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Callosal Contributions to Simultaneous Bimanual Finger Movements
Open accessAbstract
Corpus callosum (CC) is involved in the performance of bimanual motor tasks. We asked whether its functional role could be investigated by combining a motor behavioral study on bimanual movements in multiple sclerosis (MS) patients with a quantitative magnetic resonance diffusion tensor imaging (DTI) analysis of CC, which is shown to be damaged in this disease. MS patients and normal subjects were asked to perform sequences of bimanual finger opposition movements at different metronome rates; then we explored the structural integrity of CC by means of DTI. Significant differences in motor performance, mainly referred to timing accuracy, were observed between MS patients and control subjects. Bimanual motor coordination was impaired in MS patients as shown by the larger values of the interhand interval observed at all the tested metronome rates with respect to controls. Furthermore, DTI revealed a significant reduction of fractional anisotropy (FA), indicative of microstructural tissue damage, in the CC of MS patients. By correlating the mean FA values with the different motor behavior parameters, we found that the degree of damage in the anterior callosal portions mainly influences the bimanual coordination and, in particular, the movement phase preceding the finger touch. Finally, the described approach, which correlates quantitative measures of tissue damage obtained by advanced magnetic resonance imaging tools with appropriate behavioral measurements, may help the exploration of different aspects of motor performance impairment attributable to the disease.
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“Finally, increasing FA in the CC suggests more efficient sensory, motor, and cognitive interaction taking place between the two hemispheres. 55-57”
From Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. (2015) · cites this paper as [56]
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Citations
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, F. A., Ebers, G. C., Johnson, K. P., Sibley, W. A., Silberberg, D. H., & Tourtellotte, W. W. (1983) · Annals of Neurology · doi:10.1002/ana.410130302 · Cited by 7,384
Diffusion tensor imaging: Concepts and applications
Le Bihan, D., Mangin, J., Poupon, C., Clark, C. A., Pappata, S., Molko, N., & Chabriat, H. (2001) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1076 · Cited by 3,547
Characterization and propagation of uncertainty in diffusion-weighted MR imaging
Behrens, T. E. J., Woolrich, M. W., Jenkinson, M., Johansen‐Berg, H., Nunes, R. G., Clare, S., Matthews, P. M., Brady, J. M., & Smith, S. M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10609 · Cited by 3,038
The prefontral cortex and cognitive control
Miller, E. K. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036228 · Cited by 2,016
Fiber composition of the human corpus callosum
Aboitiz, F., Scheibel, A. B., Fisher, R. S., & Eran Zaidel, B. (1992) · Brain Research · doi:10.1016/0006-8993(92)90178-c · Cited by 1,467
Neil, J. J., Shiran, S. I., McKinstry, R. C., Schefft, G. L., Snyder, A. Z., Almli, C. R., Akbudak, E., Aronovitz, J. A., Miller, J. P., Lee, B. C., et al. (1998) · Radiology · doi:10.1148/radiology.209.1.9769812 · Cited by 645
Topography of the Human Corpus Callosum
LACOSTE, M. C. D., Kirkpatrick, J. B., & Ross, E. D. (1985) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198511000-00004 · Cited by 530
Broca's Area and the Hierarchical Organization of Human Behavior
Koechlin, É., & Jubault, T. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.017 · Cited by 507
Brinkman, J., & Kuypers, H. G. J. M. (1973) · Brain · doi:10.1093/brain/96.4.653 · Cited by 480
Evangelou, N. (2000) · Brain · doi:10.1093/brain/123.9.1845 · Cited by 416
Temporal Control of Movements in Sensorimotor Synchronization
Aschersleben, G. (2002) · Brain and Cognition · doi:10.1006/brcg.2001.1304 · Cited by 413
A human cerebral deconnection syndrome
Geschwind, N., & Kaplan, E. (1962) · Neurology · doi:10.1212/wnl.12.10.675 · Cited by 334
Integrity of white matter in the corpus callosum correlates with bimanual co-ordination skills
Johansen-Berg, H., Della-Maggiore, V., Behrens, T. E. J., Smith, S. M., & Paus, T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.041 · Cited by 272
Callosotomy patients exhibit temporal uncoupling during continuous bimanual movements
Kennerley, S., Diedrichsen, J., Hazeltine, E., Semjén, A., & Ivry, R. (2002) · Nature Neuroscience · doi:10.1038/nn822 · Cited by 225
Dyspraxia Following Division of the Cerebral Commissures
Gazzaniga, M. S., Bogen, J. E., & Sperry, R. W. (1967) · Archives of Neurology · doi:10.1001/archneur.1967.00470240044005 · Cited by 210
Possible contribution of the anterior forebrain commissures to bilateral motor coordination
Preilowski, B. (1972) · Neuropsychologia · doi:10.1016/0028-3932(72)90018-8 · Cited by 208
Brinkman, J., & Kuypers, H. G. J. M. (1972) · Science · doi:10.1126/science.176.4034.536 · Cited by 203
Cognitive Interaction After Staged Callosal Section: Evidence for Transfer of Semantic Activation
Sidtis, J. J., Volpe, B. T., Holtzman, J. D., Wilson, D. H., & Gazzaniga, M. S. (1981) · Science · doi:10.1126/science.6782673 · Cited by 176
Hasan, K. M., Gupta, R. K., Santos, R. M., Wolinsky, J. S., & Narayana, P. A. (2005) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20296 · Cited by 169
Functional consequences of the transcallosal removal of intraventricular tumours.
Jeeves, M. A., Simpson, D. A., & Geffen, G. M. (1979) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.42.2.134 · Cited by 166
Hemiparetic stroke impairs anticipatory control of arm movement
Takahashi, C. D., & Reinkensmeyer, D. J. (2003) · Experimental Brain Research · doi:10.1007/s00221-002-1340-1 · Cited by 142
Eliassen, J. C. (2000) · Brain · doi:10.1093/brain/123.12.2501 · Cited by 135
Diffusion anisotropy in the corpus callosum.
Chepuri, N. B., Yen, Y., Burdette, J. H., Li, H., Moody, D. M., & Maldjian, J. A. (2002) · PubMed Central · Cited by 134
A human cerebral deconnection syndrome
Geschwind, N., & Kaplan, E. (1998) · Neurology · doi:10.1212/wnl.50.5.1201-a · Cited by 124
A Human Cerebral Deconnection Syndrome
Geschwind, N. (1974) · Boston studies in the philosophy of science · doi:10.1007/978-94-010-2093-0_3 · Cited by 119
Preilowski, B. (1975) · Springer eBooks · doi:10.1007/978-3-642-66204-1_9 · Cited by 117
Eliassen, J. C., Baynes, K., & Gazzaniga, M. S. (1999) · Experimental Brain Research · doi:10.1007/s002210050884 · Cited by 114
Observations on visual processes after posterior callosal section
Gazzaniga, M. S., & Freedman, H. (1973) · Neurology · doi:10.1212/wnl.23.10.1126 · Cited by 111
Applications of Diffusion Tensor MR Imaging in Multiple Sclerosis
Ge, Y., Law, M., & Grossman, R. I. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1340.039 · Cited by 105
Interhemispheric Transfer in Patients With Incomplete Section of the Corpus Callosum
Risse, G. L. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520400097026 · Cited by 103
Cortical mechanisms involved in praxis
Volpe, B. T., Sidtis, J. J., Holtzman, J. D., Wilson, D. H., & Gazzaniga, M. S. (1982) · Neurology · doi:10.1212/wnl.32.6.645 · Cited by 96
Ge, Y., Law, M., Johnson, G., Herbert, J., Babb, J. S., Mannon, L. J., & Grossman, R. I. (2004) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20083 · Cited by 93
Functional and Magnetic Resonance Imaging Correlates of Callosal Involvement in Multiple Sclerosis
Pelletier, J., Habib, M., Lyon‐Caen, O., Salamon, G., Poncet, M., & Khalil, R. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540100066018 · Cited by 92
Serrien, D. J., Nirkko, A. C., & Wiesendanger, M. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01798.x · Cited by 75
The effect of sensory feedback on the timing of movements: Evidence from deafferented patients
Stenneken, P., Prinz, W., Cole, J. D., Paillard, J., & Aschersleben, G. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.057 · Cited by 69
Oh, J. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.039032 · Cited by 67
Caillé, S., Sauerwein, H. C., Schiavetto, A., Villemure, J., & Lassonde, M. C. (2005) · Neurosurgery · doi:10.1227/01.neu.0000163089.31657.08 · Cited by 66
Visuomotor integration in split-brain monkeys with other cerebral lesions
Gazzaniga, M. S. (1966) · Experimental Neurology · doi:10.1016/0014-4886(66)90065-3 · Cited by 50
Sound lateralization in subjects with callosotomy, callosal agenesis, or hemispherectomy
Hausmann, M., Corballis, M. C., Mara Fabri, C., Paggi, A., & Lewald, J. (2005) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2005.08.008 · Cited by 50
The effects of rate and sequence complexity on repetitive finger movements
Bove, M., Tacchino, A., Novellino, A., Trompetto, C., Abbruzzese, G., & Ghilardi, M. F. (2007) · Brain Research · doi:10.1016/j.brainres.2007.03.063 · Cited by 48
Self-citationCallosal Function in Multiple Sclerosis: Bimanual Motor Coordination
Larson, E. B., Burnison, D. S., & Brown, W. S. (2002) · Cortex · doi:10.1016/s0010-9452(08)70650-6 · Cited by 45
Pathways of interhemispheric transfer in normals and in a split-brain subject
Marzi, C. A., Perani, D., Tassinari, G., Colleluori, A., Maravita, A., Miniussi, C., Paulesu, E., Scifo, P., & Fazio, F. (1999) · Experimental Brain Research · doi:10.1007/s002210050752 · Cited by 41
Callosal disconnection in multiple sclerosis
Schnider, A., Benson, D. F., & Rosner, L. J. (1993) · Neurology · doi:10.1212/wnl.43.6.1243 · Cited by 38
Sternad, D., Wei, K., Diedrichsen, J., & Ivry, R. B. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0640-2 · Cited by 37
Lessard, N., Leporé, F., Villemagne, J., & Lassonde, M. C. (2002) · Brain · doi:10.1093/brain/awf096 · Cited by 36
Najenson, T., Ron, S., & Behroozi, K. (2008) · Brain Behavior and Evolution · doi:10.1159/000115924 · Cited by 18
Interhemispheric transfer in multiple sclerosis
Wishart, H. A., Strauss, E., Hunter, M., & Moll, A. (1995) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639508402442 · Cited by 13
Iacoboni, M., & Zaidel, E. (1999) · Experimental Brain Research · doi:10.1007/s002210050864 · Cited by 12
[Interhemispheric transfer in multiple sclerosis. Morphofunctional correlations].
Pelletier, J., Habib, M., Brouchon, M., Poncet, M., Lyon‐Caen, O., Salamon, G., & Khalil, R. (1992) · PubMed · Cited by 7
Coordinating movements in time: The role of sensory movement consequences
Stenneken, P., Cole, J., Paillard, J., & Aschersleben, G. (2003) · Max Planck Digital Library · Cited by 2
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van Wijk, B. C. M., Beek, P. J., & Daffertshofer, A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00252 · Cited by 263
Interactions between brain structure and behavior: The corpus callosum and bimanual coordination
Gooijers, J., & Swinnen, S. P. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.008 · Cited by 184
Motor control and neural plasticity through interhemispheric interactions
Takeuchi, N., Oouchida, Y., & Izumi, S.-I. (2012) · Neural Plasticity · doi:10.1155/2012/823285 · Cited by 171
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Fabri, M. (2014) · World Journal of Radiology · doi:10.4329/wjr.v6.i12.895 · Cited by 165
Johnson, N. F., Kim, C., Clasey, J. L., Bailey, A. L., & Gold, B. T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.032 · Cited by 172
Metadata
- Authors
- Bonzano, L., Tacchino, A., Roccatagliata, L., Abbruzzese, G., Mancardi, G. L., & Bove, M.
- Affiliations
- University of Genoa (IT)
- Corresponding author
- Bove, Marco
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-03-19
- Volume
- 28
- Issue
- 12
- Pages
- 3227-3233
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6670695
- OpenAlex
- W2032019919
- Cited by
- 136
- References
- 53
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 11 · 2020: 9 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 2 · 2015: 8 · 2014: 7 · 2013: 14 · 2012: 11
- FWCI
- 7.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, cc-by)
- Funders
- Fondazione Italiana Sclerosi Multipla
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- corpus callosum, bimanual coordination, finger opposition, multiple sclerosis, diffusion tensor imaging, fractional anisotropy, movement timing, anterior corpus callosum, motor coordination impairment, white matter microstructural damage
- MeSH terms
- Adult, Analysis of Variance, Brain Mapping, Corpus Callosum, Female, Fingers, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Movement, Multiple Sclerosis, Psychomotor Performance, Diffusion Magnetic Resonance Imaging
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