FGF21 and Cardiac Physiopathology
Open accessAbstract
The heart is not traditionally considered either a target or a site of fibroblast growth factor-21 (FGF21) production. However, recent findings indicate that FGF21 can act as a cardiomyokine; that is, it is produced by cardiac cells at significant levels and acts in an autocrine manner on the heart itself. The heart is sensitive to the effects of FGF21, both systemic and locally generated, owing to the expression in cardiomyocytes of β-Klotho, the key co-receptor known to confer specific responsiveness to FGF21 action. FGF21 has been demonstrated to protect against cardiac hypertrophy, cardiac inflammation, and oxidative stress. FGF21 expression in the heart is induced in response to cardiac insults, such as experimental cardiac hypertrophy and myocardial infarction in rodents, as well as in failing human hearts. Intracellular mechanisms involving PPARα and Sirt1 mediate transcriptional regulation of the FGF21 gene in response to exogenous stimuli. In humans, circulating FGF21 levels are elevated in coronary heart disease and atherosclerosis, and are associated with a higher risk of cardiovascular events in patients with type 2 diabetes. These findings provide new insights into the role of FGF21 in the heart and may offer potential therapeutic strategies for cardiac disease.
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Administration of FGF21 is cardioprotective in numerous rodent models.
“administration of FGF21 is actually cardioprotective in numerous rodent models93–95.”
From Metabolic messengers: FGF21 (2021) · cites this paper as [93]
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FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works
Gnecchi, M., He, H., Liang, O. D., Melo, L. G., Morello, F., Mu, H., Noiseux, N., Zhang, L., Pratt, R. E., Ingwall, J. S., et al. (2005) · Nature Medicine · doi:10.1038/nm0405-367 · Cited by 1,677 · see citing works
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504 · see citing works
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works
Purushotham, A., Schug, T. T., Xu, Q., Surapureddi, S., Guo, X., & Li, X. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.006 · Cited by 1,112 · see citing works
Transcriptional control of mitochondrial biogenesis: the central role of PGC-1
Ventura-Clapier, R., Garnier, A., & Veksler, V. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn098 · Cited by 932 · see citing works
Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908 · see citing works
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885 · see citing works
Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
Fisher, F. M., Chui, P. C., Antonellis, P. J., Bina, H. A., Kharitonenkov, A., Flier, J. S., & Maratos-Flier, E. (2010) · Diabetes · doi:10.2337/db10-0193 · Cited by 830 · see citing works
Kim, K. H., Jeong, Y. T., Oh, H., Kim, S. H., Cho, J. M., Kim, Y.-N., Kim, S. S., Kim, D. H., Hur, K. Y., Kim, H. K., et al. (2013) · Nature Medicine · doi:10.1038/nm.3014 · Cited by 774 · see citing works
Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748 · see citing works
Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0142 · Cited by 700 · see citing works
Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue
Hondares, E., Iglesias, R., Giralt, A., Gonzalez, F. J., Giralt, M., Mampel, T., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215889 · Cited by 623 · see citing works
Self-citationCirculating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M., & Potthoff, M. J. (2014) · Diabetes · doi:10.2337/db14-0595 · Cited by 590 · see citing works
Gälman, C., Lundåsen, T., Kharitonenkov, A., Bina, H. A., Eriksson, M., Hafström, I., Dahlin, M., Åmark, P., Angelin, B., & Rudling, M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.014 · Cited by 512 · see citing works
Suomalainen, A., Elo, J. M., Pietiläinen, K. H., Hakonen, A. H., Sevastianova, K., Korpela, M., Isohanni, P., Marjavaara, S. K., Tyni, T., Kiuru-Enari, S., et al. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70155-7 · Cited by 427 · see citing works
FGF21 is an Akt‐regulated myokine
Izumiya, Y., Bina, H. A., Ouchi, N., Akasaki, Y., Kharitonenkov, A., & Walsh, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.021 · Cited by 415 · see citing works
Hondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Iglesias, R., & Villarroya, F. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.001 · Cited by 377 · see citing works
Self-citationFibroblast growth factor 21 protects against cardiac hypertrophy in mice
Planavila, A., Redondo‐Angulo, I., Hondares, E., Vinciguerra, M., Munts, C., Iglesias, R., Gabrielli, L., Sitges, M., Giralt, M., van Bilsen, M., et al. (2013) · Nature Communications · doi:10.1038/ncomms3019 · Cited by 371 · see citing works
Self-citationFGF‐21/FGF‐21 receptor interaction and activation is determined by βKlotho
Kharitonenkov, A., Dunbar, J. D., Bina, H. A., Bright, S. W., Moyers, J. S., Zhang, C., Ding, L., Micanovic, R., Mehrbod, S. F., Knierman, M. D., et al. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21357 · Cited by 329 · see citing works
Mitochondrial myopathy induces a starvation-like response
Tyynismaa, H., Carroll, C. J., Raimundo, N., Ahola-Erkkilä, S., Wenz, T., Ruhanen, H., Guse, K., Hemminki, A., Peltola-Mjøsund, K. E., Tulkki, V., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq310 · Cited by 300 · see citing works
Muise, E. S., Azzolina, B., Kuo, D. W., El-Sherbeini, M., Tan, Y., Yuan, X., Mu, J., Thompson, J. R., Berger, J. P., & Wong, K. K. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.044826 · Cited by 294 · see citing works
Fibroblast growth factor 21 protects the heart from oxidative stress
Planavila, A., Redondo‐Angulo, I., Ribas‐Aulinas, F., Garrabou, G., Casademont, J., Giralt, M., & Villarroya, F. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu263 · Cited by 265 · see citing works
Self-citationLehman, J. J., & Kelly, D. P. (2002) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2002.03655.x · Cited by 257 · see citing works
Molecular and Functional Signature of Heart Hypertrophy During Pregnancy
Eghbali, M., Deva, R., Alioua, A., Minosyan, T. Y., Ruan, H., Wang, Y., Toro, L., & Stefani, E. (2005) · Circulation Research · doi:10.1161/01.res.0000170652.71414.16 · Cited by 233 · see citing works
Doğan, Ş. A., Pujol, C., Maiti, P., Kukat, A., Wang, S., Hermans, S., Senft, K., Wibom, R., Rugarli, E. I., & Trifunović, A. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.004 · Cited by 222 · see citing works
Gallego-Escuredo, J. M., Gómez‐Ambrosi, J., Catalán, V., Domingo, P., Giralt, M., Frühbeck, G., & Villarroya, F. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.76 · Cited by 212 · see citing works
Self-citationFibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia
Hojman, P., Pedersen, M., Nielsen, A. R., Krogh-Madsen, R., Yfanti, C., Åkerstrom, T., Nielsen, S., & Pedersen, B. K. (2009) · Diabetes · doi:10.2337/db09-0713 · Cited by 198 · see citing works
Díaz-Delfín, J., Hondares, E., Iglesias, R., Giralt, M., Caelles, C., & Villarroya, F. (2012) · Endocrinology · doi:10.1210/en.2012-1193 · Cited by 195 · see citing works
Self-citationChow, W. S., Xu, A., Woo, Y. C., Tso, A. W. K., Cheung, S., Fong, C. H.-Y., Tse, H., Chau, M. T., Cheung, B. M. Y., & Lam, K. S. L. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301599 · Cited by 193 · see citing works
Eisele, P. S., Salatino, S., Sobek, J., Hottiger, M. O., & Handschin, C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.375253 · Cited by 187 · see citing works
Álvarez-Guardia, D., Palomer, X., Coll, T., Davidson, M. M., Chan, T. O., Feldman, A. M., Laguna, J. C., & Vázquez‐Carrera, M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq080 · Cited by 187 · see citing works
Lin, Z., Wu, Z., Yin, X., Liu, Y., Yan, X., Lin, S., Xiao, J., Wang, X., Feng, W., & Li, X. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015534 · Cited by 179 · see citing works
Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue
Liu, S. Q., Roberts, D., Kharitonenkov, A., Zhang, B., Hanson, S., Li, Y. C., Zhang, L., & Wu, Y. (2013) · Scientific Reports · doi:10.1038/srep02767 · Cited by 179 · see citing works
Novel Insights into the Cardio-Protective Effects of FGF21 in Lean and Obese Rat Hearts
Patel, V., Adya, R., Chen, J., Ramanjaneya, M., Bari, M. F., Bhudia, S. K., Hillhouse, E. W., Tan, B. K., & Randeva, H. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087102 · Cited by 124 · see citing works
Schilling, J. D., Lai, L., Sambandam, N., Dey, C. E., Leone, T. C., & Kelly, D. P. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.959833 · Cited by 121 · see citing works
The cardiokine story unfolds: ischemic stress-induced protein secretion in the heart
Doroudgar, S., & Glembotski, C. C. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.12.003 · Cited by 116 · see citing works
Fredj, S., Bescond, J., Louault, C., & Potreau, D. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20197 · Cited by 114 · see citing works
Joki, Y., Ohashi, K., Yuasa, D., Shibata, R., Ito, M., Matsuo, K., Kambara, T., Uemura, Y., Hayakawa, S., Hiramatsu‐Ito, M., et al. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.081 · Cited by 114 · see citing works
Zhang, C., Huang, Z., Gu, J., Yan, X., Lu, X., Zhou, S., Wang, S., Shao, M., Zhang, F., Cheng, P., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3630-8 · Cited by 113 · see citing works
Stachowiak, E. K., Fang, X., Myers, J. A., Dunham-Ems, S. M., & Stachowiak, M. K. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01624.x · Cited by 109 · see citing works
Št́astná, M., Chimenti, I., Marbán, E., & Eyk, J. E. V. (2009) · PROTEOMICS · doi:10.1002/pmic.200900515 · Cited by 101 · see citing works
Ong, K. L., Januszewski, A. S., O'Connell, R. L., Jenkins, A. J., Xu, A., SULLIVAN, D. R., Barter, P. J., Hung, W.-T., Scott, R. S., Taskinen, M., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3458-7 · Cited by 93 · see citing works
Aubert, G., Vega, R. B., & Kelly, D. P. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.08.015 · Cited by 91 · see citing works
Semba, R. D., Crasto, C., Strait, J., Sun, K., Schaumberg, D. A., & Ferrucci, L. (2012) · Journal of Human Hypertension · doi:10.1038/jhh.2012.52 · Cited by 87 · see citing works
FGF 21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation
Yan, X., Chen, J., Zhang, C., Zhou, S., Zhang, Z., Chen, J., Feng, W., Li, X., & Tan, Y. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12530 · Cited by 85 · see citing works
Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia
Liu, S. Q., Tefft, B. J., Roberts, D., Zhang, L., Ren, Y., Li, Y. C., Huang, Y., Zhang, D., Phillips, H. R., & Wu, Y. H. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00362.2012 · Cited by 75 · see citing works
Zhang, W., Chu, S., Ding, W., & Wang, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129791 · Cited by 70 · see citing works
Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
Brahma, M. K., Adam, R. C., Pollak, N. M., Jaeger, D., Zierler, K. A., Poecher, N., Schreiber, R., Romauch, M., Moustafa, T., Eder, S., et al. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m044784 · Cited by 70 · see citing works
An, S.-Y., Lee, M. S., Yi, S., Ha, E. S., Han, S. J., Kim, H. J., Kim, D. J., & Lee, K. W. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.01.004 · Cited by 69 · see citing works
Ribas, F., Villarroya, J., Hondares, E., Giralt, M., & Villarroya, F. (2014) · Biochemical Journal · doi:10.1042/bj20140403 · Cited by 69 · see citing works
Self-citationFrost, R. J., & Engelhardt, S. H. (2007) · Circulation · doi:10.1161/circulationaha.107.696468 · Cited by 59 · see citing works
Serum fibroblast growth factor 21 levels are increased in atrial fibrillation patients
Han, X., Chen, C., Cheng, G., Xie, C., Yang, M., Shou, X., & Sun, C. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.019 · Cited by 35 · see citing works
Lisa, F. D., & Itoh, N. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv050 · Cited by 28 · see citing works
Fibroblast Growth Factor‐21 and the Beneficial Effects of Long‐Chain n‐3 Polyunsaturated Fatty Acids
Villarroya, J., Flachs, P., Redondo‐Angulo, I., Giralt, M., Medříková, D., Villarroya, F., Kopecký, J., & Planavila, A. (2014) · Lipids · doi:10.1007/s11745-014-3948-x · Cited by 25 · see citing works
Self-citationHepatic FGF21 production is increased in late pregnancy in the mouse
Cui, Y., Giesy, S. L., Hassan, M., Davis, K., Zhao, S., & Boisclair, Y. R. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00554.2013 · Cited by 21 · see citing works
Liver cell-mediated alleviation of acute ischemic myocardial injury
Liu, S. Q. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e131 · Cited by 18 · see citing works
Shamagian, L. G., Romo, A. I., Castro, A. A. D. M., Alonso, J. A. B., Sáez, A. O., Blázquez, I. T. G., Sepulveda, J. A. S., Verdes, M. B. C., Correa, A. S., & Juan‐Salvadores, P. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu324 · Cited by 9 · see citing works
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The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
Geng, L., Lam, K. S. L., & Xu, A. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0386-0 · Cited by 607 · see citing works
Flippo, K. H., & Potthoff, M. J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00354-2 · Cited by 311 · see citing works
Wang, Q., Yuan, J., Yu, Z., Lin, L., Jiang, Y., Cao, Z., Zhuang, P., Whalen, M. J., Song, B., Wang, X., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0663-7 · Cited by 157 · see citing works
Roles of FGF Signals in Heart Development, Health, and Disease
Itoh, N., Ohta, H., Nakayama, Y., & Konishi, M. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00110 · Cited by 152 · see citing works
‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk
Aldiss, P., Davies, G., Woods, R., Budge, H., Sacks, H. S., & Symonds, M. E. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.074 · Cited by 148 · see citing works
New developments in the biology of fibroblast growth factors
Ornitz, D. M., & Itoh, N. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1549 · Cited by 143 · see citing works
Adipokines and cardiovascular disease: A comprehensive review
Smékal, A., & Václavík, J. (2017) · Biomedical Papers · doi:10.5507/bp.2017.002 · Cited by 105 · see citing works
Chou, R., Huang, P., Hsu, C., Chang, C. C., Leu, H., Huang, C., Chen, J., & Lin, S. (2016) · Scientific Reports · doi:10.1038/srep33953 · Cited by 82 · see citing works
Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis
Lakhani, I., Gong, M., Wong, W. T., Bazoukis, G., Lampropoulos, K. M., Wong, S. H., Wu, W. K. K., Wong, M. C. S., Ong, K. L., Liu, T., et al. (2018) · Metabolism · doi:10.1016/j.metabol.2018.01.017 · Cited by 76 · see citing works
An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction
Sun, J.-Y., Du, L., Shi, X., Zhang, Y., Liu, Y., Wang, Y.-L., Chen, B., Liu, T., Zhu, H., Liu, Y., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade4110 · Cited by 76 · see citing works
High Levels of Frataxin Overexpression Lead to Mitochondrial and Cardiac Toxicity in Mouse Models
Belbellaa, B., Reutenauer, L., Messaddeq, N., Monassier, L., & Puccio, H. M. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.08.018 · Cited by 75 · see citing works
Khosravi, F., Ahmadvand, N., Bellusci, S., & Sauer, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.672935 · Cited by 74 · see citing works
Use of FGF-21 as a Biomarker of Mitochondrial Disease in Clinical Practice
Morovat, A., Weerasinghe, G. R., Nesbitt, V., Hofer, M., Agnew, T., Quaghebeur, G., Sergeant, K., Fratter, C., Guha, N., Mirzazadeh, M., et al. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6080080 · Cited by 68 · see citing works
Jiang, Y., Lin, L., Liu, N., Wang, Q., Yuan, J., Li, Y., Chung, K. K., Guo, S., Yu, Z., & Wang, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030824 · Cited by 66 · see citing works
Croon, M., Szczepanowska, K., Popović, M., Lienkamp, C., Senft, K., Brandscheid, C. P., Bock, T., Gnatzy-Feik, L., Ashurov, A., Acton, R., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn7105 · Cited by 58 · see citing works
Growth Factors as Immunotherapeutic Targets in Cardiovascular Disease
Mindur, J. E., & Świrski, F. K. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.311994 · Cited by 57 · see citing works
New Treatment Strategies for Alcohol-Induced Heart Damage
Fernández‐Solà, J., & Porta, A. P. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101651 · Cited by 49 · see citing works
Jiang, Y., Liu, N., Wang, Q., Yu, Z., Lin, L., Yuan, J., Guo, S., Ahn, B. J., Wang, X., Li, X., et al. (2018) · Stroke · doi:10.1161/strokeaha.118.022119 · Cited by 49 · see citing works
Fgf21 is required for cardiac remodeling in pregnancy
Redondo‐Angulo, I., Mas‐Stachurska, A., Sitges, M., Tinahones, F. J., Giralt, M., Villarroya, F., & Planavila, A. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx088 · Cited by 48 · see citing works
Self-citationIntracellular to Interorgan Mitochondrial Communication in Striated Muscle in Health and Disease
Boardman, N. T., Trani, G., Scalabrin, M., Romanello, V., & Wüst, R. C. I. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad004 · Cited by 49 · see citing works
FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model
Xiao, Z., King, G. D., Mancarella, S., Munkhsaikhan, U., Cao, L., Cai, C., & Quarles, L. D. (2019) · JCI Insight · doi:10.1172/jci.insight.132820 · Cited by 46 · see citing works
Fibroblast growth factor 21 in heart failure
Tucker, W., Tucker, B., Rye, K., & Ong, K. L. (2022) · Heart Failure Reviews · doi:10.1007/s10741-022-10268-0 · Cited by 44 · see citing works
LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress
Xu, S., Wang, Y., Yu, M., Wang, D., Liang, Y., Chen, Y., Liao, C., Xie, Z., Zhao, B., Han, J., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109803 · Cited by 44 · see citing works
Gao, J., Liu, J., Meng, Z., Li, Y., Hong, Y., Wang, L., He, L., Hu, B. Q., Zheng, Y., Li, T., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.015 · Cited by 44 · see citing works
McCarty, M. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073321 · Cited by 40 · see citing works
Characterization of a robust mouse model of heart failure with preserved ejection fraction
Matsiukevich, D., Kovács, A. D., Li, T., Kokkonen-Simon, K. M., Matkovich, S. J., Oladipupo, S. S., & Ornitz, D. M. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00038.2023 · Cited by 37 · see citing works
Cardiokines as Modulators of Stress-Induced Cardiac Disorders
Planavila, A., Fernández‐Solà, J., & Villarroya, F. (2017) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2017.01.002 · Cited by 35 · see citing works
Self-citationChiba, A., Watanabe‐Takano, H., Miyazaki, T., & Mochizuki, N. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2723-6 · Cited by 35 · see citing works
Zhao, J., & Pei, L. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2020.05.007 · Cited by 35 · see citing works
Wei, Y., Wang, J., Cheng, F., Xu, H.-J., Chen, J., Xiong, J., & Wang, J. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00822-z · Cited by 34 · see citing works
Basurto, L., Gregory, M. A., Barrera-Hernández, S., Sánchez-Huerta, L., Martínez, A. D., Manuel‐Apolinar, L., Avelar‐Garnica, F. J., Alonso, L. A. M., & Sánchez‐Arenas, R. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.05.013 · Cited by 33 · see citing works
Ren, Z., Xiao, W., Zeng, Y., Liu, M., Li, G., Tang, Z., Qu, S., Hao, Y., Yuan, H., & Jiang, Z. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4071 · Cited by 33 · see citing works
Hu, S., Cao, S., & Liu, J. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4564 · Cited by 31 · see citing works
Ye, D., Li, H., Wang, Y., Jia, W., Zhou, J., Fan, J., Man, K., Lo, C., Wong, C., Wang, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep19776 · Cited by 32 · see citing works
Arias‐Calderón, M., Casas, M., Balanta‐Melo, J., Morales, C., Hernández, N., Llanos, P., Jaimovich, E., & Buvinic, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1059020 · Cited by 28 · see citing works
Yan, B., Mei, Z., Tang, Y., Song, H., Wu, H., Jing, Q., Zhang, X., Yan, C., & Han, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05842-9 · Cited by 28 · see citing works
Wang, N., Xu, T.-Y., Zhang, X., Li, J.-Y., Wang, Y.-X., Guo, X.-C., Li, S.-M., Wang, W.-F., & Li, D.-S. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.01.048 · Cited by 23 · see citing works
Ferrer‐Curriu, G., Guitart‐Mampel, M., Rupérez, C., Zamora, M., Crispi, F., Villarroya, F., Fernández‐Solà, J., Garrabou, G., & Planavila, A. (2020) · The Journal of Pathology · doi:10.1002/path.5573 · Cited by 26 · see citing works
Self-citationSchmitz, T., Harmel, E. K., Heier, M., Peters, A., Linseisen, J., & Meisinger, C. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03644-9 · Cited by 26 · see citing works
HFpEF and MASLD: converging mechanisms and clinical implications
Capone, F., Häseli, S. P., Liu, L., Strocchi, S., Langenberg, C., Lusis, A. J., Pietzner, M., Muoio, D. M., Rider, O. J., Raman, B., et al. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-026-01257-z · Cited by 32 · see citing works
Yanucil, C., Kentrup, D., Li, X., Grabner, A., Schramm, K. J., Martinez, E. C., Li, J., Campos, I. D., Czaya, B. A., Heitman, K., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11033-x · Cited by 25 · see citing works
Puengel, T., & Tacke, F. (2023) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2023.2230115 · Cited by 24 · see citing works
Pérez‐Martí, A., Sandoval, V., Marrero, P. F., Haro, D., & Relat, J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0034 · Cited by 24 · see citing works
Cao, F., Liu, X., Cao, X., Wang, S., Fu, K., Zhao, Y., Shen, F., & Liu, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.160 · Cited by 24 · see citing works
Gu, L., Jiang, W., Huidong, Q., Zheng, R., & Li, W. (2021) · PeerJ · doi:10.7717/peerj.12235 · Cited by 23 · see citing works
Crosstalk between adipose tissue and the heart: An update
Li, C., Sun, X., Zhao, S., & Scherer, P. E. (2022) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2022-0039 · Cited by 22 · see citing works
Fan, L., Gu, L., Yao, Y., & Ma, G. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/7138776 · Cited by 20 · see citing works
Kaur, N., Gare, S. R., Ruiz‐Velasco, A., Miller, J. M., Abouleisa, R., Ou, Q., Shen, J., Soran, H., Mohamed, T., & Liu, W. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14952 · Cited by 18 · see citing works
Lurins, J., Lūriņa, D., Svirskis, Š., Nora-Krūkle, Z., Tretjakovs, P., Mackēvičs, V., Lejnieks, A., Rapisarda, V., & Baylon, V. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7254 · Cited by 18 · see citing works
Huang, W., Chen, C., Lin, T., Kuo, C., Huang, H., Huang, P., & Lin, S. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17273 · Cited by 18 · see citing works
Cheung, J., Cheung, B. M. Y., Yiu, K., Tse, H., & Chan, Y. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1573841 · Cited by 15 · see citing works
Lee, M., Kim, K. J., Chung, T., Bae, J., Lee, Y., Lee, B., Cha, B., Yun, M., & Kang, E. S. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14310 · Cited by 15 · see citing works
Jung, C., Jung, S.-H., Kim, B., Kim, C., Kang, S., & Mok, J. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.10.017 · Cited by 15 · see citing works
Fibroblast growth factor-21 as a novel metabolic factor for regulating thrombotic homeostasis
Li, S., Jia, H., Liu, Z., Wang, N., Guo, X., Cao, M., Fang, F., Yang, J., Li, J., He, Q., et al. (2022) · Scientific Reports · doi:10.1038/s41598-021-00906-2 · Cited by 14 · see citing works
Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress
Liu, A., Zhang, Y., Xun, S., Zhou, G., Lin, L., & Mei, Y. (2022) · Peptides · doi:10.1016/j.peptides.2022.170786 · Cited by 14 · see citing works
Increased serum chemerin level to predict early onset of aortic valve stenosis
Lurins, J., Lūriņa, D., Tretjakovs, P., Mackēvičs, V., Lejnieks, A., Rapisarda, V., & Baylon, V. (2017) · Biomedical Reports · doi:10.3892/br.2017.1010 · Cited by 12 · see citing works
From Beats to Metabolism: the Heart at the Core of Interorgan Metabolic Cross Talk
Romero-Becerra, R., Santamans, A. M., Arcones, A. C., & Sabio, G. (2023) · Physiology · doi:10.1152/physiol.00018.2023 · Cited by 12 · see citing works
Xiao, M., Tang, Y., Wang, S., Wang, J., Wang, J., Guo, Y., Zhang, J., & Gu, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.598008 · Cited by 12 · see citing works
García‐Carrizo, F., Galmés, S., Picó, C., Palou, A., & Rodríguez, A. M. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c03143 · Cited by 11 · see citing works
Prognostic Utility of Circulating Growth Factors in Aortic Valve Stenosis: A Pilot Study
Hofmanis, J., Tretjakovs, P., Svirskis, Š., Gersone, G., Hofmane, D., Rozenberga, U., Blumfelds, L., Bahs, G., Lejnieks, A., & Mackēvičs, V. (2021) · Medicina · doi:10.3390/medicina57010078 · Cited by 11 · see citing works
Li, J., Li, Y., Liu, Y., Yu, H., Xu, N., Huang, D., Xue, Y., Li, S., Chen, H., Liu, J., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.715466 · Cited by 10 · see citing works
Intermittent Fasting as Possible Treatment for Heart Failure
Garza-González, S., Nieblas, B., Solbes-Gochicoa, M. M., Altamirano, J., & Garcı́a, N. (2022) · Current Vascular Pharmacology · doi:10.2174/1570161120666220610151915 · Cited by 11 · see citing works
Gu, L., Jiang, W., Jiang, W., Xu, Z., Li, W., & Zhang, H. (2023) · PeerJ · doi:10.7717/peerj.14855 · Cited by 9 · see citing works
Aleem, M., Maqsood, H., Younus, S., Zafar, A. F., Talpur, A. S., & Shakeel, H. A. (2021) · Cureus · doi:10.7759/cureus.17723 · Cited by 9 · see citing works
Hepatokines and their role in cardiohepatic interactions in heart failure
Shouman, W. A., Najmeddine, S., Sinno, L., Nehme, R. D., Ghawi, A. E., Ziade, J. A., Altara, R., Amin, G., Booz, G. W., & Zouein, F. A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177356 · Cited by 8 · see citing works
Emerging Evidence Linking the Liver to the Cardiovascular System: Liver-derived Secretory Factors
Liu, X., Shao, Y., Han, L., Zhang, R., & Chen, J. (2023) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2022.00122 · Cited by 8 · see citing works
Functions of FGF21 and its role in cardiac hypertrophy
Chen, L., Gao, M., Ong, S., & Gong, G. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.03.007 · Cited by 7 · see citing works
The Adipokine Axis in Heart Failure: Linking Obesity, Sarcopenia and Cardiac Dysfunction in HFpEF
Komić, L., Komic, J., Pavlović, N., Kumrić, M., Bukić, J., Tomić, I. J., & Božić, J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020612 · Cited by 7 · see citing works
Feng, E., Wang, J., Wang, X., Wang, Z., Chen, X., Zhu, X. C., & Hou, W. (2021) · Europe PMC (PubMed Central) · doi:10.22037/ijpr.2020.113584.14384 · Cited by 7 · see citing works
Thioredoxin-1 and Correlations of the Plasma Cytokines Regarding Aortic Valve Stenosis Severity
Tretjakovs, P., Lurins, J., Svirskis, Š., Gersone, G., Lūriņa, D., Rozenberga, U., Blumfelds, L., Bahs, G., Lejnieks, A., & Mackēvičs, V. (2021) · Biomedicines · doi:10.3390/biomedicines9081041 · Cited by 7 · see citing works
Research Progress of Fibroblast Growth Factor 21 in Fibrotic Diseases
Jia, M.-Q., Guan, C., Tao, J., & Zhou, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5042762 · Cited by 7 · see citing works
The burn repair molecule? Evaluating FGF-21 in thermal injury – A systematic review
Niederegger, T., Schaschinger, T., Brandt, J., Knoedler, L., Knoedler, S. A., Palackic, A., Klimitz, F. J., Noll, D., Most, P., Ritterhoff, J., et al. (2025) · Burns · doi:10.1016/j.burns.2025.107785 · Cited by 6 · see citing works
Liu, X., Dong, M., Li, T., & Wang, J. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156591 · Cited by 6 · see citing works
Role of serum cytokines in the prediction of heart failure in patients with coronary artery disease
Hou, Q., Sun, Z., Zhao, L., Liu, Y., Zhang, J., Huang, J., Luo, Y., Xiao, Y., Hu, Z., & Shen, A. (2023) · ESC Heart Failure · doi:10.1002/ehf2.14491 · Cited by 5 · see citing works
Rama, K., Jahagirdar, V., & Sanyal, A. J. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s560034 · Cited by 6 · see citing works
Heart Failure and Osteoporosis: Shared Challenges in the Aging Population
Spoladore, R., Ciampi, C. M., Ossola, P., Sultana, A., Spreafico, L. P., Farina, A., & Fragasso, G. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12020069 · Cited by 5 · see citing works
Peng, Z., Gao, L., Zhang, L., Yao, R., Li, X., Deng, L. J., Fan, J., Ying, L., & Wang, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146577 · Cited by 5 · see citing works
Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases
Srivastava, H., Pozzoli, M., & Lau, E. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.884321 · Cited by 5 · see citing works
UPRmt-regulated mitokines: novel strategies for myocardial injury repair
Gao, W., Liu, J., Zhang, W., Liu, B., & Shen, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1652353 · Cited by 4 · see citing works
Prognostic Utility Of Novel Biomarkers in Aortic Valve Stenosis
Tretjakovs, P., Hofmanis, J., Hofmane, D., Krieviņa, G., Blumfelds, L., Mackēvičs, V., Lejnieks, A., & Bahs, G. (2019) · Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences · doi:10.2478/prolas-2019-0016 · Cited by 4 · see citing works
Michaëlsson, K., Lemming, E. W., Larsson, S. C., Höijer, J., Melhus, H., Svennblad, B., Baron, J. A., Wolk, A., & Byberg, L. (2024) · BMC Medicine · doi:10.1186/s12916-024-03651-1 · Cited by 4 · see citing works
Pedersen, A. K. N., Hage, C., Jessen, N., Mellbin, L., & Bjerre, M. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111738 · Cited by 4 · see citing works
Therapeutic potential of FGF21 in diabetes
Davis, D., Garg, C., & Lahiri, S. (2017) · Journal of Medicinal Plants Studies · Cited by 4 · see citing works
Pinheiro, F., Lail, H. L., Neves, J. S., Negrão, R., & Wanders, D. (2024) · Nutrients · doi:10.3390/nu16244347 · Cited by 3 · see citing works
Li, Y., Song, W., Huan, C., Xu, K., Sun, J., Zhen, X., Ouyang, H., Tang, H., Fan, Q., Zhi, W., et al. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109089 · Cited by 3 · see citing works
Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism
Yang, Z., Zarbl, H., & Guo, G. L. (2024) · Molecular Pharmacology · doi:10.1124/molpharm.123.000831 · Cited by 3 · see citing works
Zhu, Z., Gao, Z., Chen, B., Hall, D. D., Minerath, R. A., Koval, O. M., Sierra, A., Subbotina, E., Zhu, X., Kim, Y. R., et al. (2021) · EP Europace · doi:10.1093/europace/euab273 · Cited by 3 · see citing works
The Role of Adipose Tissue in Cardiovascular Pathophysiology
Maya-Ramos, L., Gillette, T. G., Hill, J. A., & Scherer, P. E. (2023) · CardioMetabolic Syndrome Journal · doi:10.51789/cmsj.2023.3.e9 · Cited by 3 · see citing works
FGF21: a promising therapeutic agent for alcoholic cardiomyopathy?†
Romanello, V. (2021) · The Journal of Pathology · doi:10.1002/path.5654 · Cited by 3 · see citing works
Chen, L., Zheng, L., Qin, Y. H., Liu, B., Zheng, Y., Tong, X., Dai, M., & Gong, G. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.10.053 · Cited by 2 · see citing works
Li, M. (2021) · Aging Pathobiology and Therapeutics · doi:10.31491/apt.2021.09.065 · Cited by 2 · see citing works
Alieva, A. M., Baikova, I. E., Reznik, E. V., Valiev, R. K., Akhmatov, I. Z., Arakelyan, R. A., Saryev, M. N., & Nikitin, I. G. (2022) · Russian Medicine · doi:10.17816/medjrf108900 · Cited by 2 · see citing works
Shanehbandpour-Tabari, F., Gholamnataj, F., Neamati, N., Zabihi, E., Feizi, F., & Parsian, H. (2024) · Iranian journal of pharmaceutical research · doi:10.5812/ijpr-142903 · Cited by 2 · see citing works
Hung, W., Yu, T., Wang, C.-P., Hsu, C., Lu, Y., Wei, C., Chung, F., Lee, Y., Wu, C., & Tang, W.-H. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02868-3 · Cited by 1 · see citing works
Cappellini, F., Zorzan, D., Tomay, F., Toccaceli, M., Marinelli, A., Mancini, M., Bucchi, A., Tonelli, C., & Petroni, K. (2025) · Oxidative Medicine and Cellular Longevity · doi:10.1155/omcl/7786043 · Cited by 1 · see citing works
Chetana, S., & Kalyani, B. (2025) · Cardiovascular Toxicology · doi:10.1007/s12012-025-10079-3 · Cited by 1 · see citing works
Lin, X., Davidsohn, N., Boyce, S., McIntyre, M., Zhang, M., Gencarelli, M., Ascheim, D. D., Delmar, M., & Cerrone, M. (2026) · Heart Rhythm · doi:10.1016/j.hrthm.2026.02.030 · Cited by 1 · see citing works
Therapeutic potential of FGF21 in cardiorenal syndrome
Li, F., Tang, C., & Dong, Z. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.03.142 · Cited by 1 · see citing works
Heart dysfunction in a rat model with autosomal recessive polycystic kidney disease
Gayrard, N., Plawecki, M., Lauret, C., Fila, M., Sicard, P., Duranton, F., Boukhaled, J. H., Cortijo, I., Lotierzo, M., Jover, B. F., et al. (2025) · The Journal of Physiology · doi:10.1113/jp286364 · Cited by 1 · see citing works
Correlations between vessel stiffness and biomarkers of senescent cell in elderly patients
Sorokina, A. G., Efimenko, A. Y., Grigorieva, O., Novoseletskaya, E. S., Basalova, N. A., Aleksandrushkina, N. A., Vigovskiy, M. A., Kirillova, K. I., Strazhesko, I. D., Orlov, A. V., et al. (2022) · Kardiologiia · doi:10.18087/cardio.2022.6.n2033 · Cited by 1 · see citing works
- Authors
- Planavila, A., Redondo-Angulo, I., & Villarroya, F.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Corresponding author
- Villarroya, Francesc
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2015-08-31
- Volume
- 6
- Pages
- 133-133
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC4553397
- OpenAlex
- W1800862889
- Cited by
- 123
- References
- 59
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 8 · 2023: 16 · 2022: 21 · 2021: 21 · 2020: 5 · 2019: 10 · 2018: 3 · 2017: 10 · 2016: 8
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fundación BBVA
- European Commission (277713)
- Generalitat de Catalunya (2014SGR-141, 2014SGR)
- Eusko Jaurlaritza
- Banco Bilbao Vizcaya Argentaria
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
- Keywords
- FGF21, β-Klotho, cardiac hypertrophy, myocardial infarction, cardiac inflammation, oxidative stress, PPARα, SIRT1, coronary artery disease, atherosclerosis, type 2 diabetes, heart failure, cardiovascular risk
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