The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Endogenous sex hormones in men aged 40-80 years
Abstract
OBJECTIVE: To determine the relationship between aging, life-style factors and health-related factors and endogenous sex hormone levels. DESIGN: Cross-sectional study of 400 independently living men between 40 and 80 Years of age. METHODS: After exclusion of subjects who were not physically or mentally able to visit the study center, 400 men were randomly selected from a population-based sample. Total testosterone (TT), bioavailable testosterone (BT) (i.e. not bound to sex hormone-binding globulin (SHBG)), SHBG, estradiol (E(2)) and dehydroepiandrosterone-sulfate (DHEA-S) were investigated for their relationship with age, body mass index (BMI), waist circumference, smoking, physical activity and general health status. Multivariate models using ANCOVA analyses were used to examine the contribution of life-style factors to sex hormone variability. RESULTS: TT, BT and DHEA-S decreased with age; 0.2, 0.7 and 1.2%/Year respectively. SHBG showed an increase with age of 1.1%/Year. No changes with age were found for E(2). General health status modified the association of TT and SHBG with age (P interaction 0.10 and 0.002 respectively). Increased BMI and waist circumference were associated with decreased TT, BT, SHBG and DHEA-S and increased E(2) (all P<0.01). Current smoking, lower alcohol intake and a higher physical activity score were associated with higher TT and SHBG levels. CONCLUSION: This study showed the important determinants of sex hormones were age, BMI, waist circumference, smoking, general health status and physical activity. Furthermore, it can be concluded that general health status modified the effect between sex hormones and age. For future observational studies it should be taken into account that the above-mentioned determinants may alter the association between sex hormones and diseases and related conditions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Previous studies of cigarette smoking, alcohol consumption and physical activity with sex steroid hormones and SHBG levels in men were limited by small sample sizes [22], were restricted to older men [17], or both [20].”
From Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men (2009) · cites this paper as [17]
In the citing paper
“Few studies have addressed the association between physical activity and hormone levels, with inconsistent findings [16–19].”
From Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men (2009) · cites this paper as [17]
In the citing paper
“Adiposity is a well-known modifiable predictor of sex steroid hormones in men [14, 16–20]”
From Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men (2009) · cites this paper as [17]
In the citing paper
“The association between alcohol consumption and sex steroid hormone concentrations has been inconsistent, with some evidence suggesting no association [16–19], and other evidence supporting increased levels of androstanediol glucuronide [16], and estradiol [17], and decreased levels of SHBG [18] with increased alcohol consumption.”
From Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men (2009) · cites this paper as [17]
In the citing paper
“The mean total and bioavailable testosterone levels in our diabetic men were also lower in all age-groups compared with data reported by Leifke et al. (11) in healthy nonobese males and by Muller et al. (33) in independently living men.”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [33]
Citations
Cites
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760
Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8201 · Cited by 1,861
Gray, A., Feldman, H. A., McKinlay, J. B., & Longcope, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,104
Lamberts, S. W. J., van den Beld, A. W., & van der Lely, A.-J. (1997) · Science · doi:10.1126/science.278.5337.419 · Cited by 980
A physical activity questionnaire for the elderly
VOORRIPS, L. E., Ravelli, A. C. J., Dongelmans, P. C. A., Deurenberg, P., & van Staveren, W. A. (1991) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199108000-00015 · Cited by 906
Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., Morley, P. M. K., Stauber, P. M., Vellas, B., Baumgartner, R. N., & Garry, P. J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90057-3 · Cited by 830
Peripheral Arterial Disease in the Elderly
Meijer, W. T., Hoes, A. W., Rutgers, D., Bots, M. L., Albert Hofman, D., & Grobbee, D. E. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.2.185 · Cited by 764
Self-citationvan den Beld, A. W., de Jong, F. H., Grobbee, D. E., Pols, H. A. P., & Lamberts, S. W. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6825 · Cited by 618
Self-citationAndropause: clinical implications of the decline in serum testosterone levels with aging in men
Matsumoto, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.m76 · Cited by 490
Cited by
Sorted by citations
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Kaufman, J. M., & Vermeulen, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0013 · Cited by 1,079
Wu, F. C. W., Tajar, A., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F., Forti, G., Giwercman, A., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1972 · Cited by 939
Maninger, N., Wolkowitz, O. M., Reus, V. I., Epel, E. S., & Mellon, S. H. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.11.002 · Cited by 769
Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies
Larsson, S. C., & Wolk, A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.556 · Cited by 644
Frequent Occurrence of Hypogonadotropic Hypogonadism in Type 2 Diabetes
Dhindsa, S., Prabhakar, S., Sethi, M., Bandyopadhyay, A., Chaudhuri, A., & Dandona, P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0804 · Cited by 631
Metadata
- Authors
- Muller, M., den Tonkelaar, I., Thijssen, J., Grobbee, D., & van der Schouw, Y.
- Affiliations
- University Medical Center Utrecht (NL)
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12-01
- Volume
- 149
- Issue
- 6
- Pages
- 583-589
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2007326249
- Cited by
- 346
- References
- 42
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 15 · 2022: 13 · 2021: 16 · 2020: 11 · 2019: 5 · 2018: 14 · 2017: 10 · 2016: 16 · 2015: 17 · 2014: 22 · 2013: 20 · 2012: 28
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- endogenous sex hormones, aging, men, testosterone, bioavailable testosterone, sex hormone-binding globulin, estradiol, dehydroepiandrosterone sulfate, body mass index, waist circumference, smoking, physical activity, alcohol consumption, health status, lifestyle factors
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Estradiol, Health Status, Humans, Life Style, Male, Middle Aged, Sex Hormone-Binding Globulin, Testosterone, Body Mass Index, Dehydroepiandrosterone Sulfate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
