Cited by 119Sleep and Wakefulness ResearchNeuroscience of respiration and sleepSleep and Work-Related Fatigue

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Locus Ceruleus Control of Slow-Wave Homeostasis

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Cirelli, Chiara, Huber, Reto, Gopalakrishnan, Anupama, Southard, Teresa L., Tononi, Giulio·2005·The Journal of Neuroscience

DOI 10.1523/jneurosci.4845-04.2005PMC PMC6725032

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Abstract

Sleep intensity is regulated by the duration of previous wakefulness, suggesting that waking results in the progressive accumulation of sleep need (Borbély and Achermann, 2000). In mammals, sleep intensity is reflected by slow-wave activity (SWA) in the nonrapid eye movement (NREM) sleep electroencephalogram, which increases in proportion to the time spent awake. However, the mechanisms responsible for the increase of NREM SWA after wakefulness remain unclear. According to a recent hypothesis (Tononi and Cirelli, 2003), the increase in SWA occurs because during wakefulness, many cortical circuits undergo synaptic potentiation, as evidenced by the widespread induction of long-term potentiation (LTP)-related genes in the brain of awake animals. A direct prediction of this hypothesis is that manipulations interfering with the induction of LTP-related genes should result in a blunted SWA response. Here, we examined SWA response in rats in which cortical norepinephrine (NA) was depleted, a manipulation that greatly reduces the induction of LTP-related genes during wakefulness (Cirelli and Tononi, 2004). We found that the homeostatic response of the lower-range SWA was markedly and specifically reduced after NA depletion. These data suggest that the wake-dependent accumulation of sleep need is causally related to cellular changes dependent on NA release, such as the induction of LTP-related genes, and support the hypothesis that sleep SWA homeostasis may be related to synaptic potentiation during wakefulness.

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Authors: Cirelli, C., Huber, R., Gopalakrishnan, A., Southard, T. L., & Tononi, G.
Affiliations: University of Wisconsin–Madison (US)
ORCID: Cirelli, Chiara
Huber, Reto
Southard, Teresa L.
Tononi, Giulio
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2005-05-04
Volume: 25
Issue: 18
Pages: 4503-4511
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4845-04.2005
PMC: PMC6725032
OpenAlex: W2007283165
Cited by: 119
References: 89
Citations by year: 2026: 2 · 2025: 1 · 2024: 6 · 2023: 1 · 2022: 7 · 2021: 2 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 11 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 13 · 2012: 11
FWCI: 2.64
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: locus coeruleus, slow-wave activity, sleep homeostasis, norepinephrine depletion, synaptic potentiation, long-term potentiation, sleep need, wakefulness, NREM sleep, sleep-wake regulation
MeSH terms: Analysis of Variance, Animals, Behavior, Animal, Benzylamines, Brain, Brain Chemistry, Dopamine, Drug Interactions, Electroencephalography, Fluoxetine, Homeostasis, Locus Coeruleus, Male, Norepinephrine, Rats, Inbred WKY, Serotonin, Sleep Wake Disorders, Sleep Stages, Spectrum Analysis, Time Factors, Wakefulness, Selective Serotonin Reuptake Inhibitors, Rats

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Locus Ceruleus Control of Slow-Wave Homeostasis

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