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Endocytosis and signalling: intertwining molecular networks

Sorkin, Alexander, von Zastrow, Mark·2009·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm2748PMC PMC2895425
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  • Neurodegeneration is linked to impaired autophagy and trafficking.

    “Neurodegeneration is linked to impaired autophagy and trafficking (Dobrowolski and De Robertis 2011), (Sorkin and von Zastrow 2009), (Taelman et al. 2010), (Killisch et al. 1991), (Lipinski et al. 2010), (Nixon 2013).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Sorkin and von Zastrow 2009

    The section “Retrograde endosome signalling in neurons” describes endosomal transport as necessary for neuronal survival signalling, but does not link impaired trafficking to neurodegeneration. Searches for “autophagy,” “neurodegeneration,” and Alzheimer’s disease found no passage in our copy establishing the claimed link. (LLM, conf=0.73)

    Experimental — accuracy not yet measured

  • Impairment of the autophagosome-lysosomal system and the resulting disruption of intracellular signaling and trafficking are strongly linked to neurodegeneration.

    “Together, impairment of the autophagosome-lysosomal system and the resulting disruption of intracellular signaling and trafficking have been strongly linked to neurodegeneration (Sorkin and von Zastrow 2009;Dobrowolski and De Robertis 2011), (Taelman et al. 2010), (Killisch et al. 1991), (Lipinski et al. 2010), (Nixon 2013).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Sorkin and von Zastrow 2009

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Metadata

Authors
Sorkin, A., & von Zastrow, M.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2009-09
Volume
10
Issue
9
Pages
609-622
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm2748
PMC
PMC2895425
Cited by
1,064
References
3
Language
en
Licence
www.springer.com/tdm (tdm)

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