Cited by 76Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsNeuropeptides and Animal Physiology

Involvement of the opioid and cannabinoid systems in pain control: New insights from knockout studies

Nadal, Xavier, La Porta, Carmen, Andreea Bura, S., Maldonado, Rafael·2013·European Journal of Pharmacology

Abstract

The endogenous opioid and cannabinoid systems are involved in the physiological inhibitory control of pain and are of particular interest for the development of therapeutic approaches for pain management. The involvement of these endogenous systems in pain control has been studied from decades by the use of compounds with different affinities for each cannabinoid and opioid receptor or for the different enzymes involved in endocannabinoid and endogenous opioid metabolism. However, the selectivity of these pharmacological tools in vivo has represented an important limitation for these studies. The generation of genetically modified mice with selective mutations in specific components of the endocannabinoid and endogenous opioid system has provided important advances in the identification of the specific contribution of each component of these endogenous systems in the perception of noxious stimuli and the development of pathological pain states. Different lines of constitutive and conditional knockout mice deficient in specific cannabinoid and opioid receptors, specific precursors of the endogenous opioid peptides and the main enzymes involved in endocannabinoid and endogenous opioid degradation are now available. These knockout mice have also been used to evaluate the contribution of each component of the endocannabinoid and opioid system in the antinociceptive effects of cannabinoid and opioid agonists, including those currently used to treat pain in humans. This review summarizes the main advances provided in the last 15 years by the use of these genetic tools in the knowledge of the physiological control of pain and the pharmacology of cannabinoid and opioid compounds for pain management.

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Crossref · 10.1016/j.ejphar.2013.01.077

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Authors
Nadal, X., La Porta, C., Andreea Bura, S., & Maldonado, R.
Affiliations
Universitat Pompeu Fabra (ES)
Corresponding author
Maldonado, Rafael
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2013-09
Volume
716
Issue
1-3
Pages
142-157
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2094638520
Cited by
76
References
161
Citations by year
2026: 7 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 9 · 2016: 8 · 2015: 7 · 2014: 6 · 2013: 1
FWCI
0.93
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
endogenous opioid system, endocannabinoid system, pain management, knockout mice, cannabinoid receptors, opioid receptors, endogenous opioids, antinociception, pathological pain, cannabinoid receptor agonists, opioid agonists
MeSH terms
Analgesics, Opioid, Animals, Cannabinoids, Pain, Gene Knockout Techniques

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