Cited by 107Malaria Research and ControlBlood groups and transfusionHemoglobinopathies and Related Disorders

Plasmodium falciparum: Chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta

Fried, Michal, Domingo, Gonzalo J., Gowda, Channe D., Mutabingwa, Theonest K., Duffy, Patrick E.·2006·Experimental Parasitology

Abstract

Plasmodium falciparum parasites that sequester in the placenta bind to the molecule chondroitin sulfate A (CSA). Women become resistant to malaria during pregnancy as they acquire antibodies that inhibit parasite adhesion to CSA, suggesting that a vaccine against placental malaria is feasible. Hyaluronic acid (HA) and non-immune IgG have also been proposed as receptors for P. falciparum adhesion in the placenta, but evidence for their roles is inconclusive. In this study, CSA, HA, and IgG were simultaneously assessed for their relative contributions to placental adhesion. Placental parasites collected in Tanzania uniformly adhered to the molecule CSA, and soluble CSA completely inhibited adhesion of most samples to placental cryosections. Three of 46 placental parasite samples also adhered to immobilized HA, but HA failed to inhibit adhesion of any placental parasites to placental cryosections. Similarly, non-immune IgG and protein A failed to inhibit adhesion of parasite samples to placental cryosection. P. falciparum adhesion in the placenta appears to be a non-redundant process that requires CSA as a receptor. Vaccines that elicit functional antibodies against CSA-binding parasites may confer resistance to pregnancy malaria.

Integrity signals

Registry

Crossref · 10.1016/j.exppara.2005.12.003

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  • Current evidence suggests that additional placental adhesion receptors are less important than CSA.

    “Although some studies point to the existence of additional receptors (Beeson et al. , 2000), current evidence suggests that they are less important than CSA (Fried et al. , 2006).”

    From Towards a vaccine against pregnancy-associated malaria (2008) · cites this paper as Fried et al., 2006

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Authors
Fried, M., Domingo, G. J., Gowda, C. D., Mutabingwa, T. K., & Duffy, P. E.
Affiliations
  • Center for Infectious Disease Research (US)
  • Pennsylvania State University (US)
Corresponding author
Fried, Michal
Venue
Experimental Parasitology
Publisher
Elsevier BV
Published
2006-05
Volume
113
Issue
1
Pages
36-42
ISSN
0014-4894 (ISSN-L)
OpenAlex
W2084381085
Cited by
107
References
27
Citations by year
2026: 4 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 1 · 2017: 8 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 7
FWCI
15.31
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Parasitology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Bill and Melinda Gates Foundation
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (AI52059, R01AI052059)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Hematology › Blood groups and transfusion
  • Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Keywords
Plasmodium falciparum, chondroitin sulfate A, placental malaria, parasite adhesion, receptor specificity, hyaluronic acid, placental sequestration
MeSH terms
Adolescent, Adult, Animals, Cell Adhesion, Chondroitin Sulfates, Erythrocytes, Female, Humans, Hyaluronic Acid, Immunoglobulin G, Middle Aged, Placenta, Plasmodium falciparum, Pregnancy, Tanzania, Malaria Vaccines

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