Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary
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Objective To investigate whether angiotensin (Ang)-(1-7), its receptor Mas, and angiotensin-converting enzyme type 2 (ACE2) are present in human ovary. Design Cross-sectional study. Setting Academic hospital. Patient(s) Twelve reproductive-age women and five postmenopausal women undergoing oophorectomy for nonovarian diseases and seven women having controlled ovarian hyperstimulation for IVF. Intervention(s) Ovarian tissue was obtained from the reproductive-age women and postmenopausal women undergoing oophorectomy for nonovarian diseases. Follicular fluid (FF) samples were obtained from the women having controlled ovarian hyperstimulation for IVF. Main outcome measure(s) Localization of Ang-(1-7) and Mas by immunohistochemistry; measurement of Ang-(1-7) in ovarian FF by RIA; detection of messenger RNAs encoding Mas and ACE2 with use of real-time polymerase chain reaction; assessment of 125I-labeled Ang-(1-7) binding to ovarian sections with use of autoradiographic binding assay. Result(s) Angiotensin-(1-7) and the receptor Mas were localized to primordial, primary, secondary, and antral follicles, stroma, and corpora lutea of reproductive-age ovaries. Postmenopausal women expressed both the peptide and its receptor in the ovarian stroma. Angiotensin-(1-7) was detectable in FF (mean±SE: 191±54 pg/mL). Both Mas and ACE2 messenger RNAs were expressed in ovarian tissue, as revealed by real-time polymerase chain reaction, and ovarian binding sites for 125I-labeled Ang-(1-7) were identified by autoradiography. Conclusion(s) Angiotensin-(1-7), its receptor Mas, and ACE2 are expressed in the human ovary. The peptide is present in several ovarian compartments and can be quantified in FF.
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In the human ovary, local RAS is involved in supporting oogenesis, regulating ovulation function, synthesizing steroid hormones, and mediating gonadotropin function.
“In the human ovary, local RAS is involved in many important physiological processes such as supporting oogenesis, regulating ovulation function, synthesizing steroid hormones, and mediating gonadotropin function [7, 23–25].”
Cites
Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M. L., Stagliano, N. E., Donovan, M. J., Woolf, B., Robison, K. E., Jeyaseelan, R., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.5.e1 · Cited by 3,084 · see citing works
Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
Santos, R. A. S., Silva, A. C. S. E., Maric, C., Silva, D. M. R., Machado, R. P., de Buhr, I., Heringer‐Walther, S., Pinheiro, S. V. B., Lopes, M. T., Bäder, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432869100 · Cited by 1,805 · see citing works
Self-citationIntercellular Communication in the Mammalian Ovary: Oocytes Carry the Conversation
Matzuk, M. M., Burns, K. H., Viveiros, M. M., & Eppig, J. J. (2002) · Science · doi:10.1126/science.1071965 · Cited by 947 · see citing works
Recent advances in the angiotensin‐converting enzyme 2–angiotensin(1–7)–Mas axis
Santos, R. A. S., Ferreira, A. J., & Silva, A. C. S. E. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2008.042002 · Cited by 433 · see citing works
Self-citationSantos, R. A. S., Campagnole‐Santos, M. J., & Andrade, S. P. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00138-5 · Cited by 382 · see citing works
Self-citationNavot, D., Margalioth, E. J., Laufer, N., Birkenfeld, A., Relou, A., Rösler, A., & Schenker, J. G. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59290-5 · Cited by 185 · see citing works
Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain
Becker, L. K., Etelvino, G. M., Walther, T., Santos, R. A. S., & Campagnole‐Santos, M. J. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00141.2007 · Cited by 155 · see citing works
Self-citationBlockage of Ovulation by an Angiotensin Antagonist
Pellicer, A., Palumbo, A., DeCherney, A. H., & Naftolin, F. N. (1988) · Science · doi:10.1126/science.3381087 · Cited by 153 · see citing works
Vaz‐Silva, J., Carneiro, M. M., Ferreira, M. C. F., Pinheiro, S. V. B., Silva, D. A., Silva, A. L., Witz, C. A., dos Reis, A. M., Santos, R. A. S., & dos Reis, F. M. (2009) · Reproductive Sciences · doi:10.1177/1933719108327593 · Cited by 139 · see citing works
Self-citationLightman, A., Tarlatzis, B. C., Rzasa, P. J., Culler, M. D., Caride, V. J., Negro-Vilar, A. F., Lennard, D. E., DeCherney, A. H., & Naftolin, F. N. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(87)90336-x · Cited by 120 · see citing works
Yoshimura, Y., Karube, M., Aoki, H., Oda, T., Koyama, N., Nagai, A., Akimoto, Y., Hirano, H., & Nakamura, Y. (1996) · Endocrinology · doi:10.1210/endo.137.4.8625890 · Cited by 108 · see citing works
The Ovarian Renin–Angiotensin System in Reproductive Physiology
Yoshimura, Y. (1997) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1997.0152 · Cited by 108 · see citing works
Gonadotropin stimulates ovarian renin-angiotensin system in the rabbit.
Yoshimura, Y., Koyama, N., Karube, M., Oda, T., Akiba, M., Yoshinaga, A., Shiokawa, S., Jinno, M., & Nakamura, Y. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116943 · Cited by 98 · see citing works
Yoshimura, Y., Karube, M., Oda, T., Koyama, N., Shiokawa, S., Akiba, M., Yoshinaga, A., & Nakamura, Y. (1993) · Endocrinology · doi:10.1210/endo.133.4.8404601 · Cited by 98 · see citing works
Relationship between endogenous testosterone and cardiovascular risk in early postmenopausal women
Maturana, M. A., Breda, V., Lhullier, F. L. R., & Spritzer, P. M. (2008) · Metabolism · doi:10.1016/j.metabol.2008.02.012 · Cited by 95 · see citing works
The pathogenesis of the ovarian hyperstimulation syndrome (OHS): a possible role for ovarian renin
Ong, A. C. M., Eisen, V. D., Rennie, D. P., Homburg, R., Lachelin, G. C. L., Jacobs, H. S., & Slater, J. D. (1991) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1991.tb01734.x · Cited by 91 · see citing works
Angiotensin II directly induces follicle rupture and oocyte maturation in the rabbit
Yoshimura, Y., Karube, M., Koyama, N., Shiokawa, S., Nanno, T., & Nakamura, Y. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80701-h · Cited by 90 · see citing works
Pereira, V. M., Reis, F. M., Santos, R. A. S., Cassali, G. D., Santos, S. H. S., Honorato-Sampaio, K., & dos Reis, A. M. (2009) · Reproductive Sciences · doi:10.1177/1933719109343309 · Cited by 88 · see citing works
Self-citationBotelho, L. M. O., Block, C. H., Khosla, M. C., & Santos, R. A. S. (1994) · Peptides · doi:10.1016/0196-9781(94)90103-1 · Cited by 82 · see citing works
Self-citationAngiotensin-(1–7): A Novel Peptide in the Ovary
Costa, A. P. R., Fagundes-Moura, C. R., Pereira, V. M., Silva, L. F., Vieira, M. A. R., Santos, R. A. S., & dos Reis, A. M. (2003) · Endocrinology · doi:10.1210/en.2002-220787 · Cited by 75 · see citing works
Self-citationSilva, A. C. S. E., Diniz, J. S. S., Filho, A. R., & Santos, R. A. S. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.03.055 · Cited by 68 · see citing works
Self-citationGonçalves, A. C. D. C., Leite, R., Fraga-Silva, R. A., Pinheiro, S. V. B., Reis, A. B., dos Reis, F. M., Touyz, R. M., Webb, R. C., Alenina, N. V., Bäder, M., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00173.2007 · Cited by 64 · see citing works
Self-citationPalumbo, A., Pourmotabbed, G., Carcangiu, M. L., Andrade‐Gordon, P., Roa, L., DeCherney, A. H., & Naftolin, F. N. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56098-1 · Cited by 63 · see citing works
STRUCTURAL VARIATIONS IN THE ADULT OVARY. CLINICAL SIGNIFICANCE.
Jh, B., Scully, R. E., Kh, W., & Rb, C. (1965) · PubMed · Cited by 63 · see citing works
Angiotensin II: An Intraovarian Regulatory Peptide
Bumpus, F. M., Pucell, A. G., DAUD, A. I., & Husain, A. (1988) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198804000-00031 · Cited by 48 · see citing works
Involvement of Angiotensin II in the Process of Gonadotropin-lnduced Ovulation in Rabbits
Kuji, N., Sueoka, K., Miyazaki, T., Tanaka, M., Oda, T., Kobayashi, T., & Yoshimura, Y. (1996) · Biology of Reproduction · doi:10.1095/biolreprod55.5.984 · Cited by 47 · see citing works
DAUD, A. I., Bumpus, F. M., & Husain, A. (1990) · Endocrinology · doi:10.1210/endo-126-6-2927 · Cited by 47 · see citing works
Harata, T., Ando, H., Iwase, A., Nagasaka, T., Mizutani, S., & Kikkawa, F. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.01.041 · Cited by 40 · see citing works
Serum total renin is elevated in women with polycystic ovarian syndrome
Jaatinen, T.-A., Matinlauri, I. H., Anttila, L., Koskinen, P. J., Erkkola, R., & Irjala, K. M. A. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57537-2 · Cited by 30 · see citing works
Ohta, N., Takahashi, T., Mori, T., Park, M. K., Kawashima, S., Takahashi, K., & Kobayashi, H. (1992) · European Journal of Endocrinology · doi:10.1530/acta.0.1270262 · Cited by 28 · see citing works
Pereira, V. M., Costa, A. P. R., Rosa-e-Silva, A. A., Vieira, M. A. R., & dos Reis, A. M. (2008) · Peptides · doi:10.1016/j.peptides.2008.08.005 · Cited by 12 · see citing works
Self-citationNeutral endopeptidase is expressed on the follicular granulosa cells of rabbit ovaries
Zappulla, J. P., & DesGroseillers, L. (2001) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(01)00390-6 · Cited by 11 · see citing works
Angiotensin-(1-7) in the Rabbit Ovary: A Novel Local Regulator of Ovulation.
dos Reis, A. M., Viana, G. E. N., Pereira, V. M., & Santos, R. A. S. (2009) · Biology of Reproduction · doi:10.1093/biolreprod/81.s1.566 · Cited by 4 · see citing works
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The ACE2/angiotensin-(1-7)/MAS Axis of the renin-angiotensin system: focus on angiotensin-(1-7)
Santos, R. A. S., Sampaio, W. O., Alzamora, A. C., Motta-Santos, D., Alenina, N., Bader, M., & Campagnole-Santos, M. J. (2018) · Physiological Reviews · doi:10.1152/physrev.00023.2016 · Cited by 1,144 · see citing works
Self-citationPotential influence of COVID-19/ACE2 on the female reproductive system
Jing, Y., Li, R.-Q., Wang, H., Hao-Ran, C., Liu, Y.-B., Gao, Y., & Chen, F. (2020) · Molecular Human Reproduction · doi:10.1093/molehr/gaaa030 · Cited by 411 · see citing works
Karnik, S. S., Ünal, H., Kemp, J. R., Tirupula, K. C., Eguchi, S., Vanderheyden, P., & Thomas, W. G. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.010454 · Cited by 302 · see citing works
Angiotensin-(1–7): beyond the cardio-renal actions
Passos-Silva, D. G., Verano‐Braga, T., & Santos, R. A. S. (2012) · Clinical Science · doi:10.1042/cs20120461 · Cited by 241 · see citing works
Self-citationPotential risks of SARS-CoV-2 infection on reproductive health
Li, R., Yin, T., Fang, F., Li, Q., Chen, J., Wang, Y., Hao, Y., Wu, G., Duan, P., Wang, Y., et al. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.04.018 · Cited by 198 · see citing works
Madjunkov, M., Dviri, M., & Librach, C. L. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00737-1 · Cited by 184 · see citing works
Mas and Its Related G Protein–Coupled Receptors, Mrgprs
Bäder, M., Alenina, N. V., Andrade-Navarro, M. A., & Santos, R. A. S. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008136 · Cited by 179 · see citing works
Self-citationUterine bleeding: how understanding endometrial physiology underpins menstrual health
Jain, V., Chodankar, R. R., Maybin, J. A., & Critchley, H. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00629-4 · Cited by 188 · see citing works
Ding, T., Wang, T., Zhang, J., Cui, P., Chen, Z., Zhou, S., Yuan, S., Ma, W., Zhang, M., Rong, Y., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.635255 · Cited by 165 · see citing works
Does mRNA SARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle?
Orvieto, R., Noach‐Hirsh, M., Segev-Zahav, A., Haas, J., Nahum, R., & Aizer, A. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00757-6 · Cited by 133 · see citing works
Sex Disparities in COVID-19 Severity and Outcome: Are Men Weaker or Women Stronger?
Pivonello, R., Auriemma, R. S., Pivonello, C., Isidori, A. M., Corona, G., Colao, A. A. L., & Millar, R. P. (2020) · Neuroendocrinology · doi:10.1159/000513346 · Cited by 132 · see citing works
Impact of COVID-19 on the Endocrine System: A Mini-review
Clarke, S. A., Abbara, A., & Dhillo, W. S. (2021) · Endocrinology · doi:10.1210/endocr/bqab203 · Cited by 112 · see citing works
Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury
Rey-Parra, G., Vadivel, A., Coltan, L., Hall, A., Eaton, F., Schuster, M., Loibner, H., Penninger, J. M., Kassiri, Z., Oudit, G. Y., et al. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0859-2 · Cited by 112 · see citing works
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Pan, P., Zhan, Q., Fang, L., Zheng, Y., & Jin, F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141021071 · Cited by 113 · see citing works
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Anifandis, G., Messini, C. I., Daponte, A. I., & Messinis, I. E. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.05.001 · Cited by 110 · see citing works
Wang, M., Yang, Q., Ren, X., Hu, J., Zhou, L., Long, R., Xi, Q., Zhu, L., & Jin, L. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2021.101013 · Cited by 103 · see citing works
Wicik, Z., Eyileten, C., Jakubik, D., Simões, S. N., Martins, D., Pavão, R., Siller-Matula, J. M., & Postula, M. A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113743 · Cited by 100 · see citing works
Garg, I., Shekhar, R., Sheikh, A. B., & Pal, S. (2021) · Infectious Disease Reports · doi:10.3390/idr13030064 · Cited by 99 · see citing works
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Herr, D., Bekes, I., & Wulff, C. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00150 · Cited by 91 · see citing works
Does COVID-19 infection influence patients’ performance during IVF-ET cycle?: an observational study
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Herrero, Y., Pascuali, N., Velázquez, C., Oubiña, G., Hauk, V. C., de Zúñiga, I., Peña, M. G., Martínez, G., Lavolpe, M., Veiga, M. F., et al. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166295 · Cited by 80 · see citing works
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Narasimhan, K., Anantharaj, R., Xue, B., Yew, W. S., Velan, S. S., Karnani, N., & Leow, M. K. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00480.2020 · Cited by 77 · see citing works
Honorato‐Sampaio, K., Pereira, V. M., Santos, R. A. S., & Reis, A. M. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2011.061960 · Cited by 75 · see citing works
Self-citationThe Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature
Carp-Velişcu, A., Mehedințu, C., Frîncu, F., Brătilă, E., Rasu, S., Iordache, I., Bordea, A. E., & BRAGA, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19020984 · Cited by 69 · see citing works
IVF under COVID-19: treatment outcomes of fresh ART cycles
Youngster, M., Avraham, S., Yaakov, O., Rabbi, M. L., Gat, I., Yerushalmi, G., Sverdlove, R., Baum, M., Maman, E., Hourvitz, A., et al. (2022) · Human Reproduction · doi:10.1093/humrep/deac043 · Cited by 69 · see citing works
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Rajak, P., Roy, S., Dutta, M., Podder, S., Sarkar, S., Ganguly, A., Mandi, M., & Khatun, S. (2021) · Reproductive Biology · doi:10.1016/j.repbio.2021.100559 · Cited by 60 · see citing works
Oocyte Cryopreservation in Domestic Animals and Humans: Principles, Techniques and Updated Outcomes
Tharasanit, T., & Thuwanut, P. (2021) · Animals · doi:10.3390/ani11102949 · Cited by 60 · see citing works
Gonçalves, P. B., Ferreira, R., Gasperin, B., & Oliveira, J. F. (2012) · Reproduction · doi:10.1530/rep-11-0192 · Cited by 57 · see citing works
Tonellotto dos Santos, J., Ferreira, R., Gasperin, B. G., Siqueira, L. C., de Oliveira, J. F., Santos, R. A., Reis, A. M., & Gonçalves, P. B. (2012) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320311417273 · Cited by 57 · see citing works
Self-citationThe effect of Covid-19 mRNA vaccine on serum anti-Müllerian hormone levels
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Early and late endocrine complications of COVID-19
Kazakou, P., Paschou, S. Α., Ψαλτοπούλου, Θ., Gavriatopoulou, M., Korompoki, E., Stefanaki, K., Kanouta, F., Kassi, G., Dimopoulos, M. A., & Mitrakou, A. (2021) · Endocrine Connections · doi:10.1530/ec-21-0184 · Cited by 56 · see citing works
Almeida-Santos, A. F., Kangussu, L. M., Moreira, F. A., Santos, R. A. S., de Aguiar, D. C., & Campagnole‐Santos, M. J. (2016) · Clinical Science · doi:10.1042/cs20160116 · Cited by 51 · see citing works
Self-citationViana, G. E. N., Pereira, V. M., Honorato-Sampaio, K., Oliveira, C. A., Santos, R. A. S., & Reis, A. M. (2011) · Experimental Physiology · doi:10.1113/expphysiol.2011.058453 · Cited by 51 · see citing works
Self-citationAngiotensin-(1–7) in human follicular fluid correlates with oocyte maturation
Cavallo, I. K., Dela Cruz, C., Oliveira, M. L., Del Puerto, H. L., Dias, J. A., Lobach, V. N., Casalechi, M., Camargos, M. G., Reis, A. M., Santos, R. A., et al. (2017) · Human Reproduction · doi:10.1093/humrep/dex072 · Cited by 51 · see citing works
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Sharma, I., Kumari, P., Sharma, A., & Saha, S. C. (2021) · Middle East Fertility Society Journal · doi:10.1186/s43043-020-00046-z · Cited by 49 · see citing works
Singh, B., Gornet, M. E., Sims, H., Kisanga, E. P., Knight, Z., & Segars, J. H. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13351 · Cited by 48 · see citing works
Ziaja, M., Urbanek, K. A., Kowalska, K., & Piastowska‐Ciesielska, A. W. (2021) · Cells · doi:10.3390/cells10020381 · Cited by 46 · see citing works
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dos Reis, F. M., & dos Reis, A. M. (2020) · Clinical Science · doi:10.1042/cs20200865 · Cited by 34 · see citing works
Self-citationFernandes, B. H. V., Feitosa, N. M., Barbosa, A. P., Bomfim, C. G., Garnique, A. M. B., da Rosa, I. F., Rodrigues, M. D. S., Doretto, L. B., da Costa, D. F., Camargo-Dos-Santos, B., et al. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.152345 · Cited by 34 · see citing works
RetractedPiticchio, T., Moli, R. L., Tumino, D., & Frasca, F. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01486-0 · Cited by 33 · see citing works
The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos
Wang, L., Liang, J., & Leung, P. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128216 · Cited by 32 · see citing works
COVID-19 during Pregnancy and Postpartum:
Naidu, S. A. G., Clemens, R., Pressman, P., Zaigham, M., Davies, K. J. A., & Naidu, A. S. (2020) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1834047 · Cited by 31 · see citing works
Racilan, A. M., de Assis, W. A., Casalechi, M., Spagnuolo-Souza, A., Pascoal-Xavier, M. A., Silva, A. C. S. E., Puerto, H. L. D., & dos Reis, F. M. (2020) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/2284026520954068 · Cited by 30 · see citing works
Self-citationPotential impacts of COVID-19 on reproductive health: Scientific findings and social dimension
Hashem, N. M., Abdelnour, S. A., Alhimaidi, A. R., & Swelum, A. A. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.12.012 · Cited by 29 · see citing works
COVID-19 infection and vaccine have no impact on in-vitro fertilization (IVF) outcome
Albeitawi, S., Al‐Alami, Z. M., Hamadneh, J., Alqam, H., Qublan, H., & Natsheh, M. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-25757-3 · Cited by 29 · see citing works
Emerging Human Coronavirus Infections (SARS, MERS, and COVID-19): Where They Are Leading Us
Kumar, V. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1800688 · Cited by 28 · see citing works
Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era
Yang, K., Wen, G., Wang, J., Zhou, S., Da, W., Meng, Y., Xue, Y., & Tao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.711741 · Cited by 24 · see citing works
Viruses and Endocrine Diseases
Nekoua, M. P., Debuysschere, C., Vergez, I., Morvan, C., Mbani, C. J., Sané, F., Alidjinou, E. K., & Hober, D. (2023) · Microorganisms · doi:10.3390/microorganisms11020361 · Cited by 24 · see citing works
COVID-19 Infection in the Human Reproductive Tract of Men and Nonpregnant Women
Morelli, F., Meirelles, L. E. D. F., de Souza, M. V. F., Mari, N. L., Mesquita, C. S. S., Dartibale, C. B., Damke, G. M. Z. F., Damke, E., da Silva, V. R. S., Souza, R. P., et al. (2021) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.20-1098 · Cited by 22 · see citing works
Newson, L. R., Manyonda, I., Lewis, R., Preißner, R., Preißner, S., & Seeland, U. (2021) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.651752 · Cited by 22 · see citing works
Kunvariya, A. D., Dave, S. A., Modi, Z. J., Patel, P. K., & Sagar, S. R. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15644 · Cited by 21 · see citing works
After corona: there is life after the pandemic
Tesařík, J. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.04.002 · Cited by 21 · see citing works
Current status of the COVID‐19 and male reproduction: A review of the literature
Borges, E., Setti, A. S., Iaconelli, A., & Braga, D. P. A. F. (2021) · Andrology · doi:10.1111/andr.13037 · Cited by 20 · see citing works
Kim, Y. J., Kim, Y. Y., Kang, B.-C., Kim, M. S., Ko, I. K., Liu, H. C., Rosenwaks, Z., & Ku, S. (2016) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2214 · Cited by 20 · see citing works
Premature Ovarian Failure Related to SARS-CoV-2 Infection
Puca, E., & Puca, E. (2022) · Journal of Medical Cases · doi:10.14740/jmc3791 · Cited by 20 · see citing works
Physiological and pathological roles of Ang II and Ang- (1-7) in the female reproductive system
Liu, Y., Hao, H., Lan, T., Jia, R., Cao, M., Zhou, L., Zhao, Z., & Pan, W. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1080285 · Cited by 20 · see citing works
Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins
Costa-Neto, C. M., Duarte, D. Â., Lima, V. M., Maria, A. G., Munhoz, É. P., Rodríguez-Sarmiento, D. Y., Santos, G. A., de Souza, P. C., & Parreiras‐e‐Silva, L. T. (2014) · Clinical Science · doi:10.1042/cs20130414 · Cited by 20 · see citing works
A recommendation for IVF lab practice in light of the current COVID-19 pandemic
Arav, A. (2020) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-020-01841-3 · Cited by 19 · see citing works
COVID-19 impact on reproduction and fertility
Mali, A. S., Magdum, M., & Novotný, J. (2021) · JBRA · doi:10.5935/1518-0557.20200103 · Cited by 19 · see citing works
Functional consequences of SARS-CoV-2 infection in pregnant women, fetoplacental unit, and neonate
Jorge Carvajal, C., Casanello, P. C., Toso, A., Farías, M., Carrasco‐Negüe, K., Araujo, K., Valero, P., Fuenzalida, J., Solari, C., & Sobrevía, L. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166582 · Cited by 23 · see citing works
Choi, Y., Jeon, H., Brännström, M., Akin, J. W., Curry, T. E., & Jo, M. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.08.009 · Cited by 19 · see citing works
Stopping the misinformation: BNT162b2 COVID-19 vaccine has no negative effect on women’s fertilityPreprint
Safrai, M., Rottenstreich, A., Herzberg, S., Imbar, T., Reubinoff, B. E., & Ben‐Meir, A. (2021) · medRxiv · doi:10.1101/2021.05.30.21258079 · Cited by 19 · see citing works
Hammoud, S. H., Wehbe, Z., Abdelhady, S., Kobeissy, F. H., Eid, A. H., & EL‐Yazbi, A. F. (2020) · Molecular Pharmacology · doi:10.1124/molpharm.120.000119 · Cited by 18 · see citing works
Interplay between endocrinology, metabolism and COVID-19 infection
Mung, S. M., & Jude, E. B. (2021) · Clinical Medicine · doi:10.7861/clinmed.2021-0200 · Cited by 17 · see citing works
Female reproductive health during the COVID-19 pandemic: latest evidence and understanding
Li, S., Liu, H., Li, D., & Chen, F. (2023) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-06976-z · Cited by 16 · see citing works
Yousefi, M., Lee, W. S., Chan, W. O. Y., He, W., Mah, M. G., Yong, C. L., Deerain, J. M., Wang, L., Arcinas, C., Yan, B., et al. (2023) · Emerging Microbes & Infections · doi:10.1080/22221751.2023.2256416 · Cited by 16 · see citing works
COVID-19 pandemic: what about the gonads?
Selek, A., Güçlü, M., & Bolu, Ş. E. (2021) · HORMONES · doi:10.1007/s42000-021-00277-3 · Cited by 11 · see citing works
Mild and Asymptomatic Covid-19 Infections: Implications for Maternal, Fetal, and Reproductive Health
Sun, B., & Yeh, J. (2020) · Frontiers in Reproductive Health · doi:10.3389/frph.2020.00001 · Cited by 15 · see citing works
Hasdemir, P. S., Akar, Ş. Ş., Göker, A., Kosova, F., Ucar, D., Ateş, F. S. Ö., & Akçalı, S. (2023) · Human Fertility · doi:10.1080/14647273.2023.2181710 · Cited by 15 · see citing works
COVID-19 and immunomodulation treatment for women with reproductive failures
Kwak-Kim, J. Y.-H., Ota, K., Sung, N., Huang, C., Alsubki, L., Lee, S., Han, J. W., Han, A. R., Yang, X., Saab, W., et al. (2020) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2020.103168 · Cited by 14 · see citing works
Han, A. R., Lee, D., Kim, S. K., Choo, C., Park, J. C., Lee, J. R., Choi, W. J., Jun, J. H., Rhee, J. H., Kim, S. H., et al. (2022) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2022.05225 · Cited by 12 · see citing works
The effects of Covid-19 mRNA vaccine on adolescence gynecological well-being
Sasson, A. M., Haas, J., Sivan, M., Zehori, Y., Hemi, R., Orvieto, R., Afek, A. B., & Rabinovici, J. (2023) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-06981-2 · Cited by 13 · see citing works
Gao, S., Wang, J., Wei, L., Luo, C., Qian, F., Bo, L., & Mao, C. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-023-01337-5 · Cited by 13 · see citing works
From ACE2 to COVID-19: A multiorgan endothelial disease
Stein, R. A., & Young, L. M. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.08.083 · Cited by 13 · see citing works
Schwentner, L., Wöckel, A., Herr, D., & Wulff, C. (2011) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320311418140 · Cited by 12 · see citing works
Wei, L., Bo, L., Luo, C., Yin, N., Jiang, W., Qian, F., Zhou, A., Lu, X., Guo, H., & Mao, C. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03997-6 · Cited by 11 · see citing works
“In the human ovary, local RAS is involved in many important physiological processes such as supporting oogenesis, regulating ovulation function, synthesizing steroid hormones, and mediating gonadotropin function [7, 23–25].”
BackgroundA scoping review of SARS-CoV-2 and male infertility
Al-Khikani, F. H. O., & Ayit, A. S. (2022) · Asian Pacific Journal of Reproduction · doi:10.4103/2305-0500.341111 · Cited by 10 · see citing works
Effect of SARS-CoV-2 infection and vaccine on ovarian reserve: A systematic review
Zhu, S., Luan, C., Zhang, S., Wang, X., Long, F., Zhang, Q., & Yan, J. (2023) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2023.10.029 · Cited by 10 · see citing works
Mas receptor contributes to pregnancy-induced cardiac remodelling
Silva, C. D. C. E., Almeida, J. F., Macedo, L. M., Melo, M. B., Pedrino, G. R., dos Santos, F. C. A., Biancardi, M. F., Santos, R. A. S., de Carvalho, A. A. V., Mendes, E. P., et al. (2016) · Clinical Science · doi:10.1042/cs20160095 · Cited by 10 · see citing works
Self-citationKahyaoğlu, S., Özakşit, M. G., Kahyaoğlu, İ., Filiz, A. A., Pekcan, M. K., Atalay, E., & Tekın, Ö. M. (2022) · Journal of Human Reproductive Sciences · doi:10.4103/jhrs.jhrs_121_22 · Cited by 10 · see citing works
Fernandes, B. H. V., Feitosa, N. M., Barbosa, A. P., Bomfim, C. G., Garnique, A. M. B., Gomes, F. I. F., Nakajima, R. T., Belo, M. A. D. A., Eto, S. F., Fernandes, D. C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.20.346262 · Cited by 10 · see citing works
Šuštaršič, A., Hadžić, V., Meulenberg, C. J. W., Abazović, E., Videmšek, M., Papler, T. B., & Paravlic, A. H. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1264947 · Cited by 9 · see citing works
Xue, Y., Xiong, Y., Cheng, X., & Li, K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1233986 · Cited by 9 · see citing works
Genetic deletion of the Angiotensin-(1–7) receptor Mas leads to a reduced ovulatory rate
Honorato-Sampaio, K., Andrade, R. F., Bader, M., Martins, A. D. S., Santos, R. A. S., & Reis, A. M. (2018) · Peptides · doi:10.1016/j.peptides.2018.08.007 · Cited by 9 · see citing works
Self-citationEffects of SARS-CoV-2 infection on human reproduction
Yang, M., Wang, J., Chen, Y., Kong, S., & Qiao, J. (2021) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjab025 · Cited by 8 · see citing works
Xu, Z., Wu, Y., Lin, Y., Cao, M., Liang, Z., Li, L., Lin, J., Chen, Q., Liu, J., & Liu, H. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.966826 · Cited by 9 · see citing works
Braga, D. P. A. F., Setti, A. S., Iaconelli, A., & Borges, E. (2022) · Molecular Reproduction and Development · doi:10.1002/mrd.23658 · Cited by 7 · see citing works
Chaudhari, S., Pereira, S. D., Asare-Werehene, M., Naha, R., Kabekkodu, S. P., Tsang, B. K., & Satyamoorthy, K. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-021-00787-z · Cited by 8 · see citing works
- Authors
- Reis, F. M., Bouissou, D. R., Pereira, V. M., Camargos, A. F., dos Reis, A. M., & Santos, R. A.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Corresponding author
- Reis, Fernando M.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 95
- Issue
- 1
- Pages
- 176-181
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1980157773
- Cited by
- 193
- References
- 33
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 15 · 2023: 26 · 2022: 34 · 2021: 47 · 2020: 31 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- angiotensin-(1-7), Mas receptor, human ovary, follicular fluid, ovarian follicles, corpus luteum, ovarian stroma, postmenopausal women, controlled ovarian stimulation, renin-angiotensin system
- MeSH terms
- Angiotensin-Converting Enzyme 2, Proto-Oncogene Mas, Adult, Angiotensin I, Angiotensin II, Autoradiography, Female, Fertilization in Vitro, Humans, Immunohistochemistry, Iodine Radioisotopes, Peptidyl-Dipeptidase A, Middle Aged, Ovary, Ovulation Induction, Peptide Fragments, Proto-Oncogene Proteins, RNA, Messenger, Follicular Fluid, Premenopause, Postmenopause, Reverse Transcriptase Polymerase Chain Reaction, Receptors, G-Protein-Coupled
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