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Genetic Architecture of Tameness in a Rat Model of Animal Domestication
Open accessAbstract
A common feature of domestic animals is tameness—i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coat spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.
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“Similarly, linkage mapping of rat lines selected for high and low aggression, initially by Belyaev himself, (Albert et al. 2009) found only weak linkage between domestication traits.”
From The neural crest cell hypothesis: no unified explanation for domestication (2021) · cites this paper as Albert et al. 2009
Citations
Cites
nlme : Linear and nonlinear mixed effects models
DebRoy, S. (2006) · Medical Entomology and Zoology · Cited by 10,009
Genetics and Analysis of Quantitative Traits
(2002) · Journal of Animal Breeding and Genetics · doi:10.1046/j.1439-0388.2002.00356.x · Cited by 6,176
Kalinowski, S. T., Taper, M. L., & MARSHALL, T. C. (2007) · Molecular Ecology · doi:10.1111/j.1365-294x.2007.03089.x · Cited by 5,367
Empirical threshold values for quantitative trait mapping.
Churchill, G. A., & Doerge, R. W. (1994) · Genetics · doi:10.1093/genetics/138.3.963 · Cited by 4,935
An economic method for the fluorescent labeling of PCR fragments
Schuelke, M. (2000) · Nature Biotechnology · doi:10.1038/72708 · Cited by 3,616
Genome sequence of the Brown Norway rat yields insights into mammalian evolution
Gibbs, R. A., Weinstock, G. M., Metzker, M. L., Muzny, D. M., Sodergren, E. J., Scherer, S. E., Scott, G., Steffen, D. L., Worley, K. C., Burch, P. E., et al. (2004) · Nature · doi:10.1038/nature02426 · Cited by 2,170
PedCheck: A Program for Identification of Genotype Incompatibilities in Linkage Analysis
O'Connell, J. R., & Weeks, D. E. (1998) · The American Journal of Human Genetics · doi:10.1086/301904 · Cited by 2,063
Haley, C. S., & Knott, S. A. (1992) · Heredity · doi:10.1038/hdy.1992.131 · Cited by 1,991
Evolution, consequences and future of plant and animal domestication
Diamond, J. M. (2002) · Nature · doi:10.1038/nature01019 · Cited by 1,772
The variation of animals and plants under domestication /
Darwin, C. R. (1905) · J. Murray eBooks · doi:10.5962/bhl.title.84435 · Cited by 1,712
Phillips, P. C. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2452 · Cited by 1,633
Genetic Evidence for an East Asian Origin of Domestic Dogs
Savolainen, P., Zhang, Y.-P., Luo, J., Lundeberg, J., & Leitner, T. (2002) · Science · doi:10.1126/science.1073906 · Cited by 960
Worldwide Phylogeography of Wild Boar Reveals Multiple Centers of Pig Domestication
Larson, G., Dobney, K. M., Albarella, U., Fang, M., Matisoo-Smith, E. A., Robins, J. H., Lowden, S., Finlayson, H. A., Brand, T. B., Willerslev, E., et al. (2005) · Science · doi:10.1126/science.1106927 · Cited by 912
Self-citationMapping quantitative trait loci in crosses between outbred lines using least squares.
Haley, C., Knott, S., & Elsen, J. M. J. M. (1994) · Genetics · doi:10.1093/genetics/136.3.1195 · Cited by 699
Genetic Evidence for Near-Eastern Origins of European Cattle
Troy, C. S., MacHugh, D. E., Bailey, J. F., Magee, D. A., Loftus, R. T., Cunningham, P., Chamberlain, A. T., Sykes, B. C., & Bradley, D. G. (2001) · Nature · doi:10.1038/35074088 · Cited by 627
Early canid domestication: the farm-fox experiment.
Trut, L. (1999) · American Scientist · doi:10.1511/1999.2.160 · Cited by 626
Self-citationThe Near Eastern Origin of Cat Domestication
Driscoll, C. A., Menotti-Raymond, M., Roca, A. L., Hupe, K., Johnson, W. E., Geffen, E., Harley, E. H., Delibes, M., Pontier, D., Kitchener, A. C., et al. (2007) · Science · doi:10.1126/science.1139518 · Cited by 573
Widespread Origins of Domestic Horse Lineages
Vilà, C., Leonard, J. A., Götherström, A., Marklund, S. L., Sandberg, K., Lidén, K., Wayne, R. K., & Ellegren, H. (2001) · Science · doi:10.1126/science.291.5503.474 · Cited by 510
Identification of the Yellow Skin Gene Reveals a Hybrid Origin of the Domestic Chicken
Eriksson, J., Larson, G., Gunnarsson, U., Bed'hom, B., Tixier-Boichard, M., Strömstedt, L., Wright, D., Jungerius, A., Vereijken, A., Randi, E., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000010 · Cited by 426
Self-citationMiller, C. T., Beleza, S., Pollen, A. A., Schluter, D., Kittles, R. A., Shriver, M. D., & Kingsley, D. M. (2007) · Cell · doi:10.1016/j.cell.2007.10.055 · Cited by 388
Naderi, S., Rezaei, H. R., Pompanon, F., Blum, M. G. B., Negrini, R., Naghash, H.-R., Balkız, Ö., Mashkour, M., Gaggiotti, O. E., Ajmone‐Marsan, P., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804782105 · Cited by 357
Social Cognitive Evolution in Captive Foxes Is a Correlated By-Product of Experimental Domestication
Hare, B., Plyusnina, I., Ignacio, N., Schepina, O., Stepika, A., Wrangham, R., & Trut, L. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.040 · Cited by 347
Self-citationPielberg, G., Golovko, A., Sundström, E., Čurik, I., Lennartsson, J., Seltenhammer, M. H., Druml, T., Binns, M. M., Fitzsimmons, C., Lindgren, G., et al. (2008) · Nature Genetics · doi:10.1038/ng.185 · Cited by 335
Self-citationComparative analysis of ACTH and corticosterone sampling methods in rats
Vahl, T. P., Ulrich-Lai, Y. M., Ostrander, M. M., Dolgas, C. M., Elfers, E. E., Seeley, R. J., D'Alessio, D. A., & Herman, J. P. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00122.2005 · Cited by 304 · cited 1×
“This is consistent with their high values compared to basal measures reported in the literature (VAHL et al. 2005).”
ResultEpistasis and the release of genetic variation during long-term selection
Carlborg, Ö., Jacobsson, L., Åhgren, P., Siegel, P. B., & Andersson, L. (2006) · Nature Genetics · doi:10.1038/ng1761 · Cited by 288
Self-citationYalcin, B., Willis‐Owen, S. A. G., Fullerton, J. M., Meesaq, A., Deacon, R. M. J., Rawlins, J. N. P., Copley, R. R., Morris, A. P., Flint, J., & Mott, R. (2004) · Nature Genetics · doi:10.1038/ng1450 · Cited by 283
MOLECULAR AND DEVELOPMENTAL GENETICS OF MOUSE COAT COLOR
Jackson, I. J. (1994) · Annual Review of Genetics · doi:10.1146/annurev.ge.28.120194.001201 · Cited by 277
A Global Search Reveals Epistatic Interaction Between QTL for Early Growth in the ChickenPreprint
Carlborg, Ö., Kerje, S., Schütz, K. E., Jacobsson, L., Jensen, P., & Andersson, L. (2003) · Genome Research · doi:10.1101/gr.528003 · Cited by 252
Self-citationÁlvarez-Castro, J. M., & Carlborg, Ö. (2007) · Genetics · doi:10.1534/genetics.106.067348 · Cited by 219
Fabp7 Maps to a Quantitative Trait Locus for a Schizophrenia Endophenotype
Watanabe, A., Toyota, T., Owada, Y., Hayashi, T., Iwayama, Y., Matsumata, M., Ishitsuka, Y., Nakaya, A., Maekawa, M., Ohnishi, T., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050297 · Cited by 217
Kruk, M. R., Halász, J., Meelis, W., & Haller, J. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.5.1062 · Cited by 212
Analysis of quantitative trait loci that influence animal behavior
Jonathan Flint, C. (2002) · Journal of Neurobiology · doi:10.1002/neu.10161 · Cited by 210
Molecular Basis for the Dominant White Phenotype in the Domestic PigPreprint
Marklund, S. L., Kijas, J. M. H., Rodríguez‐Martínez, H., Rönnstrand, L., Funa, K., Moller, M. J., Lange, D., Edfors‐Lilja, I., & Andersson, L. (1998) · Genome Research · doi:10.1101/gr.8.8.826 · Cited by 198
Self-citationSNP and haplotype mapping for genetic analysis in the rat
Saar, K., Heinig, M., Hummel, O., Lee, Y.-A., Patone, G., Schulz, H., Zimdahl, H., Hübner, N., Beck, A., Klages, S., et al. (2008) · Nature Genetics · doi:10.1038/ng.124 · Cited by 189
A Quantitative Trait Locus Influencing Anxiety in the Laboratory RatPreprint
Fernández‐Teruel, A., Escorihuela, R. M., Gray, J. A., Aguilar, R., Gil, L., Giménez‐Llort, L., Tobeña, A., Bhomra, A., Nicod, A., Mott, R., et al. (2002) · Genome Research · doi:10.1101/gr.203402 · Cited by 161
Albert, F. W., Shchepina, O., Winter, C., Römpler, H., Teupser, D., Palme, R., Ceglarek, U., Kratzsch, J., Sohr, R., Trut, L. N., et al. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.11.010 · Cited by 160
Self-citationReview: Melanocyte Migration and Survival Controlled by SCF/c-kit Expression
Yoshida, H., Grimm, T., Nishimura, E. K., Nishioka, E., Nishikawa, S., & Kunisada, T. (2001) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.0022-202x.2001.00006.x · Cited by 160
Carlborg, Ö., Andersson, L., & Kinghorn, B. P. (2000) · Genetics · doi:10.1093/genetics/155.4.2003 · Cited by 156
Self-citationAllelic Heterogeneity at the Equine KIT Locus in Dominant White (W) Horses
Haase, B., Brooks, S. A., Schlumbaum, A., Azor, P. J., Bailey, E., Alaeddine, F., Mevissen, M., Burger, D., Poncet, P.-A., Rieder, S., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030195 · Cited by 143
Qxpak: a versatile mixed model application for genetical genomics and QTL analyses
Pérez‐Enciso, M., & Misztal, I. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth331 · Cited by 141
A simple and rapid method for calculating identity-by-descent matrices using multiple markers
Pong‐Wong, R., George, A. W., Woolliams, J. A., & Haley, C. (2001) · Genetics Selection Evolution · doi:10.1051/gse:2001127 · Cited by 129
Naumenko, E. V., Popova, N. K., Nikulina, E. M., Dygalo, N. N., Shishkina, G. T., Borodin, P. M., & Markel, A. L. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90434-6 · Cited by 127
Early Canid Domestication: The Farm-Fox Experiment
Trut, L. (1999) · American Scientist · doi:10.1511/1999.20.160 · Cited by 118
Self-citationGlucocorticoid interaction with aggression in non-mammalian vertebrates: Reciprocal action
Summers, C. H., Watt, M. J., Ling, T. J., Forster, G. L., Carpenter, R. E., Korzan, W. J., Lukkes, J. L., & Øverli, Ø. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.059 · Cited by 106
PLYUSNINA, I., & OSKINA, I. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00445-3 · Cited by 98
Self-citationCarlborg, Ö., Hocking, P. M., Burt, D. W., & Haley, C. (2004) · Genetics Research · doi:10.1017/s0016672304006779 · Cited by 97
Popova, N. K., Naumenko, V. S., Plyusnina, I. Z., & Kulikov, A. V. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20456 · Cited by 77
Self-citationGenetic analysis of the stress-responsive adrenocortical axis
Solberg, L. C., Baum, A. E., Ahmadiyeh, N., Shimomura, K., Li, R., Turek, F. W., Takahashi, J. S., Churchill, G. A., & Redei, E. E. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00052.2006 · Cited by 55
Use of randomization testing to detect multiple epistatic QTLs
Carlborg, Ö., & Andersson, L. (2002) · Genetics Research · doi:10.1017/s001667230200558x · Cited by 50
Self-citationKeeler, C. E., & King, H. D. (1942) · Journal of comparative psychology · doi:10.1037/h0057244 · Cited by 45
Hayssen, V. (1997) · Journal of comparative psychology · doi:10.1037/0735-7036.111.4.419 · Cited by 41
Epistatic regulation of behavioural and morphological traits in the zebrafish (Danio rerio)
Wright, D., Butlin, R. K., & Carlborg, Ö. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9080-9 · Cited by 38
Cottle, C. A., & Price, E. O. (1987) · Journal of comparative psychology · doi:10.1037/0735-7036.101.4.390 · Cited by 36
Conti, L. H., Jirout, M., Breen, L., Vanella, J. J., Schork, N. J., & Printz, M. P. (2003) · Behavior Genetics · doi:10.1023/b:bege.0000009479.02183.1f · Cited by 35
Estimation of Genetic Effects and Genotype-Phenotype Maps
Rouzic, A. L., & Álvarez-Castro, J. M. (2008) · Evolutionary Bioinformatics · doi:10.4137/ebo.s756 · Cited by 34
Terenina, E. E., Moisan, M., Colas, A., Beaugé, F. J., Shah, K. V., Jones, B. C., & Mormède, P. (2003) · PubMed · doi:10.1097/01.fpc.0000054120.14659.8c · Cited by 32
Terenina-Rigaldie, E., Moisan, M., Colas, A., Beaug, F. O., Shah, K. V., Jones, B. C., & Mormède, P. (2003) · Pharmacogenetics · doi:10.1097/00008571-200309000-00003 · Cited by 32
Bailey, J. S., Grabowski-Boase, L., Steffy, B. M., Wiltshire, T., Churchill, G. A., & Tarantino, L. M. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00415.x · Cited by 25
Trut, L. N., Pliusnina, I. Z., & Prasolova, L. A. (2000) · PubMed · Cited by 10
Self-citationBesnier, F., & Carlborg, Ö. (2007) · BMC Bioinformatics · doi:10.1186/1471-2105-8-440 · Cited by 7
Self-citation
Flagged first, then by citations
Research works printed but not linked: 6
- 1982, Biol. Zent. Bl., 100, 705
- 2007, PLoS Genet., 3, 2101
- 2008, Evol. Bioinform. Online, 4, 225
- 2001, Genet. Sel. Evol., 33, 453, 10.1186/1297-9686-33-5-453 · DOI
- 2000, Russ. J. Genet., 36, 668
- 2007, PLoS Biol., 5, 2469
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Garland, T., Schutz, H., Chappell, M. A., Keeney, B. K., Meek, T. H., Copes, L. E., Acosta, W., Drenowatz, C., Maciel, R. C., van Dijk, G., et al. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048397 · Cited by 444
Metadata
- Authors
- Albert, F. W., Carlborg, O., Plyusnina, I., Besnier, F., Hedwig, D., Lautenschläger, S., Lorenz, D., McIntosh, J., Neumann, C., Richter, H., Zeising, C., Kozhemyakina, R., Shchepina, O., Kratzsch, J., Trut, L., Teupser, D., Thiery, J., Schöneberg, T., Andersson, L., & Pääbo, S.
- Affiliations
- Max Planck Institute for Evolutionary Anthropology (DE)
- Department of Animal Breeding and Genetics , Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden
- Institute of Cytology and Genetics (RU)
- Department of Evolutionary Genetics , Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
- Institute of Laboratory Medicine , Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, 04103 Leipzig, Germany
- University Hospital Leipzig (DE)
- Institute of Biochemistry, Molecular Biochemistry, Medical Faculty , University of Leipzig, 04103 Leipzig, Germany
- Uppsala University (SE)
- Corresponding author
- Albert, Frank W
- ORCID
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-06-01
- Volume
- 182
- Issue
- 2
- Pages
- 541-554
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- PMC
- PMC2691762
- OpenAlex
- W2170665517
- Cited by
- 136
- References
- 60
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 14 · 2019: 9 · 2018: 21 · 2017: 10 · 2016: 12 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 8
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Stiftelsen för Strategisk Forskning
- Svenska Forskningsrådet Formas
- Max-Planck-Gesellschaft
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- tameness, animal domestication, aggression, quantitative trait loci, epistasis, genetic architecture, adrenal weight, Rattus norvegicus, serum components, organ weight
- MeSH terms
- Aggression, Animals, Animals, Domestic, Behavior, Animal, Female, Genetic Markers, Hair, Humans, Hybridization, Genetic, Male, Phenotype, Pigmentation, Species Specificity, Genomics, Models, Animal, Quantitative Trait Loci, Rats
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