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Cited by 312Influenza Virus Research StudiesRespiratory viral infections researchPneumonia and Respiratory Infections

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Influenza-Associated Pediatric Mortality in the United States: Increase of Staphylococcus aureus Coinfection

Finelli, Lyn, Fiore, Anthony, Dhara, Rosaline, Brammer, Lynnette, Shay, David K., Kamimoto, Laurie, Fry, Alicia, Hageman, Jeffrey, Gorwitz, Rachel, Bresee, Joseph, Uyeki, Timothy·2008·PEDIATRICS
DOI 10.1542/peds.2008-1336
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Abstract

OBJECTIVE: Pediatric influenza-associated death became a nationally notifiable condition in the United States during 2004. We describe influenza-associated pediatric mortality from 2004 to 2007, including an increase of Staphylococcus aureus coinfections. METHODS: Influenza-associated pediatric death is defined as a death of a child who is younger than 18 years and has laboratory-confirmed influenza. State and local health departments report to the Centers for Disease Control and Prevention demographic, clinical, and laboratory data on influenza-associated pediatric deaths. RESULTS: During the 2004-2007 influenza seasons, 166 influenza-associated pediatric deaths were reported (n = 47, 46, and 73, respectively). Median age of the children was 5 years. Children often progressed rapidly to death; 45% died within 72 hours of onset, including 43% who died at home or in an emergency department. Of 90 children who were recommended for influenza vaccination, only 5 (6%) were fully vaccinated. Reports of bacterial coinfection increased substantially from 2004-2005 to 2006-2007 (6%, 15%, and 34%, respectively). S aureus was isolated from a sterile site or endotracheal tube culture in 1 case in 2004-2005, 3 cases in 2005-2006, and 22 cases in 2006-2007; 64% were methicillin-resistant S aureus. Children with S aureus coinfection were significantly older and more likely to have pneumonia and acute respiratory distress syndrome than those who were not coinfected. CONCLUSIONS: Influenza-associated pediatric mortality is rare, but the proportion of S aureus coinfection identified increased fivefold over the past 3 seasons. Research is needed to identify risk factors for influenza coinfection with invasive bacteria and to determine the impact of influenza vaccination and antiviral agents in preventing pediatric mortality.

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Crossref · 10.1542/peds.2008-1336

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Research works printed but not linked: 2

  1. Jakab GJ. Immune impairment of alveolar macrophage phagocytosis during influenza virus pneumonia. Am Rev Respir Dis. 1982;126(5):778–782
  2. Adam H, McGeer A, Simor A. Fatal case of post-influenza, community-associated MRSA pneumonia in an Ontario teenager with subsequent familial transmission. Can Commun Dis Rep. 2007;33(4):45–48

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Metadata

Authors
Finelli, L., Fiore, A., Dhara, R., Brammer, L., Shay, D. K., Kamimoto, L., Fry, A., Hageman, J., Gorwitz, R., Bresee, J., & Uyeki, T.
Affiliations
  • National Center for Immunization and Respiratory Diseases (US)
  • Centers for Disease Control and Prevention (US)
Corresponding author
Finelli, Lyn
ORCID
Venue
PEDIATRICS
Publisher
American Academy of Pediatrics (AAP)
Published
2008-10-01
Volume
122
Issue
4
Pages
805-811
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.2008-1336
OpenAlex
W2032287546
Cited by
312
References
45
Citations by year
2026: 4 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 15 · 2021: 14 · 2020: 13 · 2019: 18 · 2018: 19 · 2017: 18 · 2016: 14 · 2015: 13 · 2014: 13 · 2013: 27 · 2012: 31
FWCI
23.75
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Keywords
methicillin-resistant Staphylococcus aureus, bacterial co-infection, influenza vaccination coverage, pneumonia, acute respiratory distress syndrome, influenza surveillance
MeSH terms
Adolescent, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Influenza, Human, Influenza Vaccines, Male, Prognosis, Retrospective Studies, Risk Factors, Staphylococcal Infections, Staphylococcus aureus, United States, Superinfection, Incidence, Survival Rate, Age Distribution, Sex Distribution

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