suh, K. Y., Tang, L. T. H., & Schuman, E. M. (1996) · Learning & Memory · doi:10.1101/lm.3.2-3.188 · Cited by 70
Choe, E. S., & Wang, J. Q. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02258-3 · Cited by 69
Qian, M. D., Zhang, J., Tan, X.-Y., Wood, A., Gill, D., & Cho, S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1118-06.2006 · Cited by 67 · cited 1×
“Trk antibodies lead to the same activation, and have been shown to initiate the downstream signaling and functional consequences to the same degree as agonist application for both TrkA and TrkB (Clary et al., 1994; Qian et al., 2006).”
Differential translation and fragile X syndrome
Vanderklish, P. W., & Edelman, G. M. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00134.x · Cited by 59
Kundel, M., Jones, K. J., Shin, C. Y., & Wells, D. G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2910-08.2009 · Cited by 57
Ho, O. H., Delgado, J. Y., & O’Dell, T. J. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02815.x · Cited by 52
Berkeley, J. L., & Levey, A. I. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.1.128 · Cited by 47
Limbic Epileptogenesis in a Mouse Model of Fragile X Syndrome
Qiu, L.-F., Lu, T., Hu, X.-L., Yi, Y., Liao, W., & Xiong, Z. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn163 · Cited by 33
García, S. Z., López, E., & López-Colomé, A. M. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21633 · Cited by 33
Krueger‐Burg, D., & Nairn, A. C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05901.x · Cited by 12
Autoradiographic Measurements of Protein Synthesis in Hippocampal Slices from Rats and Guinea Pigs
Lipton, P., & Raley‐Susman, K. M. (1999) · Methods · doi:10.1006/meth.1999.0766 · Cited by 9
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- 10.1017/S0012162201002833 · DOI · Paper page
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Hagerman, R. J., Berry-Kravis, E., Hazlett, H. C., Bailey, D. B., Moine, H., Kooy, R. F., Tassone, F., Gantois, I., Sonenberg, N., Mandel, J. L., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.65 · Cited by 838
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Metadata
- Authors
- Osterweil, E. K., Krueger, D. D., Reinhold, K., & Bear, M. F.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bear, Mark F.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-11-17
- Volume
- 30
- Issue
- 46
- Pages
- 15616-15627
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3400430
- OpenAlex
- W2092491372
- Cited by
- 384
- References
- 81
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 18 · 2023: 15 · 2022: 17 · 2021: 24 · 2020: 27 · 2019: 23 · 2018: 22 · 2017: 34 · 2016: 33 · 2015: 29 · 2014: 30 · 2013: 31 · 2012: 24
- FWCI
- 14.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Howard Hughes Medical Institute
- FRAXA Research Foundation
- Simons Foundation
- National Institute of Mental Health
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD046943)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- fragile X syndrome, FMRP, mGluR5, ERK1/2, protein synthesis, hippocampus, metabotropic glutamate receptors, mRNA translation, Fmr1 knockout mice, audiogenic seizures, mTOR, therapeutic target
- MeSH terms
- Animals, Disease Models, Animal, Fragile X Syndrome, Hippocampus, Isoenzymes, Male, Mice, Inbred C57BL, Pyridines, Protein Biosynthesis, Up-Regulation, Receptors, Metabotropic Glutamate, Mice, Knockout, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Mice, Fragile X Messenger Ribonucleoprotein 1, Fragile X Mental Retardation Protein, Receptor, Metabotropic Glutamate 5
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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