CB1Receptors Mediate the Analgesic Effects of Cannabinoids on Colorectal Distension-Induced Visceral Pain in Rodents
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Activation of cannabinoid receptors (CB 1, CB 2 and GPR 55) produces analgesic effects in several experimental pain models, including visceral pain arising from the gastrointestinal tract. We assessed the role of CB 1, CB 2, and GPR 55 receptors and the endogenous cannabinoid system on basal pain responses and acute mechanical hyperalgesia during colorectal distension (CRD) in rodents. The effects of cannabinoid receptor agonists and antagonists on pain-related responses to CRD were assessed in rats and in wild-type and CB 1 receptor knock-out mice. The dual CB 1/2 agonist, WIN55,212-2, and the peripherally acting CB 1-selective agonist, SAB-378, inhibited pain-related responses to repetitive noxious CRD (80 mmHg) in a dose-related manner in rats. The analgesic effects of WIN55,212-2 and SAB-378 were blocked by the selective CB 1 antagonist SR141716, but were not affected by the selective CB 2 antagonist SR144528. SR141716, per se, increased the responses to repetitive noxious CRD, indicative of hyperalgesia, and induced pain-related responses during non-noxious CRD (20 mmHg), indicative of allodynia. The cannabinoid receptor agonists anandamide, virodhamine and O-1602 had no effect. At analgesic doses, WIN55,212-2 did not affect colonic compliance. In accordance to the rat data, WIN55,212-2 produced analgesia, whereas SR141716 induced hyperalgesia, during noxious CRD (55 mmHg) in wild-type but not in CB 1-knock-out mice. These data indicate that peripheral CB 1 receptors mediate the analgesic effects of cannabinoids on visceral pain from the gastrointestinal tract. The allodynic and hyperalgesic responses induced by SR141716 suggest the existence of an endogenous cannabinoid tone and the activation of CB 1 receptors during noxious CRD.
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Cannabinoid receptors and MOR are directly involved in visceral pain, eliciting analgesic responses.
“Cannabinoid receptors and MOR are directly involved in visceral pain, eliciting analgesic responses.42,44”
From Antibiotic-induced dysbiosis alters host-bacterial interactions and leads to colonic sensory and motor changes in mice (2015) · cites this paper as [44]
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- Authors
- Brusberg, M., Arvidsson, S., Kang, D., Larsson, H., Lindström, E., & Martinez, V.
- Affiliations
- AstraZeneca (Sweden) (SE)
- Universitat Autònoma de Barcelona (ES)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-02-04
- Volume
- 29
- Issue
- 5
- Pages
- 1554-1564
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6666086
- OpenAlex
- W2010857508
- Cited by
- 88
- References
- 76
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- CB1 receptor, CB2 receptor, GPR55, endocannabinoid system, visceral pain, colorectal distension, cannabinoid analgesia, mechanical hyperalgesia, allodynia, WIN 55,212-2, SR141716, CB1 receptor knockout mice, colonic compliance, gastrointestinal pain
- MeSH terms
- Animals, Cannabinoids, Colon, Female, Gastrointestinal Diseases, Mice, Inbred C57BL, Pain, Pain Measurement, Rectum, Rats, Sprague-Dawley, Visceral Afferents, Mice, Knockout, Analgesics, Non-Narcotic, Receptor, Cannabinoid, CB1, Mice, Rats
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