Effects of fibroblast growth factor 21 on the heart

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Fibroblast growth factor 21 protects against cardiac hypertrophy in mice

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Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver

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βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

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FGF‐21/FGF‐21 receptor interaction and activation is determined by βKlotho

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Molecular cloning and expression analyses of mouse βklotho, which encodes a novel Klotho family protein

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Fibroblast growth factor 21 protects the heart from oxidative stress

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Serum Fibroblast Growth Factor-21 Levels Are Associated With Carotid Atherosclerosis Independent of Established Cardiovascular Risk Factors

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Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

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Serum Levels of FGF-21 Are Increased in Coronary Heart Disease Patients and Are Independently Associated with Adverse Lipid Profile

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Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue

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FGF21 N‐ and C‐termini play different roles in receptor interaction and activation

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Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease

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FGFs and metabolism

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Novel Insights into the Cardio-Protective Effects of FGF21 in Lean and Obese Rat Hearts

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FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism

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Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway

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Fibroblast growth factor (FGF21) protects mouse liver against d-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways

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Isoproterenol induces in vivo functional and metabolic abnormalities: similar to those found in the infarcted rat heart.

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The relationship of fibroblast growth factor 21 with cardiovascular outcome events in the Fenofibrate Intervention and Event Lowering in Diabetes study

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FGF 21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation

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Serum FGF 21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status

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Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia

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Proteomic study on the protective mechanism of fibroblast growth factor 21 to ischemia–reperfusion injury

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Fatty acid utilization during development of the rat

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Fibroblast growth factor 21 as a possible endogenous factor inhibits apoptosis in cardiac endothelial cells.

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Possible role of fibroblast growth factor 21 on atherosclerosis via amelioration of endoplasmic reticulum stress-mediated apoptosis in apoE−/− mice

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Serum fibroblast growth factor 21 levels is associated with lower extremity atherosclerotic disease in Chinese female diabetic patients

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Serum fibroblast growth factor 21 is predictive of combined cardiovascular morbidity and mortality in patients with type 2 diabetes at a relatively short-term follow-up

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Serum fibroblast growth factor 21 levels are increased in atrial fibrillation patients

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Increased Circulating and Epicardial Adipose Tissue mRNA Expression of Fibroblast Growth Factor-21 After Cardiac Surgery: Possible Role in Postoperative Inflammatory Response and Insulin Resistance

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Metabolic messengers: FGF21

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FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages

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FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice

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New developments in the biology of fibroblast growth factors

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Exercise Training Alleviates Cardiac Fibrosis through Increasing Fibroblast Growth Factor 21 and Regulating TGF-β1-Smad2/3-MMP2/9 Signaling in Mice with Myocardial Infarction

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Fibroblast growth factor 21 protects the heart from angiotensin II-induced cardiac hypertrophy and dysfunction via SIRT1

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Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity

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Circulating Fibroblast Growth Factor 21 is Associated with Diastolic Dysfunction in Heart Failure Patients with Preserved Ejection Fraction

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Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis

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Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction

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Lysyl oxidase overexpression accelerates cardiac remodeling and aggravates angiotensin II–induced hypertrophy

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Multi-organ FGF21-FGFR1 signaling in metabolic health and disease

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Fibroblast growth factor 21 ( FGF 21) therapy attenuates left ventricular dysfunction and metabolic disturbance by improving FGF 21 sensitivity, cardiac mitochondrial redox homoeostasis and structural changes in pre‐diabetic rats

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Autophagic control of cardiac steatosis through FGF21 in obesity-associated cardiomyopathy

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FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis

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FGF21 alleviates chronic inflammatory injury in the aging process through modulating polarization of macrophages

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Modulation of energy balance by fibroblast growth factor 21

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The SLC6A15–SLC6A20 Neutral Amino Acid Transporter Subfamily: Functions, Diseases, and Their Therapeutic Relevance

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Role of angiopoietin-2 in the cardioprotective effect of fibroblast growth factor 21 on ischemia/reperfusion-induced injury in H9c2 cardiomyocytes

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Fibroblast Growth Factor 21 Protects Against Atrial Remodeling via Reducing Oxidative Stress

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Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis

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Increased plasma FGF21 level as an early biomarker for insulin resistance and metabolic disturbance in obese insulin-resistant rats

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Inflammatory plasma proteins predict short-term mortality in patients with an acute myocardial infarction

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Cardioprotective Role of SIRT5 in Response to Acute Ischemia Through a Novel Liver-Cardiac Crosstalk Mechanism

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Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα), Lowers Serum Triglyceride Levels by Targeting Hepatic PPARα in Mice

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FGF21, a modulator of astrocyte reactivity, protects against ischemic brain injury through anti-inflammatory and neurotrophic pathways

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FGF21/FGFR1-β-KL cascade in cardiomyocytes modulates angiogenesis and inflammation under metabolic stress

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BV2 Membrane‐Coated PEGylated‐Liposomes Delivered hFGF21 to Cortical and Hippocampal Microglia for Alzheimer's Disease Therapy

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Vildagliptin and caloric restriction for cardioprotection in pre-diabetic rats

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FGF21 promotes myocardial angiogenesis and mediates the cardioprotective effects of exercise in myocardial infarction mice

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Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris

Cheng, J., Su, X., Qiao, L., Zhai, C., & Chen, W. (2018) · Bioscience Reports · doi:10.1042/bsr20181099 · Cited by 16 · see citing works

Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study

Buell‐Acosta, J. D., Garcés, M. F., Baños, A. J. P., Ángel‐Müller, E., Páez, M. C., Eslava-Schmalbach, J. H., Escobar-Córdoba, F., Caminos-Cepeda, S. A., Lacunza, E., Castano, J. P., et al. (2022) · Cells · doi:10.3390/cells11142251 · Cited by 15 · see citing works

Fibroblast growth factor 21 and prognosis of patients with cardiovascular disease: A meta-analysis

Yan, B., Ma, S., Yan, C., & Han, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1108234 · Cited by 12 · see citing works

Fibroblast growth factor 21; review on its participation in vascular calcification pathology

Olapoju, S. O., Adejobi, O. I., & Thi, X. L. (2019) · Vascular Pharmacology · doi:10.1016/j.vph.2019.106636 · Cited by 12 · see citing works

Elevated serum FGF21 levels predict heart failure during hospitalization of STEMI patients after emergency percutaneous coronary intervention

Gu, L., Jiang, W., Jiang, W., Xu, Z., Li, W., & Zhang, H. (2023) · PeerJ · doi:10.7717/peerj.14855 · Cited by 9 · see citing works

Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles Improves Therapeutic Efficacy for Myocardial Ischemia–Reperfusion Injury

Rao, Z., Tang, Y., Zhu, J., Lu, Z., Chen, Z., Wang, J., Bao, Y., Mukondiwa, A. V., Wang, C., Wang, X., et al. (2025) · Nanomaterials · doi:10.3390/nano15050346 · Cited by 8 · see citing works

Adenosine A2A receptor activation prevents DOCA-salt induced hypertensive cardiac remodeling via iBAT

Zhou, Y., Ruan, C., Kong, L., & Gao, P. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.02.035 · Cited by 8 · see citing works

Functions of FGF21 and its role in cardiac hypertrophy

Chen, L., Gao, M., Ong, S., & Gong, G. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.03.007 · Cited by 7 · see citing works

Strategies to improve the therapeutic effect of pluripotent stem cell-derived cardiomyocytes on myocardial infarction

Xiao, Y., Chen, Y., Shao, C., Wang, Y., Hu, S., & Lei, W. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.973496 · Cited by 7 · see citing works

Research Progress of Fibroblast Growth Factor 21 in Fibrotic Diseases

Jia, M.-Q., Guan, C., Tao, J., & Zhou, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5042762 · Cited by 7 · see citing works

Transitions in chromatin conformation shaped by fatty acids and the circadian clock underlie hepatic transcriptional reorganization in obese mice

Pacheco-Bernal, I., Becerril-Pérez, F., Bustamante-Zepeda, M., González-Suárez, M., Olmedo-Suárez, M. Á., Hernández-Barrientos, L. R., del Carmen, A. A., Escalante‐Covarrubias, Q., Mendoza-Viveros, L., Lemus, E. H., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05364-3 · Cited by 6 · see citing works

Increased levels of circulating fibroblast growth factor 21 in children with Kawasaki disease

Peng, Y., Pei, Q., Feng, S., Su, Y., Liu, R., Yi, Q., & Guo, P. (2019) · Clinical and Experimental Medicine · doi:10.1007/s10238-019-00577-4 · Cited by 6 · see citing works

Physiological and pathological gestational cardiac hypertrophy: what can we learn from rodents?

Sampaolesi, M., & Calsteren, K. V. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx192 · Cited by 6 · see citing works

High serum fibroblast growth factor 21 levels were related to the prognosis and ventricular remodeling of heart failure patients with mildly reduced and reduced ejection fraction

Fan, L., Gu, L., Yao, Y., & Ma, G. (2022) · Perfusion · doi:10.1177/02676591221137482 · Cited by 5 · see citing works

The secretome as a biomarker and functional agent in heart failure

Nyarko, O. O., & Sucharov, C. C. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.15 · Cited by 5 · see citing works

Clinical Insights from Proteomics in Heart Failure

Lotfinaghsh, A., Imam, A., Pompian, A., Stitziel, N. O., & Javaheri, A. (2025) · Current Heart Failure Reports · doi:10.1007/s11897-025-00698-w · Cited by 4 · see citing works

Hypertensive Heart Disease: A Narrative Review Series—Part 3: Vasculature, Biomarkers and the Matrix of Hypertensive Heart Disease

Nemtsova, V. D., Vischer, A. S., & Burkard, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020505 · Cited by 4 · see citing works

Key Signaling Pathways in the Cardiovascular System

Trindade, F., Falcão‐Pires, I., Kavazis, A. N., Leite-Moreira, A. F., Moreira‐Gonçalves, D., & Nogueira‐Ferreira, R. (2020) · Springer eBooks · doi:10.1007/978-3-030-44436-5_12 · Cited by 4 · see citing works

Association of fibroblast growth factor 21 with oxidative stress and lipid profile in type 2 diabetes

Vineetha, K. R., Santha, K., Inmozhi, R., Periyasamy, S., Kanakasabai, G., & Baskaran, K. (2020) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20205302 · Cited by 4 · see citing works

Connecting the Dots: FGF21 as a Potential Link between Obesity and Cardiovascular Health in Acute Coronary Syndrome Patients

Negroiu, C. E., Riza, A., Streață, I., Tudorașcu, I., Bezna, C. M., Ungureanu, A., & Dănoiu, S. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46080501 · Cited by 3 · see citing works

Sulfur Amino Acid Restriction Mitigates High-Fat Diet-Induced Molecular Alterations in Cardiac Remodeling Primarily via FGF21-Independent Mechanisms

Pinheiro, F., Lail, H. L., Neves, J. S., Negrão, R., & Wanders, D. (2024) · Nutrients · doi:10.3390/nu16244347 · Cited by 3 · see citing works

Synthetic Fibroblasts: Terra Incognita in Cardiac Regeneration

Chang, A., Tam, J., Agrawal, D. K., Liu, H. H., Varadarajan, P., Pai, R. G., & Thankam, F. G. (2022) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2022.0050 · Cited by 3 · see citing works

Batokine in Central Nervous System Diseases

Shen, M., Zhang, M., Mao, N., & Lin, Z. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03490-w · Cited by 3 · see citing works

FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway

Chen, L., Zheng, L., Qin, Y. H., Liu, B., Zheng, Y., Tong, X., Dai, M., & Gong, G. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.10.053 · Cited by 2 · see citing works

Endocrinology and metabolism

Li, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15793-6.00003-2 · Cited by 2 · see citing works

Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina

Hung, W., Yu, T., Wang, C.-P., Hsu, C., Lu, Y., Wei, C., Chung, F., Lee, Y., Wu, C., & Tang, W.-H. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02868-3 · Cited by 1 · see citing works

Circulating fibroblast growth factor-21 in coronary artery disease: a systematic review and meta-analysis

Shawa, F., Izzeddin, F., & Koç, G. (2026) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-026-04472-2 · Cited by 1 · see citing works

Morphological and histopathological heart changes in autopsies of heroin abusers

Aleksic, I., Marinkovic, N., & Dzambas, J. (2017) · Vojnosanitetski pregled · doi:10.2298/vsp160418053a · Cited by 1 · see citing works

Molecular description of fibroblast growth factor and mechanisms by which fibroblast growth factor-21 mediating biological actions and acting as a biologic biomarker of cardiovascular diseases

Melaku, L. S., & Debela, N. (2020) · Indian Journal of Health Sciences and Biomedical Research (KLEU) · doi:10.4103/kleuhsj.kleuhsj_92_20

Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the FGF21 locus

Bayoumi, A. (2020) · The Sydney eScholarship Repository (The University of Sydney)

Development of a fibroblast growth factor 21 assay

Tamassia, G. V. (2017) · doi:10.32469/10355/62371

Faculty Opinions recommendation of Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.

Aguilar-Salinas, C. A. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734059638.793558319

Peer Review #3 of "Elevated serum FGF21 levels predict heart failure during hospitalization of STEMI patients after emergency percutaneous coronary intervention (v0.1)"

(2023) · PeerJ · doi:10.7287/peerj.14855v0.1/reviews/3

Peer Review #2 of "Elevated serum FGF21 levels predict heart failure during hospitalization of STEMI patients after emergency percutaneous coronary intervention (v0.1)"

(2023) · PeerJ · doi:10.7287/peerj.14855v0.1/reviews/2

Peer Review #3 of "Elevated serum FGF21 levels predict heart failure during hospitalization of STEMI patients after emergency percutaneous coronary intervention (v0.2)"

(2023) · PeerJ · doi:10.7287/peerj.14855v0.2/reviews/3

Peer Review #1 of "Elevated serum FGF21 levels predict heart failure during hospitalization of STEMI patients after emergency percutaneous coronary intervention (v0.1)"

(2023) · PeerJ · doi:10.7287/peerj.14855v0.1/reviews/1

ROLE OF MATERNAL SERUM FIBROBLAST GROWTH FACTOR 21 LEVEL IN PREDICTION OF PREECLAMPSIA

El-din, A. M. A. K., Kolaib, M. H., Bakhat, G. S. A.-R., & Yehia, A. H. (2024) · Neonatology surgery and perinatal medicine · doi:10.24061/2413-4260.xiv.1.51.2024.13

Additional file 1 of Inflammatory plasma proteins predict short-term mortality in patients with an acute myocardial infarction

Schmitz, T., Harmel, E. K., Heier, M., Peters, A., Linseisen, J., & Christa, M. (2022) · Figshare · doi:10.6084/m9.figshare.21303090

Additional file 1 of Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina

Hung, W.-C., Yu, T.-H., Wang, C.-P., Hsu, C.-C., Lu, Y.-C., Wei, C.-T., Chung, F.-M., Lee, Y.-J., Wu, C.-C., & Tang, W.-H. (2022) · Figshare · doi:10.6084/m9.figshare.21256969

Affinity screening and cardioprotective evaluation of FRS2α-targeted components from the ethyl-acetate fraction of Gualou-Xiebai-Banxia decoction

Gao, H., Liu, L., Wang, H., Zhao, P., & Zhao, Q. (2026) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2026.117746

Liver-derived FGF21 contributes to protection against Alzheimer’s disease pathogenesis

Al‐Lahham, R., Dweik, Q., Murthy, S. G. S. S., Gill, S. K., Krishnan, B., Valdebenito, S., Eugenín, E. A., & Elferink, C. J. (2026) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2026-0020

Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases

Cheng, P., Zhang, F., Yu, L., Lin, X., He, L., Li, X., Lu, X., Yan, X., Tan, Y., & Zhang, C. (2016) · Journal of Diabetes Research · doi:10.1155/2016/1540267 · Cited by 67 · see citing works

Molecular description of fibroblast growth factor and mechanisms by which fibroblast growth factor-21 mediating biological actions and acting as a biologic biomarker of cardiovascular diseases

Melaku, L. S., & Debela, N. (2020) · Indian Journal of Health Sciences and Biomedical Research (KLEU) · doi:10.4103/kleuhsj.kleuhsj_92_20

The role of FGF21 in the pathogenesis of cardiovascular disease

Zhang, Y., Liu, D., Long, X.-X., Fang, Q.-C., Jia, W.-P., & Li, H.-T. (2021) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001890 · Cited by 68 · see citing works

FGF21 and Cardiac Physiopathology

Planavila, A., Redondo-Angulo, I., & Villarroya, F. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00133 · Cited by 123 · see citing works

Novel Insights into the Cardio-Protective Effects of FGF21 in Lean and Obese Rat Hearts

Patel, V., Adya, R., Chen, J., Ramanjaneya, M., Bari, M. F., Bhudia, S. K., Hillhouse, E. W., Tan, B. K., & Randeva, H. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087102 · Cited by 124 · see citing works