The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The Role of Sleep Spindles and Slow-Wave Activity in Integrating New Information in Semantic Memory
Open accessAbstract
Assimilating new information into existing knowledge is a fundamental part of consolidating new memories and allowing them to guide behavior optimally and is vital for conceptual knowledge (semantic memory), which is accrued over many years. Sleep is important for memory consolidation, but its impact upon assimilation of new information into existing semantic knowledge has received minimal examination. Here, we examined the integration process by training human participants on novel words with meanings that fell into densely or sparsely populated areas of semantic memory in two separate sessions. Overnight sleep was polysomnographically monitored after each training session and recall was tested immediately after training, after a night of sleep, and 1 week later. Results showed that participants learned equal numbers of both word types, thus equating amount and difficulty of learning across the conditions. Measures of word recognition speed showed a disadvantage for novel words in dense semantic neighborhoods, presumably due to interference from many semantically related concepts, suggesting that the novel words had been successfully integrated into semantic memory. Most critically, semantic neighborhood density influenced sleep architecture, with participants exhibiting more sleep spindles and slow-wave activity after learning the sparse compared with the dense neighborhood words. These findings provide the first evidence that spindles and slow-wave activity mediate integration of new information into existing semantic networks.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
McClelland, J. L., McNaughton, B. L., & O'Reilly, R. C. (1995) · Psychological Review · doi:10.1037/0033-295x.102.3.419 · Cited by 5,256
Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
The University of South Florida free association, rhyme, and word fragment norms
Nelson, D. L., McEvoy, C. L., & Schreiber, T. A. (2004) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03195588 · Cited by 1,961
Huber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854
Selective suppression of hippocampal ripples impairs spatial memory
Girardeau, G., Benchenane, K., Wiener, S. I., Buzsáki, G., & Zugaro, M. B. (2009) · Nature Neuroscience · doi:10.1038/nn.2384 · Cited by 1,560
Schemas and Memory Consolidation.
Tse, D., Langston, R. F., Kakeyama, M., Bethus, I., Spooner, P. A., Wood, E. R., Witter, M. P., & Morris, R. G. M. (2007) · Science · doi:10.1126/science.1135935 · Cited by 1,244
Coordinated interactions between hippocampal Ripples and Cortical Spindles during Slow-Wave Sleep
Siapas, A. G., & Wilson, M. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80629-7 · Cited by 1,052
Communication between neocortex and hippocampus during sleep in rodents
Sirota, A., Csicsvari, J., Buhl, D., & Buzsáki, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437938100 · Cited by 930
How schema and novelty augment memory formation
van Kesteren, M. T. R., Ruiter, D. J., Fernández, G., & Henson, R. N. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.02.001 · Cited by 860
Learning-dependent increases in sleep spindle density
Gais, S., Mölle, M., Helms, K., & Born, J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06830.2002 · Cited by 859
The contribution of sleep to hippocampus-dependent memory consolidation
Marshall, L., & Born, J. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.09.001 · Cited by 667
Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity
Huber, R., Ghilardi, M. F., Massimini, M., Ferrarelli, F., Riedner, B. A., Peterson, M. J., & Tononi, G. (2006) · Nature Neuroscience · doi:10.1038/nn1758 · Cited by 579
Mölle, M., Bergmann, T. O., Marshall, L., & Born, J. (2011) · Sleep · doi:10.5665/sleep.1290 · Cited by 557
Reduced sleep spindle activity in schizophrenia patients
Ferrarelli, F., Huber, R., Peterson, M. J., Massimini, M., Murphy, M., Riedner, B. A., Watson, A., Bria, P., & Tononi, G. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.3.483 · Cited by 541 · cited 1×
“Automated detection (Ferrarelli et al., 2007) derived the number of discrete spindle events: for each channel, amplitude fluctuations in the filtered time series exceeding a predetermined threshold counted as spindles.”
BackgroundReduced Sleep Spindle Activity in Schizophrenia Patients
Ferrarelli, F., Huber, R., Peterson, M. J., Massimini, M., Murphy, M., Riedner, B. A., Watson, A., Bria, P., & Tononi, G. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.483 · Cited by 531
Coherent concepts are computed in the anterior temporal lobes
Ralph, M. A. L., Sage, K., Jones, R. W., & Mayberry, E. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907307107 · Cited by 492
Sleep spindle activity is associated with the integration of new memories and existing knowledge
Tamminen, J., Payne, J. D., Stickgold, R., Wamsley, E. J., & Gaskell, M. G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3028-10.2010 · Cited by 478
Self-citationPattern-Specific Associative Long-Term Potentiation Induced by a Sleep Spindle-Related Spike Train
Rosanova, M., & Ulrich, D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2149-05.2005 · Cited by 413
McClelland, J. L. (2013) · Journal of Experimental Psychology General · doi:10.1037/a0033812 · Cited by 296
McClelland, J. L., & Goddard, N. (1996) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:6 · Cited by 264
Encoding Difficulty Promotes Postlearning Changes in Sleep Spindle Activity during Napping
Schmidt, C., Peigneux, P., Muto, V., Schenkel, M., Knoblauch, V., Münch, M. Y., de Quervain, D. J. ‐., Wirz‐Justice, A., & Cajochen, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2464-06.2006 · Cited by 230
Sleep Spindles and Hippocampal Functional Connectivity in Human NREM Sleep
Andrade, K. C., Spoormaker, V. I., Dresler, M., Wehrle, R., Holsboer, F., Sämann, P., & Czisch, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5660-10.2011 · Cited by 218
Retrograde amnesia following electroconvulsive therapy
Squire, L. R., Chace, P. M., & Slater, P. C. (1976) · Nature · doi:10.1038/260775a0 · Cited by 91
NoA’s ark: Influence of the number of associates in visual word recognition
Duñabeitia, J. A., Avilés, A., & Carreiras, M. (2008) · Psychonomic Bulletin & Review · doi:10.3758/pbr.15.6.1072 · Cited by 81
Sleep spindles are locally modulated by training on a brain–computer interface
Johnson, L. A., Blakely, T. M., Hermes, D., Hakimian, S., Ramsey, N. F., & Ojemann, J. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207532109 · Cited by 73
The Neural Consequences of Semantic Richness
Pexman, P. M., Hargreaves, I. S., Edwards, J. D., Henry, L. C., & Goodyear, B. G. (2007) · Psychological Science · doi:10.1111/j.1467-9280.2007.01913.x · Cited by 66
The ties that bind what is known to the recall of what is new
Nelson, D. L., & Zhang, N. (2000) · Psychonomic Bulletin & Review · doi:10.3758/bf03212998 · Cited by 55
The Effect of Semantic Set Size on Word Learning by Preschool Children
Storkel, H. L., & Adlof, S. M. (2009) · Journal of Speech Language and Hearing Research · doi:10.1044/1092-4388(2009/07-0175 · Cited by 48
Sleep-dependent directional coupling between human neocortex and hippocampus
Wagner, T., Axmacher, N., Lehnertz, K., Elger, C. E., & Fell, J. (2009) · Cortex · doi:10.1016/j.cortex.2009.05.012 · Cited by 47
Cited by
Sorted by citations
Neurobiology of Schemas and Schema-Mediated Memory
Gilboa, A., & Marlatte, H. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.04.013 · Cited by 742
Lane, R. D., Ryan, L., Nadel, L., & Greenberg, L. S. (2014) · Behavioral and Brain Sciences · doi:10.1017/s0140525x14000041 · Cited by 611
Differential Effects of Non-REM and REM Sleep on Memory Consolidation?
Ackermann, S., & Rasch, B. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0430-8 · Cited by 297
How memory replay in sleep boosts creative problem-solving
Lewis, P. A., Knoblich, G., & Poe, G. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.03.009 · Cited by 210
Generalization of word meanings during infant sleep
Friedrich, M., Wilhelm, I., Born, J., & Friederici, A. D. (2015) · Nature Communications · doi:10.1038/ncomms7004 · Cited by 176
Metadata
- Authors
- Tamminen, J., Lambon Ralph, M. A., & Lewis, P. A.
- Affiliations
- Royal Holloway University of London (GB)
- University of Manchester (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-09-25
- Volume
- 33
- Issue
- 39
- Pages
- 15376-15381
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3782619
- OpenAlex
- W2058819676
- Cited by
- 152
- References
- 31
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 17 · 2023: 4 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 8 · 2018: 15 · 2017: 21 · 2016: 11 · 2015: 15 · 2014: 14
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council (BB/F003048/1)
- Economic and Social Research Council (ES/H030107/1, RES-062-23-, ES/H011730/1, 062-23-2268, PTA-026-27-2540, RES-062-23-2268)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- sleep spindles, slow-wave activity, semantic memory, memory consolidation, novel word learning, sleep architecture, semantic interference, word recognition speed, polysomnography
- MeSH terms
- Adult, Female, Humans, Learning, Male, Mental Recall, Semantics, Sleep Stages, Brain Waves
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
