The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
The Mother or the Fetus? 11β-Hydroxysteroid Dehydrogenase Type 2 Null Mice Provide Evidence for Direct Fetal Programming of Behavior by Endogenous Glucocorticoids
Open accessAbstract
Low birth weight associates with increased susceptibility to adult cardiometabolic and affective disorders spawning the notion of fetal “programming.” Prenatal exposure to excess glucocorticoids may be causal. In support, maternal stress or treatment during pregnancy with dexamethasone (which crosses the placenta) or inhibitors of fetoplacental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), the physiological “barrier” to maternal glucocorticoids, reduces birth weight and programs permanent offspring hypertension, hyperglycemia, and anxiety behaviors. It remains uncertain whether such effects are mediated indirectly via altered maternal function or directly on the fetus and its placenta. To dissect this critical issue, we mated 11β-HSD2 +/− mice such that each pregnant female produces +/+, +/−, and −/− offspring and compared them with offspring of homozygous wild-type and −/− matings. We show that 11β-HSD2 −/− offspring of either +/− or −/− mothers have lower birth weight and exhibit greater anxiety than 11β-HSD2 +/+ littermates. This provides clear evidence for the key role of fetoplacental 11β-HSD2 in prenatal glucocorticoid programming.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition, deletion of the 11-ßHSD2 gene in mice is associated with fetal growth restriction (261).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [261]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Self-citationMaternal care, hippocampal synaptogenesis and cognitive development in rats
Liu, D., Diorio, J., Day, J. C., Francis, D. D., & Meaney, M. J. (2000) · Nature Neuroscience · doi:10.1038/77702 · Cited by 1,195
Owens, P. C., Smith, R., Brinsmead, M. W., Hall, C., Foureur, M. J., Hurt, D., Lovelock, M., Chan, E.-C., Cubis, J., & Lewin, T. J. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90603-5 · Cited by 958
Prenatal glucocorticoids and long-term programming
Seckl (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.151u049 · Cited by 825
The developmental origins of chronic adult disease
Barker, D. (2004) · Acta Paediatrica · doi:10.1111/j.1651-2227.2004.tb00236.x · Cited by 790 · cited 1×
“An adverse prenatal environment “programs” lifelong susceptibility to adult disorders such as hypertension, diabetes/insulin resistance, heart disease, as well as depression and schizophrenia (Barker, 2004; Eriksson et al., 2004; Huizink et al., 2004).”
Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress
Maccari, S., Piazza, P., Kabbaj, M., Barbazanges, A., Simon, H., & Moal, M. L. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00110.1995 · Cited by 580
Does Prenatal Stress Impair Coping and Regulation of Hypothalamic-Pituitary-Adrenal Axis?
Weinstock, M. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00014-0 · Cited by 539
Levitt, N. S., Lindsay, R. S., Holmes, M. C., & Seckl, J. R. (2008) · Neuroendocrinology · doi:10.1159/000127146 · Cited by 535
Self-citationPrenatal stress and long-term consequences: implications of glucocorticoid hormones
Maccari, S., Darnaudéry, M., Morley‐Fletcher, S., Zuena, A. R., Cinque, C., & Reeth, O. V. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00014-9 · Cited by 529
11β-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess*
White, P. C., Mune, T., & Agarwal, A. K. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0288 · Cited by 517
Morton, N. M., Paterson, J. M., Masuzaki, H., Holmes, M. C., Staels, B., Fievet, C., Walker, B. R., Flier, J. S., Mullins, J. J., & Seckl, J. R. (2004) · Diabetes · doi:10.2337/diabetes.53.4.931 · Cited by 512 · cited 1×
“Moreover, carbenoxolone also inhibits 11 -HSD1, an oxidoreductase that locally regenerates glucocorticoids and is expressed in liver and adipose tissue and plays a key role in metabolic control (Morton et al., 2004).”
BackgroundSelf-citationHuizink, A. C., Mulder, E. J. H., & Buitelaar, J. K. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.1.115 · Cited by 473
Dalziel, S. R., Walker, N. K., Parag, V., Mantell, C., Rea, H. H., Rodgers, A., & Harding, J. E. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66617-2 · Cited by 461
Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.
Stewart, P. M., Corrie, J. E. T., Shackleton, C. H. L., & Edwards, C. R. W. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113592 · Cited by 429
Welberg, L., Seckl, J. R., & Holmes, M. C. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00065-3 · Cited by 420
Self-citationWelberg, L., Seckl, J. R., & Holmes, M. C. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00958.x · Cited by 344
Self-citationProgrammed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition
Desai, M., Gayle, D. A., Babu, J., & Ross, M. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00340.2004 · Cited by 336
Brown, R. W., Diaz, R., Robson, A. C., Kotelevtsev, Y. V., Mullins, J. J., Kaufman, M. H., & Seckl, J. R. (1996) · Endocrinology · doi:10.1210/endo.137.2.8593833 · Cited by 307
Self-citationLindsay, R. S., Lindsay, R. M., Edwards, C. R. W., & Seckl, J. R. (1996) · Hypertension · doi:10.1161/01.hyp.27.6.1200 · Cited by 301
Self-citationHypertension in mice lacking 11β-hydroxysteroid dehydrogenase type 2
Kotelevtsev, Y. V., Brown, R. W., Fleming, S., Kenyon, C. J., Edwards, C. R. W., Seckl, J. R., & Mullins, J. J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4445 · Cited by 278
Self-citationDiaz, R., Brown, R. W., & Seckl, J. R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02570.1998 · Cited by 240
Self-citationTrautman, P. D., Meyer-Bahlburg, H. F. L., Postelnek, J., & New, M. I. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)00070-0 · Cited by 217
Harris, H. J., Kotelevtsev, Y. V., Mullins, J. J., Seckl, J. R., & Holmes, M. C. (2001) · Endocrinology · doi:10.1210/endo.142.1.7887 · Cited by 215
Self-citation11 -Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess
White, P. C. (1997) · Endocrine Reviews · doi:10.1210/er.18.1.135 · Cited by 213
Blood Pressure in Late Adolescence and Very Low Birth Weight
Doyle, L. W., Faber, B., Callanan, C., & Morley, R. (2003) · PEDIATRICS · doi:10.1542/peds.111.2.252 · Cited by 189
Murphy, V. E., Zakár, T., Smith, R., Giles, W. B., Gibson, P. G., & Clifton, V. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8377 · Cited by 132
Holmes, M. C., French, K. L., & Seckl, J. R. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04056.1997 · Cited by 110
Self-citationHolmes, M. C., Yau, J. L. W., French, K. L., & Seckl, J. R. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00407-v · Cited by 86
Self-citationGenetic manipulation of 11β-hydroxysteroid dehydrogenases in mice
Paterson, J. M., Seckl, J. R., & Mullins, J. J. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00017.2005 · Cited by 40
Self-citationWaddell, B. J., Benediktsson, R., & Seckl, J. R. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940361 · Cited by 35
Self-citationEriksson, M., Wallander, M. ‐., Krakau, I., Wedel, H., & Svärdsudd, K. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01412.x · Cited by 29
Waddell, B. J. (1996) · Endocrinology · doi:10.1210/en.137.12.5386 · Cited by 11
Cited by
Sorted by citations
The long-term behavioural consequences of prenatal stress
Weinstock, M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.002 · Cited by 1,098
11β-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action
Chapman, K., Holmes, M., & Seckl, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00020.2012 · Cited by 887
Self-citationGlucocorticoids, prenatal stress and the programming of disease
Harris, A., & Seckl, J. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.007 · Cited by 871
Self-citationSeckl, J. R., & Holmes, M. C. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0515 · Cited by 754
Self-citationPlacental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717
Metadata
- Authors
- Holmes, M. C., Abrahamsen, C. T., French, K. L., Paterson, J. M., Mullins, J. J., & Seckl, J. R.
- Affiliations
- The Queen's Medical Research Institute (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-04-05
- Volume
- 26
- Issue
- 14
- Pages
- 3840-3844
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6445356
- OpenAlex
- W1971789895
- Cited by
- 200
- References
- 33
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 2 · 2023: 9 · 2022: 4 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 3 · 2017: 10 · 2016: 16 · 2015: 21 · 2014: 22 · 2013: 9 · 2012: 18
- FWCI
- 10.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (079009)
- Medical Research Council
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- 11β-hydroxysteroid dehydrogenase type 2, fetal programming, antenatal glucocorticoids, anxiety-like behavior, birth weight, placenta, dexamethasone, maternal stress, low birth weight, offspring behavior, glucocorticoid metabolism
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Birth Weight, Female, Fetus, Glucocorticoids, Male, Mice, Inbred C57BL, Mothers, Placenta, Pregnancy, Mineralocorticoid Excess Syndrome, Apparent, 11-beta-Hydroxysteroid Dehydrogenase Type 2, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
