Pattern-Specific Associative Long-Term Potentiation Induced by a Sleep Spindle-Related Spike Train
Open accessAbstract
Spindles are non-rapid eye movement (non-REM) sleep EEG rhythms (7-14 Hz) that occur independently or in association with slow oscillations (0.6-0.8 Hz). Despite their proposed function in learning and memory, their role in synaptic plasticity is essentially unknown. We studied the ability of a neuronal firing pattern underlying spindles in vivo to induce synaptic plasticity in neocortical pyramidal cells in vitro. A spindle stimulation pattern (SSP) was extracted from a slow oscillation upstate that was recorded in a cat anesthetized with ketamine-xylazine, which is known to induce a sleep-like state. To mimic the recurrence of spindles grouped by the slow oscillation, the SSP was repeated every 1.5 s (0.6 Hz). Whole-cell patch-clamp recordings were obtained from layer V pyramidal cells of rat somatosensory cortex with infrared videomicroscopy, and composite EPSPs were evoked within layers II-III. Trains of EPSPs and action potentials simultaneously triggered by the SSP induced an NMDA receptor-dependent short-term potentiation (STP) and an L-type Ca2+ channel-dependent long-term potentiation (LTP). The number of spindle sequences affected the amount of STP-LTP. In contrast, spindle trains of EPSPs alone led to long-term depression. LTP was not consistently induced by a regular firing pattern, a mirrored SSP, or a randomized SSP; however, a synthetic spindle pattern consisting of repetitive spike bursts at 10 Hz reliably induced STP-LTP. Our results show that spindle-associated spike discharges are efficient in modifying excitatory neocortical synapses according to a Hebbian rule. This is in support of a role for sleep spindles in memory consolidation.
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Repeated spindle-associated spike discharges efficiently triggered LTP in neocortical synapses in in vitro models.
“Repeated spindle-associated spike discharges efficiently triggered LTP in neocortical synapses in in vitro models (1012, 1197).”
From About Sleep's Role in Memory (2013) · cites this paper as [1012]
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- Authors
- Rosanova, M., & Ulrich, D.
- Affiliations
- University of Bern (CH)
- Corresponding author
- Ulrich, Daniel
- ORCID
- Rosanova, Mario
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-10-12
- Volume
- 25
- Issue
- 41
- Pages
- 9398-9405
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6725710
- OpenAlex
- W2003326720
- Cited by
- 413
- References
- 6
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 21 · 2023: 15 · 2022: 20 · 2021: 16 · 2020: 27 · 2019: 42 · 2018: 25 · 2017: 28 · 2016: 32 · 2015: 22 · 2014: 26 · 2013: 28 · 2012: 14
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sleep spindles, long-term potentiation, short-term potentiation, slow oscillations, synaptic plasticity, NMDA receptor, L-type calcium channels, Hebbian learning, spike trains, memory consolidation, somatosensory cortex, pyramidal neurons, NREM sleep
- MeSH terms
- Action Potentials, Animals, Cats, Male, Sleep, Somatosensory Cortex, Rats, Wistar, Long-Term Potentiation, Rats
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