Behavioral and anatomical interactions between dopamine and corticotropin-releasing factor in the rat

Meloni, Edward G.; Gerety, Lyle P.; Knoll, Allison T.; Cohen, Bruce M.; Carlezon, William A.

doi:10.1523/jneurosci.4957-05.2006

Cited by 109Neuropeptides and Animal PhysiologyStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Behavioral and anatomical interactions between dopamine and corticotropin-releasing factor in the rat

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Meloni, Edward G., Gerety, Lyle P., Knoll, Allison T., Cohen, Bruce M., Carlezon, William A.·2006·The Journal of Neuroscience

DOI 10.1523/jneurosci.4957-05.2006PMC PMC6674129

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Abstract

The neuropeptide corticotropin-releasing factor (CRF) is believed to play a role in a number of psychiatric conditions, including anxiety disorders and depression. In the present study, male Sprague Dawley rats were used to examine the behavioral effects of altering dopamine transmission on CRF-enhanced startle, a behavioral assay believed to reflect stress- or anxiety-like states. Systemic administration of the selective dopamine D1 receptor antagonist SCH 23390 [R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride] (0, 0.01, 0.05, 0.1, 0.5 mg/kg) dose dependently blocked the effect of CRF (1 microg, i.c.v.) on startle at doses that had no effect on baseline startle response. Immunohistochemical studies showed that most CRF-containing cells in the dorsolateral division of the bed nucleus of the stria terminalis (BSTld), part of the critical brain area mediating CRF-enhanced startle, are surrounded by a dense plexus of tyrosine hydroxylase (TH)-positive fibers. Intra-BSTld injections of the retrograde tracer Fluorogold (FG) into the TH field identified neurons in the major dopaminergic areas (A8-A10), but not the major noradrenergic areas [A5, A6 (locus ceruleus), A7], as a significant source of TH-positive innervation. The majority of FG-filled cells double-labeled for TH were found in the dorsocaudal A10 cell group (A10dc) located in the periaqueductal gray area. Together, these data suggest that neuronal regulation of the BSTld by specific dopaminergic pathways and receptors may be an important mechanism for controlling CRF-dependent moods and affective states. These data also suggest that compounds with D1 receptor antagonist properties might have anxiolytic-like effects that could be useful for treating conditions associated with hyperactive CRF systems.

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eYFP expression in DRN DA somata resulted in terminal expression in several regions including mPFC, BNST, lateral hypothalamus, CeA, entorhinal cortex, and basolateral amygdala.
“Consistent with previous reports, eYFP expression in DRN DA somata resulted in terminal expression in several regions including the medial prefrontal cortex (mPFC), bed nucleus of the stria terminalis (BNST), lateral hypothalamus, central amygdala (CeA), entorhinal cortex, and basolateral amygdala (Hasue and Shammah-Lagnado, 2002, Meloni et al., 2006, Swanson, 1982, Yoshida et al., 1989).”
From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Meloni et al., 2006
DRN DA neurons have a relative bias in their projections to the BNST and CeA.
“The relative bias of the DRN DA neurons in their projections to the BNST and CeA (Hasue and Shammah-Lagnado, 2002, Meloni et al., 2006)”
From Dorsal raphe dopamine neurons represent the experience of social isolation (2016) · cites this paper as Meloni et al., 2006

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“Indeed, Meloni et al have speculated that the interactions between PAG and BNST are similar to the BNST –VTA interaction, with CRF neurons innervating PAG DA neurons (Meloni et al., 2006).”
Influential
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Alcohol effects on synaptic transmission in periaqueductal gray dopamine neurons
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Role of dopamine D1 and D2 receptors in CRF-induced disruption of sensorimotor gating
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Adolescent intermittent ethanol exposure diminishes anhedonia during ethanol withdrawal in adulthood
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Oxytocin induces penile erection and yawning when injected into the bed nucleus of the stria terminalis: Involvement of glutamic acid, dopamine, and nitric oxide
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Cocaine Augments Dopamine-Mediated Inhibition of Neuronal Activity in the Dorsal Bed Nucleus of the Stria Terminalis
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Dopaminergic innervation at the central nucleus of the amygdala reveals distinct topographically segregated regions
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Dopaminergic afferents from midbrain to dorsolateral bed nucleus of stria terminalis inhibit release and expression of corticotropin‐releasing hormone in paraventricular nucleus
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Chapter 4.1 Peptide receptor ligands to treat anxiety disorders
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Dopamine in the dorsal bed nucleus of stria terminalis signals Pavlovian sign-tracking and reward violations
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Endogenous Nitric Oxide and Dopamine Regulate Feeding Behavior in Neonatal Layer-type Chickens
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Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like statePreprint
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Chronic Ethanol Exposure Modulates Periaqueductal Gray to Extended Amygdala Dopamine Circuit
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Nuclear organization of catecholaminergic neurons in the brains of a lar gibbon and a chimpanzee
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Ghrelin Amplifies the Nicotine-Induced Release of Dopamine in the Bed Nucleus of Stria Terminalis (BNST)
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Bed Nucleus of Stria Terminalis (BNST) circuits
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Glucocorticoids Regulate Kisspeptin Neurons during Stress and Contribute to Infertility and Obesity in Leptin-Deficient Mice
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Authors: Meloni, E. G., Gerety, L. P., Knoll, A. T., Cohen, B. M., & Carlezon, W. A.
Affiliations: Harvard University (US)
ORCID: Meloni, Edward G.
Cohen, Bruce M.
Carlezon, William A.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2006-04-05
Volume: 26
Issue: 14
Pages: 3855-3863
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4957-05.2006
PMC: PMC6674129
OpenAlex: W2063743575
Cited by: 109
References: 75
Citations by year: 2026: 1 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 9 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 10 · 2012: 7
FWCI: 2.15
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Stanley Medical Research Institute
National Institutes of Health (5r01mh063266-25)
National Institute of Mental Health (MH63266)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: corticotropin-releasing factor, dopamine, dopamine D1 receptor, SCH 23390, anxiety, stress, bed nucleus of the stria terminalis, tyrosine hydroxylase, dopaminergic innervation, periaqueductal gray, retrograde tracing, Fluoro-Gold, anxiolytic effects, noradrenergic neurons
MeSH terms: Animals, Behavior, Animal, Brain, Corticotropin-Releasing Hormone, Dopamine, Male, Reflex, Startle, Signal Transduction, Rats, Sprague-Dawley, Neurotransmitter Agents, Rats

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Behavioral and anatomical interactions between dopamine and corticotropin-releasing factor in the rat

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