An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo

Keen, Kim L.; Wegner, Frederick H.; Bloom, Stephen R.; Ghatei, Mohammad A.; Terasawa, Ei

doi:10.1210/en.2008-0231

Cited by 273Hypothalamic control of reproductive hormonesNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo

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Keen, Kim L., Wegner, Frederick H., Bloom, Stephen R., Ghatei, Mohammad A., Terasawa, Ei·2008·Endocrinology

DOI 10.1210/en.2008-0231PMC PMC2488227

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Abstract

The G-protein coupled receptor GPR54 and its ligand, KiSS-1-derived peptide kisspeptin-54, appear to play an important role in the mechanism of puberty. This study measures the release of kisspeptin-54 in the stalk-median eminence (S-ME) during puberty and examines its potential role in the pubertal increase in LHRH-1 release in female rhesus monkeys. First, developmental changes in release of kisspeptin-54 and LHRH-1 were assessed in push-pull perfusate samples obtained from the S-ME of prepubertal, early pubertal, and midpubertal female rhesus monkeys. Whereas LHRH-1 levels in 10-min intervals had been measured previously for other experiments, kisspeptin-54 levels in 40-min pooled samples were newly measured by RIA. The results indicate that a significant increase in kisspeptin-54 release occurred in association with the pubertal increase in LHRH-1 release and that a nocturnal increase in kisspeptin-54 release was already observed in prepubertal monkeys and continued through the pubertal period. Second, we measured kisspeptin-54 release in the S-ME of midpubertal monkeys at 10-min intervals using a microdialysis method. Kisspeptin-54 release in the S-ME was clearly pulsatile with an interpulse interval of about 60 min, and approximately 75% of kisspeptin-54 pulses were correlated with LHRH-1 pulses. Finally, the effect of kisspeptin-10 on LHRH-1 release was examined with the microdialysis method. Kisspeptin-10 infusion through a microdialysis probe significantly stimulated LHRH-1 release in a dose-dependent manner. Collectively, the results are consistent with the hypothesis that kisspeptin plays a role in puberty.

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Kisspeptin is released in a pulsatile manner.
“As kisspeptin is released in a pulsatile manner (34), intermittent, repetitive kisspeptin administration was chosen as the method of administration in this study to mimic human physiology more closely.”
From Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans (2022) · cites this paper as [34]

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Errata
Young, J., George, J. T., Tello, J. A., Francou, B., Bouligand, J., Guiochon‐Mantel, A., Brailly‐Tabard, S., Anderson, R. A., Millar, R. P., Schang, A., et al. (2013) · Neuroendocrinology · doi:10.1159/000348265
Developmental Increase in Kisspeptin-54 Release in Vivo Is Independent of the Pubertal Increase in Estradiol in Female Rhesus Monkeys (Macaca mulatta)
Guerriero, K. A., Keen, K. L., & Terasawa, E. (2012) · Endocrinology · doi:10.1210/en.2011-1701 · Cited by 46 · see citing works
Repetitive Activation of Hypothalamic G Protein-Coupled Receptor 54 with Intravenous Pulses of Kisspeptin in the Juvenile Monkey (Macaca mulatta) Elicits a Sustained Train of Gonadotropin-Releasing Hormone Discharges
Plant, T. M., Ramaswamy, S., & DiPietro, M. J. (2005) · Endocrinology · doi:10.1210/en.2005-1261 · Cited by 292 · see citing works
Developmental Changes in GnRH Release in Response to Kisspeptin Agonist and Antagonist in Female Rhesus Monkeys (Macaca mulatta): Implication for the Mechanism of Puberty
Guerriero, K. A., Keen, K. L., Millar, R. P., & Terasawa, E. (2011) · Endocrinology · doi:10.1210/en.2011-1565 · Cited by 104 · see citing works
Increased hypothalamic GPR54 signaling: A potential mechanism for initiation of puberty in primates
Shahab, M., Mastronardi, C. A., Seminara, S. B., Crowley, W. F., Ojeda, S. R., & Plant, T. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409822102 · Cited by 875 · see citing works

Authors: Keen, K. L., Wegner, F. H., Bloom, S. R., Ghatei, M. A., & Terasawa, E.
Affiliations: University of Wisconsin–Madison (US)
Imperial College London (GB)
Corresponding author: Terasawa, Ei
ORCID: Bloom, Stephen R.
Terasawa, Ei
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2008-05-01
Volume: 149
Issue: 8
Pages: 4151-4157
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2008-0231
PMC: PMC2488227
OpenAlex: W2019501332
Cited by: 273
References: 41
Citations by year: 2026: 2 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 14 · 2021: 16 · 2020: 11 · 2019: 13 · 2018: 14 · 2017: 15 · 2016: 15 · 2015: 15 · 2014: 29 · 2013: 29 · 2012: 34
FWCI: 21.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Endocrinology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute for Health and Care Research (NF-SI-0507-10337)
Biotechnology and Biological Sciences Research Council (BB/E52708X/1)
National Center for Research Resources (RR020141, C06RR020141, RR15459, C06RR015459, P51RR000167)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01-HD-11355, R01HD015433, R01 HD15433, R01HD011355)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: kisspeptin-54, kisspeptin-10, gonadotropin-releasing hormone, puberty, stalk-median eminence, GPR54, pulsatile hormone secretion, rhesus monkeys, female reproduction
MeSH terms: Animals, Dose-Response Relationship, Drug, Female, Gonadotropin-Releasing Hormone, Macaca mulatta, Median Eminence, Oligopeptides, Pulsatile Flow, Sexual Maturation, Time Factors, Microdialysis, Tumor Suppressor Proteins, Kisspeptins

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An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo

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