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Cited by 187

Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory

Bolduc, François V, Bell, Kimberly, Cox, Hilary, Broadie, Kendal S, Tully, Tim·2008·Nature Neuroscience
DOI 10.1038/nn.2175PMC PMC3038669
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Crossref · 10.1038/nn.2175

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  • FMRP interacts with proteins in RISC and with miRNAs, but FMRP itself is not essential for RNAi-mediated mRNA cleavage.

    “FMRP interacts with proteins (e.g. Argonaute and Dicer) in the RNA interference silencing complex (RISC) and with miRNAs, but FMRP itself is not essential for RNAi-mediated mRNA cleavage (Bolduc et al., 2008; Caudy et al., 2002; Cheever and Ceman, 2009; Hock et al., 2007; Ishizuka et al., 2002; Jin et al., 2004b; Okamura et al., 2004; Plante et al., 2006).”

    From Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 (2010) · cites this paper as Bolduc et al., 2008

  • Heterozygous loss of AGO1 enhances the phenotype of heterozygous loss of FMRP in flies, suggesting AGO1 facilitates translational repression by FMRP.

    “Heterozygous loss of AGO1 enhances the phenotype of heterozygous loss of FMRP in flies, suggesting AGO1 facilitates translational repression by FMRP (Bolduc et al., 2008; Jin et al., 2004b).”

    From Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 (2010) · cites this paper as Bolduc et al., 2008

  • AGO1 knockdown enhanced NR2A reporter expression similar to FMRP knockdown, which is consistent with the genetic interaction between FMRP and Argonaute found in flies.

    “We found that AGO1 knockdown enhanced NR2A reporter expression similar to FMRP knockdown, which is consistent with the genetic interaction between FMRP and Argonaute found in flies (Bolduc et al., 2008; Jin et al., 2004b).”

    From Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 (2010) · cites this paper as Bolduc et al., 2008

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Research works printed but not linked: 13

  1. [1]Qin M Kang J Burlin TV Jiang C Smith CB Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the FMR1 null mouse J Neurosci 2005 25 5087 5095 15901791 PMC6724856
  2. [3]Barbee SA Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies Neuron 2006 52 997 1009 17178403 PMC1955741
  3. [4]Dubnau J The staufen/pumilio pathway is involved in Drosophila long-term memory Curr Biol 2003 13 286 296 12593794
  4. [5]Jin P Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway Nat Neurosci 2004 7 113 117 14703574
  5. [6]Ashraf SI McLoon AL Sclarsic SM Kunes S Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila Cell 2006 124 191 205 16413491
  6. [7]Tully T Preat T Boynton SC Del Vecchio M Genetic dissection of consolidated memory in Drosophila Cell 1994 79 35 47 7923375
  7. [8]Michel CI Kraft R Restifo LL Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants J Neurosci 2004 24 5798 5809 15215302 PMC6729208
  8. [9]Didelot G Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila Science 2006 313 851 853 16902143
  9. [10]de Belle JS Heisenberg M Associative odor learning in Drosophila abolished by chemical ablation of mushroom bodies Science 1994 263 692 695 8303280
  10. [11]McBride SM Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome Neuron 2005 45 753 764 15748850
  11. [12]Chuang SC Prolonged epileptiform discharges induced by altered group I metabotropic glutamate receptor-mediated synaptic responses in hippocampal slices of a fragile X mouse model J Neurosci 2005 25 8048 8055 16135762 PMC6725444
  12. [13]Vanderklish PW Edelman GM Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons Proc Natl Acad Sci U S A 2002 99 1639 1644 11818568 PMC122243
  13. [15]Muddashetty RS Kelic S Gross C Xu M Bassell GJ Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome J Neurosci 2007 27 5338 5348 17507556 PMC6672337

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Authors
Bolduc, F. V., Bell, K., Cox, H., Broadie, K. S., & Tully, T.
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2008-09-07
Volume
11
Issue
10
Pages
1143-1145
ISSN
  • 1097-6256
  • 1546-1726
DOI
10.1038/nn.2175
PMC
PMC3038669
Cited by
187
References
2
Language
en
Licence
www.springer.com/tdm (tdm)

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