Cited by 179Curcumin's Biomedical ApplicationsAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

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Clinical development of curcumin in neurodegenerative disease

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Hu, Shuxin, Maiti, Panchanan, Ma, Qiulan, Zuo, Xiaohong, Jones, Mychica R, Cole, Greg M, Frautschy, Sally A·2015·Expert Review of Neurotherapeutics

DOI 10.1586/14737175.2015.1044981PMC PMC6800094

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Abstract

Curcumin, a polyphenolic antioxidant derived from the turmeric root has undergone extensive preclinical development, showing remarkable efficacy in wound repair, cancer and inflammatory disorders. This review addresses the rationale for its use in neurodegenerative disease, particularly Alzheimer's disease. Curcumin is a pleiotropic molecule, which not only directly binds to and limits aggregation of the β-sheet conformations of amyloid characteristic of many neurodegenerative diseases but also restores homeostasis of the inflammatory system, boosts the heat shock system to enhance clearance of toxic aggregates, scavenges free radicals, chelates iron and induces anti-oxidant response elements. Although curcumin corrects dysregulation of multiple pathways, it may exert many effects via a few molecular targets. Pharmaceutical development of natural compounds like curcumin and synthetic derivatives have strong scientific rationale, but will require overcoming various hurdles including; high cost of trials, concern about profitability and misconceptions about drug specificity, stability, and bioavailability.

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Authors: Hu, S., Maiti, P., Ma, Q., Zuo, X., Jones, M. R., Cole, G. M., & Frautschy, S. A.
Affiliations: VA Greater Los Angeles Healthcare System (US)
University of California, Los Angeles (US)
Corresponding author: Frautschy, Sally A
ORCID: Hu, Shuxin
Maiti, Panchanan
Jones, Mychica R
Frautschy, Sally A
Venue: Expert Review of Neurotherapeutics
Publisher: Informa UK Limited
Published: 2015-06-02
Volume: 15
Issue: 6
Pages: 629-637
ISSN: 1473-7175 (ISSN-L)
1744-8360
DOI: 10.1586/14737175.2015.1044981
PMC: PMC6800094
OpenAlex: W1877722768
Cited by: 179
References: 101
Citations by year: 2026: 6 · 2025: 11 · 2024: 18 · 2023: 16 · 2022: 12 · 2021: 19 · 2020: 26 · 2019: 17 · 2018: 20 · 2017: 20 · 2016: 11 · 2015: 3
FWCI: 1.28
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Expert Review of Neurotherapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs (I01 RX000669, I01 BX001257)
National Institute on Aging (U01AG028583, R01AG021975)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: curcumin, neurodegenerative diseases, Alzheimer's disease, amyloid fibril formation, anti-inflammatory activity, heat shock response, antioxidant activity, iron chelation, drug development, bioavailability, natural product derivatives
MeSH terms: Anti-Inflammatory Agents, Non-Steroidal, Brain, Curcumin, Humans, Models, Biological, Retina, Amyloid beta-Peptides, tau Proteins, Neurodegenerative Diseases

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