Angptl3-null Mice Show Low Plasma Lipid Concentrations by Enhanced Lipoprotein Lipase Activity
Open accessAbstract
Angiopoietin-like 3 (ANGPTL3) is a secreted protein with both angiogenesis and lipid metabolism functions. We generated knockout mice that failed to express the Angptl3 gene, and analyzed the lipid metabolism. Angptl3-null mice, fed a normal diet or a high-fat, high-calorie (HFC) diet, revealed markedly low plasma lipid concentrations, especially plasma triglyceride concentration, although the body weight and liver weight were not different between Angptl3-null mice and wild-type mice. Angptl3-null mice fed an HFC diet also revealed a significantly reduced epididymal adipose tissue weight despite there being no difference in adipocyte size between them and wild-type mice. A triglyceride clearance study indicated that the lower plasma triglyceride concentration in Angptl3-null mice was caused by an accelerated clearance of triglyceride. In fact, lipoprotein lipase and hepatic lipase activities in the post-heparin plasma of Angptl3-null mice were 1.57 times and 1.42 times higher than those of wild-type mice, respectively. These results suggest that ANGPTL3 may have an effect not only on lipid metabolism but also on adipose formation.
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ANGPTL3 inhibits lipoprotein lipase, which results in increased blood lipid levels.
“ANGPTL3 inhibits the lipoprotein lipase, which results in increased blood lipid levels [143–145].”
From Established and Emerging Lipid-Lowering Drugs for Primary and Secondary Cardiovascular Prevention (2023) · cites this paper as [144]
Evinacumab is a monoclonal antibody inhibiting angiopoietin-like 3 (ANGPTL3).
“Evinacumab is a monoclonal antibody inhibiting angiopoietin-like 3 (ANGPTL3).”
From Established and Emerging Lipid-Lowering Drugs for Primary and Secondary Cardiovascular Prevention (2023) · cites this paper as [144]
The Introduction identifies ANGPTL3, and the Discussion examines its role in lipid metabolism in knockout mice. Neither section addresses evinacumab or an antibody that inhibits ANGPTL3; searches for the drug name and anti-ANGPTL3 monoclonal antibodies found no supporting passage. (LLM, conf=0.76)
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- Authors
- FUJIMOTO, K., KOISHI, R., SHIMIZUGAWA, T., & ANDO, Y.
- Affiliations
- Medicinal Safety Research Laboratories, Sankyo Co., Ltd.
- Lead Discovery Research Laboratories, Sankyo Co., Ltd.
- Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd.
- ORCID
- FUJIMOTO, Kazunori
- Venue
- Experimental Animals
- Published
- 2006
- Volume
- 55
- Issue
- 1
- Pages
- 27-34
- ISSN
- 0007-5124 (ISSN-L)
- 1341-1357
- 1881-7122
- OpenAlex
- W2067098811
- Semantic Scholar
- f700eb72cfbc3646cf6933f9b9255f41826e06b4
- Cited by
- 104
- References
- 17
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 12 · 2021: 11 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 6
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EXPERIMENTAL ANIMALS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- ANGPTL3, knockout mice, plasma triglycerides, lipoprotein lipase, hepatic lipase, triglyceride clearance, lipid metabolism, high-fat high-calorie diet, epididymal adipose tissue, adipose tissue formation, angiogenesis
- MeSH terms
- Angiopoietin-like Proteins, Angiopoietin-Like Protein 3, Adipose Tissue, Animals, Dietary Fats, Epididymis, Female, Lipids, Lipoprotein Lipase, Male, Mice, Inbred C57BL, Organ Size, Triglycerides, Adipocytes, Mice, Knockout, Intercellular Signaling Peptides and Proteins, Angiopoietins, Cell Size, Lipid Metabolism, Mice
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