The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Spontaneous Age-Related Neurite Branching in Caenorhabditis elegans
Open accessAbstract
The analysis of morphological changes that occur in the nervous system during normal aging could provide insight into cognitive decline and neurodegenerative disease. Previous studies have suggested that the nervous system of Caenorhabditis elegans maintains its structural integrity with age despite the deterioration of surrounding tissues. Unexpectedly, we observed that neurons in aging animals frequently displayed ectopic branches and that the prevalence of these branches increased with time. Within age-matched populations, the branching of mechanosensory neurons correlated with decreased response to light touch and decreased mobility. The incidence of branching was influenced by two pathways that can affect the rate of aging, the Jun kinase pathway and the insulin/IGF-1 pathway. Loss of Jun kinase signaling, which slightly shortens lifespan, dramatically increased and accelerated the frequency of neurite branching. Conversely, inhibition of the daf-2 insulin/IGF-1-like signaling pathway, which extends lifespan, delayed and suppressed branching, and this delay required DAF-16/FOXO activity. Both JNK-1 and DAF-16 appeared to act within neurons in a cell-autonomous manner to influence branching, and, through their tissue-specific expression, it was possible to disconnect the rate at which branching occurred from the overall rate of aging of the animal. Old age has generally been associated with the decline and deterioration of different tissues, except in the case of tumor cell growth. To our knowledge, this is the first indication that aging can potentiate another form of growth, the growth of neurite branches, in normal animals.
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Cites
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Self-citationStochastic and genetic factors influence tissue-specific decline in ageing C. elegans
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Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice
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Cited by
Insulin/insulin-like growth factor signaling in C. elegans
Murphy, C. T. (2013) · WormBook · doi:10.1895/wormbook.1.164.1 · Cited by 532
Fox transcription factors: from development to disease
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Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants
Bansal, A., Zhu, L. J., Yen, K., & Tissenbaum, H. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412192112 · Cited by 367
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Neurite Sprouting and Synapse Deterioration in the Aging Caenorhabditis elegans Nervous System
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Metadata
- Authors
- Tank, E. M. H., Rodgers, K. E., & Kenyon, C.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-06-22
- Volume
- 31
- Issue
- 25
- Pages
- 9279-9288
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2097413900
- Cited by
- 176
- References
- 13
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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