Effect of testosterone replacement therapy on arterial stiffness in older hypogonadal men

Yaron, Marianna; Greenman, Yona; Rosenfeld, Joseph B; Izkhakov, Elena; Limor, Rona; Osher, Etty; Shenkerman, Galina; Tordjman, Karen; Stern, Naftali

doi:10.1530/eje-09-0052

Cited by 78Hormonal and reproductive studiesCardiovascular Health and Disease PreventionSexual function and dysfunction studies

Effect of testosterone replacement therapy on arterial stiffness in older hypogonadal men

Yaron, Marianna, Greenman, Yona, Rosenfeld, Joseph B, Izkhakov, Elena, Limor, Rona, Osher, Etty, Shenkerman, Galina, Tordjman, Karen +1 more·2009·European Journal of Endocrinology

DOI 10.1530/eje-09-0052

Open this paper in CoChat — free account

Abstract

Objective: To assess arterial stiffness in a cohort of hypogonadal males and to investigate the effect of testosterone replacement therapy on arterial properties in this specific group. Design: Eighteen male patients with untreated acquired hypogonadism due to either adult-onset idiopathic hypogonadotropic hypogonadism ( n =9) or pituitary tumor ( n =9) and 12 age-, sex, and weight-matched eugonadal healthy controls were recruited for the study. Arterial properties, plasma glucose, lipid profile, total, and bioavailable testosterone (BT) levels were measured in fasting state. In the hypogonadal subjects, the effect of transdermal testosterone replacement therapy on arterial properties was studied by repeat noninvasive measurements at baseline, as well as 48 h and 90 days following the initiation of treatment. Methods: Arterial stiffness was evaluated using applanation tonometry and pulse wave analysis by three different standard devices that assess various measures of arterial stiffness: pulse wave velocity (PWV), augmentation index (AIx), and large/small artery compliance (C1 and C2). Results: Age- and blood pressure-adjusted PWV was significantly higher in hypogonadal men (8.90±2.29 vs 6.78±1.16 m/s in the control group; P =0.025). Testosterone therapy increased BT level from 2.01±1.04 to 4.68±2.43 and 7.83±6.2 nmol/l after 48 h and 3 months respectively ( P =0.001). PWV decreased from 8.9±2.29 to 8.24±1.39 and 8.25±1.82 m/s after 48 h and 3 months of treatment respectively ( P =0.03). Conclusions: Male hypogonadism is associated with increased PWV, which is rapidly but incompletely ameliorated by normalization of circulating testosterone levels.

Integrity signals

Registry

Crossref · 10.1530/eje-09-0052

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Arterial stiffness measured as pulse wave velocity decreases after 48 h, and large artery compliance improves after 3 months of testosterone treatment.
“A decrease in arterial stiffness measured as pulse wave velocity was measurable after 48 h (58) and in large artery compliance after 3 months (58).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [58]

Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
Laurent, S., Boutouyrie, P., Asmar, R., Gautier, I., Laloux, B., Guize, L., Ducimetiere, P., & Benetos, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.5.1236 · Cited by 3,856 · see citing works
Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study
Mattace-Raso, F. U. S., van der Cammen, T. J. M., Hofman, A., van Popele, N. M., Bos, M. L., Schalekamp, M. A. D. H., Asmar, R., Reneman, R. S., Hoeks, A. P. G., Breteler, M. M. B., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.555235 · Cited by 1,914 · see citing works
Aortic Stiffness Is an Independent Predictor of Primary Coronary Events in Hypertensive Patients
Boutouyrie, P., Tropeano, A., Asmar, R. G., Gautier, I., Bénétos, A., Lacolley, P. J., & Laurent, S. (2002) · Hypertension · doi:10.1161/hy0102.099031 · Cited by 1,745 · see citing works
Aortic Pulse-Wave Velocity and Its Relationship to Mortality in Diabetes and Glucose Intolerance
Cruickshank, K. J., Riste, L., Anderson, S. G., Wright, J. S., Dunn, G., & Gosling, R. G. (2002) · Circulation · doi:10.1161/01.cir.0000033824.02722.f7 · Cited by 1,526 · see citing works
Assessment of Arterial Distensibility by Automatic Pulse Wave Velocity Measurement: Validation and Clinical Application Studies
Asmar, R., Benetos, A., Topouchian, J., Laurent, P., Pannier, B., Brisac, A.-M., Target, R., & Levy, B. I. (1995) · Hypertension · doi:10.1161/01.hyp.26.3.485 · Cited by 1,376 · see citing works
Estimation of Central Aortic Pressure Waveform by Mathematical Transformation of Radial Tonometry Pressure: Validation of Generalized Transfer Function
Chen, C.-H., Nevo, E., Fetics, B., Pak, P. H., Yin, F. C. P., Maughan, W. L., & Kass, D. A. (1997) · Circulation · doi:10.1161/01.cir.95.7.1827 · Cited by 1,307 · see citing works
Prospective Evaluation of a Method for Estimating Ascending Aortic Pressure From the Radial Artery Pressure Waveform
Pauca, A. L., O’Rourke, M. F., & Kon, N. D. (2001) · Hypertension · doi:10.1161/hy1001.096106 · Cited by 1,179 · see citing works
The influence of heart rate on augmentation index and central arterial pressure in humans
Wilkinson, I. B., MacCallum, H., Flint, L., Cockcroft, J. R., Newby, D. E., & Webb, D. J. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00263.x · Cited by 1,092 · see citing works
Low Serum Testosterone and Mortality in Older Men
Laughlin, G. A., Barrett-Connor, E., & Bergstrom, J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1792 · Cited by 798 · see citing works
Aortic Pulse Wave Velocity Predicts Cardiovascular Mortality in Subjects >70 Years of Age
Meaume, S., Benetos, A., Henry, O. F., Rudnichi, A., & Safar, M. E. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1201.100226 · Cited by 731 · see citing works
Clinical applications of arterial stiffness, Task Force III: recommendations for user procedures
Bortel, L. M. V., Duprez, D. A., Kool, M. J. F., Safar, M. E., Giannattasio, C., Cockcroft, J. R., Kaiser, D. R., & Thuillez, C. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02326-3 · Cited by 631 · see citing works
Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels
Seidell, J. C., Björntorp, P., Sjöström, L., Kvist, H., & Sannerstedt, R. (1990) · Metabolism · doi:10.1016/0026-0495(90)90297-p · Cited by 567 · see citing works
Noninvasive Pulse Wave Analysis for the Early Detection of Vascular Disease
Cohn, J. N., Finkelstein, S. M., McVeigh, G. E., Morgan, D. J., LeMay, L., Robinson, J. G., & Mock, J. (1995) · Hypertension · doi:10.1161/01.hyp.26.3.503 · Cited by 471 · see citing works
The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer
Smith, J. C., Bennett, S., Evans, L. M., Kynaston, H. G., Parmar, M., Mason, M. D., Cockcroft, J. R., Scanlon, M. F., & Davies, J. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7851 · Cited by 458 · see citing works
Endogenous sex hormones and metabolic syndrome in aging men
Muller, M., Grobbee, D. E., den Tonkelaar, I., Lamberts, S. W. J., & van der Schouw, Y. T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1158 · Cited by 456 · see citing works
Testosterone Relaxes Rabbit Coronary Arteries and Aorta
Yue, P., Chatterjee, K., Beale, C., Poole-Wilson, P. A., & Collins, P. (1995) · Circulation · doi:10.1161/01.cir.91.4.1154 · Cited by 414 · see citing works
Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial
Malkin, C. J., Pugh, P. J., West, J. N., van Beek, E. J. R., Jones, T. H., & Channer, K. S. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi443 · Cited by 413 · see citing works
Acute Anti-Ischemic Effect of Testosterone in Men With Coronary Artery Disease
Rosano, G. M. C., Leonardo, F., Pagnotta, P., Pelliccia, F., Panina, G., Cerquetani, E., della Monica, P. L., Bonfigli, B., Volpe, M., & Chierchia, S. L. (1999) · Circulation · doi:10.1161/01.cir.99.13.1666 · Cited by 367 · see citing works
Insulin Resistance, Body Fat Distribution, and Sex Hormones in Men
Haffner, S. M., Karhapää, P., Mykkänen, L. M., & Laakso, M. (1994) · Diabetes · doi:10.2337/diab.43.2.212 · Cited by 305 · see citing works
Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemia
Dockery, F., Bulpitt, C. J., AGARWAL, S., Donaldson, M., & Rajkumar, C. (2003) · Clinical Science · doi:10.1042/cs20020209 · Cited by 294 · see citing works
Natural Androgens Inhibit Male Atherosclerosis
Alexandersen, P., Haarbo, J., Byrjalsen, I., Lawaetz, H., & Christiansen, C. (1999) · Circulation Research · doi:10.1161/01.res.84.7.813 · Cited by 251 · see citing works
Androgen-dependent angiotensinogen and renin messenger RNA expression in hypertensive rats.
Chen, Y., Naftilan, A. J., & Oparil, S. (1992) · Hypertension · doi:10.1161/01.hyp.19.5.456 · Cited by 245 · see citing works
Androgen Deprivation Is Associated With Enhanced Endothelium-Dependent Dilatation in Adult Men
Herman, S. M., Robinson, J. T. C., McCredie, R. J., Adams, M. R., Boyer, M. J., & Celermajer, D. S. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.2004 · Cited by 165 · see citing works
Assessment of central and peripheral arterial stiffnessStudies indicating the need to use a combination of techniques
Woodman, R. J., Kingwell, B. A., Beilin, L. J., HAMILTON, S., Dart, A. M., & Watts, G. F. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.08.038 · Cited by 151 · see citing works
Physiologic Testosterone Levels in Normal Men Suppress High-Density Lipoprotein Cholesterol Levels
Bagatell, C. J., Knopp, R. H., Vale, W., Rivier, J. E., & Bremner, W. J. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-12-967 · Cited by 129 · see citing works
Pulmonary Vasodilatory Action of Testosterone: Evidence of a Calcium Antagonistic Action
Jones, R. D., English, K. M., Pugh, P. J., Morice, A. H., Jones, T. H., & Channer, K. S. (2002) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200206000-00006 · Cited by 123 · see citing works
Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements
Hougaku, H., Fleg, J. L., Najjar, S. S., Lakatta, E. G., Harman, S. M., Blackman, M. R., & Metter, E. J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00059.2005 · Cited by 123 · see citing works
Physiological Testosterone Replacement Therapy Attenuates Fatty Streak Formation and Improves High-Density Lipoprotein Cholesterol in the Tfm Mouse
Nettleship, J. E., Jones, T. H., Channer, K. S., & Jones, R. D. (2007) · Circulation · doi:10.1161/circulationaha.107.708768 · Cited by 119 · see citing works
Testosterone-induced relaxation of rat aorta is androgen structure specific and involves K+channel activation
Ding, A. Q., & Stallone, J. N. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.6.2742 · Cited by 119 · see citing works
Suppression of Plasma Testosterone Leads to an Increase in Serum Total and High Density Lipoprotein Cholesterol and Apoproteins A-I and B*
Goldberg, R. B., Rabin, D., ALEXANDER, A. N., Doelle, G. C., & Getz, G. S. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-1-203 · Cited by 114 · see citing works
Validity of pulse pressure and augmentation index as surrogate measures of arterial stiffness during beta-adrenergic stimulation
Lemogoum, D., Flores, G., den Abeele, W. V., Ciarka, A., Leeman, M., Degaute, J.-P., van de Borne, P., & Bortel, L. M. V. (2004) · Journal of Hypertension · doi:10.1097/00004872-200403000-00013 · Cited by 110 · see citing works
Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease
Reckelhoff, J. F., Yanes, L. L., Iliescu, R., Fortepiani, L. A., & Granger, J. P. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00034.2005 · Cited by 105 · see citing works
The Effects of Sex Steroids on Plasma Levels of Marker Proteins of Endothelial Cell Functioning
van Kesteren, P. J. M., Kooistra, T., Lansink, M., van Kamp, G. J., Asscheman, H., Gooren, L. J., EMEIS, J. J., Vischer, U. M., & Stehouwer, C. D. A. (1998) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615115 · Cited by 104 · see citing works
Effects of Oral Testosterone Treatment on Myocardial Perfusion and Vascular Function in Men With Low Plasma Testosterone and Coronary Heart Disease
Webb, C. M., Elkington, A. G., Kraidly, M., Keenan, N., Pennell, D. J., & Collins, P. D. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.09.114 · Cited by 103 · see citing works
Effect of testosterone on <i>ex vivo</i> vascular reactivity in man
Malkin, C. J., Jones, R. D., Jones, T. H., & Channer, K. S. (2006) · Clinical Science · doi:10.1042/cs20050354 · Cited by 81 · see citing works
The Relationship Between Androgens and Arterial Stiffness in Older Men
Dockery, F., Bulpitt, C. J., Donaldson, M., Fernandez, S., & Rajkumar, C. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51515.x · Cited by 68 · see citing works
Serum Testosterone Levels and Arterial Blood Pressure in the Elderly
Fogari, R., Preti, P. S., Zoppi, A., Fogari, E., Rinaldi, A., Corradi, L., & Mugellini, A. (2005) · Hypertension Research · doi:10.1291/hypres.28.625 · Cited by 65 · see citing works
Vascular Reactivity in Congenital Hypogonadal Men before and after Testosterone Replacement Therapy
Bernini, G., Versari, D., Moretti, A., Virdis, A., Ghiadoni, L., Bardini, M., Taurino, C., Canale, D., Taddei, S., & Salvetti, A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1398 · Cited by 60 · see citing works
Assessment of 5α‐reductase activity in hirsute women: comparison of serum androstanediol glucuronide with urinary androsterone and aetiocholanolone excretion
Gilad, S., Chayen, R., Tordjman, K. M., Kisch, E. S., & Stern, N. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02484.x · Cited by 10 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Sex differences in mechanisms of arterial stiffness
DuPont, J. J., Kenney, R. M., Patel, A. R., & Jaffe, I. Z. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14624 · Cited by 305 · see citing works
Onset of effects of testosterone treatment and time span until maximum effects are achieved
Saad, F., Aversa, A., Isidori, A. M., Zafalon, L., Zitzmann, M., & Gooren, L. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0221 · Cited by 232 · see citing works
Endocrine Aspects of Male Sexual Dysfunctions
Buvat, J., Maggi, M., Gooren, L., Guay, A. T., Kaufman, J., Morgentaler, A., Schulman, C., Tan, H. M., Torres, L. O., Yassin, A., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01780.x · Cited by 221 · see citing works
Testosterone deficiency: a risk factor for cardiovascular disease?
Jones, T. H. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.03.002 · Cited by 193 · see citing works
Testosterone, cardiovascular disease and the metabolic syndrome
Corona, G., Rastrelli, G., Vignozzi, L., Mannucci, E., & Maggi, M. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.07.002 · Cited by 152 · see citing works
MECHANISMS IN ENDOCRINOLOGY: The sexually dimorphic role of androgens in human metabolic disease
Schiffer, L., Kempegowda, P., Arlt, W., & O’Reilly, M. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0124 · Cited by 154 · see citing works
Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial
Hoyos, C. M., Yee, B. J., Phillips, C. L., Machan, E. A., Grunstein, R. R., & Liu, P. Y. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0525 · Cited by 145 · see citing works
New insights into arterial stiffening: does sex matter?
Ogola, B. O., Zimmerman, M. A., Clark, G. L., Abshire, C., Gentry, K. M., Miller, K. S., & Lindsey, S. H. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00132.2018 · Cited by 115 · see citing works
Do androgens play a beneficial role in the regulation of vascular tone? Nongenomic vascular effects of testosterone metabolites
Perusquı́a, M., & Stallone, J. N. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00753.2009 · Cited by 101 · see citing works
Metabolic sequelae associated with androgen deprivation therapy for prostate cancer
Faris, J. E., & Smith, M. R. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283391fd1 · Cited by 99 · see citing works
Sex differences in vascular aging in response to testosterone
Moreau, K. L., Babcock, M. C., & Hildreth, K. L. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00294-8 · Cited by 96 · see citing works
Androgens and cardiovascular disease
Yeap, B. B. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283383031 · Cited by 86 · see citing works
Testosterone and Vascular Function in Aging
Alves-Lopes, R., Neves, K. B., Carneiro, F. S., & Tostes, R. C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00089 · Cited by 84 · see citing works
Recent Progress in Vascular Aging: Mechanisms and Its Role in Age-related Diseases
Xu, X., Wang, B. Z., Ren, C., Hu, J., Greenberg, D. A., Chen, T., Xie, L., & Jin, K. (2017) · Aging and Disease · doi:10.14336/ad.2017.0507 · Cited by 71 · see citing works
Sex steroids receptors, hypertension, and vascular ageing
Connelly, P. J., Casey, H., Montezano, A. C. I., Touyz, R. M., & Delles, C. (2021) · Journal of Human Hypertension · doi:10.1038/s41371-021-00576-7 · Cited by 68 · see citing works
Androgen Receptor-dependent Transactivation of Growth Arrest-specific Gene 6 Mediates Inhibitory Effects of Testosterone on Vascular Calcification
Son, B., Akishita, M., Iijima, K., Ogawa, S., Maemura, K., Yu, J., Takeyama, K., Kato, S., Eto, M., & Ouchi, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.055087 · Cited by 67 · see citing works
Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers
Angoff, R., Mosarla, R. C., & Tsao, C. W. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.709396 · Cited by 64 · see citing works
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01130-5 · Cited by 59 · see citing works
Low testosterone in men predicts impaired arterial elasticity and microvascular function
Corrigan, F. E., Mheid, I. A., Eapen, D. J., Hayek, S. S., Sher, S., Martin, G. S., & Quyyumi, A. A. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.05.065 · Cited by 57 · see citing works
Do low testosterone levels contribute to ill-health during male ageing?
Yeap, B. B., de Araújo, A. B., & Wittert, G. (2012) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2012.725461 · Cited by 53 · see citing works
Sex Differences in Molecular Mechanisms of Cardiovascular Aging
Justina, V. D., Miguez, J. S., Priviero, F. B. M., Sullivan, J. C., Giachini, F. R. C., & Webb, R. C. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.725884 · Cited by 52 · see citing works
Hyperandrogenism is Associated with Earlier Age of Onset of Idiopathic Intracranial Hypertension in Women
Klein, A., Stern, N., Osher, E., Kliper, E., & Kesler, A. (2013) · Current Eye Research · doi:10.3109/02713683.2013.799214 · Cited by 50 · see citing works
Self-citation
Gonadotropin and Sex Steroid Levels in HIV-Infected Premenopausal Women and Their Association With Subclinical Atherosclerosis in HIV-Infected and -Uninfected Women in the Women's Interagency HIV Study (WIHS)
Karim, R., Mack, W. J., Kono, N., Tien, P. C., Anastos, K., Lazar, J., Young, M., Cohen, M. H., Golub, E. T., Greenblatt, R. M., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3195 · Cited by 49 · see citing works
Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function
Yoshida, S., Aihara, K., Azuma, H., Uemoto, R., Sumitomo-Ueda, Y., Yagi, S., Ikeda, Y., Iwase, T., Nishio, S., Kawano, H., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.05.011 · Cited by 45 · see citing works
Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness
Weiss, E. P., Villareal, D. T., Ehsani, A. A., Fontana, L., & Holloszy, J. O. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00852.x · Cited by 42 · see citing works
Plasma Total Testosterone and Incident Cardiovascular Events in Hypertensive Patients
Vlachopoulos, C., Ioakeimidis, N., Terentes-Printzios, D. G., Aznaouridis, K., Rokkas, K., Aggelis, A., Synodinos, A., Lazaros, G. A., & Stefanadis, C. (2013) · American Journal of Hypertension · doi:10.1093/ajh/hps056 · Cited by 41 · see citing works
Hormonal effects on blood vessels
Akishita, M., & Yu, J. (2012) · Hypertension Research · doi:10.1038/hr.2012.4 · Cited by 41 · see citing works
Androgens and cardiovascular disease in women and men
Armeni, E., & Lambrinoudaki, I. V. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.07.010 · Cited by 38 · see citing works
Low muscle mass is associated with carotid atherosclerosis in patients with type 2 diabetes
Seo, D. H., Lee, Y., Suh, Y. J., Ahn, S. H., Hong, S., Choi, Y. J., Huh, B. W., Park, S. W., Lee, E. J., & Kim, S. H. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.05.021 · Cited by 35 · see citing works
Effects of androgens on cardiovascular remodeling
Ikeda, Y., Aihara, K., Yoshida, S., Akaike, M., & Matsumoto, T. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0126 · Cited by 33 · see citing works
Late‐onset hypogonadism: Reductio ad absurdum of the cardiovascular risk‐benefit of testosterone replacement therapy
Sesti, F. F., Pofi, R., Minnetti, M., Tenuta, M., Gianfrilli, D., & Isidori, A. M. (2020) · Andrology · doi:10.1111/andr.12876 · Cited by 31 · see citing works
Arterial properties in acromegaly: relation to disease activity and associated cardiovascular risk factors
Yaron, M., Izkhakov, E., Sack, J., Azzam, I., Osher, E., Tordjman, K. M., Stern, N., & Greenman, Y. (2016) · Pituitary · doi:10.1007/s11102-016-0710-9 · Cited by 30 · see citing works
Self-citation
Roles of the Androgen – Androgen Receptor System in Vascular Angiogenesis
Yoshida, S., Ikeda, Y., & Aihara, K. (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.31047 · Cited by 28 · see citing works
Role of Testosterone in the Treatment of Cardiovascular Disease
Webb, C. M., & Collins, P. D. (2017) · European Cardiology Review · doi:10.15420/ecr.2017:21:1 · Cited by 29 · see citing works
Testosterone and coronary artery disease in men
Webb, C. M., & Collins, P. D. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.03.029 · Cited by 25 · see citing works
Acute endothelial response to testosterone gel administration in men with severe hypogonadism and its relationship to androgen receptor polymorphism: a pilot study
Francomano, D., Fattorini, G., Gianfrilli, D., Paoli, D., Sgrò, P., Radicioni, A. F., Romanelli, F., Luigi, L. D., Gandini, L., Lenzi, A., et al. (2015) · Journal of Endocrinological Investigation · doi:10.1007/s40618-015-0325-4 · Cited by 23 · see citing works
Association of Sex Hormones With Carotid Artery Distensibility in Men and Postmenopausal Women
Vaidya, D. M., Golden, S. H., Haq, N., Heckbert, S. R., Liu, K., & Ouyang, P. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04826 · Cited by 22 · see citing works
Testosterone replacement therapy and cardiovascular risk factors modification
Chahla, E. J., Hayek, M. E., & Morley, J. E. (2011) · The Aging Male · doi:10.3109/13685538.2010.541538 · Cited by 21 · see citing works
Effects of testosterone and progressive resistance exercise on vascular function in older men
Hildreth, K. L., Schwartz, R. S., Griend, J. P. V., Kohrt, W. M., Blatchford, P. J., & Moreau, K. L. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00165.2018 · Cited by 21 · see citing works
Sex steroids and cardiovascular disease
Yeap, B. B. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122357 · Cited by 20 · see citing works
Differential effects of androgens on coronary blood flow regulation and arteriolar diameter in intact and castrated swine
O'Connor, E., Ivey, J. R., & Bowles, D. K. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-10 · Cited by 19 · see citing works
The effects of dehydroepiandrosterone (DHEA) supplementation on body composition and blood pressure: A meta-analysis of randomized clinical trials
Wang, F., He, Y., Santos, H. O., Sathian, B., Price, J. C., & Diao, J. (2020) · Steroids · doi:10.1016/j.steroids.2020.108710 · Cited by 17 · see citing works
Low testosterone in ageing men: a modifiable risk factor for frailty?
O’Connell, M. D. L., Ravindrarajah, R., Tajar, A., & Wu, F. C. W. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.08.003 · Cited by 16 · see citing works
Associations between Blood Pressure Indices and Brachial–ankle Pulse Wave Velocity in Treated Hypertensive Adults: results from the China Stroke Primary Prevention Trial (CSPPT)
Hu, L., Zhang, Y., Huang, X. B., Song, Y., Qin, X., Wang, B., Zhang, Y., Tang, G., Li, J., Li, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44740-z · Cited by 16 · see citing works
Hormones and Arterial Stiffness in Patients with Chronic Kidney Disease
Güngör, Ö., Kırçelli, F., Voroneanu, L. E., Covic, A. C., & Ok, E. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.18580 · Cited by 13 · see citing works
Testosterone and the heart
Hackett, G. I. (2012) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2012.02922.x · Cited by 13 · see citing works
Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis
Shiraki, N., Nakashima, A., Doi, S., Carrero, J. J., Sugiya, N., Ueno, T., Stenvinkel, P., Kohno, N., & Masaki, T. (2013) · Clinical and Experimental Nephrology · doi:10.1007/s10157-013-0840-6 · Cited by 12 · see citing works
Impact of Sex on the Association between Flexibility and Arterial Stiffness in Older Adults
Yoo, T., Park, S., Park, S., & Lee, J. (2022) · Medicina · doi:10.3390/medicina58060789 · Cited by 11 · see citing works
Effects of a typical acute oral calcium load on arterial properties and endothelial function in healthy subjects
Yaron, M., Rouach, V., Izkhakov, E., Ish‐Shalom, M., Sack, J., Sofer, Y., Azzam, I., Ray, A., Stern, N., & Tordjman, K. M. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.22 · Cited by 10 · see citing works
Self-citation
Androgens have Forgotten and Emerging Roles Outside of their Reproductive Functions, with Implications for Diseases and Disorders
Dart, D. A. (2014) · Cited by 8 · see citing works
Endogenous sex hormones and subclinical atherosclerosis in middle-aged and older men
Brand, J. S., den Ouden, M. E. M., Schuurmans, M. J., Bots, M. L., & van der Schouw, Y. T. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.01.242 · Cited by 8 · see citing works
Sex Differences in Children and Young Adults With Bicuspid Aortic Valve Disease in First Two Decades of Life
Niaz, T., Johnson, J. N., Cetta, F., Poterucha, J. T., & Hagler, D. J. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.12.033 · Cited by 7 · see citing works
Impaired aortic elastic properties in patients with adult-onset hypogonadism
Canpolat, U., Tokgözoğlu, L. S., Aydın, K., Dural, M., Gürses, K. M., Yorgun, H., Canpolat, A. G., Kaya, E. B., Kabakçı, G., Usman, A., et al. (2012) · Blood Pressure · doi:10.3109/08037051.2012.732777 · Cited by 7 · see citing works
Gonadal status modulates large elastic artery stiffness in healthy middle-aged and older men
DuBose, L. E., Babcock, M. C., Kohrt, W. M., Stauffer, B. L., Hildreth, K. L., Walker, J., Armstrong, M. K., & Moreau, K. L. (2024) · GeroScience · doi:10.1007/s11357-024-01293-y · Cited by 6 · see citing works
Testosterone Increases Myogenic Reactivity of Second-Order Mesenteric Arteries in both Defective and Normal Androgen Receptor Adult Male Rats
Toot, J., Reho, J. J., Novak, J., Dunphy, G., Ely, D., & Ramirez, R. (2011) · Gender Medicine · doi:10.1016/j.genm.2011.01.002 · Cited by 6 · see citing works
Systemic effects of the hormonal treatment of male hypogonadism with preliminary indications for the management of COVID-19 patients
Cannarella, R., Calogero, A. E., Condorelli, R. A., Aversa, A., & Vignera, S. L. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820966438 · Cited by 6 · see citing works
The Gut Microbiome and Men’s Sexual Health
Osman, M. M., El‐Khatib, F. M., Roberts, N. H., Huynh, L. M., & Yafi, F. A. (2019) · Current Sexual Health Reports · doi:10.1007/s11930-019-00230-x · Cited by 5 · see citing works
Testosterone in men with hypogonadism and high cardiovascular risk, Pros
Rosano, G. M. C., Vitale, C., & Fini, M. (2015) · Endocrine · doi:10.1007/s12020-015-0561-6 · Cited by 4 · see citing works
Effects of Physical Activity in the High School Curriculum on Cardiovascular Health, Cognitive and Physical Performance
Jagomast, T., Mohr, T., Axt, P., Mortensen, K., Brinkmann, F., Weckmann, M., Ring, G., Reppel, M., Drömann, D., & Franzen, K. (2023) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk8030101 · Cited by 3 · see citing works
Late Onset Hypogonadism, Testosterone Replacement Therapy, and Sexual Health in Elderly Men
Griebling, T. L. (2013) · Current Translational Geriatrics and Experimental Gerontology Reports · doi:10.1007/s13670-013-0042-9 · Cited by 1 · see citing works
Effects of Oral Testosterone Undecanoate (Kyzatrex) Versus Testosterone Gel (Androgel) on Long-Term (to 12 Months) Blood Pressure Levels
White, W. B., Bernstein, J. S., Morgentaler, A., & Dhingra, O. (2022) · Androgens Clinical Research and Therapeutics · doi:10.1089/andro.2022.0011 · Cited by 1 · see citing works
Effect of nitric oxide on cholinoreceptors of heart of animals at damage by adrenaline in terms of sex and activity of the gonads
Хара, М. Р., Кузів, О. В., & Pelykh, V. Y. (2015) · ScienceRise · doi:10.15587/2313-8416.2015.43305 · Cited by 1 · see citing works
Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men
Kumagai, H., Zempo‐Miyaki, A., Yoshikawa, T., Myoenzono, K., Tanahashi, K., Akazawa, N., & Maeda, S. (2021) · Journal of Men s Health · doi:10.31083/jomh.2021.013 · Cited by 1 · see citing works
Low Achieved Diastolic Pressure in Tightly Controlled Mid-Older Hypertensive Subjects Is Associated With Favorable Arterial Properties
Yaron, M., Osher, E., Izkhakov, E., Rosenfeld, J. B., & Stern, N. (2011) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2011.628728
Self-citation
Cardiovascular Benefits of Testosterone Replacement Therapy in the Andropausal Male
Vatti, S. K., Madanieh, R., Madanieh, A., Kosmas, C. E., & Vittorio, T. J. (2015) · Health · doi:10.4236/health.2015.79135 · Cited by 1 · see citing works
Low Testosterone Levels in Male Patients with Hypertension,
Agarwal, S. K. (2015)
Benefits and Harms of Testosterone Replacement Therapy in Hypogonadal Men: A Systematic Review and Network Meta-analysis
Elliott, J. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-5176
Erectile Dysfunction and Testosterone
Vlachopoulos, C. V. (2014) · Springer eBooks · doi:10.1007/978-3-319-08272-1_4
The impact of long term testosterone withdrawal on cardiac excitation-contraction coupling in the mouse
Ayaz, M. (2019) · DalSpace (Dalhousie University)
Current World Literature
(2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328339f31e
Autonomic and neuroendocrine modulation of arterial stiffness and hemodynamics
Millar, P. J., Nardone, M., & Floras, J. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91391-1.00024-8
Does Patient‐Applied Testosterone Replacement Therapy Pose Risk for Blood Pressure Elevation? Circadian Medicine Perspectives
Smolensky, M. H., Hermida, R. C., Sackett-Lundeen, L. L., Hermida‐Ayala, R. G., & Geng, Y. (2022) · Comprehensive physiology · doi:10.1002/cphy.c220014
Does Patient‐Applied Testosterone Replacement Therapy Pose Risk for Blood Pressure Elevation? Circadian Medicine Perspectives
Smolensky, M. H., Hermida, R. C., Sackett-Lundeen, L. L., Hermida‐Ayala, R. G., & Geng, Y. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00245.x
Recent Publications on Medications and Pharmacy
Sterling, J. A. (2008) · Hospital Pharmacy · doi:10.1310/hpj4312-1024
Developing a persona-driven, mHealth-enabled care model for young men with hypogonadism: a methods-based approach to early risk stratification and prevention
Garifalos, F., Menafra, D., de Angelis, C., Larocca, A., Virgolesi, M., Aprano, S., Luca, V. D., Rea, T., Attaianese, E., Perillo, M., et al. (2026) · Frontiers in Reproductive Health · doi:10.3389/frph.2025.1691309
Daily tadalafil administration improves cardiac autonomic regulation in men with non-organic erectile dysfunction: a prospective heart rate variability study
Yıldız, G., & Kunak, T. (2026) · Sexual Medicine · doi:10.1093/sexmed/qfag029
Sex Differences in Blood Pressure Trajectories Across the Life Course
Warsi, W., Kwong, J. L., Lee, Y., & Cheng, S. C. (2026) · Physiology in health and disease · doi:10.1007/978-3-032-26472-5_8
The association between androgenic profile and cardiometabolic risk factors in young men: insights from a large observational cohort study
Menafra, D., de Angelis, C., Garifalos, F., Chiodini, P., Verde, N., Piscopo, M., Galdiero, G., Fraia, D. A. D., Mazzarella, A., Paola, N. D., et al. (2026) · Journal of Endocrinological Investigation · doi:10.1007/s40618-026-03037-5

Summary
Yaron, M., Greenman, Y., Rosenfeld, J. B., Izkhakov, E., Limor, R., Osher, E., Tordjman, K., Stern, N., & D, N. S. M. (2013)
Self-citation
Effect of long-term testosterone replacement therapy on arterial stiffness and systemic endothelial function in male patients with hypogonadism
Ioakeimidis, N., Angelis, A., Rokkas, K., Terentes-Printzios, D. G., Saad, F., Tousoulis, D., Tsioufis, K. P., & Vlachopoulos, C. V. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab724.2832 · Cited by 2 · see citing works
Impaired aortic elastic properties in patients with adult-onset hypogonadism
Canpolat, U., Tokgözoğlu, L. S., Aydın, K., Dural, M., Gürses, K. M., Yorgun, H., Canpolat, A. G., Kaya, E. B., Kabakçı, G., Usman, A., et al. (2012) · Blood Pressure · doi:10.3109/08037051.2012.732777 · Cited by 7 · see citing works
Arterial Stiffness in Transgender Men Receiving Long-term Testosterone Therapy
Cunha, F. S., Bachega, T. A. S. S., Costa, E. M. F., Brito, V. N., Alvares, L. A. M., Costa‐Hong, V., Verardino, R. G. S., Sircili, M. H. P., Mendonca, B. B., Bortolotto, L. A., et al. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad040 · Cited by 20 · see citing works
0013-7227/01/$03.00/0 The Journal of Clinical Endocrinology & Metabolism 86(9):4261–4267 Printed in U.S.A. Copyright © 2001 by The Endocrine Society The Effects of Induced Hypogonadism on Arterial Stiffness, Body Composition, and Metabolic Parameters in M
Smith, J. C., Bennett, S., Evans, L. M., Kynaston, H. G., Parmar, M., Mason, M. D., Cockcroft, J. R., Scanlon, M. F., & Davies, J. S. (2013)

Authors: Yaron, M., Greenman, Y., Rosenfeld, J. B., Izkhakov, E., Limor, R., Osher, E., Shenkerman, G., Tordjman, K., & Stern, N.
Affiliations: Tel Aviv University (IL)
Corresponding author: Stern, Naftali
ORCID: Yaron, Marianna
Greenman, Yona
Izkhakov, Elena
Tordjman, Karen
Stern, Naftali
Venue: European Journal of Endocrinology
Publisher: Oxford University Press (OUP)
Published: 2009-05
Volume: 160
Issue: 5
Pages: 839-846
ISSN: 0804-4643 (ISSN-L)
1479-683X
DOI: 10.1530/eje-09-0052
OpenAlex: W2133761842
Cited by: 78
References: 39
Citations by year: 2026: 4 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 8 · 2014: 4 · 2013: 7 · 2012: 9
FWCI: 5.81
Type: journal article
Language: en
Open access: closed
Locations: European Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Keywords: testosterone replacement therapy, arterial stiffness, male hypogonadism, pulse wave velocity, idiopathic hypogonadotropic hypogonadism, pituitary tumors, transdermal testosterone, applanation tonometry, pulse wave analysis, arterial compliance, older men
MeSH terms: Age Factors, Aged, Arteries, Blood Flow Velocity, Blood Pressure, Follicle Stimulating Hormone, Humans, Hypogonadism, Luteinizing Hormone, Male, Middle Aged, Prolactin, Testosterone, Vascular Resistance, Age of Onset, Hormone Replacement Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of testosterone replacement therapy on arterial stiffness in older hypogonadal men

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks