CoChat
Sign Up
Cited by 138Genetic and phenotypic traits in livestockHuman-Animal Interaction StudiesGenetic Mapping and Diversity in Plants and Animals

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Genetic Architecture of Tameness in a Rat Model of Animal Domestication

Open access
Albert, Frank W, Carlborg, Örjan, Plyusnina, Irina, Besnier, Francois, Hedwig, Daniela, Lautenschläger, Susann, Lorenz, Doreen, McIntosh, Jenny, Neumann, Christof, Richter, Henning, Zeising, Claudia, Kozhemyakina, Rimma, Shchepina, Olesya, Kratzsch, Jürgen, Trut, Lyudmila, Teupser, Daniel, Thiery, Joachim, Schöneberg, Torsten, Andersson, Leif, Pääbo, Svante·2009·Genetics
DOI 10.1534/genetics.109.102186PMC PMC2691762
Open this paper in CoChat — free accountOpen PDF

Abstract

A common feature of domestic animals is tameness—i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coat spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.

Overview

Integrity signals

Registry

Crossref · 10.1534/genetics.109.102186

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 60 references

Research works printed but not linked: 6

  1. 1982, Biol. Zent. Bl., 100, 705
  2. 2007, PLoS Genet., 3, 2101
  3. 2008, Evol. Bioinform. Online, 4, 225
  4. 2001, Genet. Sel. Evol., 33, 453, 10.1186/1297-9686-33-5-453 · DOI
  5. 2000, Russ. J. Genet., 36, 668
  6. 2007, PLoS Biol., 5, 2469

Cited by

Sorted by citations

See all 138

Related

Metadata

Authors
Albert, F. W., Carlborg, O., Plyusnina, I., Besnier, F., Hedwig, D., Lautenschläger, S., Lorenz, D., McIntosh, J., Neumann, C., Richter, H., Zeising, C., Kozhemyakina, R., Shchepina, O., Kratzsch, J., Trut, L., Teupser, D., Thiery, J., Schöneberg, T., Andersson, L., & Pääbo, S.
Affiliations
  • Max Planck Institute for Evolutionary Anthropology (DE)
  • Department of Animal Breeding and Genetics , Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden
  • Institute of Cytology and Genetics (RU)
  • Department of Evolutionary Genetics , Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
  • Institute of Laboratory Medicine , Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany
  • University Hospital Leipzig (DE)
  • Institute of Biochemistry, Molecular Biochemistry, Medical Faculty , University of Leipzig, 04103 Leipzig, Germany
  • Uppsala University (SE)
Corresponding author
Albert, Frank W
ORCID
Venue
Genetics
Publisher
Oxford University Press (OUP)
Published
2009-06-01
Volume
182
Issue
2
Pages
541-554
ISSN
  • 0016-6731 (ISSN-L)
  • 1943-2631
DOI
10.1534/genetics.109.102186
PMC
PMC2691762
OpenAlex
W2170665517
Cited by
136
References
60
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 14 · 2019: 9 · 2018: 21 · 2017: 10 · 2016: 12 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 8
FWCI
4.68
Type
journal article
Language
en
Open access
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Genetics (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • Stiftelsen för Strategisk Forskning
  • Svenska Forskningsrådet Formas
  • Max-Planck-Gesellschaft
  • Vetenskapsrådet
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords
tameness, animal domestication, aggression, quantitative trait loci, epistasis, genetic architecture, adrenal weight, Rattus norvegicus, serum components, organ weight
MeSH terms
Aggression, Animals, Animals, Domestic, Behavior, Animal, Female, Genetic Markers, Hair, Humans, Hybridization, Genetic, Male, Phenotype, Pigmentation, Species Specificity, Genomics, Models, Animal, Quantitative Trait Loci, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review