Cited by 145Vitamin D Research StudiesAutism Spectrum Disorder ResearchChild Nutrition and Feeding Issues

The DOI matches its Crossref record; 24 of the 25 references it cites were found in a registry or an index.

Core Symptoms of Autism Improved After Vitamin D Supplementation

Jia, Feiyong, Wang, Bing, Shan, Ling, Xu, Zhida, Staal, Wouter G., Du, Lin·2015·Pediatrics

DOI 10.1542/peds.2014-2121

Open this paper in CoChat — free account

Abstract

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by a complex interaction between genetic and environmental risk factors. Among the environmental factors, vitamin D3 (cholecaliferol) seems to play a significant role in the etiology of ASD because this vitamin is important for brain development. Lower concentrations of vitamin D3 may lead to increased brain size, altered brain shape, and enlarged ventricles, which have been observed in patients with ASD. Vitamin D3 is converted into 25-hydroxyvitamin D3 in the liver. Higher serum concentrations of this steroid may reduce the risk of autism. Importantly, children with ASD are at an increased risk of vitamin D deficiency, possibly due to environmental factors. It has also been suggested that vitamin D3 deficiency may cause ASD symptoms. Here, we report on a 32-month-old boy with ASD and vitamin D3 deficiency. His core symptoms of autism improved significantly after vitamin D3 supplementation. This case suggests that vitamin D3 may play an important role in the etiology of ASD, stressing the importance of clinical assessment of vitamin D3 deficiency and the need for vitamin D3 supplementation in case of deficiency.

Integrity signals

Registry

Crossref · 10.1542/peds.2014-2121

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Global Assessment Scale: A Procedure for Measuring Overall Severity of Psychiatric Disturbance
Endicott, J. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770060086012 · Cited by 4,982
Vitamin D for health: a global perspective
Hossein-nezhad, A., & Holick, M. F. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.05.011 · Cited by 1,298
Most genetic risk for autism resides with common variation
Gaugler, T., Klei, L., Sanders, S. J., Bodea, C. A., Goldberg, A. P., Lee, A. B., Mahajan, M., Manaa, D., Pawitan, Y., Reichert, J., et al. (2014) · Nature Genetics · doi:10.1038/ng.3039 · Cited by 1,239
The Familial Risk of Autism
Sandin, S., Lichtenstein, P., Kuja-Halkola, R., Larsson, H., Hultman, C. M., & Reichenberg, A. (2014) · JAMA · doi:10.1001/jama.2014.4144 · Cited by 1,073
Vitamin D hormone regulates serotonin synthesis. Part 1: Relevance for autism
Patrick, R. P., & Ames, B. N. (2014) · The FASEB Journal · doi:10.1096/fj.13-246546 · Cited by 414
Blood serotonin levels in autism spectrum disorder: A systematic review and meta-analysis
Gabriele, S., Sacco, R., & Persico, A. M. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.02.004 · Cited by 346
Vitamin D: a pleiotropic hormone
Verstuyf, A., Carmeliet, G., Bouillon, R., & Mathieu, C. (2010) · Kidney International · doi:10.1038/ki.2010.17 · Cited by 339
Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC) Correspondence and Conflicts with DSM-IV Criteria in Diagnosis of Autism
Rellini, E., Tortolani, D., Trillo, S., Carbone, S., & Montecchi, F. (2004) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-004-5290-2 · Cited by 301
Autism and vitamin D
Cannell, J. J. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.08.016 · Cited by 287
Paternal Age at Childbearing and Offspring Psychiatric and Academic Morbidity
D’Onofrio, B. M., Rickert, M. E., Frans, E., Kuja-Halkola, R., Almqvist, C., Sjölander, A., Larsson, H., & Lichtenstein, P. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.4525 · Cited by 282

Show all 25 references

Sorted by citations

Identification, Evaluation, and Management of Children With Autism Spectrum Disorder
Hyman, S. L., Levy, S. E., Myers, S. M., COUNCIL ON CHILDREN WITH DISABILITIES, S. O. D. A. B. P., Kuo, D. Z., Apkon, S., Davidson, L. F., Ellerbeck, K. A., Foster, J. E. A., Noritz, G. H., et al. (2020) · Pediatrics · doi:10.1542/peds.2019-3447 · Cited by 1,798
The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease
Berridge, M. J. (2016) · Physiological Reviews · doi:10.1152/physrev.00006.2016 · Cited by 779
Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians
Saggese, G., Vierucci, F., Prodam, F., Cardinale, F., Cetin, I., Chiappini, E., Angelis, G. L. D., Massari, M., del Giudice, E. M., del Giudice, M. M., et al. (2018) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-018-0488-7 · Cited by 255
Autistic spectrum disorders: A review of clinical features, theories and diagnosis
Fakhoury, M. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.04.003 · Cited by 227
Vitamin D and autism, what’s new?
Cannell, J. J. (2017) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-017-9409-0 · Cited by 178
Correlation between Nutrition and Symptoms: Nutritional Survey of Children with Autism Spectrum Disorder in Chongqing, China
Liu, X., Liu, J., Xiong, X.-Q., Yang, T., Hou, N., Liang, X., Chen, J., Cheng, Q., & Li, T. (2016) · Nutrients · doi:10.3390/nu8050294 · Cited by 156
Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis
Wang, T., Shan, L., Du, L., Feng, J., Xu, Z., Staal, W., & Jia, F. (2015) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-015-0786-1 · Cited by 152
Self-citation
Clinical improvement following vitamin D3 supplementation in Autism Spectrum Disorder
Feng, J., Shan, L., Du, L., Wang, B., Li, H., Wang, W., Wang, T., Dong, H., Yue, X., Xu, Z., et al. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1123847 · Cited by 141
Self-citation
Vitamin D and Autism Spectrum Disorder: A Literature Review
Mazahery, H., Camargo, C., Conlon, C., Beck, K., Kruger, M., & Von Hurst, P. (2016) · Nutrients · doi:10.3390/nu8040236 · Cited by 110
Repetitive Restricted Behaviors in Autism Spectrum Disorder: From Mechanism to Development of Therapeutics
Tian, J., Gao, X., & Yang, L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.780407 · Cited by 136
Autism: Will vitamin D supplementation during pregnancy and early childhood reduce the recurrence rate of autism in newborn siblings?
Stubbs, G., Henley, K., & Green, J. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.01.015 · Cited by 107
Vitamin D and mental health in children and adolescents
Föcker, M., Antel, J., Ring, S., Hahn, D., Kanal, Ö., Öztürk, D., Hebebrand, J., & Libuda, L. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-0949-3 · Cited by 108
Diet: the keystone of autism spectrum disorder?
Peretti, S., Mariano, M. R. G., Mazzocchetti, C., Mazza, M., Pino, M. C., di Pianella, A. V., & Valenti, M. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1464819 · Cited by 112
Retracted: Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder
Saad, K., Abdelrahman, A. A., Elserogy, Y., Al-Atram, A. A., Elhoufey, A. A., Othman, H. A. K., Bjørklund, G., Jia, F., Urbina, M. A., Abo‐Elela, M. G. M., et al. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12652 · Cited by 99
Self-citation
Retracted
Lower maternal serum 25(OH) D in first trimester associated with higher autism risk in Chinese offspring
Chen, J., Xin, K., Wei, J., Zhang, K., & Xiao, H. (2016) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.08.013 · Cited by 96
Lack of effect of vitamin D3supplementation in autism: a 20-week, placebo-controlled RCT
Kerley, C. P., Power, C., Gallagher, L., & Coghlan, D. (2017) · Archives of Disease in Childhood · doi:10.1136/archdischild-2017-312783 · Cited by 81
Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia)
Berridge, M. J. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00188.2017 · Cited by 74
Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers
Egorova, O., Myte, R., Schneede, J., Hägglöf, B., Bölte, S., Domellöf, E., A’roch, B. I., Elgh, F., Ueland, P. M., & Silfverdal, S. (2020) · Molecular Autism · doi:10.1186/s13229-020-0315-z · Cited by 72
Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy
Marchezan, J., Winkler dos Santos, E. G. A., Deckmann, I., & Riesgo, R. D. S. (2018) · Neuroimmunomodulation · doi:10.1159/000492225 · Cited by 70
Association Between Atopic Dermatitis and Autism Spectrum Disorders: A Systematic Review
Billeci, L., Tonacci, A., Tartarisco, G., Ruta, L., Pioggia, G., & Gangemi, S. (2015) · American Journal of Clinical Dermatology · doi:10.1007/s40257-015-0145-5 · Cited by 74
A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children
Mazahery, H., Conlon, C. A., Beck, K. L., Mugridge, O., Kruger, M. C., Stonehouse, W., Camargo, C. A., Meyer, B. J., Tsang, B., Jones, B., et al. (2019) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-018-3860-y · Cited by 78
Effects of vitamin D supplementation on core symptoms, serum serotonin, and interleukin-6 in children with autism spectrum disorders: A randomized clinical trial
Javadfar, Z., Abdollahzad, H., Moludi, J., Rezaeian, S., Amirian, H., Foroughi, A., Nachvak, S. M., Goharmehr, N., & Mostafai, R. (2020) · Nutrition · doi:10.1016/j.nut.2020.110986 · Cited by 70
Emphasizing the Health Benefits of Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities
Grant, W. B., Wimalawansa, S. J., Holick, M. F., Cannell, J. J., Płudowski, P., Lappe, J. M., Pittaway, M., & May, P. (2015) · Nutrients · doi:10.3390/nu7031538 · Cited by 69
The Role of Vitamins in Autism Spectrum Disorder: What Do We Know?
Bjørklund, G., Waly, M. I., Al-Farsi, Y. M., Saad, K., Dadar, M., Rahman, M. M., Elhoufey, A. A., Chirumbolo, S., Jóźwik-Pruska, J., & Kałużna‐Czaplińska, J. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1237-5 · Cited by 72
Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain
Benítez‐Burraco, A., Lattanzi, W., & Murphy, E. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00373 · Cited by 64
The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper
Gillberg, C., Fernell, E., Kočovská, E., Minnis, H., Bourgeron, T., Thompson, L., & Allely, C. S. (2017) · Autism Research · doi:10.1002/aur.1777 · Cited by 65
Vitamin D Deficiency and Autism Spectrum Disorder
Siracusano, M., Riccioni, A., Abate, R., Benvenuto, A., Curatolo, P., & Mazzone, L. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200415174311 · Cited by 63
Maternal folic acid and micronutrient supplementation is associated with vitamin levels and symptoms in children with autism spectrum disorders
Tan, M., Yang, T., Zhu, J., Li, Q., Lai, X., Li, Y., Tang, T., Chen, J., & Li, T. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.11.009 · Cited by 63
A Revolutionizing Approach to Autism Spectrum Disorder Using the Microbiome
Johnson, D., Letchumanan, V., Thurairajasingam, S., & Lee, L. (2020) · Nutrients · doi:10.3390/nu12071983 · Cited by 64
Plant food bioactives and its effects on gut microbiota profile modulation for better brain health and functioning in Autism Spectrum Disorder individuals: A review
Shanmugam, H., Ganguly, S., & Priya, B. (2021) · Food Frontiers · doi:10.1002/fft2.125 · Cited by 56
Relationship between diet, the gut microbiota, and brain function
Tengeler, A. C., Kozicz, T., & Kiliaan, A. J. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy016 · Cited by 61
1,25-Dihydroxyvitamin D and Klotho
Haussler, M. R., Whitfield, G. K., Haussler, C. A., Sabir, M. S., Khan, Z., Sandoval, R., & Jurutka, P. W. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2015.11.005 · Cited by 54
Relationship between Vitamin Deficiencies and Co-Occurring Symptoms in Autism Spectrum Disorder
Robea, M. A., Luca, A.-C., & Ciobica, A. S. (2020) · Medicina · doi:10.3390/medicina56050245 · Cited by 54
The effect of vitamin D supplementation in treatment of children with autism spectrum disorder: a systematic review and meta-analysis of randomized controlled trials
Li, B., Xu, Y., Zhang, X., Zhang, L., Wu, Y., Wang, X., & Zhu, C. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1815332 · Cited by 48
The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder
Indika, N.-L. R., Frye, R. E., Rossignol, D. A., Owens, S. C., Senarathne, U. D., Grabrucker, A. M., Perera, R., ENGELEN, M. P. K. J., & Deutz, N. E. P. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13020252 · Cited by 49
Vitamin D, Neurosteroids and Autism
Máčová, L., Bičíková, M., Ostatníková, D., Hill, M., & Stárka, L. (2017) · Physiological Research · doi:10.33549/physiolres.933721 · Cited by 47
Supplement intervention associated with nutritional deficiencies in autism spectrum disorders: a systematic review
Li, Y., Li, Y., & Xiang, D.-X. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1528-6 · Cited by 52
The Role of Vitamin D Supplementation in Children with Autism Spectrum Disorder: A Narrative Review
Kittana, M., Ahmadani, A., Stojanovska, L., & Attlee, A. (2021) · Nutrients · doi:10.3390/nu14010026 · Cited by 48
Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders
Ogbu, D., Xia, E., & Sun, J. (2020) · Open Biology · doi:10.1098/rsob.200063 · Cited by 45
The mTOR Signaling Pathway Activity and Vitamin D Availability Control the Expression of Most Autism Predisposition Genes
Trifonova, E. A., Klimenko, A. I., Мустафин, З. С., Lashin, S. A., & Kochetov, A. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246332 · Cited by 43
Vitamin D Deficiency During Pregnancy and Autism Spectrum Disorders Development
Principi, N., & Esposito, S. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00987 · Cited by 46
Behavioral improvements in a valproic acid rat model of autism following vitamin D supplementation
Du, L., Zhao, G., Duan, Z., & Li, F. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.03.003 · Cited by 42
Self-citation
The effect of dietary supplements on clinical aspects of autism spectrum disorder: A systematic review of the literature
Γώγου, Μ., & Kolios, G. C. (2017) · Brain and Development · doi:10.1016/j.braindev.2017.03.029 · Cited by 44
Bench to bedside review: Possible role of vitamin D in autism spectrum disorder
Jia, F., Shan, L., Wang, B., Li, H., Miao, C., Xu, Z., Lin, C., & Saad, K. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.12.005 · Cited by 44
Self-citation
14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders
Xu, X., Jaehne, E. J., Greenberg, Z., McCarthy, P., Saleh, E., Parish, C. L., Camera, D., Heng, J. I., Haas, M., Baune, B. T., et al. (2015) · Scientific Reports · doi:10.1038/srep12434 · Cited by 41
Epilepsy and vitamin D: a comprehensive review of current knowledge
Yazdi, S. A. M., Abbasi, M., & Yazdi, S. M. M. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0044 · Cited by 39
Research Progress on the Role of Vitamin D in Autism Spectrum Disorder
Wang, J., Huang, H., Liu, C., Zhang, Y., Wang, W., Zou, Z., Yang, L. F., He, X., Wu, J.-T., Ma, J., et al. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.859151 · Cited by 38
Comparison of the effects of perceptual-motor exercises, vitamin D supplementation and the combination of these interventions on decreasing stereotypical behavior in children with autism disorder
Moradi, H., Sohrabi, M., Taheri, H., Khodashenas, E., & Movahedi, A. (2018) · International Journal of Developmental Disabilities · doi:10.1080/20473869.2018.1502068 · Cited by 36
The role of geographical ecological studies in identifying diseases linked to UVB exposure and/or vitamin D
Grant, W. B. (2016) · Dermato-Endocrinology · doi:10.1080/19381980.2015.1137400 · Cited by 38
Vitamin D3-Loaded Nanoemulsions as a Potential Drug Delivery System for Autistic Children: Formulation Development, Safety, and Pharmacokinetic Studies
Asfour, M. H., El-Alim, S. H. A., Kassem, A. A., Salama, A., Gouda, A. S., Nazim, W. S., Nashaat, N. H., Hemimi, M., & Meguid, N. A. (2023) · AAPS PharmSciTech · doi:10.1208/s12249-023-02501-2 · Cited by 35
Antineuroinflammatory therapy: potential treatment for autism spectrum disorder by inhibiting glial activation and restoring synaptic function
Li, Y., Zhang, X., & Li, Y. (2019) · CNS Spectrums · doi:10.1017/s1092852919001603 · Cited by 33
Vitamin D levels in children and adolescents with autism
Şengenç, E., Kıykım, E., & Saltık, S. (2020) · Journal of International Medical Research · doi:10.1177/0300060520934638 · Cited by 33
Dietary interventions for autism spectrum disorder: An updated systematic review of human studies
Amadi, C. N., Orish, C. N., Frazzoli, C., & Orisakwe, O. E. (2022) · Psychiatriki · doi:10.22365/jpsych.2022.073 · Cited by 37
Omega-3 PUFAs and vitamin D co-supplementation as a safe-effective therapeutic approach for core symptoms of autism spectrum disorder: case report and literature review
Infante, M., Sears, B., Rizzo, A. M., Cerati, D. M., Caprio, M., Ricordi, C., & Fabbri, A. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1557385 · Cited by 31
Effects of Vitamin D Supplementation on Children with Autism Spectrum Disorder: A Systematic Review and Meta-analysis
Zhang, M., Wu, Y., Lu, Z., Song, M., Huang, X., Mi, L., Yang, J., & Cui, X. (2023) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2023.21.2.240 · Cited by 30
Serum Vitamin D, Folate and Fatty Acid Levels in Children with Autism Spectrum Disorders: A Systematic Review and Meta-Analysis
Gallardo-Carrasco, M. C., Jiménez‐Barbero, J. A., Bravo, M. D. M. P., Martín-Castillo, D., & Sánchez-Muñoz, M. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05335-8 · Cited by 34
Association of low 25-OH-vitamin D levels and peripheral inflammatory markers in patients with autism spectrum disorder
Esnafoğlu, E., & Subaşı, B. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114735 · Cited by 30
Month of Conception and Learning Disabilities: A Record-Linkage Study of 801,592 Children
Mackay, D., Smith, G. C. S., Cooper, S., Wood, R., King, A., Clark, D. N., & Pell, J. P. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww096 · Cited by 28
Relationship between vitamin D deficiency and psychophysiological variables: a systematic review of the literature
Silva, M. R. M., Barros, W. M. A., da Silva, M. L., da Silva, J. M. L., Souza, A. P. D. S., da Silva, A. B. J., Fernandes, M. S. D. S., de Souza, S. L., & Souza, V. D. O. N. (2021) · Clinics · doi:10.6061/clinics/2021/e3155 · Cited by 28
Practitioner’s review: medication for children and adolescents with autism spectrum disorder (ASD) and comorbid conditions
Popow, C., Ohmann, S., & Plener, P. L. (2021) · Neuropsychiatrie · doi:10.1007/s40211-021-00395-9 · Cited by 37
Omega-3 polyunsaturated fatty acids and/or vitamin D in autism spectrum disorders: a systematic review
Jiang, Y., Dang, W., Hong, N., Kong, X., Jiang, Z., & Guo, J. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1238973 · Cited by 30
Vitamin D Supplementation Rescues Aberrant NF-κB Pathway Activation and Partially Ameliorates Rett Syndrome Phenotypes inMecp2Mutant Mice
Ribeiro, M. C., Moore, S. M., Kishi, N., Macklis, J. D., & MacDonald, J. L. (2020) · eNeuro · doi:10.1523/eneuro.0167-20.2020 · Cited by 25
Fluctuations in clinical symptoms with changes in serum 25(OH) vitamin D levels in autistic children: Three cases report
Jia, F., Shan, L., Wang, B., Li, H., Feng, J., Xu, Z., & Saad, K. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1458421 · Cited by 25
Self-citation
Vitamin D‐related genes are subjected to significant de novo mutation burdens in autism spectrum disorder
Li, J., Wang, L., Yu, P., Shi, L., Zhang, K., Sun, Z. S., & Xia, K. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32543 · Cited by 22
The Association Between Serum Vitamin D3 Levels and Autism Among Jordanian Boys
Alzghoul, L., AL-Eitan, L. N., Aladawi, M., Odeh, M., & Hantash, O. A. (2019) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-019-04017-w · Cited by 23
Autism Spectrum Disorder Interventions in Mainland China: a Systematic Review
Sullivan, O. A., & Wang, C. (2019) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-019-00191-w · Cited by 22
Brain region-dependent gene networks associated with selective breeding for increased voluntary wheel-running behavior
Zhang, P., Rhodes, J. S., Garland, T., Perez, S. D., Southey, B. R., & Rodriguez‐Zas, S. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201773 · Cited by 21
Vitamin D and omega-3 fatty acid supplements in children with autism spectrum disorder: a study protocol for a factorial randomised, double-blind, placebo-controlled trial
Mazahery, H., Conlon, C. A., Beck, K. L., Kruger, M. C., Stonehouse, W., Camargo, C. A., Meyer, B. J., Tsang, B., Mugridge, O., & von Hurst, P. R. (2016) · Trials · doi:10.1186/s13063-016-1428-8 · Cited by 22
Role of Vitamin D in Autism Spectrum Disorder
Alzghoul, L. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191122092215 · Cited by 16
Nutrition in autism spectrum disorders: A review of evidences for an emerging central role in aetiology, expression, and management
Onaolapo, O. J., & Onaolapo, A. Y. (2018) · AIMS Medical Science · doi:10.3934/medsci.2018.2.122 · Cited by 16
Paving Plant‐Food‐Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder
Martins, N. A., Quispe, C., Kırkın, C., Şenol, E., Zuluğ, A., Özçelik, B., Ademiluyi, A. O., Oyeniran, O. H., Semwal, P., Kumar, M., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1131280 · Cited by 15
The metabolic role of vitamin D in children’s neurodevelopment: a network study
Marzio, M. D., Lasky-Su, J. A., Chu, S. H., Prince, N., Litonjua, A. A., Weiss, S. T., Kelly, R. S., & Glass, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-67835-8 · Cited by 21
Proteomic and transcriptional changes associated with MeCP2 dysfunction reveal nodes for therapeutic intervention in Rett syndrome
Marballi, K. K., & MacDonald, J. L. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105076 · Cited by 15
Oxidative stress and neuroimmune proteins in a mouse model of autism
Uddin, M. N., Mondal, T. K., Yao, Y., MANLEY, K. M., & Lawrence, D. A. (2023) · Cell Stress and Chaperones · doi:10.1007/s12192-023-01331-2 · Cited by 17
Blunted serum 25(OH)D response to vitamin D3supplementation in children with autism
Kerley, C. P., Elnazir, B., Greally, P., & Coghlan, D. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1529342 · Cited by 16
Do Autism Spectrum and Autoimmune Disorders Share Predisposition Gene Signature Due to mTOR Signaling Pathway Controlling Expression?
Trifonova, E. A., Klimenko, A. I., Мустафин, З. С., Lashin, S. A., & Kochetov, A. V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105248 · Cited by 14
Successive clinical application of vitamin D and bumetanide in children with autism spectrum disorder
Feng, J., Li, H., Wang, B., Shan, L., & Jia, F. (2020) · Medicine · doi:10.1097/md.0000000000018661 · Cited by 12
Self-citation
Genomics as a Clinical Decision Support Tool: Successful Proof of Concept for Improved ASD Outcomes
Way, H., Williams, G. E., Hausman-Cohen, S., & Reeder, J. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11070596 · Cited by 12
Vitamin D deficiency is not related to eating habits in children with Autistic Spectrum Disorder
Riccio, M. P., Catone, G., Siracusano, R., Occhiati, L., Bernardo, P., Sarnataro, E., Corrado, G., & Bravaccio, C. (2020) · AIMS Public Health · doi:10.3934/publichealth.2020061 · Cited by 12
A Probable Way Vitamin D Affects Autism Spectrum Disorder: The Nitric Oxide Signaling Pathway
Wang, B., Dong, H., Li, H., Yue, X., & Xie, L. Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.908895 · Cited by 12
Self-citation
Biological pathways associated with vitamins in autism spectrum disorder
Gusso, D., Prauchner, G. R. K., Rieder, A. S., & Wyse, A. T. S. (2023) · Neurotoxicity Research · doi:10.1007/s12640-023-00674-z · Cited by 10
Dietary pattern in autism increases the need for probiotic supplementation: A comprehensive narrative and systematic review on oxidative stress hypothesis
Zarezadeh, M., Mahmoudinezhad, M., Hosseini, B., Khorraminezhad, L., Razaghi, M., Alvandi, E., & Saedisomeolia, A. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.014 · Cited by 12
Molecular mechanisms of autism as a form of synaptic dysfunction
Trifonova, E. A., Khlebodarova, T. M., & Gruntenko, N. E. (2017) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059717080020 · Cited by 10
A review of prevalence studies of Autism Spectrum Disorder by latitude and solar irradiance impact
Syed, S., Moore, K., & March, E. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.09.012 · Cited by 10
Effects of vitamin D on brain function in preschool children with autism spectrum disorder: a resting-state functional MRI study
Tian, P., Zhu, X., Liu, Z., Bian, B., Jia, F., Dou, L., Jie, Y., Lv, X., Zhao, T., & Li, D. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06534-8 · Cited by 9
Self-citation
The role and impact of abnormal vitamin levels in autism spectrum disorders
Cui, J., Zhai, Z., Wang, S., Song, X., Qiu, T., Yu, L., Zhai, Q., & Zhang, H. (2024) · Food & Function · doi:10.1039/d3fo03735e · Cited by 11
Nutritional and environmental contributions to autism spectrum disorders: Focus on nutrigenomics as complementary therapy
Jaureguiberry, S., & Venturino, A. (2020) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000630 · Cited by 9
Immune Modulatory Treatments for Autism Spectrum Disorder
Thom, R. P., & McDougle, C. J. (2020) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2020.100836 · Cited by 9
A vitamin D enriched diet attenuates sex-specific behavioral deficits, increases the lifespan, but does not rescue bone abnormalities in a mouse model of cortical dysplasia
Womble, P. D., Hodges, S. L., Nolan, S. O., Binder, M. S., Holley, A. J., Herrera, R., Senger, S., Kwok, E. M., Narviaz, D. A., Faust, A. M., et al. (2021) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2021.108297 · Cited by 7
Reduced growth during early infancy in very low birth weight children with autism spectrum disorder
Ikejiri, K., Hosozawa, M., Mitomo, S., Tanaka, K., & Shimizu, T. (2016) · Early Human Development · doi:10.1016/j.earlhumdev.2016.05.001 · Cited by 9
Vitamin D Deficiency in Children with Psychiatric Illness in a Tertiary Care Hospital in North India
Chauhan, N., Padhy, S. K., Shah, R., & Malhotra, S. (2019) · Journal of Neurosciences in Rural Practice · doi:10.4103/jnrp.jnrp_169_18 · Cited by 6
Rickets treatment improves more than bone health in toddler with autism spectrum disorder: A brief report
Stalnaker, L., Prasher, P., & Flesher, S. (2019) · SAGE Open Medical Case Reports · doi:10.1177/2050313x19870026 · Cited by 5
Genes Positively Selected in Domesticated Mammals Are Significantly Dysregulated in the Blood of Individuals with Autism Spectrum Disorders
Benítez‐Burraco, A. (2019) · Molecular Syndromology · doi:10.1159/000505116 · Cited by 4
Vitamin D and Autism Spectrum Disorder: An Intriguing Association
Siddiqui, R. W., Siddiqui, T. W., & Siddiqui, S. W. (2024) · Annals of Child Neurology · doi:10.26815/acn.2023.00353 · Cited by 4
Autism Spectrum Disorder
Harrington, J. W., & Bora, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00008-6 · Cited by 4
DIETARY APPROACHES AND NUTRITIONAL SUPPLEMENTS IN THE MANAGEMENT OF AUTISM SPECTRUM DISORDER
Adıgüzel, E., & Çiçek, B. (2023) · Editora Científica Digital eBooks · doi:10.37885/230613484 · Cited by 3
A Review of Therapeutic Approaches for Autism Spectrum Disorder
Hai, Y., Bai, S., Qiao, H., Li, D., Wang, D., & Xia, M. (2025) · Brain Sciences · doi:10.3390/brainsci15121280 · Cited by 5
Autismo: aspectos nutrológicos das dietas e possível etiologia
Anderle, T., & de Mello, E. D. (2018) · International Journal of Nutrology · doi:10.1055/s-0038-1670668 · Cited by 4
Role of nutritional deficiency in the development of autism spectrum disorders
Oommen, A., & AlOmar, R. S. (2020) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20201959 · Cited by 4
Vitamin D in the prevention and treatment of comorbid conditions in Duchenne muscular dystrophy
Андреевна, Г. Т., Souslov, V. M., Ержановна, С. Г., & Stepanov, A. A. (2021) · L O Badalyan Neurological Journal · doi:10.46563/2686-8997-2021-2-1-38-50 · Cited by 3

Authors: Jia, F., Wang, B., Shan, L., Xu, Z., Staal, W. G., & Du, L.
Affiliations: First Hospital of Jilin University (CN)
University Medical Center Utrecht (NL)
Radboud University Medical Center (NL)
Corresponding author: Du, Lin
ORCID: Jia, Feiyong
Wang, Bing
Shan, Ling
Xu, Zhida
Staal, Wouter G.
Du, Lin
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 2015-01-01
Volume: 135
Issue: 1
Pages: e196-e198
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.2014-2121
OpenAlex: W2124239189
Cited by: 145
References: 25
Citations by year: 2026: 5 · 2025: 6 · 2024: 6 · 2023: 15 · 2022: 7 · 2021: 14 · 2020: 22 · 2019: 13 · 2018: 17 · 2017: 17 · 2016: 17 · 2015: 6
FWCI: 9.90
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords: autism spectrum disorder, vitamin D3 deficiency, vitamin D3 supplementation, 25-hydroxyvitamin D3, core autism symptoms, brain development, environmental risk factors
MeSH terms: Child Development Disorders, Pervasive, Child, Preschool, Cholecalciferol, Humans, Male, Vitamin D Deficiency, Vitamins, Treatment Outcome, Dietary Supplements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Core Symptoms of Autism Improved After Vitamin D Supplementation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks