The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Immunomodulatory and antimicrobial effects of vitamin C
Open accessAbstract
Humans have lost their vitamin C-synthesizing capacities during evolution. Therefore, the uptake of this essential compound from external sources is mandatory in order to prevent vitamin C-deficient conditions resulting in severe morbidities such as scurvy. The potent antioxidant, immunomodulatory, and antiinfectious effects of vitamin C are known since the 1930s. We here (i) review the impact of vitamin C on innate and adaptive immune functions, (ii) provide an overview of its antimicrobial, antibacterial, antiviral, antiparasitic, and antifungal properties, and finally, (iii) discuss vitamin C as an adjunct treatment option for the combat of human infections by bacteria, particularly by emerging multidrug-resistant species.
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Citations
Cites
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417 · cited 1×
“…from oxidative damage, neutrophils accumulate millimolar (mM) concentrations of vitamin C [65], resulting in improved cellular motility and migration in response of chemotactic stimuli [66] and, subsequently, in enhanced phagocytosis of microbes and generation of reactive oxygen species (ROS) [17].”
BackgroundCarr, A. C., & Frei, B. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1086 · Cited by 940
A family of mammalian Na+-dependent L-ascorbic acid transporters
Tsukaguchi, H., Tokui, T., Mackenzie, B., Berger, U. V., Chen, X.-Z., Wang, Y., Brubaker, R. F., & Hediger, M. A. (1999) · Nature · doi:10.1038/19986 · Cited by 882
A new recommended dietary allowance of vitamin C for healthy young women
Levine, M., Wang, Y., Padayatty, S. J., & Morrow, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171318198 · Cited by 496
Hemilä, H. (2017) · Nutrients · doi:10.3390/nu9040339 · Cited by 461
SVCT1 and SVCT2: Key proteins for vitamin C uptake
Savini, I., Rossi, A., Pierro, C., Avigliano, L., & Catani, M. V. (2008) · Amino Acids · doi:10.1007/s00726-007-0555-7 · Cited by 358
Telang, P. S. (2013) · Indian Dermatology Online Journal · doi:10.4103/2229-5178.110593 · Cited by 244
Ascorbic Acid: Its Role in Immune System and Chronic Inflammation Diseases
Sorice, A., Guerriero, E., Capone, F., Colonna, G., Castello, G., & Costantini, S. (2014) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557514666140428112602 · Cited by 212
Kuiper, C., & Vissers, M. C. M. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00359 · Cited by 163
Rajan, D. P., Huang, W., Dutta, B., Devoe, L. D., Leibach, F. H., Ganapathy, V., & Prasad, P. D. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1272 · Cited by 162
Cited by
Alberts, A., Moldoveanu, E.-T., Niculescu, A.-G., & Grumezescu, A. M. (2025) · Molecules · doi:10.3390/molecules30030748 · Cited by 161
Trends in Vitamin C consumption in the United States: 1999-2018
Brauchla, M., Dekker, M. J., & Rehm, C. D. (2021) · Nutrients · doi:10.3390/nu13020420 · Cited by 35
Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors
Zhang, X., Li, H., Lv, X., Hu, L., Li, W., Zi, M., & He, Y. (2022) · Life · doi:10.3390/life12030409 · Cited by 18
Metadata
- Authors
- Mousavi, S., Bereswill, S., & Heimesaat, M. M.
- Venue
- European Journal of Microbiology and Immunology
- Publisher
- Akademiai Kiado Zrt.
- Published
- 2019-09
- Volume
- 9
- Issue
- 3
- Pages
- 73-79
- ISSN
- 2062-509X (ISSN-L)
- 2062-8633
- OpenAlex
- W2968212857
- Cited by
- 266
- References
- 12
- FWCI
- 21.94
- Type
- journal article
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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