Cited by 135Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

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The proatherogenic cytokine interleukin-18 is secreted by human adipocytes

Skurk, Thomas, Kolb, Hubert, Müller-Scholze, Sylvia, Röhrig, Karin, Hauner, Hans, Herder, Christian·2005·European Journal of Endocrinology

DOI 10.1530/eje.1.01897

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Abstract

OBJECTIVE: Interleukin (IL)-18, an important mediator of innate immunity and strong risk factor for the development of cardiovascular disease, was shown recently to be elevated in obesity. The aim of our study was to investigate whether human adipocytes produce IL-18. METHODS: Human adipose tissue was obtained from lean women undergoing elective plastic surgery and from obese individuals undergoing laparoscopic surgery (gastric banding). Preadipocytes from mammary adipose tissue were isolated and differentiated under defined adipogenic conditions. IL-18 expression was analyzed by real-time reverse transcriptase PCR, ELISA and immunocytochemistry. RESULTS: Human preadipocytes of all differentiation stages spontaneously secreted IL-18. In parallel significant amounts of IL-18 mRNA were detected. Freshly isolated mature adipocytes from subcutaneous and omental depots also released IL-18. IL-18 release from adipocytes from obese donors was about 3-fold higher compared to adipocytes from non-obese donors. CONCLUSIONS: We conclude that human adipose tissue produces IL-18 and thereby contributes to systemic IL-18 concentrations. This finding supports the concepts that adipocytes behave as primitive immune cells and that IL-18 may mediate some of the detrimental complications of obesity such as cardiovascular disease and type 2 diabetes.

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Authors: Skurk, T., Kolb, H., Müller-Scholze, S., Röhrig, K., Hauner, H., & Herder, C.
Affiliations: Technical University of Munich (DE)
Deutsches Diabetes-Zentrum e.V. (DE)
Corresponding author: Herder, Christian
ORCID: Skurk, Thomas
Kolb, Hubert
Hauner, Hans
Herder, Christian
Venue: European Journal of Endocrinology
Publisher: Oxford University Press (OUP)
Published: 2005-06
Volume: 152
Issue: 6
Pages: 863-868
ISSN: 0804-4643 (ISSN-L)
1479-683X
DOI: 10.1530/eje.1.01897
OpenAlex: W2159226285
Cited by: 135
References: 32
Citations by year: 2025: 1 · 2024: 4 · 2023: 1 · 2022: 6 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 7
FWCI: 10.99
Type: journal article
Language: en
Open access: closed
Locations: European Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
mediaTUM (Technical University of Munich) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: IL-18, adipocytes, adipose tissue, obesity, preadipocytes, adipogenesis, cytokine production, atherosclerosis, cardiovascular disease, type 2 diabetes, innate immunity, omental adipose tissue, subcutaneous adipose tissue
MeSH terms: Adipose Tissue, Adult, Aged, Cell Differentiation, Female, Glycerolphosphate Dehydrogenase, Humans, Immunohistochemistry, Male, Middle Aged, Obesity, RNA, Messenger, Adipocytes, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-18

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The proatherogenic cytokine interleukin-18 is secreted by human adipocytes

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