The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Continued Impact of Pneumococcal Conjugate Vaccine on Carriage in Young Children
Open accessAbstract
OBJECTIVES: The goals were to assess serial changes in Streptococcus pneumoniae serotypes and antibiotic resistance in young children and to evaluate whether risk factors for carriage have been altered by heptavalent pneumococcal conjugate vaccine (PCV7). METHODS: Nasopharyngeal specimens and questionnaire/medical record data were obtained from children 3 months to <7 years of age in primary care practices in 16 Massachusetts communities during the winter seasons of 2000–2001 and 2003–2004 and in 8 communities in 2006–2007. Antimicrobial susceptibility testing and serotyping were performed with S pneumoniae isolates. RESULTS: We collected 678, 988, and 972 specimens during the sampling periods in 2000–2001, 2003–2004, and 2006–2007, respectively. Carriage of non-PCV7 serotypes increased from 15% to 19% and 29% (P < .001), with vaccine serotypes decreasing to 3% of carried serotypes in 2006–2007. The relative contribution of several non-PCV7 serotypes, including 19A, 35B, and 23A, increased across sampling periods. By 2007, commonly carried serotypes included 19A (16%), 6A (12%), 15B/C (11%), 35B (9%), and 11A (8%), and high-prevalence serotypes seemed to have greater proportions of penicillin nonsusceptibility. In multivariate models, common predictors of pneumococcal carriage, such as child care attendance, upper respiratory tract infection, and the presence of young siblings, persisted. CONCLUSIONS: The virtual disappearance of vaccine serotypes in S pneumoniae carriage has occurred in young children, with rapid replacement with penicillin-nonsusceptible nonvaccine serotypes, particularly 19A and 35B. Except for the age group at highest risk, previous predictors of carriage, such as child care attendance and the presence of young siblings, have not been changed by the vaccine.
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Cites
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Efficacy of a Pneumococcal Conjugate Vaccine against Acute Otitis Media
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Immunogenicity and Impact on Nasopharyngeal Carriage of a Nonavalent Pneumococcal Conjugate Vaccine
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Cited by
The Diagnosis and Management of Acute Otitis Media
Lieberthal, A. S., Carroll, A. E., Chonmaitree, T., Ganiats, T. G., Hoberman, A., Jackson, M. A., Joffe, M. D., Miller, D. T., Rosenfeld, R. M., Sevilla, X. D., et al. (2013) · Pediatrics · doi:10.1542/peds.2012-3488 · Cited by 1,442
Serotype replacement in disease after pneumococcal vaccination
Weinberger, D. M., Malley, R., & Lipsitch, M. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62225-8 · Cited by 1,020
Self-citationU.S. Hospitalizations for Pneumonia after a Decade of Pneumococcal Vaccination
Griffin, M. R., Zhu, Y., Moore, M. R., Whitney, C. G., & Grijalva, C. G. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209165 · Cited by 506
Healthcare utilization and cost of pneumococcal disease in the United States
Huang, S. S., Johnson, K. M., Ray, G. T., Wroe, P., Lieu, T. A., Moore, M. R., Zell, E. R., Linder, J. A., Grijalva, C. G., Metlay, J. P., et al. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.02.088 · Cited by 296
Self-citationFlasche, S., Van Hoek, A. J., Sheasby, E., Waight, P., Andrews, N., Sheppard, C., George, R., & Miller, E. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001017 · Cited by 277
Metadata
- Authors
- Huang, S. S., Hinrichsen, V. L., Stevenson, A. E., Rifas-Shiman, S. L., Kleinman, K., Pelton, S. I., Lipsitch, M., Hanage, W. P., Lee, G. M., & Finkelstein, J. A.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2009-07-01
- Volume
- 124
- Issue
- 1
- Pages
- e1-e11
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2077913253
- Cited by
- 269
- References
- 35
- FWCI
- 23.03
- Type
- journal article
- Language
- en
- Open access
- green
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