Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process

Kash, Thomas L.; Nobis, William P.; Matthews, Robert T.; Winder, Danny G.

doi:10.1523/jneurosci.4715-08.2008

Cited by 125Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology

Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process

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Kash, Thomas L., Nobis, William P., Matthews, Robert T., Winder, Danny G.·2008·The Journal of Neuroscience

DOI 10.1523/jneurosci.4715-08.2008PMC PMC2630395

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Abstract

A common feature of drugs of abuse is their ability to increase extracellular dopamine levels in key brain circuits. The actions of dopamine within these circuits are thought to be important in reward and addiction-related behaviors. Current theories of addiction also posit a central role for corticotrophin-releasing factor (CRF) and an interaction between CRF and monoaminergic signaling. One region where drugs of abuse promote robust rises in extracellular dopamine levels is the bed nucleus of the stria terminalis (BNST), a CRF-rich component of the extended amygdala. We find that dopamine rapidly enhances glutamatergic transmission in the BNST through activation of a combination of D(1)- and D(2)-like receptors. This enhancement is activity-dependent and requires the downstream action of CRF receptor 1 (CRF-R1), suggesting that dopamine induces CRF release through a local network mechanism. Furthermore, we found that both in vivo and ex vivo cocaine induced a dopamine receptor and CRF-R1-dependent enhancement of a form of NMDA receptor-dependent short-term potentiation in the BNST. These data highlight a direct and rapid interaction between dopamine and CRF systems that regulates excitatory transmission and plasticity in a brain region key to reinforcement and reinstatement. Because a rise in extracellular dopamine levels in the BNST is a shared consequence of multiple classes of drugs of abuse, this suggests that the CRF-R1-dependent enhancement of glutamatergic transmission in this region may be a common key feature of substances of abuse.

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DA receptor signaling in the BNST and CeA modulates synaptic transmission and activity.
“DA receptor signaling in these regions modulates synaptic transmission and activity (Kash et al., 2008, de la Mora et al., 2010).”
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Cai, J., Xu, Y., Jiang, Z., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.05.539422

Authors: Kash, T. L., Nobis, W. P., Matthews, R. T., & Winder, D. G.
Affiliations: Vanderbilt University (US)
ORCID: Kash, Thomas L.
Nobis, William P.
Matthews, Robert T.
Winder, Danny G.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2008-12-17
Volume: 28
Issue: 51
Pages: 13856-13865
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4715-08.2008
PMC: PMC2630395
OpenAlex: W2095210029
Cited by: 125
References: 60
Citations by year: 2025: 6 · 2023: 7 · 2022: 4 · 2021: 11 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 11 · 2012: 9
FWCI: 4.32
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AA13641, AA017668)
National Institute on Alcohol Abuse and Alcoholism (U01AA013641, F32AA016025, AA13641, R01AA019455, K99AA017668, AA017668, AA016025, R00AA017668, U01AA015635, U24AA013641)
National Institute on Drug Abuse (DA 19112, R01DA019112)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: dopamine, corticotropin-releasing factor, CRF1 receptor, bed nucleus of the stria terminalis, extended amygdala, glutamatergic neurotransmission, dopamine D1 receptor, dopamine D2 receptor, cocaine, drug addiction, activity-dependent plasticity, monoaminergic signaling
MeSH terms: CRF Receptor, Type 1, Amygdala, Animals, Cocaine, Corticotropin-Releasing Hormone, Dopamine, Male, Mice, Inbred C57BL, Mice, Transgenic, Synaptic Transmission, Neuronal Plasticity, Organ Culture Techniques, Septal Nuclei, Illicit Drugs, Receptors, Dopamine D1, Receptors, Dopamine D2, Receptors, Corticotropin-Releasing Hormone, Patch-Clamp Techniques, Glutamic Acid, Excitatory Postsynaptic Potentials, Mice

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Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process

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