Thyroid hormone status within the physiological range affects bone mass and density in healthy men at the age of peak bone mass
Open accessAbstract
Context: The hormonal factors involved in the regulation of peak bone mass (PBM) in men have not been fully investigated. Apart from gonadal steroids and somatotropic hormones, thyroid hormones are known to affect bone maturation and homeostasis and are additional candidate determinants of adult bone mass. Objective: We aimed to investigate between-subject physiological variation in free and total thyroid hormone concentrations, TSH, and thyroid binding globulin (TBG) in relation to parameters of bone mass, geometry, and mineral density in healthy men at the age of PBM. Design and setting: We recruited 677 healthy male siblings aged 25–45 years in a cross-sectional, population-based study. Areal and volumetric bone parameters were determined using dual-energy x-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). Total and free thyroid hormones, TBG, and TSH were determined using immunoassays. Results: Free and total thyroid hormone concentrations were inversely associated with bone mineral density (BMD) and bone mineral content (BMC) at the hip and total body (free triiodothyronine (FT 3), total T 3 (TT 3), and total T 4 (TT 4)) and at the spine (FT 3). TBG was negatively associated with BMC and areal BMD at all sites. At the radius, cortical bone area was inversely associated with TT 3, TT 4, and TBG, and trabecular bone density was inversely associated with free thyroxine, TT 4, and TBG. We observed inverse associations between cortical bone area at the mid-tibia and FT 3, TT 3, TT 4, and TBG. No associations between TSH and DXA or pQCT measurements were found. Conclusion: In healthy men at the age of PBM, between-subject variation in thyroid hormone concentrations affects bone density, with higher levels of FT 3, TT 3, TT 4, and TBG being associated with less favorable bone density and content.
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Variation in thyroid status within the reference range in post-menopausal women is associated with altered bone mineral density and fracture risk.
“Population studies have also shown that variation in thyroid status within the reference range in post-menopausal women is associated with altered BMD and fracture risk.”
From Thyroid diseases and bone health (2018) · cites this paper as [48]
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- Authors
- Roef, G., Lapauw, B., Goemaere, S., Zmierczak, H., Fiers, T., Kaufman, J.-M., & Taes, Y.
- Affiliations
- Ghent University Hospital (BE)
- Corresponding author
- Roef, Greet
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06
- Volume
- 164
- Issue
- 6
- Pages
- 1027-1034
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2138275857
- Cited by
- 54
- References
- 41
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 12 · 2012: 7
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Servier
- Vlaamse regering (G.0662.07)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- thyroid hormones, peak bone mass, bone mineral density, bone mineral content, thyroxine-binding globulin, triiodothyronine, thyroxine, thyroid-stimulating hormone, bone geometry, cortical bone area, trabecular bone density, men, healthy siblings
- MeSH terms
- Adult, Aging, Anthropometry, Body Composition, Bone and Bones, Bone Development, Cross-Sectional Studies, Humans, Life Style, Male, Middle Aged, Sex Hormone-Binding Globulin, Gonadal Steroid Hormones, Smoking, Thyroid Hormones, Tomography, X-Ray Computed, Biomarkers, Absorptiometry, Photon, Bone Density
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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