Cited by 165Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesFamily and Disability Support Research

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Early Identification of Autism Spectrum Disorder Among Children Aged 4 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018

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Abstract

PROBLEM/CONDITION: Autism spectrum disorder (ASD). PERIOD COVERED: 2018. DESCRIPTION OF SYSTEM: The Autism and Developmental Disabilities Monitoring Network is an active surveillance program that estimates ASD prevalence and monitors timing of ASD identification among children aged 4 and 8 years. This report focuses on children aged 4 years in 2018, who were born in 2014 and had a parent or guardian who lived in the surveillance area in one of 11 sites (Arizona, Arkansas, California, Georgia, Maryland, Minnesota, Missouri, New Jersey, Tennessee, Utah, and Wisconsin) at any time during 2018. Children were classified as having ASD if they ever received 1) an ASD diagnostic statement (diagnosis) in an evaluation, 2) a special education classification of ASD (eligibility), or 3) an ASD International Classification of Diseases (ICD) code. Suspected ASD also was tracked among children aged 4 years. Children who did not meet the case definition for ASD were classified as having suspected ASD if their records contained a qualified professional's statement indicating a suspicion of ASD. RESULTS: For 2018, the overall ASD prevalence was 17.0 per 1,000 (one in 59) children aged 4 years. Prevalence varied from 9.1 per 1,000 in Utah to 41.6 per 1,000 in California. At every site, prevalence was higher among boys than girls, with an overall male-to-female prevalence ratio of 3.4. Prevalence of ASD among children aged 4 years was lower among non-Hispanic White (White) children (12.9 per 1,000) than among non-Hispanic Black (Black) children (16.6 per 1,000), Hispanic children (21.1 per 1,000), and Asian/Pacific Islander (A/PI) children (22.7 per 1,000). Among children aged 4 years with ASD and information on intellectual ability, 52% met the surveillance case definition of co-occurring intellectual disability (intelligence quotient ≤70 or an examiner's statement of intellectual disability documented in an evaluation). Of children aged 4 years with ASD, 72% had a first evaluation at age ≤36 months. Stratified by census-tract-level median household income (MHI) tertile, a lower percentage of children with ASD and intellectual disability was evaluated by age 36 months in the low MHI tertile (72%) than in the high MHI tertile (84%). Cumulative incidence of ASD diagnosis or eligibility received by age 48 months was 1.5 times as high among children aged 4 years (13.6 per 1,000 children born in 2014) as among those aged 8 years (8.9 per 1,000 children born in 2010). Across MHI tertiles, higher cumulative incidence of ASD diagnosis or eligibility received by age 48 months was associated with lower MHI. Suspected ASD prevalence was 2.6 per 1,000 children aged 4 years, meaning for every six children with ASD, one child had suspected ASD. The combined prevalence of ASD and suspected ASD (19.7 per 1,000 children aged 4 years) was lower than ASD prevalence among children aged 8 years (23.0 per 1,000 children aged 8 years). INTERPRETATION: Groups with historically lower prevalence of ASD (non-White and lower MHI) had higher prevalence and cumulative incidence of ASD among children aged 4 years in 2018, suggesting progress in identification among these groups. However, a lower percentage of children with ASD and intellectual disability in the low MHI tertile were evaluated by age 36 months than in the high MHI group, indicating disparity in timely evaluation. Children aged 4 years had a higher cumulative incidence of diagnosis or eligibility by age 48 months compared with children aged 8 years, indicating improvement in early identification of ASD. The overall prevalence for children aged 4 years was less than children aged 8 years, even when prevalence of children suspected of having ASD by age 4 years is included. This finding suggests that many children identified after age 4 years do not have suspected ASD documented by age 48 months. PUBLIC HEALTH ACTION: Children born in 2014 were more likely to be identified with ASD by age 48 months than children born in 2010, indicating increased early identification. However, ASD identification among children aged 4 years varied by site, suggesting opportunities to examine developmental screening and diagnostic practices that promote earlier identification. Children aged 4 years also were more likely to have co-occurring intellectual disability than children aged 8 years, suggesting that improvement in the early identification and evaluation of developmental concerns outside of cognitive impairments is still needed. Improving early identification of ASD could lead to earlier receipt of evidence-based interventions and potentially improve developmental outcomes.

Overview

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Written from the paper’s full text.

TL;DR

For 2018 ADDM Network surveillance, ASD prevalence among children aged 4 years across 11 sites was 17.0 per 1,000 (1 in 59), ranging from 9.1 per 1,000 in Utah to 41.6 per 1,000 in California. Early identification improved compared with children born in 2010, but timely evaluation disparities persisted for children with ASD and intellectual disability in the low median household income tertile.

Key findings

  • Overall ASD prevalence was 17.0 per 1,000 children aged 4 years; male-to-female prevalence ratio was 3.4 (25.9 vs. 7.7 per 1,000). By race/ethnicity, prevalence was 12.9 per 1,000 among White children, 16.6 among Black children, 21.1 among Hispanic children, 22.7 among Asian/Pacific Islander children, and 11.5 among American Indian/Alaska Native children.
  • Among children with ASD and available intellectual ability information, 51.6% had co-occurring intellectual disability; 72% had their earliest recorded evaluation by age 36 months. Among children with ASD and intellectual disability, 72% in the low MHI tertile were evaluated by age 36 months versus 84% in the high MHI tertile.
  • Cumulative incidence of ASD diagnosis or eligibility by age 48 months was 13.6 per 1,000 for children born in 2014 versus 8.9 per 1,000 for children born in 2010, a 1.5 times higher incidence in the younger cohort. Suspected ASD prevalence was 2.6 per 1,000, and combined ASD plus suspected ASD prevalence was 19.7 per 1,000, still lower than ASD prevalence among children aged 8 years (23.0 per 1,000).
  • Cumulative incidence by age 48 months was 13.8, 12.8, and 11.7 per 1,000 among low, middle, and high MHI tertiles, respectively, indicating higher ASD identification with lower MHI.

Methods

  • Active population-based surveillance in 11 ADDM Network sites (Arizona, Arkansas, California, Georgia, Maryland, Minnesota, Missouri, New Jersey, Tennessee, Utah, and Wisconsin) among children aged 4 years in 2018, born in 2014, with a parent or guardian living in the surveillance area at least one day during 2018; total denominator was 220,394 and 3,754 children met the ASD case definition.
  • Children met the ASD case definition if they ever received an ASD diagnostic statement, special education classification of ASD, or ASD ICD-9 code 299.00–299.99 or ICD-10 F84 code; suspected ASD was classified when records contained a qualified professional’s statement indicating suspicion of ASD without meeting the ASD case definition. Records were linked to health, education, birth certificate, and census-tract median household income data.
  • Prevalence was calculated per 1,000 with Wilson 95% CIs; prevalence ratios compared sex and race/ethnicity groups; cumulative incidence by month of age compared children aged 4 years with children aged 8 years; risk ratios and Cochran-Armitage tests assessed differences and trends across MHI tertiles; analyses used R version 4.0.3.

Limitations

  • Stated in the paper: surveillance area populations are subsets of state populations and not necessarily generalizable to entire states or the United States; sample size, demographics, and practices/policies vary among sites; differences in sites or study areas complicate comparisons over time; data completeness varied across sites; and the surveillance case definition of intellectual disability is not the same as a clinical diagnosis, with IQ measurements potentially unstable and younger children possibly not receiving an intellectual disability diagnosis.
  • Evident from the text: the 2018 ASD case definition no longer required clinician review of records, which could affect prevalence estimates and comparisons, including possibly contributing to higher prevalence among Black and Hispanic children.
  • Evident from the text: the ADDM Network collected data about children evaluated for and identified with ASD but not about screening and referrals, limiting interpretation of barriers to timely and equitable identification.

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Integrity signals

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Crossref · 10.15585/mmwr.ss7010a1

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    Non-White and lower median household income groups have historically had lower ASD prevalence.

    “Groups with historically lower prevalence of ASD (non-White and lower MHI) had higher prevalence and cumulative incidence of ASD among children aged 4 years in 2018, suggesting progress in identification among these groups.”
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Metadata

Authors
Shaw, K. A., Maenner, M. J., Bakian, A. V., Bilder, D. A., Durkin, M. S., Furnier, S. M., Hughes, M. M., Patrick, M., Pierce, K., Salinas, A., Shenouda, J., Vehorn, A., Warren, Z., Zahorodny, W., Constantino, J. N., DiRienzo, M., Esler, A., Fitzgerald, R. T., Grzybowski, A., Hudson, A., Spivey, M. H., Ali, A., Andrews, J. G., Baroud, T., Gutierrez, J., Hallas, L., Hall-Lande, J., Hewitt, A., Lee, L.-C., Lopez, M., Mancilla, K. C., McArthur, D., Pettygrove, S., Poynter, J. N., Schwenk, Y. D., Washington, A., Williams, S., & Cogswell, M. E.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • University of Utah (US)
  • University of Wisconsin–Madison (US)
  • University of California San Diego (US)
  • Rutgers New Jersey Medical School (US)
  • Vanderbilt University Medical Center (US)
  • Washington University in St. Louis (US)
  • University of Minnesota (US)
  • University of Arkansas for Medical Sciences (US)
  • Johns Hopkins University (US)
  • University of Arizona (US)
Corresponding author
Shaw, Kelly A.
Venue
MMWR. Surveillance Summaries
Published
2021-12-03
Volume
70
Issue
10
Pages
1-14
ISSN
  • 1545-8636 (ISSN-L)
  • 1546-0738
OpenAlex
W3216090687
Cited by
165
References
22
Citations by year
2026: 7 · 2025: 50 · 2024: 31 · 2023: 48 · 2022: 28 · 2021: 1
FWCI
14.20
Type
journal article
Language
en
Open access
Licence
public-domain
Locations
  • MMWR Surveillance Summaries (publishedVersion, public-domain)
  • PubMed Central (publishedVersion, public-domain)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD103537)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
Keywords
autism spectrum disorder, autism prevalence, early detection, racial and ethnic disparities, sex differences, household income, special education eligibility, intellectual disability
MeSH terms
Autism Spectrum Disorder, Child, Preschool, Female, Humans, Male, Population Surveillance, United States, Early Diagnosis, Epidemiological Monitoring

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