Integrity of white matter in the corpus callosum correlates with bimanual co-ordination skills
Open accessAbstract
Variation in brain structure may reflect variation in functional properties of specific brain systems. Structural variation may therefore reflect variation in behavioural performance. Here, we use diffusion-weighted magnetic resonance imaging to show that variation in white matter integrity in a specific region in the body of the corpus callosum is associated with variation in performance of a bimanual co-ordination task. When the callosal region showing this association is used as a seed for probabilistic tractography, inter-hemispheric pathways are generated to the supplementary motor area and caudal cingulate motor area. This provides further evidence for the role of medial wall motor areas in bimanual co-ordination and supports the idea that variation in brain structure reflects inter-individual differences in skilled performance.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increasing FA in the CC suggests more efficient sensory, motor, and cognitive interaction between the two hemispheres.
“Finally, increasing FA in the CC suggests more efficient sensory, motor, and cognitive interaction taking place between the two hemispheres. 55-57”
From Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. (2015) · cites this paper as [57]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C., Watkins, K., Ciccarelli, O., Cader, M., Matthews, P., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,035 · see citing works
Self-citationNonrigid registration using free-form deformations: application to breast mr images
Rueckert, D., Sonoda, L. I., Hayes, C., Hill, D. L. G., Leach, M. O., & Hawkes, D. J. (1999) · IEEE Transactions on Medical Imaging · doi:10.1109/42.796284 · Cited by 5,265 · see citing works
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,653 · see citing works
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
Estimation of the Effective Self-Diffusion Tensor from the NMR Spin Echo
Basser, P. J., Mattiello, J., & Bihan, D. L. (1994) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1994.1037 · Cited by 3,656 · see citing works
Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?
Behrens, T. E. J., Berg, H. J., Jbabdi, S., Rushworth, M. F. S., & Woolrich, M. W. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.018 · Cited by 3,471 · see citing works
Self-citationNavigation-related structural change in the hippocampi of taxi drivers
Maguire, E. A., Gadian, D. G., Johnsrude, I. S., Good, C. D., Ashburner, J., Frackowiak, R. S. J., & Frith, C. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070039597 · Cited by 3,225 · see citing works
Characterization and propagation of uncertainty in diffusion-weighted MR imaging
Behrens, T. E. J., Woolrich, M. W., Jenkinson, M., Johansen‐Berg, H., Nunes, R. G., Clare, S., Matthews, P. M., Brady, J. M., & Smith, S. M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10609 · Cited by 3,038 · see citing works
Self-citationBrain Structures Differ between Musicians and Non-Musicians
Christian Gaser, B., & Gottfried Schlaug, A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09240.2003 · Cited by 1,626 · see citing works
Fiber composition of the human corpus callosum
Aboitiz, F., Scheibel, A. B., Fisher, R. S., & Eran Zaidel, B. (1992) · Brain Research · doi:10.1016/0006-8993(92)90178-c · Cited by 1,467 · see citing works
Extensive piano practicing has regionally specific effects on white matter development
Bengtsson, S. L., Nagy, Z., Skare, S., Forsman, L., Forssberg, H., & Ullén, F. (2005) · Nature Neuroscience · doi:10.1038/nn1516 · Cited by 1,193 · see citing works
Structural plasticity in the bilingual brain
Mechelli, A., Crinion, J. T., Noppeney, U., O'Doherty, J., Ashburner, J., Frackowiak, R. S., & Price, C. J. (2004) · Nature · doi:10.1038/431757a · Cited by 1,005 · see citing works
Clinical consequences of corticectomies involving the supplementary motor area in man
Laplane, D., Talairach, J., Meininger, V., Bancaud, J., & Orgogozo, J. M. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90148-4 · Cited by 559 · see citing works
Kleim, J. A., Chan, S., Pringle, E., Schallert, K., Procaccio, V., Jimenez, R., & Cramer, S. C. (2006) · Nature Neuroscience · doi:10.1038/nn1699 · Cited by 529 · see citing works
Turner, A. M., & Greenough, W. T. (1985) · Brain Research · doi:10.1016/0006-8993(85)90525-6 · Cited by 459 · see citing works
BDNF Val66Met Allele Is Associated with Reduced Hippocampal Volume in Healthy Subjects
Bueller, J. A., Aftab, M., Sen, S., Gomez‐Hassan, D. M., Burmeister, M., & Zubieta, J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.022 · Cited by 458 · see citing works
Experience-driven brain plasticity: Beyond the synapse
MARKHAM, J. A., & GREENOUGH, W. T. (2004) · Neuron Glia Biology · doi:10.1017/s1740925x05000219 · Cited by 437 · see citing works
Rouiller, E. M., Babalian, A. L., Kazennikov, O. V., Moret, V., Yu, X.-H., & Wiesendanger, M. (1994) · Experimental Brain Research · doi:10.1007/bf00227511 · Cited by 392 · see citing works
Two Hemispheres—One Brain: Functions of the Corpus Callosum
Swayze, V. W. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.10.1351-a · Cited by 389 · see citing works
Brinkman, C. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-04-00918.1984 · Cited by 383 · see citing works
Deutsch, G. K., Dougherty, R. F., Bammer, R., Siok, W. T., Gabrieli, J. D. E., & Wandell, B. A. (2005) · Cortex · doi:10.1016/s0010-9452(08)70272-7 · Cited by 380 · see citing works
Madden, D. J., Whiting, W. L., Huettel, S. A., White, L. E., MacFall, J. R., & Provenzale, J. M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.004 · Cited by 369 · see citing works
Tuch, D. S., Salat, D. H., Wisco, J. J., Zaleta, A. K., Hevelone, N. D., & Rosas, H. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407259102 · Cited by 364 · see citing works
Sadato, N., Yonekura, Y., Waki, A., Yamada, H., & Ishii, Y. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-24-09667.1997 · Cited by 361 · see citing works
Sluming, V., Barrick, T. R., Howard, M. A., Cezayirli, E., Mayes, A. R., & Roberts, N. (2002) · NeuroImage · doi:10.1006/nimg.2002.1288 · Cited by 346 · see citing works
Distributed brain sites for the g-factor of intelligence
Colom, R., Jung, R. E., & Haier, R. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.006 · Cited by 283 · see citing works
Schulte, T., Sullivan, E. V., Müller-Oehring, E. M., Adalsteinsson, E., & Pfefferbaum, A. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi020 · Cited by 275 · see citing works
Sex and environmental influences on the size and ultrastructure of the rat corpus callosum
Juraska, J. M., & Kopcik, J. R. (1988) · Brain Research · doi:10.1016/0006-8993(88)91538-7 · Cited by 208 · see citing works
Some long-term motor effects of cerebral commissurotomy in man
Zaidel, D. W., & Sperry, R. W. (1977) · Neuropsychologia · doi:10.1016/0028-3932(77)90028-8 · Cited by 195 · see citing works
Stephan, K. M. (1999) · Brain · doi:10.1093/brain/122.2.351 · Cited by 187 · see citing works
Interhemispheric control of manual motor activity
Geffen, G. M., Jones, D. L., & Geffen, L. B. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90125-2 · Cited by 163 · see citing works
Mulkern, R. V., Zengingönül, H. P., Robertson, R. L., Bogner, P., Zou, K. H., Guðbjartsson, H., Guttmann, C. R. G., Holtzman, D. H., Kyriakos, W. E., Jolesz, F. A., et al. (2000) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200008)44:2 · Cited by 109 · see citing works
Cader, S., Johansen‐Berg, H., Wylezinska, M., Palace, J. A., Behrens, T. E. J., Smith, S. M., & Matthews, P. M. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.02.036 · Cited by 100 · see citing works
Self-citationEffect of the richness of the environment on the cat visual cortex
Beaulieu, C., & Colonnier, M. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902660404 · Cited by 99 · see citing works
Cellular aspects of callosal connections and their development
Innocenti, G. (1995) · Neuropsychologia · doi:10.1016/0028-3932(95)00033-y · Cited by 79 · see citing works
Serrien, D. J., Nirkko, A. C., & Wiesendanger, M. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01798.x · Cited by 75 · see citing works
Staniak, A. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.5.475 · Cited by 67 · see citing works
Wolbers, T., Schoell, E. D., & Büchel, C. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.011 · Cited by 49 · see citing works
Callosal Function in Multiple Sclerosis: Bimanual Motor Coordination
Larson, E. B., Burnison, D. S., & Brown, W. S. (2002) · Cortex · doi:10.1016/s0010-9452(08)70650-6 · Cited by 45 · see citing works
Effect of differential rearing on synapses and soma size in rat medial amygdaloid nucleus
Ichikawa, M., Matsuoka, M., & Mori, Y. (1993) · Synapse · doi:10.1002/syn.890130107 · Cited by 34 · see citing works
Transcallosal Connections of the Cingulum of Man
Locke, S., & Yakovlev, P. I. (1965) · Archives of Neurology · doi:10.1001/archneur.1965.00470050019002 · Cited by 22 · see citing works
Cann, S. A. H., Netten, J. P. V., & Netten, C. V. (2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200003)47:3
Flagged first, then by citations
Research works printed but not linked: 1
- Behrens T Johansen-Berg H Rushworth MFS Woolrich M Multi-fibre modelling of diffusion data: What can it add NeuroImage in press
Cited by
Sorted by citations
Plasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685 · see citing works
Self-citationTraining induces changes in white-matter architecture
Scholz, J., Klein, M. C., Behrens, T. E. J., & Johansen-Berg, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2412 · Cited by 1,508 · see citing works
Self-citationThe structural basis of inter-individual differences in human behaviour and cognition
Kanai, R., & Rees, G. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3000 · Cited by 1,055 · see citing works
Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain
Yeung, M. S. Y., Zdunek, S., Bergmann, O., Bernard, S., Salehpour, M., Alkass, K., Perl, S., Tisdale, J., Possnert, G., Brundin, L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.011 · Cited by 541 · see citing works
Rojkova, K., Volle, E., Urbanski, M., Humbert, F., Dell’Acqua, F., & Thiebaut de Schotten, M. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1001-3 · Cited by 361 · see citing works
Steele, C. J., Bailey, J. A., Zatorre, R. J., & Penhune, V. B. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3578-12.2013 · Cited by 388 · see citing works
Measuring macroscopic brain connections in vivo
Jbabdi, S., Sotiropoulos, S. N., Haber, S. N., Van Essen, D. C., & Behrens, T. E. (2015) · Nature Neuroscience · doi:10.1038/nn.4134 · Cited by 334 · see citing works
Self-citationChanges in white matter microstructure during adolescence
Giorgio, A., Watkins, K. E., Douaud, G., James, A. C., James, S., De Stefano, N., Matthews, P. M., Smith, S. M., & Johansen-Berg, H. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.043 · Cited by 278 · see citing works
Self-citationEngvig, A., Fjell, A. M., Westlye, L. T., Moberget, T., Sundseth, Ø., Larsen, V. A., & Walhovd, K. B. (2012) · Human Brain Mapping · doi:10.1002/hbm.21370 · Cited by 250 · see citing works
Motor control and neural plasticity through interhemispheric interactions
Takeuchi, N., Oouchida, Y., & Izumi, S.-I. (2012) · Neural Plasticity · doi:10.1155/2012/823285 · Cited by 171 · see citing works
The role of diffusion MRI in neuroscience
Assaf, Y., Johansen‐Berg, H., & Thiebaut de Schotten, M. (2019) · NMR in Biomedicine · doi:10.1002/nbm.3762 · Cited by 158 · see citing works
Self-citationAdvanced MRI techniques to improve our understanding of experience-induced neuroplasticity
Tardif, C. L., Gauthier, C. J., Steele, C. J., Bazin, P.-L., Schäfer, A., Schaefer, A., Turner, R., & Villringer, A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.08.047 · Cited by 127 · see citing works
Callosal Contributions to Simultaneous Bimanual Finger Movements
Bonzano, L., Tacchino, A., Roccatagliata, L., Abbruzzese, G., Mancardi, G. L., & Bove, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4076-07.2008 · Cited by 136 · see citing works
Svatkova, A., Mandl, R. C. W., Scheewe, T. W., Cahn, W., Kahn, R. S., & Hulshoff Pol, H. E. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv033 · Cited by 120 · see citing works
The neuroanatomical correlates of training-related perceptuo-reflex uncoupling in dancers
Nigmatullina, Y., Hellyer, P. J., Nachev, P., Sharp, D. J., & Seemungal, B. M. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht266 · Cited by 108 · see citing works
- Authors
- Johansen-Berg, H., Della-Maggiore, V., Behrens, T. E. J., Smith, S. M., & Paus, T.
- Affiliations
- John Radcliffe Hospital (GB)
- Montreal Neurological Institute and Hospital (CA)
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2007
- Volume
- 36
- Pages
- T16-T21
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3119816
- OpenAlex
- W2029334347
- Cited by
- 272
- References
- 42
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 8 · 2023: 24 · 2022: 10 · 2021: 8 · 2020: 11 · 2019: 13 · 2018: 12 · 2017: 11 · 2016: 9 · 2015: 19 · 2014: 20 · 2013: 17 · 2012: 22
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (078204)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- corpus callosum, white matter integrity, bimanual coordination, individual differences, supplementary motor area, probabilistic tractography, diffusion-weighted imaging, motor performance
- MeSH terms
- Adult, Brain Mapping, Corpus Callosum, Female, Humans, Functional Laterality, Male, Middle Aged, Psychomotor Performance, Anisotropy, Diffusion Magnetic Resonance Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
