FGF21 N‐ and C‐termini play different roles in receptor interaction and activation

Yie, Junming; Hecht, Randy; Patel, Jennifer; Stevens, Jennitte; Wang, Wei; Hawkins, Nessa; Steavenson, Shirley; Smith, Steve; Winters, Dwight; Fisher, Seth; Cai, Ling; Belouski, Ed; Chen, Ching; Michaels, Mark L.; Li, Yue-Sheng; Lindberg, Richard; Wang, Minghan; Véniant, Murielle; Xu, Jing

doi:10.1016/j.febslet.2008.11.023

Cited by 149Fibroblast Growth Factor ResearchParathyroid Disorders and TreatmentsConnective Tissue Growth Factor Research

FGF21 N‐ and C‐termini play different roles in receptor interaction and activation

Yie, Junming, Hecht, Randy, Patel, Jennifer, Stevens, Jennitte, Wang, Wei, Hawkins, Nessa, Steavenson, Shirley, Smith, Steve +11 more·2009·FEBS Letters

DOI 10.1016/j.febslet.2008.11.023

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Abstract

MINT‐6799907, MINT‐6799922: FGF21 (uniprotkb: Q9NSA1) binds (MI:0407) to β‐Klotho (uniprotkb: Q86Z14) by surface plasmon resonance (MI:0107)

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FGF21 is cleaved by FAP and DPP-IV; cleavage at residue 171 inactivates FGF21 because the last ten residues are critical for KLB interaction.
“FGF21 is also subject to proteolytic cleavage by the serine proteases fibroblast activation protein (FAP) and dipeptidyl peptidase IV (DPP-IV)42,43.”
From Metabolic messengers: FGF21 (2021) · cites this paper as [45]
FGF21 directly binds to KLB, which facilitates binding to FGFR1c and initiates downstream signaling.
“FGF21 directly binds to KLB, which then facilitates binding to FGFR1c and then initiates downstream signaling events [[146], [147], [148], [149]].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [147]
Deletion of the 10 residues on the C terminus of human FGF21 disrupts its ability to interact with β-klotho and signal to target tissues.
“The deletion of these 10 residues on the C terminus of human FGF21 disrupts its ability to interact with β-klotho and signal to target tissues (89, 144).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [144]

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Different roles of N‐ and C‐ termini in the functional activity of FGF21
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FGF‐21/FGF‐21 receptor interaction and activation is determined by βKlotho
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The FGFR D3 Domain Determines Receptor Selectivity For Fibroblast Growth Factor 21
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Authors: Yie, J., Hecht, R., Patel, J., Stevens, J., Wang, W., Hawkins, N., Steavenson, S., Smith, S., Winters, D., Fisher, S., Cai, L., Belouski, E., Chen, C., Michaels, M. L., Li, Y.-S., Lindberg, R., Wang, M., Véniant, M., & Xu, J.
Affiliations: Amgen (United States) (US)
Corresponding author: Yie, Junming
ORCID: Yie, Junming
Stevens, Jennitte
Wang, Wei
Véniant, Murielle
Xu, Jing
Venue: FEBS Letters
Publisher: Wiley
Published: 2008-12-04
Volume: 583
Issue: 1
Pages: 19-24
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/j.febslet.2008.11.023
OpenAlex: W2076037986
Cited by: 149
References: 22
Citations by year: 2026: 5 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 10 · 2019: 4 · 2018: 13 · 2017: 13 · 2016: 13 · 2015: 10 · 2014: 12 · 2013: 9 · 2012: 17
FWCI: 2.19
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Keywords: FGF21, β-Klotho, receptor binding, partial agonists, co-receptors
MeSH terms: Klotho Proteins, Amino Acid Sequence, Cell Line, Fibroblast Growth Factors, Humans, Luciferases, Membrane Proteins, Molecular Sequence Data, Protein Structure, Tertiary, Genes, Reporter, Receptor, Fibroblast Growth Factor, Type 1

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FGF21 N‐ and C‐termini play different roles in receptor interaction and activation

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