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Properties and Opioid Inhibition of Mesolimbic Dopamine Neurons Vary according to Target Location
Open accessAbstract
The mesolimbic dopamine system, which mediates the rewarding properties of nearly all drugs of abuse, originates in the ventral tegmental area (VTA) and sends major projections to both the nucleus accumbens (NAc) and the basolateral amygdala (BLA). To address whether differences occur between neurons that project to these separate areas, retrograde microspheres were injected to either the BLA or the NAc of DBA/2J mice. Whole-cell recordings were made from labeled VTA dopamine neurons. We found that identified neurons that projected to the BLA and NAc originated within different quadrants of the VTA with neither group exhibiting large-amplitude h-currents. Neurons that projected to the NAc exhibited a greater outward current in response to the kappa-opioid agonist (5alpha,7alpha,8alpha)-(+)-N-methyl-N-[7-(pyrrolidinyl)-1-oxaspiro [4,5]dec-8-yl]-benzeneacetamide (U69593; 200 nM), whereas neurons that projected to the BLA exhibited greater inhibition to the mu/delta opioid agonist [Met5] enkephalin (ME; 3 microM). In addition, we found that the presynaptic inhibition of GABAergic transmission at both GABAA and GABAB receptors was differentially regulated by U69593 between the two groups. When dopamine IPSCs were examined, U69593 caused a greater inhibition in NAc- than BLA-projecting neurons. ME had no effect on either. Finally, the regulation of extracellular dopamine by dopamine uptake transporters was equal across the VTA. These results suggest that opioids differentially inhibit mesolimbic neurons depending on their target projections. Identifying the properties of projecting mesolimbic VTA dopamine neurons is crucial to understanding the action of drugs of abuse.
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“Species related quantitative differences in DA function between rats and mice may account for the differences in the results (42, 43).”
From Withdrawal from Chronic Nicotine Exposure Alters Dopamine Signaling Dynamics in the Nucleus Accumbens (2012) · cites this paper as [42]
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The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718
Opioids excite dopamine neurons by hyperpolarization of local interneurons
Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637
Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450
Mesocorticolimbic dopaminergic network: functional and regulatory roles
Moal, M. L., & Simon, H. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.155 · Cited by 1,096
Wise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Williams, J. T., Christie, M. J., & Manzoni, O. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.299 · Cited by 853
The neuropsychological basis of addictive behaviour
Everitt, B. J., Dickinson, A., & Robbins, T. W. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00088-1 · Cited by 808
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792
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- (1993), J Pharmacol Exp Ther, 264, 489
- (2002), Sci STKE, 2002, PL2
- (1998), Neuroscience, 82, 59
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Optogenetics and the Dissection of Neural Circuits Underlying Depression and Substance-use Disorders
Juarez, B., Friedman, A. K., & Han, M. (2017) · Cambridge University Press eBooks · doi:10.1017/9781107281875.020
Bird, M. F. (2015) · Leicester Research Archive (University of Leicester)
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Courtney, N. A. (2016) · OhioLink ETD Center (Ohio Library and Information Network)
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Ehrich, J. M. (2015) · ResearchWorks at the University of Washington (University of Washington)
Nawaz, S. (2011) · TSpace (University of Toronto)
Attenuating the Agent: Reducing Opioid “Virulence”
McAnally, H. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-47497-7_5
Tovar-Díaz, J., Pomrenze, M. B., Pahlavan, B., Kan, R., Drew, M. R., & Morikawa, H. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/191148
West, K. M. (2022) · Digital Archive @ GSU · doi:10.57709/12454585
Modulation of ventral periaqueductal gray dopamine neurons
Li, C. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/sk5m-2e97
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Wallace, J. B. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/m272-rx76
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Patel, S. (2020) · The Sydney eScholarship Repository (The University of Sydney)
Darcq, E. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736722229.793581998
Cox, B. M., & Toll, L. (2022) · Advances in Drug and Alcohol Research · doi:10.3389/adar.2022.10115
Russo, S. J., & Ables, J. L. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718185776.793489484
Betzler, F., & Köhler, S. (2016) · Springer eBooks · doi:10.1007/978-3-642-55214-4_67-1
Schoenbaum, G. M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.721782254.793560158
Kokhan, V. S., Anokhin, P. K., Pakhlova, E. P., Sarycheva, N. Y., & Shamakina, I. Y. (2022) · Journal Biomed · doi:10.33647/2074-5982-18-4-112-122
Nguyen, A. M., Semeano, A. T. S., Quach, V., Inoue, A., Nichols, D. E., & Yano, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.03.560682
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Reynolds, L. M., Gulmez, A., Fayad, S. L., Campos, R. C., Rigoni, D., Nguyen, C., Borgne, T. L., Topilko, T., Rajot, D., Franco, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.28.564518
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Wallace, C. W., Lopes, E. F., Holleran, K. M., & Jones, S. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.23.684229
Bonneau, N. (2010) · theses.fr (ABES) · doi:10.70675/70b0c65bzc1a6z4af4zb70fz2aee94ac71e1
Xia, Y., Zhu, W., Jiang, J., & Xu, H. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116200
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Nguyen, C. (2020) · theses.fr (ABES) · doi:10.70675/57dc4740z36f1z4ee7z87e7z960af8c4a43e
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Lopes, E. F., Estave, P. M., Curry, A. M., Beard, K. R., Dawes, M. H., Sciortino, J. H., Grant, K. A., Jayanthi, L. D., Ramamoorthy, S., Holleran, K. M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.06.722744
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Wang, R., Yau, J. O.-Y., Kalra, M., Gilchrist, S., Livermore, A., Gregoriou, G. C., Schennink, M., Moreno, C., Santhakumar, R., Rafiei, N., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.17.739254
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Bagley, E. E., Wang, R., Yau, J. O.-Y., Kalra, M., Gilchrist, S., Livermore, A., Gregoriou, G. C., Schennink, M., Moreno, C., Santhakumar, R., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10600205/v1
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Lebouc, M., Fois, G. R., Bilella, A., Baufreton, J., Barrot, M., & Georges, F. E. (2026) · Research Square · doi:10.21203/rs.3.rs-11143061/v1
Seeley, S. L., Snyder, M., & D’Souza, M. S. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116530
Madden, J. T., Clark, B. J., Hamilton, D. A., & Pentkowski, N. S. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1966221
Metadata
- Authors
- Ford, C. P., Mark, G. P., & Williams, J. T.
- Affiliations
- Oregon Health & Science University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-03-08
- Volume
- 26
- Issue
- 10
- Pages
- 2788-2797
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3623681
- OpenAlex
- W2012111567
- Cited by
- 339
- References
- 52
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 7 · 2023: 14 · 2022: 14 · 2021: 8 · 2020: 14 · 2019: 14 · 2018: 10 · 2017: 24 · 2016: 22 · 2015: 26 · 2014: 25 · 2013: 28 · 2012: 21
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- Life Sciences Research Foundation
- Fondation pour la Recherche Médicale
- National Institutes of Health
- National Institute on Drug Abuse (DA04523, DA 014639, R01DA008163, DA-08163, R01DA014639, R01DA004523)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- mesolimbic dopamine system, ventral tegmental area, nucleus accumbens, basolateral amygdala, opioid inhibition, kappa opioid receptor, [Met5]enkephalin, presynaptic inhibition, GABAA receptor, GABAB receptors, retrograde tracing, drug reward
- MeSH terms
- Amygdala, Analgesics, Animals, Bicuculline, Biotin, Cell Count, Dopamine, Dose-Response Relationship, Radiation, Drug Interactions, Electric Stimulation, Female, Immunohistochemistry, Limbic System, Male, Membrane Potentials, Mice, Inbred DBA, Microinjections, Molecular Sequence Data, Naloxone, Narcotic Antagonists, Narcotics, Neural Inhibition, Neural Pathways, Synaptic Transmission, Neurons, Nucleus Accumbens, Reaction Time, Serotonin, Tyrosine 3-Monooxygenase, Serotonin Receptor Agonists, Ventral Tegmental Area, Patch-Clamp Techniques, GABA Antagonists, Mice, In Vitro Techniques
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