Cited by 138Genetic and phenotypic traits in livestockHuman-Animal Interaction StudiesGenetic Mapping and Diversity in Plants and Animals

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Genetic Architecture of Tameness in a Rat Model of Animal Domestication

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Albert, Frank W, Carlborg, Örjan, Plyusnina, Irina, Besnier, Francois, Hedwig, Daniela, Lautenschläger, Susann, Lorenz, Doreen, McIntosh, Jenny, Neumann, Christof, Richter, Henning, Zeising, Claudia, Kozhemyakina, Rimma, Shchepina, Olesya, Kratzsch, Jürgen, Trut, Lyudmila, Teupser, Daniel, Thiery, Joachim, Schöneberg, Torsten, Andersson, Leif, Pääbo, Svante·2009·Genetics

DOI 10.1534/genetics.109.102186PMC PMC2691762

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Abstract

A common feature of domestic animals is tameness—i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coat spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.

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Authors: Albert, F. W., Carlborg, O., Plyusnina, I., Besnier, F., Hedwig, D., Lautenschläger, S., Lorenz, D., McIntosh, J., Neumann, C., Richter, H., Zeising, C., Kozhemyakina, R., Shchepina, O., Kratzsch, J., Trut, L., Teupser, D., Thiery, J., Schöneberg, T., Andersson, L., & Pääbo, S.
Affiliations: Max Planck Institute for Evolutionary Anthropology (DE)
Department of Animal Breeding and Genetics , Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden
Institute of Cytology and Genetics (RU)
Department of Evolutionary Genetics , Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
Institute of Laboratory Medicine , Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany
University Hospital Leipzig (DE)
Institute of Biochemistry, Molecular Biochemistry, Medical Faculty , University of Leipzig, 04103 Leipzig, Germany
Uppsala University (SE)
Corresponding author: Albert, Frank W
ORCID: Albert, Frank W
Hedwig, Daniela
Neumann, Christof
Richter, Henning
Kozhemyakina, Rimma
Shchepina, Olesya
Teupser, Daniel
Thiery, Joachim
Andersson, Leif
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 2009-06-01
Volume: 182
Issue: 2
Pages: 541-554
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1534/genetics.109.102186
PMC: PMC2691762
OpenAlex: W2170665517
Cited by: 136
References: 60
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 14 · 2019: 9 · 2018: 21 · 2017: 10 · 2016: 12 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 8
FWCI: 4.68
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
Max Planck Institute for Plasma Physics (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Funders: Stiftelsen för Strategisk Forskning
Svenska Forskningsrådet Formas
Max-Planck-Gesellschaft
Vetenskapsrådet
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords: tameness, animal domestication, aggression, quantitative trait loci, epistasis, genetic architecture, adrenal weight, Rattus norvegicus, serum components, organ weight
MeSH terms: Aggression, Animals, Animals, Domestic, Behavior, Animal, Female, Genetic Markers, Hair, Humans, Hybridization, Genetic, Male, Phenotype, Pigmentation, Species Specificity, Genomics, Models, Animal, Quantitative Trait Loci, Rats

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Genetic Architecture of Tameness in a Rat Model of Animal Domestication

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