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Cited by 105Adrenal and Paraganglionic TumorsHormonal Regulation and HypertensionAdrenal Hormones and Disorders

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Anthropometric, haemodynamic, humoral and hormonal evaluation in patients with incidental adrenocortical adenomas before and after surgery.

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Bernini, G, Moretti, A, Iacconi, P, Miccoli, P, Nami, R, Lucani, B, Salvetti, A·2003·European Journal of Endocrinology
DOI 10.1530/eje.0.1480213
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Abstract

OBJECTIVE: To compare clinical and humoral parameters before and after surgery in patients with incidental adrenocortical adenomas. DESIGN: Six patients with subclinical Cushing's syndrome and nine with non-functioning adenomas were investigated before and 12 Months after removal of the mass. METHODS: Anthropometric (body weight, body mass index and waist to hip ratio), haemodynamic (blood pressure and heart rate), metabolic (lipids and oral glucose tolerance test (OGTT)), hormonal (cortisol, plasma renin activity, aldosterone, androgens and catecholamines) and bone metabolism (hydroxyproline, parathyroid hormone, osteocalcin and ostase) parameters were evaluated. RESULTS: In the whole group, a significant decrease in body weight (69.7+/-3.5 vs 70.8+/-3.5 kg, P<0.03), in systolic (135.3+/-5.1 vs 145.6+/-4.9 mmHg, P<0.009) and diastolic (83.7+/-1.9 vs 91.0+/-3.5 mmHg, P<0.03) blood pressure and in glucose levels in response to OGTT (106.4+/-9.6 vs 127.5+/-6.5 mg/dl, P<0.05) was observed after surgery. All other parameters examined did not change significantly. This trend was also found in both groups separately. Analytical data showed a high frequency of overweight/obesity (66.6%), hypertension (66.6%) and impaired glucose profile (26.6%) in our patients, with a greater prevalence of these cardiovascular risk factors in the subclinical Cushing's syndrome group. After surgery, values normalized or improved in eight out of ten hypertensive patients and in three out of four patients with impaired glucose profile. CONCLUSIONS: Solid adrenocortical incidentalomas are associated with some cardiovascular risk factors which may be corrected after removal of the mass. Therefore, surgery may be an appropriate choice in patients with subclinical Cushing's syndrome but also in those with solid non-functioning adenomas and coexistent cardiovascular risk factors.

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Crossref · 10.1530/eje.0.1480213

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Metadata

Authors
Bernini, G., Moretti, A., Iacconi, P., Miccoli, P., Nami, R., Lucani, B., & Salvetti, A.
Affiliations
  • University of Pisa (IT)
  • University of Siena (IT)
Corresponding author
Bernini, G
ORCID
Miccoli, P
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2003-02-01
Volume
148
Issue
2
Pages
213-219
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje.0.1480213
OpenAlex
W2158197847
Cited by
105
References
43
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 3 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 2 · 2012: 9
FWCI
4.42
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
  • Zenodo (CERN European Organization for Nuclear Research) (other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
subclinical Cushing's syndrome, non-functioning adrenal adenoma, adrenalectomy, cardiovascular risk factors, hypertension, obesity, impaired glucose tolerance, postoperative outcomes, bone metabolism, cortisol, aldosterone, renin-angiotensin system, catecholamines, osteocalcin, parathyroid hormone
MeSH terms
Adenoma, Adrenal Cortex Neoplasms, Adult, Aged, Anthropometry, Blood Glucose, Blood Pressure, Body Weight, Cushing Syndrome, Female, Glucose Tolerance Test, Hemodynamics, Hormones, Humans, Hypertension, Male, Middle Aged, Obesity, Postoperative Period, Treatment Outcome

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