Association of Prenatal Exposure to Perfluorinated and Polyfluoroalkyl Substances with Childhood Neurodevelopment: A Systematic Review and Meta-Analysis

The PRISMA 2020 statement: An updated guideline for reporting systematic reviews

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., et al. (2021) · BMJ · doi:10.1136/bmj.n71 · Cited by 108,283 · see citing works

Quantifying heterogeneity in a meta‐analysis

Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works

The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for reporting observational studies

von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., & Vandenbroucke, J. P. (2014) · International Journal of Surgery · doi:10.1016/j.ijsu.2014.07.013 · Cited by 9,909 · see citing works

US Environmental Protection Agency

Liu, X. (1998) · Choice Reviews Online · doi:10.5860/choice.35-4455 · Cited by 5,887 · see citing works

Developmental neurotoxicity of industrial chemicals

Grandjean, P., & Landrigan, P. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69665-7 · Cited by 1,984 · see citing works

Neurobehavioural effects of developmental toxicity

Grandjean, P., & Landrigan, P. J. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70278-3 · Cited by 1,886 · see citing works

Global epigenomic reconfiguration during mammalian brain development

Lister, R., Mukamel, E. A., Nery, J. R., Urich, M., Puddifoot, C. A., Johnson, N. D., Lucero, J., Huang, Y., Dwork, A. J., Schultz, M. D., et al. (2013) · Science · doi:10.1126/science.1237905 · Cited by 1,830 · see citing works

Polyfluoroalkyl Chemicals in the U.S. Population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and Comparisons with NHANES 1999–2000

Calafat, A. M., Wong, L.-Y., Kuklenyik, Z., Reidy, J. A., & Needham, L. L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10598 · Cited by 1,247 · see citing works

Peer Reviewed: Perfluorochemical Surfactants in the Environment

Giesy, J. P., & Kannan, K. (2002) · Environmental Science & Technology · doi:10.1021/es022253t · Cited by 1,103 · see citing works

Impact of Prenatal Chlorpyrifos Exposure on Neurodevelopment in the First 3 Years of Life Among Inner-City Children

Rauh, V. A., Garfinkel, R., Perera, F. P., Andrews, H. F., Hoepner, L., Barr, D. B., Whitehead, R., Tang, D., & Whyatt, R. W. (2006) · Pediatrics · doi:10.1542/peds.2006-0338 · Cited by 734 · see citing works

Evidence on the Human Health Effects of Low-Level Methylmercury Exposure

Karagas, M. R., Choi, A. L., Oken, E., Horvat, M., Schoeny, R. S., Kamai, E. M., Cowell, W., Grandjean, P., & Korrick, S. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104494 · Cited by 649 · see citing works

Perfluoroalkyl and polyfluoroalkyl substances in consumer products

Kotthoff, M., Müller, J., Jürling, H., Schlummer, M., & Fiedler, D. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-4202-7 · Cited by 613 · see citing works

Early Life Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Latent Health Outcomes: A Review Including the Placenta as a Target Tissue and Possible Driver of Peri- and Postnatal Effects

Blake, B. E., & Fenton, S. E. (2020) · Toxicology · doi:10.1016/j.tox.2020.152565 · Cited by 499 · see citing works

Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature

Rappazzo, K., Coffman, E., & Hines, E. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14070691 · Cited by 405 · see citing works

Concentrations of perfluoroalkyl substances (PFASs) in human embryonic and fetal organs from first, second, and third trimester pregnancies

Mamsen, L. S., Björvang, R. D., Mucs, D., Vinnars, M.-T., Papadogiannakis, N., Lindh, C. H., Andersen, C. Y., & Damdimopoulou, P. (2019) · Environment International · doi:10.1016/j.envint.2019.01.010 · Cited by 338 · see citing works

Pre- and Postnatal Exposure to Perfluorinated Compounds (PFCs)

Fromme, H., Mosch, C., Morovitz, M., Alba‐Alejandre, I., Boehmer, S., Kiranoglu, M., Faber, F. L., Hannibal, I., Genzel‐Boroviczény, O., Koletzko, B. V., et al. (2010) · Environmental Science & Technology · doi:10.1021/es101184f · Cited by 332 · see citing works

Neonatal Exposure to PFOS and PFOA in Mice Results in Changes in Proteins which are Important for Neuronal Growth and Synaptogenesis in the Developing Brain

Johansson, N., Eriksson, P., & Viberg, H. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp029 · Cited by 284 · see citing works

Population-wide exposure to per- and polyfluoroalkyl substances from drinking water in the United States

Andrews, D. Q., & Naidenko, O. V. (2020) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.0c00713 · Cited by 270 · see citing works

Novel Chlorinated Polyfluorinated Ether Sulfonates and Legacy Per-/Polyfluoroalkyl Substances: Placental Transfer and Relationship with Serum Albumin and Glomerular Filtration Rate

Pan, Y., Zhu, Y., Zheng, T., Cui, Q., Buka, S. L., Zhang, B., Guo, Y., Xia, W., Yeung, L. W. Y., Li, Y., et al. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b04590 · Cited by 259 · see citing works

Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: a systematic review of epidemiologic studies

Ballesteros, V., Costa, O., Iñiguez, C., Fletcher, T., Ballester, F., & Lopez-Espinosa, M.-J. (2017) · Environment International · doi:10.1016/j.envint.2016.10.015 · Cited by 242 · see citing works

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land, M., de Wit, C. A., Bignert, A., Cousins, I. T., Herzke, D., Johansson, J. H., & Martin, J. W. (2018) · Environmental Evidence · doi:10.1186/s13750-017-0114-y · Cited by 219 · see citing works

Prenatal Polybrominated Diphenyl Ether Exposures and Neurodevelopment in U.S. Children through 5 Years of Age: The HOME Study

Chen, A., Yolton, K. A., Rauch, S. A., Webster, G. M., Hornung, R., Sjödin, A., Dietrich, K. N., & Lanphear, B. P. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307562 · Cited by 206 · see citing works

Project TENDR: Targeting Environmental Neuro-Developmental Risks The TENDR Consensus Statement

Bennett, D., Bellinger, D. C., Birnbaum, L. S., DABT, A.T.S, Bradman, A., Chen, A., Cory-Slechta, D. A., Engel, S. M., Fallin, M. D., et al. (2016) · Environmental Health Perspectives · doi:10.1289/ehp358 · Cited by 169 · see citing works

Impact of endocrine-disrupting chemicals on neural development and the onset of neurological disorders

Kajta, M., & Wójtowicz, A. K. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71524-x · Cited by 168 · see citing works

Prenatal Exposure to PFOS or PFOA Alters Motor Function in Mice in a Sex-Related Manner

Onishchenko, N., Fischer, C., Ibrahim, W. N. W., Negri, S., Spulber, S., Cottica, D., & Ceccatelli, S. (2011) · Neurotoxicity research · doi:10.1007/s12640-010-9200-4 · Cited by 152 · see citing works

Maternal exposure to perfluorinated acids and fetal growth

Hamm, M. P., Cherry, N. M., Chan, E., Martin, J. W., & Burstyn, I. (2010) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2009.57 · Cited by 151 · see citing works

Perfluoroalkyl Substances, Sex Hormones, and Insulin-like Growth Factor-1 at 6–9 Years of Age: A Cross-Sectional Analysis within the C8 Health Project

López-Espinosa, M.-J., Mondal, D., Armstrong, B., Eskenazi, B., & Fletcher, T. (2016) · Environmental Health Perspectives · doi:10.1289/ehp.1509869 · Cited by 147 · see citing works

Behavioral difficulties in 7-year old children in relation to developmental exposure to perfluorinated alkyl substances

Oulhote, Y., Steuerwald, U., Debes, F., Weihe, P., & Grandjean, P. (2016) · Environment International · doi:10.1016/j.envint.2016.09.015 · Cited by 132 · see citing works

Toxicologic evidence of developmental neurotoxicity of environmental chemicals

Andersen, H. R., Nielsen, J. B., & Grandjean, P. (2000) · Toxicology · doi:10.1016/s0300-483x(99)00198-5 · Cited by 131 · see citing works

Polyfluorinated Compounds in Serum Linked to Indoor Air in Office Environments

Fraser, A. J., Webster, T. F., Watkins, D. J., Nelson, J. W., Stapleton, H. M., Calafat, A. M., Kato, K., Shoeib, M., Vieira, V. M., & McClean, M. D. (2012) · Environmental Science & Technology · doi:10.1021/es2038257 · Cited by 127 · see citing works

Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: The Hokkaido Study

Goudarzi, H., 中島そのみ, Ikeno, T., Sasaki, S., Kobayashi, S., Miyashita, C., Ito, S., Araki, A., Nakazawa, H., & Kishi, R. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.10.017 · Cited by 118 · see citing works

Perfluorinated Compound Levels in Cord Blood and Neurodevelopment at 2 Years of Age

Chen, M., Ha, E., Liao, H., Jeng, S., Su, Y., Wen, T.-W., Lien, G., Chen, C., Hsieh, W., & Chen, P. (2013) · Epidemiology · doi:10.1097/ede.0b013e3182a6dd46 · Cited by 115 · see citing works

Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFASs) and child cognition

Harris, M. H., Oken, E., Rifas‐Shiman, S. L., Calafat, A. M., Ye, X., Bellinger, D. C., Webster, T. F., White, R. F., & Sagiv, S. K. (2018) · Environment International · doi:10.1016/j.envint.2018.03.025 · Cited by 115 · see citing works

Perfluorinated compounds in relation to birth weight in the Norwegian Mother and Child Cohort Study.

Whitworth, K. W., Haug, L., Baird, D., Becher, G., Hoppin, J., Skjærven, R., Thomsen, C., Eggesbø, M., Travlos, G., Wilson, R., et al. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kwr459 · Cited by 112 · see citing works

Prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and executive function in school-age children

Vuong, A. M., Yolton, K. A., Webster, G. M., Sjödin, A., Calafat, A. M., Braun, J. M., Dietrich, K. N., Lanphear, B. P., & Chen, A. (2016) · Environmental Research · doi:10.1016/j.envres.2016.01.008 · Cited by 112 · see citing works

Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5–9 years – a prospective study

Høyer, B. B., Ramlau‐Hansen, C. H., Obel, C., Pedersen, H. S., Hernik, A., Ogniev, V., Jönsson, B., Lindh, C. H., Rylander, L., Rignell‐Hydbom, A., et al. (2015) · Environmental Health · doi:10.1186/1476-069x-14-2 · Cited by 100 · see citing works

PFOS Induces Behavioral Alterations, Including Spontaneous Hyperactivity that Is Corrected by Dexamfetamine in Zebrafish Larvae

Spulber, S., Kilian, P., Wan Ibrahim, W. N., Onishchenko, N., Ulhaq, M., Norrgren, L., Negri, S., Di Tuccio, M., & Ceccatelli, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094227 · Cited by 98 · see citing works

The association between prenatal exposure to perfluoroalkyl substances and childhood neurodevelopment

Spratlen, M. J., Perera, F. P., Lederman, S. A., Rauh, V., Robinson, M., Kannan, K., Trasande, L., & Herbstman, J. B. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114444 · Cited by 95 · see citing works

Toxicokinetics of perfluorobutane sulfonate (PFBS), perfluorohexane-1-sulphonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration

Huang, M. C., Dzierlenga, A. L., Robinson, V. G., Waidyanatha, S., DeVito, M. J., Eifrid, M. A., Granville, C. A., Gibbs, S. T., & Blystone, C. R. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.06.016 · Cited by 94 · see citing works

Sex-specific Enhanced Behavioral Toxicity Induced by Maternal Exposure to a Mixture of Low Dose Endocrine-Disrupting Chemicals

Sobolewski, M., Conrad, K., Allen, J. L., Weston, H., Martin, K., Lawrence, B. P., & Cory-Slechta, D. A. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.09.008 · Cited by 91 · see citing works

Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study

Wang, Y., Rogan, W. J., Chen, H., Chen, P., Su, P., Chen, H.-Y., & Wang, S. (2015) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2015.07.002 · Cited by 90 · see citing works

Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort

Leung, Y., Ouyang, B., Niu, L., Xie, C., Ying, J., Medvedovic, M., Chen, A., Weihe, P., Valvi, D., Grandjean, P., et al. (2018) · Epigenetics · doi:10.1080/15592294.2018.1445901 · Cited by 89 · see citing works

Associations of prenatal PFAS exposure and early childhood neurodevelopment: Evidence from the Shanghai Maternal-Child Pairs Cohort

Zhou, Y., Li, Q., Wang, P., Li, J., Zhao, W., Zhang, L., Wang, H., Cheng, Y., Shi, H., Li, J., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.107850 · Cited by 82 · see citing works

Efficiency of maternal-fetal transfer of perfluoroalkyl and polyfluoroalkyl substances

Wang, Y., Han, W., Wang, C., Zhou, Y., Shi, R., Bonefeld‐Jørgensen, E. C., Qian, Y., Yuan, T., Gao, Y., Zhang, J., et al. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3686-3 · Cited by 80 · see citing works

Prenatal and childhood exposure to poly- and perfluoroalkyl substances (PFAS) and cognitive development in children at age 8 years

Vuong, A. M., Yolton, K. A., Xie, C., Dietrich, K. N., Braun, J. M., Webster, G. M., Calafat, A. M., Lanphear, B. P., & Chen, A. (2019) · Environmental Research · doi:10.1016/j.envres.2019.02.025 · Cited by 79 · see citing works

Per- and polyfluoroalkyl substances (PFAS) in breast milk and infant formula: A global issue

LaKind, J. S., Naiman, J., Verner, M.-A., Lévêque, L., & Fenton, S. E. (2022) · Environmental Research · doi:10.1016/j.envres.2022.115042 · Cited by 73 · see citing works

Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort

Liew, Z., Ritz, B. R., Bach, C. C., Asarnow, R. F., Bech, B. H., Nohr, E. A., Bossi, R., Henriksen, T. B., Bonefeld‐Jørgensen, E. C., & Olsen, J. (2018) · Environmental Health Perspectives · doi:10.1289/ehp2754 · Cited by 71 · see citing works

Exposure to perfluoroalkyl substances and neurodevelopment in 2-year-old children: A prospective cohort study

Luo, F., Chen, Q., Yu, G., Huo, X., Wang, H., Nian, M., Tian, Y., Xu, J., Zhang, J., & Zhang, J. (2022) · Environment International · doi:10.1016/j.envint.2022.107384 · Cited by 71 · see citing works

PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes

Davidsen, N., Ramhøj, L., Lykkebo, C. A., Kugathas, I., Poulsen, R., Rosenmai, A. K., Evrard, B., Darde, T., Axelstad, M., Bahl, M. I., et al. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119340 · Cited by 70 · see citing works

Prenatal perfluoroalkyl substance exposure and neuropsychological development throughout childhood: The INMA Project

Carrizosa, C., Murcia, M., Ballesteros, V., Costa, O., Manzano-Salgado, C. B., Ibarluzea, J. M., Íñiguez, C., Casas, M., Andiarena, A., Llop, S., et al. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.125185 · Cited by 68 · see citing works

Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration

Dzierlenga, A. L., Robinson, V. G., Waidyanatha, S., DeVito, M. J., Eifrid, M. A., Gibbs, S. T., Granville, C. A., & Blystone, C. R. (2019) · Xenobiotica · doi:10.1080/00498254.2019.1683776 · Cited by 66 · see citing works

Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFAS) and child executive function and behavioral problems

Harris, M. H., Oken, E., Rifas‐Shiman, S. L., Calafat, A. M., Bellinger, D. C., Webster, T. F., White, R. F., & Sagiv, S. K. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111621 · Cited by 66 · see citing works

Prenatal exposure to per- and polyfluoroalkyl substances, fetal thyroid hormones, and infant neurodevelopment

Yao, Q., Vinturache, A., Lei, X., Wang, Z., Pan, C., Shi, R., Yuan, T., Gao, Y., & Tian, Y. (2021) · Environmental Research · doi:10.1016/j.envres.2021.112561 · Cited by 65 · see citing works

Gender difference in the effects of interleukin-6 on grip strength – a systematic review and meta-analysis

Mikó, A., Pótó, L., Mátrai, P., Hegyi, P., Füredi, N., Garami, A., Illés, A., Solymár, M., Vincze, Á., Balaskó, M., et al. (2018) · BMC Geriatrics · doi:10.1186/s12877-018-0798-z · Cited by 64 · see citing works

Prenatal exposure to legacy PFAS and neurodevelopment in preschool-aged Canadian children: The MIREC cohort

Goodman, C. V., Till, C., Green, R. R., El-Sabbagh, J., Arbuckle, T. E., Hornung, R., Lanphear, B. P., Séguin, J. R., Booij, L., Fisher, M. M., et al. (2023) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2023.107181 · Cited by 63 · see citing works

Perfluoroalkylated Compounds Induce Cell Death and Formation of Reactive Oxygen Species in Cultured Cerebellar Granule Cells

Reistad, T., Fonnum, F., & Mariussen, E. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.01.006 · Cited by 61 · see citing works

Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature

Liu, D., Yan, S., Wang, P., Chen, Q., Liu, Y., Cui, J., Liang, Y., Ren, S., & Gao, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1103141 · Cited by 61 · see citing works

Prenatal Exposure to Legacy and Alternative Per- and Polyfluoroalkyl Substances and Neuropsychological Development Trajectories over the First 3 Years of Life

Li, Q.-Q., Huang, J., Cai, D., Chou, W.-C., Zeeshan, M., Chu, C., Zhou, Y., Lin, L., Ma, H., Tang, C., et al. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c07807 · Cited by 60 · see citing works

Influence of maternal restraint stress on the long-lasting effects induced by prenatal exposure to perfluorooctane sulfonate (PFOS) in mice

Fuentes, S., Colomina, M. T., Vicens, P., & Domingo, J. L. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.05.006 · Cited by 57 · see citing works

Assessment of neuropsychological trajectories in longitudinal population-based studies of children: Table 1

White, R. F., Campbell, R., Echeverria, D., Knox, S. S., & Janulewicz, P. A. (2008) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2007.071530 · Cited by 56 · see citing works

The Association between Prenatal Per- and Polyfluoroalkyl Substances Exposure and Neurobehavioral Problems in Offspring: A Meta-Analysis

Yao, H., Fu, Y., Weng, X., Zeng, Z., Tan, Y., Wu, X., Zeng, H., Yang, Z., Li, Y., Liang, H., et al. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20031668 · Cited by 46 · see citing works

Prenatal concentrations of Perfluoroalkyl substances and early communication development in British girls

Jeddy, Z., Hartman, T. J., Taylor, E. V., Poteete, C., & Kordas, K. (2017) · Early Human Development · doi:10.1016/j.earlhumdev.2017.04.004 · Cited by 44 · see citing works

Per- and polyfluoroalkyl substances (PFAS)—contaminants of emerging concern

Baker, E. S., & Knappe, D. R. U. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03811-9 · Cited by 39 · see citing works

Prenatal and childhood exposure to perfluoroalkyl substances (PFAS) and measures of attention, impulse control, and visual spatial abilities

Vuong, A. M., Braun, J. M., Yolton, K. A., Wang, Z., Xie, C., Webster, G. M., Ye, X., Calafat, A. M., Dietrich, K. N., Lanphear, B. P., et al. (2018) · Environment International · doi:10.1016/j.envint.2018.07.013 · Cited by 37 · see citing works

Perfluorooctanoate and perfluorooctane sulfonate in umbilical cord blood and child cognitive development: Hamamatsu Birth Cohort for Mothers and Children (HBC Study)

Oh, J., Shin, H., Nishimura, T., Rahman, M. S., Takahashi, N., & Tsuchiya, K. J. (2022) · Environment International · doi:10.1016/j.envint.2022.107215 · Cited by 37 · see citing works

Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age

Høyer, B. B., Bonde, J. ­., Tøttenborg, S. S., Ramlau‐Hansen, C. H., Lindh, C. H., Pedersen, H. S., & Toft, G. V. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.11.007 · Cited by 36 · see citing works

Chemical mixture exposures during pregnancy and cognitive abilities in school-aged children

Kalloo, G., Wellenius, G. A., McCandless, L. C., Calafat, A. M., Sjödin, A., Sullivan, A., Romano, M. E., Karagas, M. R., Chen, A., Yolton, K. A., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111027 · Cited by 32 · see citing works

Maternal co-exposure to mercury and perfluoroalkyl acid isomers and their associations with child neurodevelopment in a Canadian birth cohort

Reardon, A. J. F., Hajihosseini, M., Dinu, I. A., Field, C. J., Kinniburgh, D. W., MacDonald, A. M., Dewey, D., England-Mason, G., & Martin, J. W. (2023) · Environment International · doi:10.1016/j.envint.2023.108087 · Cited by 32 · see citing works

Association Between Prenatal and Early Postnatal Exposure to Perfluoroalkyl Substances and IQ Score in 7-Year-Old Children From the Odense Child Cohort

Beck, I. H., Bilenberg, N., Möller, S., Nielsen, F., Grandjean, P., Højsager, F. D., Halldorsson, T. I., Nielsen, C., & Jensen, T. K. (2023) · American Journal of Epidemiology · doi:10.1093/aje/kwad110 · Cited by 31 · see citing works

Prenatal exposure to perfluoroalkyl substances and child intelligence quotient: Evidence from the Shanghai birth cohort

Wang, H., Luo, F., Zhang, Y., Yang, X., Zhang, S., Zhang, J., Tian, Y., & Zheng, L. (2023) · Environment International · doi:10.1016/j.envint.2023.107912 · Cited by 28 · see citing works

Prenatal Exposure to Perfluoroalkyl Substances and Cognitive and Neurobehavioral Development in Children at 6 Years of Age

Xie, Z., Liang, H., Miao, M., Wang, Z., Chen, Y., Yang, L., Zhou, Y., Cao, W., & Yuan, W. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c06535 · Cited by 28 · see citing works

Prenatal perfluoroalkyl substances exposure and neurodevelopment in toddlers: Findings from SMBCS

Zhang, B., Wang, Z., Zhang, J., Dai, Y., Feng, C., Lin, Y., Zhang, L., Guo, J., Qi, X., Chang, X., et al. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.137587 · Cited by 26 · see citing works

Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study

Kornvig, S., Wielsøe, M., Long, M., & Bonefeld‐Jørgensen, E. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-01580-0 · Cited by 18 · see citing works

Associations of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with measures of cognition in 7.5-month-old infants: An exploratory study

Enright, E. A., Eick, S. M., Morello-Frosch, R. A., Aguiar, A., Woodbury, M., Sprowles, J. L. N., Geiger, S. D., Trowbridge, J., Andrade, A., Smith, S. C., et al. (2023) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2023.107182 · Cited by 17 · see citing works

In utero exposure to perfluoroalkyl and polyfluoroalkyl substances and attention and executive function in the offspring: A study in the Danish National Birth Cohort.

Bach, C., Liew, Z., Matthiesen, N., Henriksen, T., Bech, B., Nøhr, E., Bonefeld-Jørgensen, E., & Olsen, J. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113262 · Cited by 14 · see citing works

Exposure to PFOA, PFOS, and PFHxS induces Alzheimer's disease-like neuropathology in cerebral organoids

Lu, S., Zhu, X., Zeng, P., Hu, L., Huang, Y., Guo, X., Chen, Q., Wang, Y., Lai, L., Xue, A., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.125098 · Cited by 61 · see citing works

Prenatal exposure to per- and polyfluoroalkyl substances, fetal thyroid function, and intelligence quotient at 7 years of age: Findings from the Sheyang Mini Birth Cohort Study

Zhang, B., Wang, Z., Zhang, J., Dai, Y., Ding, J., Guo, J., Qi, X., Wu, C., & Zhou, Z. (2024) · Environment International · doi:10.1016/j.envint.2024.108720 · Cited by 24 · see citing works

Per- and polyfluoroalkyl substances and human health outcomes: An umbrella review of systematic reviews with meta-analyses of observational studies

Xing, W.-Y., Sun, J., Liu, F., Shan, L.-S., Yin, J.-L., Li, Y.-Z., Xu, H., Wei, Y., Liu, J.-X., Zheng, W., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134556 · Cited by 23 · see citing works

Hunting Metabolic Biomarkers for Exposure to Per- and Polyfluoroalkyl Substances: A Review

Ma, X., Cai, D., Chen, Q., Zhu, Z., Zhang, S., Wang, Z., Hu, Z., Shen, H., & Meng, Z. (2024) · Metabolites · doi:10.3390/metabo14070392 · Cited by 22 · see citing works

Impacts of PFAS Exposure on Neurodevelopment: A Comprehensive Literature Review

Currie, S. D., Wang, J.-S., & Tang, L. (2024) · Environments · doi:10.3390/environments11090188 · Cited by 22 · see citing works

Regrettable Substitutes and the Brain: What Animal Models and Human Studies Tell Us about the Neurodevelopmental Effects of Bisphenol, Per- and Polyfluoroalkyl Substances, and Phthalate Replacements

Morales-Grahl, E., Hilz, E. N., & Gore, A. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136887 · Cited by 22 · see citing works

Personal care product use and per- and polyfluoroalkyl substances in pregnant and lactating people in the Maternal-Infant Research on Environmental Chemicals study

Hall, A. M., Ashley‐Martin, J., Liang, C. L., Papandonatos, G. D., Arbuckle, T. E., Borghese, M. M., Buckley, J. P., Cecil, K. M., Chen, A., Dodds, L. A., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.109094 · Cited by 21 · see citing works

Cord plasma metabolomic signatures of prenatal per- and polyfluoroalkyl substance (PFAS) exposures in the Boston Birth Cohort

Li, Z., Zhang, M., Hong, X., Wang, G., Choi, G., Nadeau, K. C., Buckley, J. P., & Wang, X. (2024) · Environment International · doi:10.1016/j.envint.2024.109144 · Cited by 20 · see citing works

Per- and polyfluoroalkyl substances in environment and potential health impacts: Sources, remediation treatment and management, policy guidelines, destructive technologies, and techno-economic analysis

Chambial, P., Thakur, N., Kushawaha, J., & Kumar, R. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.178803 · Cited by 18 · see citing works

Prenatal exposure to per- and polyfluoroalkyl substances and sex-specific associations with offspring adiposity at 10 years of age: Metabolic perturbation plays a role

Wang, Z., Zhang, B., Zhang, J., Xu, S., Dai, Y., Ding, J., Guo, J., Qi, X., Chang, X., Wu, C., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.109037 · Cited by 17 · see citing works

Environmental pollutant exposure and adverse neurodevelopmental outcomes: An umbrella review and evidence grading of meta-analyses

Gao, X., Zheng, X., Wang, X., Li, Z., & Yang, L. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.137832 · Cited by 16 · see citing works

Exposure to Per- and Polyfluoroalkyl Substances (PFASs) in Healthcare: Environmental and Clinical Insights

Briassoulis, G., Ilia, S., & Briassouli, E. (2025) · Life · doi:10.3390/life15071057 · Cited by 15 · see citing works

Association between perfluoroalkyl substances and breast cancer on the National Health and Nutrition Examination Survey Database and meta-analysis

Jia, C., Li, Y., Cao, Y., Zhou, Z., Liu, Y., Guo, Y., Liu, W., & Yang, L. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135219 · Cited by 12 · see citing works

Impact of PFOS Exposure on Murine Fetal Hematopoietic Stem Cells, Associated with Intrauterine Metabolic Perturbation

Lee, W. K., Wan, H. T., CHENG, Z., Wing Yee, C. H. A. N., Lam, T. K. Y., Lai, K. P., Wang, J., Cai, Z., & Wong, C. K. C. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c02623 · Cited by 11 · see citing works

The impact of early life exposure to individual and combined PFAS on learning, memory, and bioaccumulation in C. elegans

Currie, S. D., Ji, Y., Huang, Q., Wang, J., & Tang, L. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.125257 · Cited by 10 · see citing works

Maternal concentrations of perfluoroalkyl sulfonates and alterations in white matter microstructure in the developing brains of young children

England-Mason, G., Reardon, A. J. F., Reynolds, J. E., Grohs, M. N., MacDonald, A. M., Kinniburgh, D. W., Martin, J. W., Lebel, C. A., & Dewey, D. (2024) · Environmental Research · doi:10.1016/j.envres.2024.120638 · Cited by 10 · see citing works

Screening (ant)agonistic activities of xenobiotics on the retinoic acid receptor alpha (RARα) using in vitro and in silico analysis

Su, J., Yang, X., Xu, H., Pei, Y., Liu, Q. S., Zhou, Q., & Jiang, G. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174717 · Cited by 7 · see citing works

Short-chain PFAS exposure during gestation and breastfeeding alters learning and memory in adulthood: possible mechanisms related to brain development

Lorenzini, L., Moretti, M., Zanardello, C., Gallocchio, F., Baldassarro, V. A., Moressa, A., Zanella, L., Sannia, M., Foiani, G., Quadalti, C., et al. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2025.1702330 · Cited by 5 · see citing works

Prenatal exposure to per- and polyfluoroalkyl substances and childhood executive function and behavioral difficulties at age 7: evidence from the Shanghai birth cohort study

He, X., Wu, R., Jiang, W., Tian, Y., Zhang, J., & Huang, Y. (2025) · Environment International · doi:10.1016/j.envint.2025.109687 · Cited by 4 · see citing works

Prenatal Per- and Polyfluoroalkyl Substances (PFAS) Exposures, Newborn Mitochondrial DNA Copy Number, and the Modifying Role of the Maternal Folate Level

Li, Z., Qu, X., Hong, X., Wang, G., Song, M., Choi, G., Buckley, J. P., & Wang, X. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c06494 · Cited by 4 · see citing works

Prenatal exposure to PFAS, associations with child cognitive ability and modification by maternal Vitamin D status: The MABC study

Wu, X., Tong, J., Papandonatos, G. D., Gan, H., Xing, Y., Tao, S., Geng, M., Liang, C., Yan, S., Cao, H., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.140595 · Cited by 4 · see citing works

Integrated basin-scale assessment of legacy and emerging PFAS in the Xiangjiang River Basin, China: Occurrence, source apportionment, and risk prioritization

Lin, D.-Y., Hu, L.-X., Liu, Y., Zhang, J., & Ying, G. (2026) · Water Research · doi:10.1016/j.watres.2026.125350 · Cited by 4 · see citing works

Urban air pollution and child neurodevelopmental conditions: a systematic bibliometric review

Kefas, R., Roy, R., & D’Angiulli, A. (2024) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000984 · Cited by 4 · see citing works

Prenatal exposure to persistent organic pollutants and associations with child behavior problems at 1–5 years

Eick, S. M., Ortlund, K., Barr, D. B., Dunlop, A. L., Liang, D., Corwin, E. J., Ryan, P. B., Friedman, S., Buhr, M., Panuwet, P., et al. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126123 · Cited by 4 · see citing works

Associations between maternal exposure to per- and polyfluoroalkyl substances and childhood neurodevelopment up to age 4: The Japan environment and children’s study

Mezawa, H., Eguchi, A., Yamamoto, M., Tokuda, N., Shima, M., Nakayama, S. F., & Kamijima, M. (2025) · Environment International · doi:10.1016/j.envint.2025.109824 · Cited by 3 · see citing works

Human cerebral organoids reveal PFOA-induced axonal injury as a conserved mechanism of neurodevelopmental disruption

Chen, W.-R., Huang, Y., Zhou, W., Yang, J., Ren, T., Zhang, L., Zhu, T., Shan, X., Du, Y., Zhou, G., et al. (2026) · Environment International · doi:10.1016/j.envint.2026.110233 · Cited by 3 · see citing works

Integrating Adverse Outcome Pathway–Bayesian Network and Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Developmental Neurotoxicity of F-53B under Human-Relevant Exposure Scenarios

Feng, L., Han, Y., Qin, X., Wang, J., Gu, Q., Wang, H., Jin, T., Wang, Z., Luo, H., Tao, G., et al. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.6c00505 · Cited by 3 · see citing works

Per- and polyfluoroalkyl substances induce cytotoxicity in NCI–H446 cells through modulating proliferation, apoptosis, and m6A methylation

Wei, L., Sun, X., Deng, Z., Chen, S., Han, K., Wen, L., Tan, L., & Miao, T. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115868 · Cited by 2 · see citing works

Is there a glymphatic pathway to environmental risk in neurodevelopmental disorders?

da Costa, M. D. A., Bolan, S. J., Ebs, M. F. P., Araújo, S. L., Faller, C. J., Barichello, T., Aschner, M., Generoso, J. S., & Gonçalves, C. L. (2025) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2025.107578 · Cited by 2 · see citing works

Prenatal per- and polyfluoroalkyl substances exposure and child neurodevelopment from birth to age 7: A prospective study in the Laizhou Wan Birth Cohort

Pang, Y., Wang, Z., Gao, Y., Zhang, Y., Cao, Y., Kang, W., Fan, L., Wang, R., Zhang, J., Lu, P., et al. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141933 · Cited by 2 · see citing works

Prenatal exposure to ultraviolet filters and children's cognitive and neurobehavioral development: A longitudinal study

Ying, T., Chen, Y., Su, H., Liang, H., Wang, Z., Liu, Y., Liu, J., Miao, M., & He, G. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.127560 · Cited by 1 · see citing works

Role of constitutive androstane receptor in developmental toxicology: linking chemical exposure, nutrition, and disease susceptibility

Shizu, R., & Yoshinari, K. (2026) · Critical Reviews in Toxicology · doi:10.1080/10408444.2026.2623026

Spatiotemporal distribution and risk assessment of per- and polyfluoroalkyl substances in soil from e-waste dismantling parks: A multi-year study

Ma, Q., Ji, Z., Zheng, J., Ding, H. S., Shi, Y., & Cai, Y. (2026) · Journal of Environmental Sciences · doi:10.1016/j.jes.2026.02.046

Per- and Poly-fluoroalkyl Substances in the Food Chain: A Review of Exposure Pathways and Long-term Health Consequences

(2026) · Journal of Food and Nutritional Health · doi:10.47275/2692-5222-129

Exposure to Environmental Toxicants: Glymphatic System Dysfunction and Its Implications on Neurodevelopmental Disorders

Ehsanifar, M., Gholami, A., Shenasi, R., Pahnavar, N., & Golmohammadi, M. (2026) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2602333

Stress-activated pathways mediate PFAS effects on human placental syncytiotrophoblast cells

Kozai, K., & Varberg, K. M. (2026) · Toxicological Sciences · doi:10.1093/toxsci/kfag060

Early-life PFOS exposure causes lasting impairment of neural stem cell fate, white matter maturation, and olfactory behavior

Butruille, L., Guittonneau, C., Blay, K. L., Valcárcel-Hernández, V., Aigrot, M., Fini, J.-B., Zalc, B., & Remaud, S. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120365

Gestational PFOS Exposure Induces Alveolar Developmental Defects by Affecting Immune–Epithelial Crosstalk in Offspring Rats

Zuo, J., Mo, J., Weng, S., Wang, L., Zheng, S., Wei, J., Wang, D., Chen, J., & Ye, L. (2026) · Journal of Applied Toxicology · doi:10.1002/jat.70271

Childhood exposure to legacy and emerging per- and polyfluoroalkyl substances and autistic traits in children at age 4

Guo, Y., Ao, J., Tang, W., Liu, X., Liu, J., Zhang, Q., Ge, W., & Li, F. R. (2026) · Environment International · doi:10.1016/j.envint.2026.110427

Integrating primary and meta-analytic effect size estimates on the effects of PFAS and organochlorine pesticides on human health outcomesPreprint

Morrison, K., Ricolfi, L., Gross, I. P., Mizuno, A., Pollo, P., Purgar, M., Lagisz, M., & Nakagawa, S. (2026) · doi:10.32942/x2dt2c

The microbiota at the interface of environmental toxicants and the brain

Matsuzaki, R., Caudle, W. M., & Sampson, T. R. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.08.002

Portable electrochemiluminescence detection of perfluorooctanoic acid assisted by deep learning

Duan, R., Yang, X., Wang, Y., Yu, J., Su, Z., Yang, Z., Li, X., Liu, J., Pan, P., & He, J. (2026) · Microchemical Journal · doi:10.1016/j.microc.2026.119818

Plasma per- and polyfluoroalkyl substance (PFAS) concentrations in mid-childhood and associations with DNA methylation and epigenetic aging through early adolescence

Smith, A. R., Hernandez‐Castro, I., Bozack, A. K., Rifas‐Shiman, S. L., Gold, D. R., Hivert, M., Oken, E., & Cárdenas, A. (2026) · Environmental Research · doi:10.1016/j.envres.2026.125759

Pediatric effects of forever chemicals may last for a long time

Grandjean, P. (2026) · Pediatric Research · doi:10.1038/s41390-026-05366-w

Fluorinated antifouling imprinted polymer platform for electrochemical selective detection of perfluoroalkyl and polyfluoroalkyl substances

Zhu, X., Li, J., Cheng, C., Ren, Z., & Wang, Y. (2026) · Analytica Chimica Acta · doi:10.1016/j.aca.2026.346395

Steroid 5α-reductase type 1 as a neurodevelopmental toxicological target: Hydrophobicity governs environmental inhibition within, but not across, chemical classes

Lu, X., Chen, J., Fang, H., Chen, J., Ge, R.-S., & Wang, Y. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120947

Prenatal exposure to legacy PFAS and neurodevelopment in preschool-aged Canadian children: The MIREC cohort

Goodman, C. V., Till, C., Green, R. R., El-Sabbagh, J., Arbuckle, T. E., Hornung, R., Lanphear, B. P., Séguin, J. R., Booij, L., Fisher, M. M., et al. (2023) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2023.107181 · Cited by 63 · see citing works

Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort

Liew, Z., Ritz, B. R., Bach, C. C., Asarnow, R. F., Bech, B. H., Nohr, E. A., Bossi, R., Henriksen, T. B., Bonefeld‐Jørgensen, E. C., & Olsen, J. (2018) · Environmental Health Perspectives · doi:10.1289/ehp2754 · Cited by 71 · see citing works

Association between prenatal exposure to per- and polyfluoroalkyl substances and neurodevelopment in children: Evidence based on birth cohort

Gao, X.-X., Zuo, Q.-L., Fu, X., Song, L., Cen, M., & Wu, J. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116812 · Cited by 24 · see citing works

Prenatal exposure to per- and polyfluoroalkyl substances and childhood executive function and behavioral difficulties at age 7: evidence from the Shanghai birth cohort study

He, X., Wu, R., Jiang, W., Tian, Y., Zhang, J., & Huang, Y. (2025) · Environment International · doi:10.1016/j.envint.2025.109687 · Cited by 4 · see citing works

Evaluating the Neurodevelopmental Effects of Per- and Polyfluoroalkyl Substances Exposure in Children: A Review

Yeih, N. S., Ansah, R. S., Olorunfemi, O. E., & Oware, E. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.17967995