Cited by 340Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Properties and Opioid Inhibition of Mesolimbic Dopamine Neurons Vary according to Target Location

Open access

Ford, Christopher P., Mark, Gregory P., Williams, John T.·2006·The Journal of Neuroscience

DOI 10.1523/jneurosci.4331-05.2006PMC PMC3623681

Open this paper in CoChat — free account Open PDF

Abstract

The mesolimbic dopamine system, which mediates the rewarding properties of nearly all drugs of abuse, originates in the ventral tegmental area (VTA) and sends major projections to both the nucleus accumbens (NAc) and the basolateral amygdala (BLA). To address whether differences occur between neurons that project to these separate areas, retrograde microspheres were injected to either the BLA or the NAc of DBA/2J mice. Whole-cell recordings were made from labeled VTA dopamine neurons. We found that identified neurons that projected to the BLA and NAc originated within different quadrants of the VTA with neither group exhibiting large-amplitude h-currents. Neurons that projected to the NAc exhibited a greater outward current in response to the kappa-opioid agonist (5alpha,7alpha,8alpha)-(+)-N-methyl-N-[7-(pyrrolidinyl)-1-oxaspiro [4,5]dec-8-yl]-benzeneacetamide (U69593; 200 nM), whereas neurons that projected to the BLA exhibited greater inhibition to the mu/delta opioid agonist [Met5] enkephalin (ME; 3 microM). In addition, we found that the presynaptic inhibition of GABAergic transmission at both GABAA and GABAB receptors was differentially regulated by U69593 between the two groups. When dopamine IPSCs were examined, U69593 caused a greater inhibition in NAc- than BLA-projecting neurons. ME had no effect on either. Finally, the regulation of extracellular dopamine by dopamine uptake transporters was equal across the VTA. These results suggest that opioids differentially inhibit mesolimbic neurons depending on their target projections. Identifying the properties of projecting mesolimbic VTA dopamine neurons is crucial to understanding the action of drugs of abuse.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.4331-05.2006

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · cited 2×
“This contrasts with previous anatomical studies in the rat, which identified a substantial proportion of non-DAergic cells that send projections to these target areas (Swanson, 1982).”
Result
Opioids excite dopamine neurons by hyperpolarization of local interneurons
Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637
The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450
Mesocorticolimbic dopaminergic network: functional and regulatory roles
Moal, M. L., & Simon, H. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.155 · Cited by 1,108
Neurobiology of addiction
Wise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Williams, J. T., Christie, M. J., & Manzoni, O. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.299 · Cited by 853
The neuropsychological basis of addictive behaviour
Everitt, B. J., Dickinson, A., & Robbins, T. W. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00088-1 · Cited by 808
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792

Show all 52 references

Research works printed but not linked: 3

(1993), J Pharmacol Exp Ther, 264, 489
(2002), Sci STKE, 2002, PL2
(1998), Neuroscience, 82, 59

Sorted by citations

Ventral tegmental area: cellular heterogeneity, connectivity and behaviour
Morales, M., & Margolis, E. B. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.165 · Cited by 1,108
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
Lammel, S., Hetzel, A., Häckel, O., Jones, I., Liss, B., & Roeper, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.022 · Cited by 976
Cortico-Basal Ganglia Reward Network: Microcircuitry
Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985
Reward and aversion in a heterogeneous midbrain dopamine system
Lammel, S., Lim, B. K., & Malenka, R. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.019 · Cited by 804
Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli
Brischoux, F., Chakraborty, S., Brierley, D. I., & Ungless, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811507106 · Cited by 801
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli
Lammel, S., Ion, D. I., Roeper, J., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.025 · Cited by 766
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses.
Jhou, T. C., Fields, H. L., Baxter, M. G., Saper, C. B., & Holland, P. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.001 · Cited by 696
The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?
Margolis, E. B., Lock, H., Hjelmstad, G. O., & Fields, H. L. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117069 · Cited by 527
Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease
Nobili, A., Latagliata, E. C., Viscomi, M. T., Cavallucci, V., Cutuli, D., Giacovazzo, G., Krashia, P., Rizzo, F. R., Marino, R., Federici, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms14727 · Cited by 514
The neurobiology and genetics of impulse control disorders: Relationships to drug addictions
Brewer, J. A., & Potenza, M. N. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.043 · Cited by 540
Methamphetamine: An update on epidemiology, pharmacology, clinical phenomenology, and treatment literature
Courtney, K. E., & Ray, L. A. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.08.003 · Cited by 502
Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction
Christie, M. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.100 · Cited by 493
Are you or aren’t you? Challenges associated with physiologically identifying dopamine neurons
Ungless, M. A., & Grace, A. A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.02.003 · Cited by 450
Understanding opioid reward
Fields, H. L., & Margolis, E. B. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.01.002 · Cited by 432
A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward
Stamatakis, A. M., Jennings, J. H., Ung, R. L., Blair, G. A., Weinberg, R. J., Neve, R. L., Boyce, F., Mattis, J., Ramakrishnan, C., Deisseroth, K., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.023 · Cited by 364
Chronic Nicotine Cell Specifically Upregulates Functional α4* Nicotinic Receptors: Basis for Both Tolerance in Midbrain and Enhanced Long-Term Potentiation in Perforant Path
Nashmi, R., Xiao, C., Deshpande, P., McKinney, S., Grady, S. R., Whiteaker, P., Huang, Q., McClure-Begley, T., Lindstrom, J. M., Labarca, C., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2199-07.2007 · Cited by 274
Pacemaking in Dopaminergic Ventral Tegmental Area Neurons: Depolarizing Drive from Background and Voltage-Dependent Sodium Conductances
Khaliq, Z. M., & Bean, B. P. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0143-10.2010 · Cited by 261
Ventral tegmental area dopamine revisited: effects of acute and repeated stress
Holly, E. N., & Miczek, K. A. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4151-3 · Cited by 265
Role of kappa-opioid receptors in stress and anxiety-related behavior
Veer, A. V., & Carlezon, W. A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3195-5 · Cited by 262
Corticotropin‐releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C‐dependent enhancement of Ih
Wanat, M. J., Hopf, F. W., Stuber, G. D., Phillips, P. E. M., & Bonci, A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.150078 · Cited by 256
Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice
Blednov, Y. A., Benavidez, J. M., Geil, C., Perra, S., Morikawa, H., & Harris, R. A. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.01.008 · Cited by 249
Calculating utility: preclinical evidence for cost–benefit analysis by mesolimbic dopamine
Phillips, P. E. M., Walton, M. E., & Jhou, T. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0626-6 · Cited by 237
Separate GABA Afferents to Dopamine Neurons Mediate Acute Action of Opioids, Development of Tolerance, and Expression of Withdrawal
Matsui, A., Jarvie, B. C., Robinson, B. G., Hentges, S. T., & Williams, J. T. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.030 · Cited by 237
Midbrain Dopamine Neurons: Projection Target Determines Action Potential Duration and Dopamine D 2 Receptor Inhibition
Margolis, E. B., Mitchell, J., Ishikawa, J., Hjelmstad, G. O., & Fields, H. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-08.2008 · Cited by 239
Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
Douma, E. H., & de Kloet, E. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.015 · Cited by 235
VTA GABA Neurons at the Interface of Stress and Reward
Bouarab, C., Thompson, B. V., & Polter, A. M. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00078 · Cited by 233
Glutamate neurons within the midbrain dopamine regions
Morales, M., & Root, D. H. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.032 · Cited by 218
Dopamine is necessary for cue-dependent fear conditioning
Fadok, J. P., Dickerson, T. M. K., & Palmiter, R. D. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1616-09.2009 · Cited by 213
RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area
Labouèbe, G., Lomazzi, M., Cruz, H. G., Creton, C., Luján, R., Li, M., Yanagawa, Y., Obata, K., Watanabe, M., Wickman, K., et al. (2007) · Nature Neuroscience · doi:10.1038/nn2006 · Cited by 205
The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse
Rogers, J. L., Ghee, S. M., & See, R. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.012 · Cited by 207
Identification of Rat Ventral Tegmental Area GABAergic Neurons
Margolis, E. B., Toy, B. C., Himmels, P., Morales, M., & Fields, H. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042365 · Cited by 215
Opioid-Sensitive GABA Inputs from Rostromedial Tegmental Nucleus Synapse onto Midbrain Dopamine Neurons
Matsui, A., & Williams, J. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4570-11.2011 · Cited by 191
Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons
Ehrich, J. M., Messinger, D. I., Knakal, C. R., Kuhar, J. R., Schattauer, S. S., Bruchas, M. R., Zweifel, L. S., Kieffer, B. L., Phillips, P. E. M., & Chavkin, C. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2444-15.2015 · Cited by 187
Inhibitory Inputs from Rostromedial Tegmental Neurons Regulate Spontaneous Activity of Midbrain Dopamine Cells and Their Responses to Drugs of Abuse
Lecca, S., Melis, M., Luchicchi, A., Muntoni, A. L., & Pistis, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.302 · Cited by 185
The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors
Mietlicki‐Baase, E. G., Ortinski, P. I., Rupprecht, L. E., Olivos, D. R., Alhadeff, A. L., Pierce, R. C., & Hayes, M. R. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00413.2013 · Cited by 175
An update on the connections of the ventral mesencephalic dopaminergic complex
Yetnikoff, L., Lavezzi, H. N., Reichard, R. A., & Zahm, D. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.010 · Cited by 189
New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system
Volman, S. F., Lammel, S., Margolis, E. B., Kim, Y., Richard, J. M., Roitman, M. F., & Lobo, M. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3250-13.2013 · Cited by 168
Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors
Morel, C., Montgomery, S. E., Li, L., Cuttoli, R. D.-D., Teichman, E. M., Juarez, B., Tzavaras, N., Ku, S. M., Flanigan, M. E., Cai, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29155-1 · Cited by 178
Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure
Juarez, B., & Han, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.32 · Cited by 176
Dopamine Signaling Differences in the Nucleus Accumbens and Dorsal Striatum Exploited by Nicotine
Zhang, T., Zhang, L., Liang, Y., Siapas, A. G., Zhou, F.-M., & Dani, J. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0261-09.2009 · Cited by 170
The dynorphin/κ-opioid receptor system and its role in psychiatric disorders
Tejeda, H. A., Shippenberg, T. S., & Henriksson, R. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0844-x · Cited by 161
Kappa-opioid ligands in the study and treatment of mood disorders
Carlezon, W. A., Béguin, C., Knoll, A. T., & Cohen, B. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.05.008 · Cited by 156
Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain
Reeves, K. C., Shah, N., Muñoz, B., & Atwood, B. K. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.919773 · Cited by 156
Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms
Morikawa, H., & Paladini, C. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.023 · Cited by 159
Heterogeneity of dopamine neuron activity across traits and states
Marinelli, M., & McCutcheon, J. E. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.034 · Cited by 152
Stress and VTA synapses: implications for addiction and depression
Polter, A. M., & Kauer, J. A. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12490 · Cited by 147
Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons
Borgland, S. L., Storm, E. E., & Bonci, A. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06397.x · Cited by 145
Ethanol Action on Dopaminergic Neurons in the Ventral Tegmental Area
Morikawa, H., & Morrisett, R. A. (2010) · International review of neurobiology · doi:10.1016/s0074-7742(10)91008-8 · Cited by 146
Withdrawal from Chronic Nicotine Exposure Alters Dopamine Signaling Dynamics in the Nucleus Accumbens
Zhang, L., Dong, Y., Doyon, W. M., & Dani, J. A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.024 · Cited by 135
Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons
Baimel, C., Lau, B. K., Qiao, M., & Borgland, S. L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.030 · Cited by 137
Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction
Chartoff, E. H., & Mavrikaki, M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00466 · Cited by 137
Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety
Nguyen, C., Mondoloni, S., Le Borgne, T., Centeno, I., Come, M., Jehl, J., Solié, C., Reynolds, L. M., Durand-de Cuttoli, R., Tolu, S., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.06.013 · Cited by 136
Control of Extracellular Dopamine at Dendrite and Axon Terminals
Ford, C., Gantz, S. C., Phillips, P. E. M., & Williams, J. T. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1020-10.2010 · Cited by 135
Heterogeneous composition of dopamine neurons of the rat A10 region: molecular evidence for diverse signaling properties
Li, X., Qi, J., Yamaguchi, T., Wang, H., & Morales, M. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0452-z · Cited by 129
Effect of Acute Ethanol Administration on the Release of Opioid Peptides From the Midbrain Including the Ventral Tegmental Area
Jarjour, S., Bai, L., & Gianoulakis, C. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00924.x · Cited by 132
Sex Differences and the Role of Estradiol in Mesolimbic Reward Circuits and Vulnerability to Cocaine and Opiate Addiction
Kokane, S. S., & Perrotti, L. I. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00074 · Cited by 132
Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity
Graziane, N. M., Polter, A. M., Briand, L. A., Pierce, R. C., & Kauer, J. A. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.034 · Cited by 121
Role of nicotinic acetylcholine receptors in regulating dopamine neuron activity
Faure, P., Tolu, S., Valverde, S., & Naudé, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.040 · Cited by 125
Distinct cellular properties of identified dopaminergic and GABAergic neurons in the mouse ventral tegmental area
Chieng, B. C. H., Azriel, Y., Mohammadi, S. A., & Christie, M. J. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.210807 · Cited by 120
Oxycodone in the Opioid Epidemic: High ‘Liking’, ‘Wanting’, and Abuse Liability
Kibaly, C., Alderete, J. A., Liu, S. H., Nasef, H., Law, P., Evans, C. J., & Cahill, C. M. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-01013-y · Cited by 125
Piecing together the puzzle of acetaldehyde as a neuroactive agent
Correa, M., Salamone, J. D., Segovia, K. N., Pardo, M., Longoni, R., Spina, L., Peana, A. T., Vinci, S., & Acquas, E. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.009 · Cited by 119
Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine NeuronsPreprint
Mazei‐Robison, M. S., & Nestler, E. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012070 · Cited by 113
Untitled work
Karkhanis (2017) · doi:10.1016/bs.irn.2017.08.001 · Cited by 113
Energy regulatory signals and food reward
Figlewicz, D. P., & Sipols, A. J. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.03.002 · Cited by 116
Brain Reward Circuits in Morphine Addiction
Kim, J., Ham, S., Hong, H., Moon, C., & Im, H. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.0137 · Cited by 117
Dynorphin/kappa-opioid receptor control of dopamine dynamics: Implications for negative affective states and psychiatric disorders
Tejeda, H. A., & Bonci, A. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.023 · Cited by 117
Differential Activation and Trafficking of μ-Opioid Receptors in Brain Slices
Arttamangkul, S., Quillinan, N., Low, M. J., von Zastrow, M., Pintar, J. E., & Williams, J. T. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.048512 · Cited by 112
Does the kappa opioid receptor system contribute to pain aversion?
Cahill, C. M., Taylor, A. M. W., Cook, C., Ong, E., MorÃ³n, J. A., & Evans, C. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00253 · Cited by 105
Acetaldehyde mediates alcohol activation of the mesolimbic dopamine system
Melis, M., Enrico, P., Peana, A. T., & Diana, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05887.x · Cited by 107
Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults
McCutcheon, J. E., Conrad, K. L., Carr, S. B., Ford, K. A., McGehee, D. S., & Marinelli, M. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00077.2012 · Cited by 106
The heterogeneity of ventral tegmental area neurons: Projection functions in a mood-related context
Walsh, J. J., & Han, M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.006 · Cited by 108
The Abused Inhalant Toluene Increases Dopamine Release in the Nucleus Accumbens by Directly Stimulating Ventral Tegmental Area Neurons
Riegel, A. C., Zapata, A. G., Shippenberg, T. S., & French, E. D. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301273 · Cited by 105
Direct Bidirectional μ-Opioid Control of Midbrain Dopamine Neurons
Margolis, E. B., Hjelmstad, G. O., Fujita, W., & Fields, H. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2144-14.2014 · Cited by 106
Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels
Evans, R. C., Zhu, M., & Khaliq, Z. M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0117-17.2017 · Cited by 103
Regulation of the mesolimbic dopamine circuit by feeding peptides
Liu, S., & Borgland, S. L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.046 · Cited by 104
In vitro identification and electrophysiological characterization of dopamine neurons in the ventral tegmental area
Zhang, T. A., Placzek, A. N., & Dani, J. A. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.06.004 · Cited by 100
Ethanol Enhances GABAergic Transmission Onto Dopamine Neurons in the Ventral Tegmental Area of the Rat
Theile, J. W., Morikawa, H., Gonzales, R. A., & Morrisett, R. A. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00665.x · Cited by 100
Diversity and Homogeneity in Responses of Midbrain Dopamine Neurons
Fiorillo, C. D., Yun, S. R., & Song, M. R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3886-12.2013 · Cited by 99
Progress in understanding mood disorders: optogenetic dissection of neural circuits
Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98
CRF Facilitates Calcium Release from Intracellular Stores in Midbrain Dopamine Neurons
Riegel, A. C., & Williams, J. T. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.029 · Cited by 97
Disparity Between Tonic and Phasic Ethanol‐Induced Dopamine Increases in the Nucleus Accumbens of Rats
Robinson, D. L., Howard, E. C., McConnell, S., Gonzales, R. A., & Wightman, R. M. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00942.x · Cited by 99
Pathological Gambling: A Systematic Review of Biochemical, Neuroimaging, and Neuropsychological Findings
Conversano, C., Marazziti, D., Carmassi, C., Baldini, S., Barnabei, G., & Dell’Osso, L. (2012) · Harvard Review of Psychiatry · doi:10.3109/10673229.2012.694318 · Cited by 104
Metabolic regulation of lateral hypothalamic glucose-inhibited orexin neurons may influence midbrain reward neurocircuitry
Sheng, Z., Santiago, A. M., Thomas, M. P., & Routh, V. H. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.08.001 · Cited by 95
Endogenous opiates and behavior: 2006
Bodnar, R. J. (2007) · Peptides · doi:10.1016/j.peptides.2007.09.002 · Cited by 91
Long-Term Memory for Pavlovian Fear Conditioning Requires Dopamine in the Nucleus Accumbens and Basolateral Amygdala
Fadok, J. P., Darvas, M., Dickerson, T. M. K., & Palmiter, R. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012751 · Cited by 90
Role of Mu- and Delta-Opioid Receptors in the Nucleus Accumbens in Cocaine-Seeking Behavior
Simmons, D. L., & Self, D. W. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.28 · Cited by 89
Nicotine Potentiation of Excitatory Inputs to Ventral Tegmental Area Dopamine Neurons
Mao, D., Gallagher, K., & McGehee, D. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5671-10.2011 · Cited by 96
Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation
Chen, M., Zhao, Y., Yang, H., Luan, W., Song, J., Cui, D., Dong, Y. W., Lai, B., Ma, L., & Zheng, P. (2015) · eLife · doi:10.7554/elife.09275 · Cited by 92
Spontaneous Inhibitory Synaptic Currents Mediated by a G Protein-Coupled Receptor
Gantz, S. C., Bunzow, J. R., & Williams, J. T. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.013 · Cited by 88
Enhanced serotonin and mesolimbic dopamine transmissions in a rat model of neuropathic pain
Sagheddu, C., Aroni, S., Felice, M. D., Lecca, S., Luchicchi, A., Melis, M., Muntoni, A. L., Romano, R., Palazzo, E., Guida, F., et al. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.06.003 · Cited by 90
Kappa Opioid Inhibition of Somatodendritic Dopamine Inhibitory Postsynaptic Currents
Ford, C., Beckstead, M. J., & Williams, J. T. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00963.2006 · Cited by 84
Identification of a Dopamine Receptor-Mediated Opiate Reward Memory Switch in the Basolateral Amygdala–Nucleus Accumbens Circuit
Lintas, A., Chi, N., Lauzon, N. M., Bishop, S. F., Gholizadeh, S., Sun, N., Tan, H., & Laviolette, S. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1781-11.2011 · Cited by 84
The Time Course of Dopamine Transmission in the Ventral Tegmental Area
Ford, C., Phillips, P. E. M., & Williams, J. T. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3546-09.2009 · Cited by 84
Food Restriction Increases Glutamate Receptor-Mediated Burst Firing of Dopamine Neurons
Branch, S. Y., Goertz, R. B., Sharpe, A. L., Pierce, J., Roy, S., Ko, D., Paladini, C. A., & Beckstead, M. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5099-12.2013 · Cited by 81
The highly selective dopamine D R antagonist, R-VK4-40 attenuates oxycodone reward and augments analgesia in rodents
Jordan, C. J., Humburg, B. A., RICE, M. S., Bi, G., You, Z., Shaik, A. B., Cao, J., Bonifazi, A., Gadiano, A. J., Rais, R., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.04.003 · Cited by 82
Neuroinflammation—a co-occurring phenomenon linking chronic pain and opioid dependence
Cahill, C. M., & Taylor, A. M. W. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.12.003 · Cited by 84
The Effects of Naltrexone on Subjective Response to Methamphetamine in a Clinical Sample: a Double-Blind, Placebo-Controlled Laboratory Study
Ray, L. A., Bujarski, S., Courtney, K. E., Moallem, N. R., Lunny, K. F., Roche, D., Leventhal, A. M., SHOPTAW, S. J., Heinzerling, K. G., London, E. D., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.83 · Cited by 79
Aging Decreases L-Type Calcium Channel Currents and Pacemaker Firing Fidelity in Substantia Nigra Dopamine Neurons
Branch, S. Y., Sharma, R. V., & Beckstead, M. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4228-13.2014 · Cited by 79
Functional evidence for a direct excitatory projection from the lateral habenula to the ventral tegmental area in the rat
Brown, P. L., & Shepard, P. D. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00305.2016 · Cited by 76
Dynamic, Nonlinear Feedback Regulation of Slow Pacemaking by A-Type Potassium Current in Ventral Tegmental Area Neurons
Khaliq, Z. M., & Bean, B. P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2237-08.2008 · Cited by 77

Authors: Ford, C. P., Mark, G. P., & Williams, J. T.
Affiliations: Oregon Health & Science University (US)
ORCID: Ford, Christopher P.
Williams, John T.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2006-03-08
Volume: 26
Issue: 10
Pages: 2788-2797
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4331-05.2006
PMC: PMC3623681
OpenAlex: W2012111567
Cited by: 339
References: 52
Citations by year: 2026: 12 · 2025: 9 · 2024: 7 · 2023: 14 · 2022: 14 · 2021: 8 · 2020: 14 · 2019: 14 · 2018: 10 · 2017: 24 · 2016: 22 · 2015: 26 · 2014: 25 · 2013: 28 · 2012: 21
FWCI: 7.20
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
Funders: Life Sciences Research Foundation
Fondation pour la Recherche Médicale
National Institutes of Health
National Institute on Drug Abuse (DA04523, DA 014639, R01DA008163, DA-08163, R01DA014639, R01DA004523)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: mesolimbic dopamine system, ventral tegmental area, nucleus accumbens, basolateral amygdala, opioid inhibition, kappa opioid receptor, [Met5]enkephalin, presynaptic inhibition, GABAA receptor, GABAB receptors, retrograde tracing, drug reward
MeSH terms: Amygdala, Analgesics, Animals, Bicuculline, Biotin, Cell Count, Dopamine, Dose-Response Relationship, Radiation, Drug Interactions, Electric Stimulation, Female, Immunohistochemistry, Limbic System, Male, Membrane Potentials, Mice, Inbred DBA, Microinjections, Molecular Sequence Data, Naloxone, Narcotic Antagonists, Narcotics, Neural Inhibition, Neural Pathways, Synaptic Transmission, Neurons, Nucleus Accumbens, Reaction Time, Serotonin, Tyrosine 3-Monooxygenase, Serotonin Receptor Agonists, Ventral Tegmental Area, Patch-Clamp Techniques, GABA Antagonists, Mice, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Properties and Opioid Inhibition of Mesolimbic Dopamine Neurons Vary according to Target Location

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks